Corrigendum
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Tags: Corrigendum Source Type: research

Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation
Conclusions SMC autonomous Runx2 is required for SMC differentiation towards osteoblast-like cells, SMC-derived chondrocyte maturation and AIC in atherosclerotic mice. These effects were independent of systemic lipid metabolism, RANKL expression, macrophage infiltration, and atheromatous lesion progression. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Authors: Lin, M.-E., Chen, T. M., Wallingford, M. C., Nguyen, N. B., Yamada, S., Sawangmake, C., Zhang, J., Speer, M. Y., Giachelli, C. M. Tags: Vascular biology Source Type: research

Increased activity of vascular adenosine deaminase in atherosclerosis and therapeutic potential of its inhibition
Conclusions This study highlights the importance of extracellular nucleotides and adenosine metabolism in the atherosclerotic vessel in both experimental and clinical setting. The increased eADA activity marks an early stage of atherosclerosis, contributes to its progression and could represent a novel target for therapy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Authors: Kutryb-Zajac, B., Mateuszuk, L., Zukowska, P., Jasztal, A., Zabielska, M. A., Toczek, M., Jablonska, P., Zakrzewska, A., Sitek, B., Rogowski, J., Lango, R., Slominska, E. M., Chlopicki, S., Smolenski, R. T. Tags: Vascular biology Source Type: research

MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension
Conclusion This study is the first to define a role for aberrant miR153 contributing to the hypertensive state through targeting of KCNQ4 in an animal model of hypertension, raising the possibility of the use of miR153-related therapies in vascular disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Authors: Carr, G., Barrese, V., Stott, J. B., Povstyan, O. V., Jepps, T. A., Figueiredo, H. B., Zheng, D., Jamshidi, Y., Greenwood, I. A. Tags: Vascular biology Source Type: research

Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis
Conclusions Notch signalling pathway inactivation decreases leucocyte rolling, thereby preventing endothelial dysfunction and vascular inflammation. Attenuation of Notch signalling might provide a treatment strategy for atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Authors: Nus, M., Martinez-Poveda, B., MacGrogan, D., Chevre, R., DAmato, G., Sbroggio, M., Rodriguez, C., Martinez-Gonzalez, J., Andres, V., Hidalgo, A., de la Pompa, J. L. Tags: Vascular biology Source Type: research

The nuclear pore protein Nup153 associates with chromatin and regulates cardiac gene expression in dystrophic mdx hearts
Conclusions Our data indicate that Nup153 is an epigenetic regulator which, upon altered NO signalling, mediates the activation of genes potentially associated with early dystrophic cardiac remodelling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Authors: Nanni, S., Re, A., Ripoli, C., Gowran, A., Nigro, P., DAmario, D., Amodeo, A., Crea, F., Grassi, C., Pontecorvi, A., Farsetti, A., Colussi, C. Tags: Cardiac biology and remodelling Source Type: research

Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy
Conclusion Our studies demonstrate that the expression of many lncRNAs is dynamically regulated in ICM. lncRNAs regulate the expression and function of ECM and cardiac fibrosis during the development of ICM. Our results further indicate that lncRNAs may represent novel regulators of heart function and cardiac disorders, including ICM. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Authors: Huang, Z.-P., Ding, Y., Chen, J., Wu, G., Kataoka, M., Hu, Y., Yang, J.-H., Liu, J., Drakos, S. G., Selzman, C. H., Kyselovic, J., Qu, L.-H., dos Remedios, C. G., Pu, W. T., Wang, D.-Z. Tags: Cardiac biology and remodelling Source Type: research

Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice
Conclusions We demonstrate for the first time that Sema6D is a target of BMP signalling and that Semaphorin signalling is essential for the initiation of cushion mesenchymal cell formation in the AV canal. Our study reveals a novel BMP-Sema6D-Rho axis regulating AV cushion development. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Authors: Peng, Y., Song, L., Li, D., Kesterson, R., Wang, J., Wang, L., Rokosh, G., Wu, B., Wang, Q., Jiao, K. Tags: Cardiac biology and remodelling Source Type: research

MiR-153/Kv7.4: a novel molecular axis in the regulation of hypertension
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Authors: Maffei, A., Di Mauro, V., Catalucci, D., Lembo, G. Tags: Invited Editorials Source Type: research

Rules of attraction: endothelial Notch signalling controls leucocyte homing in atherosclerosis via VCAM1
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2016 Category: Cardiology Authors: Gamrekelashvili, J., Limbourg, F. P. Tags: Invited Editorials Source Type: research

TSP1–CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction
ConclusionsIn pre-clinical models of PH CD47 targets cMyc to increase ET-1 signaling. In clinical PH TSP1–CD47 is upregulated, and in both, contributes to pulmonary arterial vasculopathy and dysfunction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2016 Category: Cardiology Source Type: research

Attenuation of carotid neointimal formation after direct delivery of a recombinant adenovirus expressing glucagon-like peptide-1 in diabetic rats
AimsEnhancement of glucagon-like peptide-1 (GLP-1) reduces glucose levels and preserves pancreatic β-cell function, but its effect against restenosis is unknown.Methods and resultsWe investigated the effect of subcutaneous injection of exenatide or local delivery of a recombinant adenovirus expressing GLP-1 (rAd-GLP-1) into carotid artery, in reducing the occurrence of restenosis following balloon injury. As a control, we inserted β-galactosidase cDNA in the same vector (rAd-βGAL). Otsuka Long-Evans Tokushima rats were assigned to three groups (n = 12 each): (1) normal saline plus rAd-βGAL...
Source: Cardiovascular Research - October 4, 2016 Category: Cardiology Source Type: research

At the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries
ConclusionsThese results indicate that Cx43 hemichannels contribute to SMC Ca2+ dynamics and contractility, by facilitating Ca2+ entry, ATP release, and purinergic signalling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 27, 2016 Category: Cardiology Source Type: research

Corrigendum
(Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Tags: Corrigendum Source Type: research

The angiotensin II type 2 receptor activates flow-mediated outward remodelling through T cells-dependent interleukin-17 production
Conclusion AT2R-dependent interleukin-17 production by T lymphocyte is necessary for collateral artery growth and could represent a new therapeutic target in ischaemic disorders. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: Caillon, A., Grenier, C., Grimaud, L., Vessieres, E., Guihot, A.-L., Blanchard, S., Lelievre, E., Chabbert, M., Foucher, E. D., Jeannin, P., Beauvillain, C., Abraham, P., Loufrani, L., Delneste, Y., Henrion, D. Tags: Vascular Biology Source Type: research

A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice
Conclusion Selective LXR activation in macrophages with NLB induces ABCA1- and ABCG1-mediated cholesterol efflux while exerting minimal effects on lipogenesis and lipid accumulation in liver, resulting in regression of atherosclerosis, and therefore might be a promising strategy for therapeutics. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: Gui, Y., Yao, S., Yan, H., Hu, L., Yu, C., Gao, F., Xi, C., Li, H., Ye, Y., Wang, Y. Tags: Vascular Biology Source Type: research

Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes
Conclusions Stimulation of IP3Rs with ET-1 induces Ca2+ release from the SR which is tunnelled to mitochondria via mitochondrial RyR leading to stimulation of mitochondrial ATP production. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: Seidlmayer, L. K., Kuhn, J., Berbner, A., Arias-Loza, P.-A., Williams, T., Kaspar, M., Czolbe, M., Kwong, J. Q., Molkentin, J. D., Heinze, K. G., Dedkova, E. N., Ritter, O. Tags: Cardiac biology and remodelling Source Type: research

Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/{beta}-catenin inhibition
Conclusions Exogenous or paracrine sources of NO promote the specification towards the myocyte lineage and expression of cardiac sarcomeric proteins of adult CPC. This is contingent upon the expression and activity of the alpha1 subunit of guanylyl cyclase in CPC that is necessary for NO-mediated inhibition of the canonical Wnt/β-catenin pathway. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: De Pauw, A., Massion, P., Sekkali, B., Andre, E., Dubroca, C., Kmecova, J., Bouzin, C., Friart, A., Sibille, C., Gilon, P., De Mulder, D., Esfahani, H., Strapart, A., Martherus, R., Payen, V., Sonveaux, P., Brouckaert, P., Janssens, S., Balligand, J.-L. Tags: Cardiac biology and remodelling Source Type: research

Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases
Conclusion By interrogating DNA methylation and gene expression data, we identify two novel mechanism contributing to the phenotypic expression of CHDs: aberrant methylation of promoter CpG islands and methylation alterations leading to differential splicing. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: Grunert, M., Dorn, C., Cui, H., Dunkel, I., Schulz, K., Schoenhals, S., Sun, W., Berger, F., Chen, W., Sperling, S. R. Tags: Cardiac biology and remodelling Source Type: research

A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism
Conclusion A mutation outside the mutational hotspot of RBM20 results in haploinsufficiency of RBM20. This leads to disturbed alternative splicing of TTN, resulting in a dramatic shift to highly compliant titin isoforms and an impaired FSM. These effects may contribute to the early onset, and malignant course of DCM caused by RBM20 mutations. Altogether, our results demonstrate that heterozygous loss of RBM20 suffices to profoundly impair myocyte biomechanics by its disturbance of TTN splicing. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: Beqqali, A., Bollen, I. A. E., Rasmussen, T. B., van den Hoogenhof, M. M., van Deutekom, H. W. M., Schafer, S., Haas, J., Meder, B., Sorensen, K. E., van Oort, R. J., Mogensen, J., Hubner, N., Creemers, E. E., van der Velden, J., Pinto, Y. M. Tags: Cardiac biology and remodelling Source Type: research

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
Conclusion Elevated wall stress reduces junctophilin-2 expression and disrupts t-tubule integrity, Ca2+ release, and contractile function. These findings provide new insight into the role of wall stress in promoting heart failure progression. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: Frisk, M., Ruud, M., Espe, E. K. S., Aronsen, J. M., Roe, A. T., Zhang, L., Norseng, P. A., Sejersted, O. M., Christensen, G. A., Sjaastad, I., Louch, W. E. Tags: Cardiac biology and remodelling Source Type: research

Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering
Proprotein convertase subtilisin kexin 9 (PCSK9) is a key regulator of low-density lipoprotein receptor levels and LDL-cholesterol levels. Loss-of-function mutations in PCSK9 gene are associated with hypocholesterolaemia and protection against cardiovascular disease, identifying PCSK9 inhibition as a valid therapeutic approach to manage hypercholesterolaemia and related diseases. Although PCSK9 is expressed mainly in the liver, it is present also in other tissues and organs with specific functions, raising the question of whether a pharmacological inhibition of PCSK9 to treat hypercholesterolaemia and associated cardiovasc...
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: Norata, G. D., Tavori, H., Pirillo, A., Fazio, S., Catapano, A. L. Tags: Review Source Type: research

Conflicting mechanisms of AT2 cardioprotection revealed
(Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: Altara, R., Didion, S. P., Booz, G. W. Tags: Invited Editorials Source Type: research

Cardiac t-tubules: where structural plasticity meets functional adaptation
(Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2016 Category: Cardiology Authors: Watson, S. A., Perbellini, F., Terracciano, C. M. Tags: Invited Editorials Source Type: research

Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent
Aim In healthy hearts, ventricular gap junctions are mainly composed by connexin43 (Cx43) and localize in the intercalated disc, enabling appropriate electrical coupling. In diseased hearts, Cx43 is heterogeneously down-regulated, whereas activity of calmodulin/calcium-calmodulin protein kinase II (CaM/CaMKII) signalling increases. It is unclear if CaM/CaMKII affects Cx43 expression/localization or impulse propagation. We analysed different models to assess this. Methods and results AC3-I mice with CaMKII genetically inhibited were subjected to pressure overload (16 weeks, TAC vs. sham). Optical and epicardial ma...
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Takanari, H., Bourgonje, V. J. A., Fontes, M. S. C., Raaijmakers, A. J. A., Driessen, H., Jansen, J. A., van der Nagel, R., Kok, B., van Stuijvenberg, L., Boulaksil, M., Takemoto, Y., Yamazaki, M., Tsuji, Y., Honjo, H., Kamiya, K., Kodama, I., Anderson, M Tags: Ion Channels and Arrhythmias Source Type: research

The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis
Conclusion These findings indicate that the AM-RAMP2 system regulates vascular integrity, whereas RAMP2 deletion promotes vascular permeability and EndMT-like change within primary lesions and formation of pre-metastatic niches in distant organs by destabilizing the vascular structure and inducing inflammation. Vascular integrity regulated by the AM-RAMP2 system could thus be a hopeful therapeutic target for suppressing tumour metastasis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Tanaka, M., Koyama, T., Sakurai, T., Kamiyoshi, A., Ichikawa-Shindo, Y., Kawate, H., Liu, T., Xian, X., Imai, A., Zhai, L., Hirabayashi, K., Owa, S., Yamauchi, A., Igarashi, K., Taniguchi, S., Shindo, T. Tags: Vascular Biology Source Type: research

B-cell-specific depletion of tumour necrosis factor alpha inhibits atherosclerosis development and plaque vulnerability to rupture by reducing cell death and inflammation
Conclusion We conclude that TNF-α produced by B2 cells is a key mechanism by which B2 cells promote atherogenesis through augmenting macrophage TNF-α production to induce cell death and inflammation that promote plaque vulnerability. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Tay, C., Liu, Y.-H., Hosseini, H., Kanellakis, P., Cao, A., Peter, K., Tipping, P., Bobik, A., Toh, B.-H., Kyaw, T. Tags: Vascular Biology Source Type: research

Expression and function of IL-1R8 (TIR8/SIGIRR): a regulatory member of the IL-1 receptor family in platelets
Conclusion These results show that platelets, which have a large repertoire of TLRs and IL-1 receptors, express high levels of IL-1R8, which plays a non-redundant function as a regulator of thrombocyte activity in vitro and in vivo. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Anselmo, A., Riva, F., Gentile, S., Soldani, C., Barbagallo, M., Mazzon, C., Feruglio, F., Polentarutti, N., Somma, P., Carullo, P., Angelini, C., Bacci, M., Mendolicchio, G. L., Voza, A., Nebuloni, M., Mantovani, A., Garlanda, C. Tags: Vascular Biology Source Type: research

Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure
Conclusion These results suggest that the alterations in mitochondrial function observed in right ventricular CH and HF can be mainly attributed to complex I dysfunction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Wüst, R. C. I., de Vries, H. J., Wintjes, L. T., Rodenburg, R. J., Niessen, H. W. M., Stienen, G. J. M. Tags: Cardiac biology and remodelling Source Type: research

Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling
Conclusion Induced overexpression of NCX1 attenuated pressure overload-induced pathological cardiac remodelling. Thus, maintaining NCX1 activity may be a potential therapeutic strategy for preventing the progression of HF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Ujihara, Y., Iwasaki, K., Takatsu, S., Hashimoto, K., Naruse, K., Mohri, S., Katanosaka, Y. Tags: Cardiac biology and remodelling Source Type: research

Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling
Conclusions A DPP-4 inhibitor may be a novel therapeutic agent against the exercise intolerance seen in HF patients by improving the mitochondrial biogenesis in their skeletal muscle. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Takada, S., Masaki, Y., Kinugawa, S., Matsumoto, J., Furihata, T., Mizushima, W., Kadoguchi, T., Fukushima, A., Homma, T., Takahashi, M., Harashima, S., Matsushima, S., Yokota, T., Tanaka, S., Okita, K., Tsutsui, H. Tags: Integrative physiology and pathophysiology Source Type: research

Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review
The aim of the present study is to identify microRNAs (miRs) with high potential to be used as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis for survival in, patients with atherosclerosis, coronary artery disease, and acute coronary syndrome (ACS). A systematic search of published original research yielded a total of 72 studies. After review of the risk of bias of the published studies, according to Cochrane Collaboration and the QUADUAS Group standards, 19 studies were selected. Overall 52 different miRs were reported. In particular, miR-133a/b (5 studies), miR-208a/b (6 studies),...
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Navickas, R., Gal, D., Laucevicius, A., Taparauskaite, A., Zdanyte, M., Holvoet, P. Tags: REVIEWS Source Type: research

Heterogeneity in the lymphatic vascular system and its origin
Lymphatic vessels have historically been viewed as passive conduits for fluid and immune cells, but this perspective is increasingly being revised as new functions of lymphatic vessels are revealed. Emerging evidence shows that lymphatic endothelium takes an active part in immune regulation both by antigen presentation and expression of immunomodulatory genes. In addition, lymphatic vessels play an important role in uptake of dietary fat and clearance of cholesterol from peripheral tissues, and they have been implicated in obesity and arteriosclerosis. Lymphatic vessels within different organs and in different physiologica...
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Ulvmar, M. H., Mäkinen, T. Tags: REVIEWS Source Type: research

Interleukin-1R8: balancing inflammation and hemostasis in platelets
(Source: Cardiovascular Research)
Source: Cardiovascular Research - August 24, 2016 Category: Cardiology Authors: Heinig, K., Sperandio, M. Tags: INVITED EDITORIAL Source Type: research

Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release
Conclusion Long-term effects of interval treadmill exercise training reduce ventricular tachycardia episodes in mice with a CPVT1-causative Ryr2 mutation through lower CaMKII-dependent phosphorylation of RyR2. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Manotheepan, R., Danielsen, T. K., Sadredini, M., Anderson, M. E., Carlson, C. R., Lehnart, S. E., Sjaastad, I., Stokke, M. K. Tags: Ion Channels and Arrhythmias Source Type: research

Elevated local [Ca2+] and CaMKII promote spontaneous Ca2+ release in ankyrin-B-deficient hearts
Conclusions The increased incidence of pro-arrhythmogenic Ca2+ sparks and waves in AnkB+/– hearts is due to enhanced CaMKII-mediated RyR phosphorylation, which is caused by higher junctional [Ca2+] and consequent local CaMKII activation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Popescu, I., Galice, S., Mohler, P. J., Despa, S. Tags: Ion Channels and Arrhythmias Source Type: research

Desmosomal junctions are necessary for adult sinus node function
Conclusion We provide evidence of a mechanism that implicates an essential role for desmosomes in cardiac pacemaker function, which has broad implications in better understanding mechanisms underlying beat-to-beat regulation as well as sinus node disease and dysfunction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Mezzano, V., Liang, Y., Wright, A. T., Lyon, R. C., Pfeiffer, E., Song, M. Y., Gu, Y., Dalton, N. D., Scheinman, M., Peterson, K. L., Evans, S. M., Fowler, S., Cerrone, M., McCulloch, A. D., Sheikh, F. Tags: Ion Channels and Arrhythmias Source Type: research

Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice
Conclusion Either Lcn2 deficiency or anti-Lcn2 antibody blockade limits AAA expansion in mice by decreasing PMN infiltration in the aorta. Lcn2 modulation may therefore be a viable new therapeutic option for the treatment of AAA. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Tarin, C., Fernandez-Garcia, C. E., Burillo, E., Pastor-Vargas, C., Llamas-Granda, P., Castejon, B., Ramos-Mozo, P., Torres-Fonseca, M. M., Berger, T., Mak, T. W., Egido, J., Blanco-Colio, L. M., Martin-Ventura, J. L. Tags: Vascular Biology Source Type: research

CD11b+Gr-1+ myeloid-derived suppressor cells reduce atherosclerotic lesion development in LDLr deficient mice
Conclusion This study demonstrates that MDSCs develop during atherosclerosis and reduce atherosclerosis via suppression of pro-inflammatory immune responses. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Foks, A. C., Van Puijvelde, G. H. M., Wolbert, J., Kröner, M. J., Frodermann, V., Van Der Heijden, T., Van Santbrink, P. J., Boon, L., Bot, I., Kuiper, J. Tags: Vascular Biology Source Type: research

Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform
Conclusions These findings establish that activation of the proteolytic processing of shCD146, in particular by sCD146, constitutes a promising pathway to improve endothelial progenitors' regenerative properties for the treatment of cardiovascular diseases. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Stalin, J., Harhouri, K., Hubert, L., Garrigue, P., Nollet, M., Essaadi, A., Muller, A., Foucault-Bertaud, A., Bachelier, R., Sabatier, F., Pisano, P., Peiretti, F., Leroyer, A. S., Guillet, B., Bardin, N., Dignat-George, F., Blot-Chabaud, M. Tags: Vascular Biology Source Type: research

Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling
Conclusion Under physiological conditions (i.e. with CO2/HCO3– present), NBCn1-mediated HCO3– uptake raises VSMC pHi and promotes filopodia, VSMC migration, and hypertrophic inward remodelling. We propose that axial pHi gradients enhance VSMC migration whereas global acidification inhibits VSMC proliferation and media hypertrophy after carotid artery ligation. These findings support a key role of acid–base transport, particularly via NBCn1, for development of occlusive artery disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Boedtkjer, E., Bentzon, J. F., Dam, V. S., Aalkjaer, C. Tags: Vascular Biology Source Type: research

Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development
Conclusions In contrast to in vitro studies, AKIP1 overexpression does not influence cardiac remodelling in response to chronic cardiac stress. AKIP1 does, however, reduce myocardial I/R injury through stabilization of the MPT pore. These findings suggest that AKIP1 deserves further investigation as a putative treatment target for cardioprotection from I/R injury during acute myocardial infarction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Booij, H. G., Yu, H., De Boer, R. A., van de Kolk, C. W. A., van de Sluis, B., Van Deursen, J. M., Van Gilst, W. H., Sillje, H. H. W., Westenbrink, B. D. Tags: Cardiac biology and remodelling Source Type: research

Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice
Conclusions Endothelial PTP1B deletion improves cardiac VEGF signalling and angiogenesis and protects against chronic afterload-induced heart failure. PTP1B may represent a useful target to preserve cardiac function during hypertrophy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Gogiraju, R., Schroeter, M. R., Bochenek, M. L., Hubert, A., Münzel, T., Hasenfuss, G., Schäfer, K. Tags: Cardiac biology and remodelling Source Type: research

The role of ADAMTS13 in acute myocardial infarction: cause or consequence?
Conclusions No correlation was found between VWF/ADAMTS13 and infarct size in patients. However, patients suffering from IMH had significantly higher VWF activity and lower ADAMTS13 activity. Intracoronary administration of rADAMTS13 did not decrease infarct size or IMH in a porcine model of myocardial ischaemia-reperfusion. These data dispute the imbalance in ADAMTS13 and VWF as the cause of no reflow. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Eerenberg, E. S., Teunissen, P. F. A., van den Born, B.-J., Meijers, J. C. M., Hollander, M. R., Jansen, M., Tijssen, R., Beliën, J. A. M., van de Ven, P. M., Aly, M. F., Kamp, O., Niessen, H. W., Kamphuisen, P. W., Levi, M., van Royen, N. Tags: Cardiac biology and remodelling Source Type: research

miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach
Conclusion These findings highlight the early role of pulmonary and right-ventricular miR-223 and the IGF-IR in the right heart failure programme initiated by pulmonary hypoxia and increased mechanical load and may lead to the development of novel therapeutic strategies that target the development of PH and right heart failure. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Shi, L., Kojonazarov, B., Elgheznawy, A., Popp, R., Dahal, B. K., Böhm, M., Pullamsetti, S. S., Ghofrani, H.-A., Gödecke, A., Jungmann, A., Katus, H. A., Müller, O. J., Schermuly, R. T., Fisslthaler, B., Seeger, W., Fleming, I. Tags: Integrative physiology and pathophysiology Source Type: research

Endothelial cell-cardiomyocyte crosstalk in diabetic cardiomyopathy
The incidence of diabetes is increasing globally, with cardiovascular disease accounting for a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease is a primary reason for this cardiovascular dysfunction, heart failure in patients with diabetes might also be an outcome of an intrinsic heart muscle malfunction, labelled diabetic cardiomyopathy. Changes in cardiomyocyte metabolism, which encompasses a shift to exclusive fatty acid utilization, are considered a leading stimulus for this cardiomyopathy. In addition to cardiomyocytes, endothelial cells (ECs) make up a significant proportion o...
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Wan, A., Rodrigues, B. Tags: REVIEW Source Type: research

Von Willebrand factor, ADAMTS13, and coronary microvascular obstruction: beautiful hypotheses, ugly facts
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: De Caterina, R., Madonna, R. Tags: INVITED EDITORIALS Source Type: research

Desmosomes and sino-atrial dysfunction
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Mangoni, M. E. Tags: INVITED EDITORIALS Source Type: research

Intracellular pH steers vascular wall remodelling
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Hordijk, P. L. Tags: INVITED EDITORIALS Source Type: research

MicroRNAs and pulmonary hypertension: a tight link
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 22, 2016 Category: Cardiology Authors: Elia, L., Condorelli, G. Tags: INVITED EDITORIALS Source Type: research