Calcification Characteristics of Low-Flow Low-Gradient Severe Aortic Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement.
nder RK Abstract Low-flow low-gradient severe aortic stenosis (LFLGAS) is associated with worse outcomes. Aortic valve calcification patterns of LFLGAS as compared to non-LFLGAS have not yet been thoroughly assessed. 137 patients undergoing transcatheter aortic valve replacement (TAVR) with preprocedural multidetector computed tomography (MDCT) and postprocedural transthoracic echocardiography were enrolled. Calcification characteristics were assessed by MDCT both for the total aortic valve and separately for each leaflet. 34 patients had LFLGAS and 103 non-LFLGAS. Total aortic valve calcification volume (p
Source: Cardiology Research and Practice - October 8, 2015 Category: Cardiology Authors: Stähli BE, Nguyen-Kim TD, Gebhard C, Frauenfelder T, Tanner FC, Nietlispach F, Maisano F, Falk V, Lüscher TF, Maier W, Binder RK Tags: Cardiol Res Pract Source Type: research

Single Center Retrospective Analysis of Conventional and Radial TIG Catheters for Transradial Diagnostic Coronary Angiography.
Abstract Current guidelines favor the radial approach for coronary angiography. Therefore, specialty radial diagnostic catheters were designed to engage both coronary arteries with a single device. However, it is unclear if single catheters are superior to conventional catheters. A retrospective analysis was performed of consecutive right radial coronary angiographies to determine catheter use, fluoroscopy time, radiation dosage, and consumption of contrast. Procedures were performed with a single TIG catheter or conventional catheters (CONV). Procedures with coronary artery bypass grafts or ventricular angiograph...
Source: Cardiology Research and Practice - October 8, 2015 Category: Cardiology Authors: Vorpahl M, Koehler T, Foerst J, Panagiotopoulos S, Schleiting H, Koss K, Ziegler G, Brinkmann H, Seyfarth M, Tiroch K Tags: Cardiol Res Pract Source Type: research

Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction.
In this study, 138 patients were admitted to cardiology clinic with diagnosis of acute MI, and angiographic assessment was performed using the Gensini Score. Blood samples were obtained from all patients in the first day. The patients with ApoE34 genotype had high Gensini scores. Besides, the patients with E4 allele carriers were associated with high Gensini score compared with the patients without E4 allele carriers (p:0,22). The patients with E4 allele carriers were associated with higher LDL cholesterol and total cholesterol compared with the patients without E4 allele carriers (p:0,001 and p:0,03, resp.). There were no...
Source: Cardiology Research and Practice - September 19, 2015 Category: Cardiology Authors: Karahan Z, Uğurlu M, Uçaman B, Uluğ AV, Kaya İ, Çevik K, Öztürk Ö, Iyem H Tags: Cardiol Res Pract Source Type: research

A Proposed Maneuver to Guide Transseptal Puncture Using Real-Time Three-Dimensional Transesophageal Echocardiography: Pilot Study.
Conclusions. Application of RT3D-TEE during TSP using RATLe-90 maneuver is feasible with shorter fluoroscopy time and minimizing TEE probe manipulations. PMID: 26106503 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - June 28, 2015 Category: Cardiology Authors: Mahmoud HM, Al-Ghamdi MA, Ghabashi AE, Anwar AM Tags: Cardiol Res Pract Source Type: research

Factors Associated with the Use of Drug-Eluting Stents in Patients Presenting with Acute ST-Segment Elevation Myocardial Infarction.
Conclusions. In this analysis, BMS implantation was associated with illicit drug or alcohol abuse and presence of cardiogenic shock. This study did not confirm previous observations that non-White race, insurance, or income predicts BMS use. PMID: 26106504 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - June 28, 2015 Category: Cardiology Authors: Chavez JF, Doll JA, Mediratta A, Maffessanti F, Friant J, Paul JD, Blair JE, Nathan S, Jolly N, Shah AP Tags: Cardiol Res Pract Source Type: research

Current status of sodium bicarbonate in coronary angiography: an updated comprehensive meta-analysis and systematic review.
Abstract This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes. We searched major electronic databases for studies in randomized controlled trials. A value of P 50% indicated significant heterogeneity between the studies. Literature search of all databases retrieved 650 studies. 29 studies enrolled in meta-analysis. Pooled analysis indicated about the incidence of CIN (OR of 0.718; 95% CI: 0.60 to 0.85; P = 0.000), requirement of hemodialysis (OR of 1.00; 95% C...
Source: Cardiology Research and Practice - May 17, 2015 Category: Cardiology Authors: Ali-Hassan-Sayegh S, Mirhosseini SJ, Rahimizadeh E, Ghodratipour Z, Sarrafan-Chaharsoughi Z, Dehghan AM, Lotfaliani MR, Rezaeisadrabadi M, Kayvanpour E, Sedaghat-Hamedani F, Zeriouh M, Weymann A, Sabashnikov A, Popov AF Tags: Cardiol Res Pract Source Type: research

Among Ectasia Patients with Coexisting Coronary Artery Disease, TIMI Frame Count Correlates with Ectasia Size and Markis Type IV Is the Commonest.
Conclusion. Among patients undergoing angiography, CAE has a prevalence of 3.8% and Markis type IV is the commonest. Larger ectasias are associated with slower coronary flow. PMID: 25705544 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - February 26, 2015 Category: Cardiology Authors: Tony H, Meng K, Wu B, Zeng Q Tags: Cardiol Res Pract Source Type: research

Cardiovascular Complications of HIV-Associated Immune Dysfunction.
Abstract Prolonged survival in HIV infection is accompanied by an increased frequency of non-HIV-related comorbidities. It is suggested that cardiovascular diseases (CVD) occur earlier among HIV-positive patients compared with HIV-negative patients, and at a higher rate. Several factors have been proposed which can be categorized into traditional and nontraditional risk factors. Immune dysfunction is a nontraditional risk factor that contributes significantly to cardiovascular pathology. Markers of inflammation are elevated in HIV-infected patients, and elevations in markers such as high-sensitivity C-reactive pro...
Source: Cardiology Research and Practice - February 6, 2015 Category: Cardiology Authors: Zaaqoq AM, Khasawneh FA, Smalligan RD Tags: Cardiol Res Pract Source Type: research

Antithrombotic therapy in patients with acute coronary syndrome in the intermountain heart collaborative study.
Abstract Objective. To determine factors associated with single antiplatelet (SAP) or dual antiplatelet (DAP) therapy and anticoagulants (AC) use in hospital and after discharge among patients with acute coronary syndrome (ACS). Methods. We evaluated 5,294 ACS patients in the Intermountain Heart Collaborative Study from 2004 to 2009. Multivariable logistic regressions were used to determine predictors of AC or AP use. Results. In hospital, 99% received an AC, 79% DAP, and 19% SAP; 78% had DAP + AC. Coronary stents were the strongest predictors of DAP use in hospital compared to SAP (P
Source: Cardiology Research and Practice - February 2, 2015 Category: Cardiology Authors: Knight S, Klaskala W, Woller SC, Horne BD, Bunch TJ, Le VT, Mills RM, Muhlestein JB Tags: Cardiol Res Pract Source Type: research

Balloon Occlusion Types in the Treatment of Coronary Perforation during Percutaneous Coronary Intervention.
Abstract Coronary artery perforation is an uncommon complication in patients with coronary heart disease undergoing percutaneous coronary intervention. However, pericardial tamponade following coronary artery perforation may be lethal, and prompt treatment is crucial in managing such patients. Balloon occlusion and the reversal of anticoagulant activity are the common methods used to prevent cardiac tamponade by reducing the amount of bleeding. Herein, we discuss the pros and cons of currently used occlusion types for coronary perforation. Optimal balloon occlusion methods should reduce the amount of bleeding and ...
Source: Cardiology Research and Practice - December 18, 2014 Category: Cardiology Authors: Wang X, Ge J Tags: Cardiol Res Pract Source Type: research

Mean platelet volume in patients with obstructive sleep apnea and its relationship with simpler heart rate derivatives.
H, Alp R Abstract Some studies show increased mean platelet volume (MPV) in obstructive sleep apnea (OSA). The aim of this study was to evaluate MPV in OSA patients without cardiovascular risk factors and the possible association of heart rate derivatives with MPV. A total of 82 patients (aged 30-70 years) were divided into 2 groups according to the presence of either OSA or non-OSA as the control group. The OSA group consisted of 52 patients and the control group consisted of 30 subjects. Neither group was significantly different in terms of MPV values as well as heart rate (HR) derivatives such as minimum HR, m...
Source: Cardiology Research and Practice - October 9, 2014 Category: Cardiology Authors: Akyüz A, Akkoyun DÇ, Oran M, Değirmenci H, Alp R Tags: Cardiol Res Pract Source Type: research

High-sensitivity troponin T: a biomarker for diuretic response in decompensated heart failure patients.
Conclusions. Episodes of ADHF are associated with transient increases in the blood levels of hsTnT that are reduced with effective acute episode treatment. The decrease in hsTnT can translate less myocardial damage along with favourable ADHF treatment. PMID: 25247106 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - September 25, 2014 Category: Cardiology Authors: Ferreira JP, Santos M, Almeida S, Marques I, Bettencourt P, Carvalho H Tags: Cardiol Res Pract Source Type: research

How aortic stiffness in postmenopausal women is related to common cardiovascular risk factors.
Abstract Objective. Our study investigates major common cardiovascular risk factors relation with aortic stiffness on 269 postmenopausal women by global pulse wave velocity (PWVg), useful to relate PWVg to risk of major cardiovascular events. Patients and Methods. Women were categorized as hypertensive (H), hypercholesterolemic (C), or diabetic (D). Aortic stiffness was assessed by PWVg measured with pulsed Doppler, at the left ventricular outflow tract (LVOT) and at the right common femoral artery. Results. All population mean PWVg was 8.2 m/s. 85 (26.5%) women were H; mean PWVg was 7.9 m/s. HC wome...
Source: Cardiology Research and Practice - August 21, 2014 Category: Cardiology Authors: Maiello M, Zito A, Ciccone MM, Palmiero P Tags: Cardiol Res Pract Source Type: research

Aerobic Exercise as an Adjunct Therapy for Improving Cognitive Function in Heart Failure.
Abstract Persons with heart failure (HF) are typically older and are at a much higher risk for developing cognitive impairment (CI) than persons without HF. Increasingly, CI is recognized as a significant, independent predictor of worse clinical outcomes, more frequent hospital readmissions, and higher mortality rates in persons with HF. CI can have devastating effects on ability to carry out HF effective self-care behaviors. If CI occurs, however, there are currently no evidence based guidelines on how to manage or improve cognitive function in this population. Improvement in cognition has been reported following...
Source: Cardiology Research and Practice - August 12, 2014 Category: Cardiology Authors: Gary RA, Brunn K Tags: Cardiol Res Pract Source Type: research

The Prevalence of Cardiovascular Disease Risk Factors among Employees in the Kingdom of Bahrain between October 2010 and March 2011: A Cross-Sectional Study from a Workplace Health Campaign.
This study aims to estimate the CVD risk factors prevalence among government employees in Bahrain. Design. A cross-sectional study design. Setting. Different government workplaces in Bahrain. Method. Data was collected from 1139 employees between October 2010 and March 2011 through interviews, including physical measurements, patient blood testing, and expired carbon monoxide (CO) levels as particles per million (ppm) for smokers. A summary of composite CVD risk factors was identified. Results. The following overall prevalence rates were reported: overweight and obesity 78.4% and reported hypertension 36.9% (included both ...
Source: Cardiology Research and Practice - August 12, 2014 Category: Cardiology Authors: Al-Nooh AA, Abdulabbas Abdulla Alajmi A, Wood D Tags: Cardiol Res Pract Source Type: research

Characterization of Pulmonary Vein Dimensions Using High-Definition 64-Slice Computed Tomography prior to Radiofrequency Catheter Ablation for Atrial Fibrillation.
Duru F Abstract Background. Contrast-enhanced computed tomography is commonly acquired before radiofrequency catheter ablation (RFCA) for atrial fibrillation (AFib) to guide the procedure. We analyzed pulmonary vein (PV) ostial diameter and volumes on a high-definition 64-slice CT (HDCT) scanner in patients with AFib prior to RFCA. Methods and Results. This retrospective study included 50 patients (mean age 60.2 ± 11.4 years, 30 males) undergoing cardiac HDCT scanning before RFCA for drug refractory AFib and 50 age-, BMI-, and sex-matched controls with normal sinus rhythm undergoing HDCT. PV ostial diamete...
Source: Cardiology Research and Practice - August 5, 2014 Category: Cardiology Authors: Gebhard C, Krasniqi N, Stähli BE, Klaeser B, Fuchs TA, Ghadri JR, Haegeli L, Lüscher TF, Kaufmann PA, Duru F Tags: Cardiol Res Pract Source Type: research

Left atrial anatomy relevant to catheter ablation.
Y, Cabrera JA, Saremi F Abstract The rapid development of interventional procedures for the treatment of arrhythmias in humans, especially the use of catheter ablation techniques, has renewed interest in cardiac anatomy. Although the substrates of atrial fibrillation (AF), its initiation and maintenance, remain to be fully elucidated, catheter ablation in the left atrium (LA) has become a common therapeutic option for patients with this arrhythmia. Using ablation catheters, various isolation lines and focal targets are created, the majority of which are based on gross anatomical, electroanatomical, and myoarchitec...
Source: Cardiology Research and Practice - July 25, 2014 Category: Cardiology Authors: Sánchez-Quintana D, López-Mínguez JR, Macías Y, Cabrera JA, Saremi F Tags: Cardiol Res Pract Source Type: research

Central arterial hemodynamic effects of dark chocolate ingestion in young healthy people: a randomized and controlled trial.
Abstract Introduction. The aim of this study was to assess the vascular benefits of dark chocolate in healthy and young individuals. Methods. A randomized and controlled trial was carried out involving 60 healthy volunteers, randomized into two groups: control group (CG; n = 30) and intervention group (IG; n = 30). The IG ingested a daily dosage of 10 g of dark chocolate (>75% cocoa) for a month. Blood pressure (BP), flow-mediated dilation (FMD), arterial stiffness index (ASI), aortic pulse wave velocity (PWV), and pulse wave analysis (PWA) were assessed at baseline and one week after the one-month inter...
Source: Cardiology Research and Practice - July 2, 2014 Category: Cardiology Authors: Pereira T, Maldonado J, Laranjeiro M, Coutinho R, Cardoso E, Andrade I, Conde J Tags: Cardiol Res Pract Source Type: research

Mortality Trends in Patients Hospitalized with the Initial Acute Myocardial Infarction in a Middle Eastern Country over 20 Years.
Abstract We aimed to define the temporal trend in the initial Acute Myocardial Infarction (AMI) management and outcome during the last two decades in a Middle Eastern country. A total of 10,915 patients were admitted with initial AMI with mean age of 53 ± 11.8 years. Comparing the two decades (1991-2000) to (2001-2010), the use of antiplatelet drugs increased from 84% to 95%, β -blockers increased from 38% to 56%, and angiotensin converting enzyme inhibitors (ACEI) increased from 12% to 36% (P
Source: Cardiology Research and Practice - May 29, 2014 Category: Cardiology Authors: Ahmed E, Al Suwaidi J, El-Menyar A, AlBinali HA, Singh R, Gehani AA Tags: Cardiol Res Pract Source Type: research

Filters in 2D and 3D Cardiac SPECT Image Processing.
Abstract Nuclear cardiac imaging is a noninvasive, sensitive method providing information on cardiac structure and physiology. Single photon emission tomography (SPECT) evaluates myocardial perfusion, viability, and function and is widely used in clinical routine. The quality of the tomographic image is a key for accurate diagnosis. Image filtering, a mathematical processing, compensates for loss of detail in an image while reducing image noise, and it can improve the image resolution and limit the degradation of the image. SPECT images are then reconstructed, either by filter back projection (FBP) analytical tech...
Source: Cardiology Research and Practice - May 8, 2014 Category: Cardiology Authors: Lyra M, Ploussi A, Rouchota M, Synefia S Tags: Cardiol Res Pract Source Type: research

Leptin Receptor Gene Gln223Arg Polymorphism Is Not Associated with Hypertension: A Preliminary Population-Based Cross-Sectional Study.
dez G Abstract Hypertension is responsible for high morbidity and mortality as one of the most important cardiometabolic risk factors. The aim of the study was to investigate whether the Gln223Arg in the leptin receptor (LEPR) influences the prevalence of hypertension. A cross-sectional study was carried out in individuals aged ≥ 18 years. Polymorphism identification was performed using PCR-RFLP analysis. Participants with blood pressure ≥ 140/90 mmHg or medication use were considered hypertensive. Frequencies, means, cross-tabulations, and multivariate models were produced to study differences in hyp...
Source: Cardiology Research and Practice - April 29, 2014 Category: Cardiology Authors: Pena Gd, Guimarães AL, Veloso RR, Reis TC, Gomes CS, Neto JF, Velasquez-Melendez G Tags: Cardiol Res Pract Source Type: research

A pathological study of the epidemiology of atherosclerosis in Mexico city.
Aguirre-Garcia J Abstract Objective. To examine the frequency and patterns of association of cardiovascular risk factors with atherosclerosis in five different arterial territories at post-mortem in Mexico City. Methods. We obtained five arterial territories arteries (circle of Willis, coronary, carotid, renal, and aorta) of 185 men and women 0 to 90 years of age who underwent autopsy at the Medical Forensic Service of Mexico City. We determined the prevalence and extent of atherosclerotic lesions by histopathology according to the classification of the American Heart Association as early (types I-III) and advanc...
Source: Cardiology Research and Practice - April 11, 2014 Category: Cardiology Authors: Rodríguez-Saldaña J, Rodriguez-Flores M, Cantú-Brito C, Aguirre-Garcia J Tags: Cardiol Res Pract Source Type: research

Arterial injury and endothelial repair: rapid recovery of function after mechanical injury in healthy volunteers.
Abstract Objective. Previous studies suggest a protracted course of recovery after mechanical endothelial injury; confounders may include degree of injury and concomitant endothelial dysfunction. We sought to define the time course of endothelial function recovery using flow-mediated dilation (FMD), after ischaemia-reperfusion (IR) and mechanical injury in patients and healthy volunteers. The contribution of circulating CD133(+)/CD34(+)/VEGFR2(+) "endothelial progenitor" (EPC) or repair cells to endothelial repair was also examined. Methods. 28 healthy volunteers aged 18-35 years underwent transient fore...
Source: Cardiology Research and Practice - April 11, 2014 Category: Cardiology Authors: Tilling L, Hunt J, Donald A, Clapp B, Chowienczyk P Tags: Cardiol Res Pract Source Type: research

A Comprehensive Review on Metabolic Syndrome.
Abstract Metabolic syndrome is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Insulin resistance, visceral adiposity, atherogenic dyslipidemia, endothelial dysfunction, genetic susceptibility, elevated blood pressure, hypercoagulable state, and chronic stress are the several factors which constitute the syndrome. Chronic inflammation is known to be associated with visceral obesity and insulin resistance which is characterized by production of abnor...
Source: Cardiology Research and Practice - April 10, 2014 Category: Cardiology Authors: Kaur J Tags: Cardiol Res Pract Source Type: research

Coronary artery disease and the profile of cardiovascular risk factors in South South Nigeria: a clinical and autopsy study.
Conclusion. CAD and its risk factors are contributing to mortality and morbidity in South South Nigeria. These risk factors include hypertension, alcohol use, diabetes mellitus, cigarette smoking, poor physical activity, and obesity. Nigerians in this locality with CAD have raised serum lipids. PMID: 24707437 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - April 8, 2014 Category: Cardiology Authors: Essien OE, Andy J, Ansa V, Otu AA, Udoh A Tags: Cardiol Res Pract Source Type: research

Atrioventricular left ventricular apical pacing improves haemodynamic, rotational, and deformation variables in comparison to pacing at the lateral wall in intact myocardium: experimental study.
Abstract Aim. To assess the effect on left ventricular (LV) function of atrioventricular (AV) and ventricular pacing at the LV apical or lateral wall and to compare the normal torsional and deformation pattern of the intact LV myocardium with those created by the aforementioned LV pacing modes and sites. Methods. Experiments were conducted in pigs (n = 21) with normal LV function to investigate the acute hemodynamic effects of epicardial AV and ventricular LV pacing at the LV apical or lateral wall. Torsional and deformation indices of LV function were assessed using speckle tracking echocardiography. Results. AV ...
Source: Cardiology Research and Practice - March 25, 2014 Category: Cardiology Authors: Toumanidis S, Kaladaridou A, Bramos D, Skaltsiotes E, Agrios J, Pamboucas C, Kottis G, Antoniou A, Papadopoulou E, Moulopoulos S Tags: Cardiol Res Pract Source Type: research

Minimizing Cardiovascular Adverse Effects of Atypical Antipsychotic Drugs in Patients with Schizophrenia.
Abstract The use of atypical antipsychotic agents has rapidly increased in the United States and worldwide in the last decade. Nonetheless, many health care practitioners do not appreciate the significance of the cardiovascular side effects that may be associated with their use and the means to minimize them. Thus, atypical antipsychotic medications can cause cardiovascular side effects such as arrhythmias and deviations in blood pressure. In rare cases, they may also cause congestive heart failure, myocarditis, and sudden death. Patients with schizophrenia have a higher risk of cardiovascular mortality than healt...
Source: Cardiology Research and Practice - March 22, 2014 Category: Cardiology Authors: Khasawneh FT, Shankar GS Tags: Cardiol Res Pract Source Type: research

Neutralization by insulin of the hypertensive effect of dermcidin isoform 2: an environmentally induced diabetogenic and hypertensive protein.
Abstract The effect of dermcidin isoform 2 (dermcidin), an environmentally induced stress protein, was investigated on the genesis of diabetes mellitus and hypertension, the two major atherosclerotic risk factors. The role of dermcidin as an atherosclerotic risk factor related to the impaired systemic insulin level was investigated. Dermcidin was prepared by electrophoresis using plasma from the subjects with acute ischemic heart disease. Injection of 0.2 μM dermcidin in mice increased the blood glucose level from 98 ± 2.45 mg/dL to 350  ± 10.2 mg/dL which was normalize...
Source: Cardiology Research and Practice - March 22, 2014 Category: Cardiology Authors: Ghosh R, Bank S, Bhattacharya R, Khan NN, Sinha AK Tags: Cardiol Res Pract Source Type: research

C-Reactive Protein: Clinical and Epidemiological Perspectives.
as J, Bermúdez V Abstract An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascular risk in both primary and secondary prevention. C-reactive protein is a plasmatic protein of the pentraxin family and an acute phase reactant, very useful as a general inflammation marker. Currently, it is one of the most profoundly researched molecules in the cardiovascular field, yet...
Source: Cardiology Research and Practice - March 22, 2014 Category: Cardiology Authors: Salazar J, Martínez MS, Chávez M, Toledo A, Añez R, Torres Y, Apruzzese V, Silva C, Rojas J, Bermúdez V Tags: Cardiol Res Pract Source Type: research

The Association between Blunt Cardiac Injury and Isolated Sternal Fracture.
This study aimed to identify the incidence, morbidity, and mortality associated with isolated fractures of the sternum and describe current practice for diagnosis and management of ISF and cardiac injury at a level I trauma center in the UK. A retrospective cohort study of adult patients (>16 years) with ISF presenting from 2006 to 2010 was conducted. Eighty-eight patients with ISF were identified. Most patients (88%, 77) were admitted to hospital with 66% (58) of them discharged within 48 hours. Two (2%) patients had an ER EKG with abnormality but both resolved to normal sinus rhythm within 6 hours of follow-up. Serum ...
Source: Cardiology Research and Practice - March 22, 2014 Category: Cardiology Authors: Dua A, McMaster J, Desai PJ, Desai SS, Kuy S, Mata M, Cooper J Tags: Cardiol Res Pract Source Type: research

What Is the Best Proximal Anastomosis for the Free Right Internal Thoracic Artery during Bilateral Internal Thoracic Artery Revascularization? A Prospective, Randomized Study.
Abstract Objective. Bilateral internal thoracic artery (BITA) grafting provides improved graft patency and potential survival advantage in selected patients as compared to single left internal thoracic artery (LITA) revascularization. The ideal functional BITA configuration remains controversial. Methods. Patients undergoing planned BITA revascularization with greater than 75% stenosis in both the left anterior descending artery (LAD) and in a circumflex branch were prospectively randomized to one of two proximal free right internal thoracic artery (RITA) connections directly off the aorta (Ao) (n = 12) or as a &q...
Source: Cardiology Research and Practice - March 22, 2014 Category: Cardiology Authors: Neragi-Miandoab S, Michler RE, Lalezarzadeh F, Bello R, Derose JJ Tags: Cardiol Res Pract Source Type: research

Exercise training in athletes with bicuspid aortic valve does not result in increased dimensions and impaired performance of the left ventricle.
Abstract Background. Bicuspid aortic valve (BAV) is one of the most common congenital heart disease (0.9%-2%) and is frequently found in the athletes and in the general population. BAV can lead to aortic valve dysfunction and to a progressive aortic dilatation. Trained BAV athletes exhibit a progressive enlargement of the left ventricle (LV) compared to athletes with normal aortic valve morphology. The present study investigates the possible relationship between different aortic valve morphology and LV dimensions. Methods. In the period from 2000 to 2011, we investigated a total of 292 BAV subjects, divided into t...
Source: Cardiology Research and Practice - March 7, 2014 Category: Cardiology Authors: Stefani L, Galanti G, Innocenti G, Mercuri R, Maffulli N Tags: Cardiol Res Pract Source Type: research

Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis.
Conclusions. Currently, the evidence is insufficient to draw any definite conclusions in favour of or against Terminalia arjuna in patients of chronic stable angina. Further, well-controlled multicentric clinical trials need to be conducted in large number of patients to explore the therapeutic potential of Terminalia arjuna if any. PMID: 24600529 [PubMed - as supplied by publisher] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - March 7, 2014 Category: Cardiology Authors: Kaur N, Shafiq N, Negi H, Pandey A, Reddy S, Kaur H, Chadha N, Malhotra S Tags: Cardiol Res Pract Source Type: research

Prenatal detection of congenital heart diseases: one-year survey performing a screening protocol in a single reference center in Brazil.
Conclusion. We observed a high rate of CHD in our population. We also found that there was higher incidence of complex cases. PMID: 24523982 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - February 14, 2014 Category: Cardiology Authors: Rocha LA, Araujo Júnior E, Rolo LC, Barros FS, da Silva KP, Leslie AT, Nardozza LM, Moron AF Tags: Cardiol Res Pract Source Type: research

Postoperative Arrhythmias after Cardiac Surgery: Incidence, Risk Factors, and Therapeutic Management.
Abstract Arrhythmias are a known complication after cardiac surgery and represent a major cause of morbidity, increased length of hospital stay, and economic costs. However, little is known about incidence, risk factors, and treatment of early postoperative arrhythmias. Both tachyarrhythmias and bradyarrhythmias can present in the postoperative period. In this setting, atrial fibrillation is the most common heart rhythm disorder. Postoperative atrial fibrillation is often self-limiting, but it may require anticoagulation therapy and either a rate or rhythm control strategy. However, ventricular arrhythmias and con...
Source: Cardiology Research and Practice - February 12, 2014 Category: Cardiology Authors: Peretto G, Durante A, Limite LR, Cianflone D Tags: Cardiol Res Pract Source Type: research

Vitamin d predicts all-cause and cardiac mortality in females with suspected acute coronary syndrome: a comparison with brain natriuretic Peptide and high-sensitivity C-reactive protein.
en DW Abstract Vitamin D may not only reflect disease but may also serve as a prognostic indicator. Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac death in patients with suspected acute coronary syndrome (ACS) and to compare its prognostic utility to brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hsCRP). Blood samples were harvested on admission in 982 patients. Forty percent were women (65.9 ± 12.6 years). Mortality was evaluated in quartiles of 25(OH)D, BNP, and hsCRP, respectively, during...
Source: Cardiology Research and Practice - December 19, 2013 Category: Cardiology Authors: Naesgaard PA, León de la Fuente RA, Nilsen ST, Woie L, Aarsland T, Staines H, Nilsen DW Tags: Cardiol Res Pract Source Type: research

Current Treatment of Heart Failure with Preserved Ejection Fraction: Should We Add Life to the Remaining Years or Add Years to the Remaining Life?
Abstract ACCORDING TO THE EJECTION FRACTION, PATIENTS WITH HEART FAILURE MAY BE DIVIDED INTO TWO DIFFERENT GROUPS: heart failure with preserved or reduced ejection fraction. In recent years, accumulating studies showed that increased mortality and morbidity rates of these two groups are nearly equal. More importantly, despite decline in mortality after treatment in regard to current guideline in patients with heart failure with reduced ejection fraction, there are still no trials resulting in improved outcome in patients with heart failure with preserved ejection fraction so far. Thus, novel pathophysiological mec...
Source: Cardiology Research and Practice - November 20, 2013 Category: Cardiology Authors: Li J, Becher PM, Blankenberg S, Westermann D Tags: Cardiol Res Pract Source Type: research

Effect of ivabradine on endothelial function in diastolic and right heart failure patients.
Conclusions. Ivabradine administration improves endothelial function (shear stress) in diastolic and right heart failure patients. PMID: 24222884 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - November 14, 2013 Category: Cardiology Authors: Orea-Tejeda A, Balderas-Muñoz K, Castillo-Martínez L, Infante-Vázquez O, Martínez Memije R, Keirns-Davis C, Dorantes-García J, Narváez-David R, Vázquez-Ortíz Z Tags: Cardiol Res Pract Source Type: research

Socioeconomic assessment and impact of social security on outcome in patients admitted with suspected coronary chest pain in the city of salta, Argentina.
In conclusion, survival was mainly tied to socioeconomic inequalities in this population, and the impact of a social security program needs further attention. PMID: 23819097 [PubMed - in process] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - July 3, 2013 Category: Cardiology Authors: León de la Fuente RA, Naesgaard PA, Nilsen ST, Woie L, Aarsland T, Staines H, Nilsen DW Tags: Cardiol Res Pract Source Type: research

Comparison of Predicted Exercise Capacity Equations and the Effect of Actual versus Ideal Body Weight among Subjects Undergoing Cardiopulmonary Exercise Testing.
Abstract Background. Oxygen uptake at maximal exercise (VO2 max) is considered the best available index for assessment of exercise capacity. The purpose of this study is to determine if the use of actual versus ideal body weight in standard regression equations for predicted VO2 max results in differences in predicted VO2 max. Methods. This is a retrospective chart review of patients who were predominantly in active military duty with complaints of dyspnea or exercise tolerance and who underwent cardiopulmonary exercise testing (CPET) from 2007 to 2009. Results. A total of 230 subjects completed CPET on a bicycle ...
Source: Cardiology Research and Practice - May 9, 2013 Category: Cardiology Authors: Ahmadian HR, Sclafani JJ, Emmons EE, Morris MJ, Leclerc KM, Slim AM Tags: Cardiol Res Pract Source Type: research

Serum uric Acid as a marker of coronary calcification in patients with asymptomatic coronary artery disease with preserved left ventricular pump function.
Abstract Objective. To evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects. Design and Methods. 126 subjects with previously documented asymptomatic coronary artery disease were enrolled in the study. Results. Mean value of serum uric acid level was 23.84 mmol/L (95% confidence interval (CI)  =  15.75-31.25 mmol/L). In multivariate Cox regression analysis, the results showed that serum uric acid levels (odds ratio (OR) = 1.42, 95% CI = 1.20-1.82; P
Source: Cardiology Research and Practice - April 23, 2013 Category: Cardiology Authors: Berezin AE, Kremzer AA Tags: Cardiol Res Pract Source Type: research

Atrial fibrillation.
PMID: 23533939 [PubMed - in process] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - March 28, 2013 Category: Cardiology Authors: Gassanov N, Caglayan E, Duru F, Er F Tags: Cardiol Res Pract Source Type: research

P2Y12 Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon?
Abstract Dual antiplatelet therapy with aspirin and a P2Y12 receptor inhibitor represents the cornerstone therapy for patients with acute coronary syndromes or undergoing percutaneous interventions, leading to a reduction of subsequent ischemic events. Variable response to clopidogrel has received close attention, and pharmacokinetic, pharmacodynamic, and pharmacogenomic factors have been identified as culprits. This led to the introduction of newer, potentially safer, and more effective antiplatelet agents (prasugrel and ticagrelor). Additionally, several point-of-care assays of platelet function have been develo...
Source: Cardiology Research and Practice - March 28, 2013 Category: Cardiology Authors: Oprea AD, Popescu WM Tags: Cardiol Res Pract Source Type: research

Heart rate variability in children with tricyclic antidepressant intoxication.
Abstract The aim of this study was to evaluate HRV in children requiring intensive care unit stays due to TCA poisoning between March 2009 and July 2010. In the time-domain nonspectral evaluation, the SDNN (P
Source: Cardiology Research and Practice - March 28, 2013 Category: Cardiology Authors: Dinleyici EC, Kilic Z, Sahin S, Tutuncu-Toker R, Eren M, Yargic ZA, Kosger P, Ucar B Tags: Cardiol Res Pract Source Type: research

Chronobiological analysis of blood pressure in a patient with atrial fibrillation at the development of heart failure and its therapeutic and surgical treatment.
Abstract Dynamics of blood pressure (BP) and heart rate (HR) was traced by automatic monitoring every 30 min uninterruptedly along several months in a patient suffering from combined atrial fibrillation and heart failure during the development of disease and its therapeutic and surgical treatment (pacemaker implanting and atrioventricular ablation). Analyses of spectral components as well as signal's shape revealed instabilities in circadian and semicircadian parameters. A new approach for signal's form description without using cosine approximation is suggested. The meaning that referring a patient as dipp...
Source: Cardiology Research and Practice - March 28, 2013 Category: Cardiology Authors: Chibisov S, Katinas G, Brodskaya I, Ertman A, Gromyko G, Konradi A, Mamontov O, Merkuryeva A, Polunicheva E, Shlyakhto E, Soboleva A, Yashin S, Bhavdip B Tags: Cardiol Res Pract Source Type: research

Brachial-ankle pulse wave velocity is the only index of arterial stiffness that correlates with a mitral valve indices of diastolic dysfunction, but no index correlates with left atrial size.
The objective of this study was to determine the optimal assessment of arterial stiffness that relates to diastolic dysfunction. Forty-one patients had measurements of brachial-ankle pulse wave velocity (baPWV), carotid-femoral pulse wave velocity (cfPWV), ankle brachial index (ABI), pulse pressure (PP), and augmentation index (AIx). Diastolic dysfunction was evaluated by echocardiographic indices of the ratio of the peak early diastolic mitral valve velocity and the peak late diastolic velocity (E/A ratio), left atrial diameter, and left atrial volume indexes. There was a significant (P
Source: Cardiology Research and Practice - March 28, 2013 Category: Cardiology Authors: Chow B, Rabkin SW Tags: Cardiol Res Pract Source Type: research

Novel Antiplatelet Agent Use for Acute Coronary Syndrome in the Emergency Department: A Review.
Conclusion. The use of ticagrelor and prasugrel as first line ED treatment of ACS is not well established. Current evidence supports the use of several agents with the final decision based on treatment protocols conjointly developed between cardiology and emergency medicine (EM). Further clinical trials involving head-to-head trials or comparisons of drug-based strategies are required to show superiority in reducing cardiac endpoints with regard to ED initiation of treatment. PMID: 23509665 [PubMed - as supplied by publisher] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - March 20, 2013 Category: Cardiology Authors: Curial M, Nath E, Lang E Tags: Cardiol Res Pract Source Type: research

Inflammatory Characteristics of Stenotic Aortic Valves: A Comparison between Rheumatic and Nonrheumatic Aortic Stenosis.
Abstract . Although our comprehension of nonrheumatic aortic stenosis (NRAS) has increased substantially during the last decade, less is known about the histopathology of rheumatic aortic stenosis (RAS). The aim of this study was to investigate rheumatic aortic stenosis by means of analyses previously used in nonrheumatic stenosis. . Valve specimens were obtained from 39 patients referred to hospital due to significant aortic stenosis. According to established macroscopic criteria the valves were divided into two groups consisting of 29 NRAS and 10 RAS valves. Mononuclear inflammatory cells and apolipoproteins wer...
Source: Cardiology Research and Practice - March 12, 2013 Category: Cardiology Authors: Wallby L, Steffensen T, Jonasson L, Broqvist M Tags: Cardiol Res Pract Source Type: research

The CYP2C19(∗)1/(∗)2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers.
The CYP2C19(∗)1/(∗)2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers. Cardiol Res Pract. 2013;2013:128795 Authors: Nasyuhana Sani Y, Sheau Chin L, Luen Hui L, Mohd Redhuan Shah Edwin NE, Teck Hwa G, Serebruany VL, Kah Hay Y Abstract Background. The CYP2C19∗2 allele may be associated with a reduced antiplatelet effect for clopidogrel. Here, we assessed whether CYP2C19∗2 alleles correlate with clopidogrel responsiveness following the administration of clopidogrel in healthy Malaysian volunteers. Methods. Ninety volunteers were genotyped fo...
Source: Cardiology Research and Practice - February 23, 2013 Category: Cardiology Authors: Nasyuhana Sani Y, Sheau Chin L, Luen Hui L, Mohd Redhuan Shah Edwin NE, Teck Hwa G, Serebruany VL, Kah Hay Y Tags: Cardiol Res Pract Source Type: research

Comparison of Atrial Fibrillation in the Young versus That in the Elderly: A Review.
Abstract The incidence and prevalence of atrial fibrillation (AF) are projected to increase significantly worldwide, imposing a significant burden on healthcare resources. The disease itself is extremely heterogeneous in its epidemiology, pathophysiology, and treatment options based on individual patient characteristics. Whilst ageing is well recognised to be an independent risk factor for the development of AF, this condition also affects the young in whom the condition is frequently symptomatic and troublesome. Traditional thinking suggests that the causal factors and pathogenesis of the condition in the young w...
Source: Cardiology Research and Practice - February 13, 2013 Category: Cardiology Authors: Sankaranarayanan R, Kirkwood G, Dibb K, Garratt CJ Tags: Cardiol Res Pract Source Type: research