Varicose Veins and Chronic Venous Disease
Chronic venous disease is a worldwide problem associated with significant morbidity and is expected to increase in prevalence as the current population ages. This is a comprehensive review of the anatomy, pathophysiology, genomics, clinical classification, and treatment modalities of chronic venous disease. (Source: Cardiology Clinics)
Source: Cardiology Clinics - October 20, 2021 Category: Cardiology Authors: Tom Alsaigh, Eri Fukaya Source Type: research

Raynaud Phenomenon and Other Vasospastic Disorders
Vasospastic disorders are prevalent in the general population and can affect individuals of any age. Primary (or idiopathic) vasospastic disorders often have a benign course; treatment focuses on the control of symptoms. Secondary vasospastic disorders occur owing to an underlying condition and have an increased risk of complications, including tissue loss and digital ulcerations; treatment should focus on the underlying condition. In this review, we discuss the pathophysiology, clinical presentation, diagnosis, and management of vasospastic disorders, including Raynaud syndrome, acrocyanosis, livedo reticularis, and perni...
Source: Cardiology Clinics - October 20, 2021 Category: Cardiology Authors: Ana I. Casanegra, Roger F. Shepherd Source Type: research

Management of Vascular Disorders in Cardiovascular Practice
Although cardiovascular disease includes common and possibly life-threatening disorders, such as peripheral artery disease (PAD), venous thromboembolism (VTE), aortic aneurysm, cerebrovascular disease, and others, peripheral vascular diseases are often underdiagnosed and undertreated. Individuals with polyvascular disease (ie, atherosclerosis in multiple arterial beds) are at higher risk of major adverse events and mortality than patients with coronary artery disease or peripheral vascular disease alone. (Source: Cardiology Clinics)
Source: Cardiology Clinics - October 20, 2021 Category: Cardiology Authors: Stanislav Henkin, Mark A. Creager Tags: Preface Source Type: research

Vascular Medicine
CARDIOLOGY CLINICS (Source: Cardiology Clinics)
Source: Cardiology Clinics - October 20, 2021 Category: Cardiology Authors: Stanislav Henkin, Mark A. Creager Source Type: research

Copyright
ELSEVIER (Source: Cardiology Clinics)
Source: Cardiology Clinics - October 20, 2021 Category: Cardiology Source Type: research

Contributors
JAMIL A. ABOULHOSN, MD, FACC, FSCAI (Source: Cardiology Clinics)
Source: Cardiology Clinics - October 20, 2021 Category: Cardiology Source Type: research

Contents
Stanislav Henkin and Mark A. Creager (Source: Cardiology Clinics)
Source: Cardiology Clinics - October 20, 2021 Category: Cardiology Source Type: research

Forthcoming Issues
Pulmonary Hypertension (Source: Cardiology Clinics)
Source: Cardiology Clinics - October 20, 2021 Category: Cardiology Source Type: research

Introduction to Nephrocardiology
The interaction between nephrology and cardiovascular medicine is much broader than the cardiorenal syndrome. Many different aspects of cardiovascular medicine are interconnected with and substantially influenced by the conditions that fall into the realm of nephrology, and vice versa. Those aspects include pathophysiology, risk factors, epidemiology, prognosis, prevention, diagnosis, monitoring, and therapy. Discovery of the interconnected areas and development of appropriate knowledge and skill to optimally approach those circumstances can improve the quality of care and outcome of a large population of patients. Therefo...
Source: Cardiology Clinics - July 9, 2021 Category: Cardiology Authors: Parta Hatamizadeh Source Type: research

Uremic Toxins and Cardiovascular System
This article reviews the main cardiotoxic mechanisms related to uremic toxin retention (endothelial dysfunction, vascular smooth muscle cell alterations, inflammation, mineral bone disorder, insulin resistance, and thrombogenicity) and the main responsible retention compounds. Therapeutic options are reviewed, such as influencing solute generation by intestinal microbiota. (Source: Cardiology Clinics)
Source: Cardiology Clinics - July 9, 2021 Category: Cardiology Authors: Sophie Valkenburg, Griet Glorieux, Raymond Vanholder Source Type: research

Anemia: A Connection Between Heart Failure and Kidney Failure
Erythropoiesis-stimulating agents (ESAs) have improved the quality of life and reduced the need for transfusions in patients with chronic kidney disease. However, randomized trials showed no benefit but possible safety issues following high doses of ESAs given to reach normal hemoglobin levels. Iron therapy is used together with ESA; when given proactively, it may reduce the risk of mortality and cardiovascular events in hemodialysis patients. Recent trials also showed benefits of intravenous iron therapy in patients with heart failure. New drugs for correcting anemia may retain the present efficacy of ESAs as antianemic d...
Source: Cardiology Clinics - July 9, 2021 Category: Cardiology Authors: Francesco Locatelli, Lucia Del Vecchio, Roberto Minutolo, Luca De Nicola Source Type: research

Pulmonary Hypertension in Chronic Kidney Disease
There is a high prevalence of pulmonary hypertension in chronic kidney disease (CKD), with rates increasing as glomerular filtration rate declines. Pulmonary hypertension is associated with a higher risk of cardiovascular events and mortality in non –dialysis-dependent CKD stages 3 to 5, dialysis-dependent CKD, as well as kidney transplant recipients. The pathophysiology of pulmonary hypertension in CKD is multifactorial and includes higher pulmonary capillary wedge pressure caused by ischemic heart disease and cardiomyopathy, higher cardiac output caused by anemia and arteriovenous access used for hemodialysis, as well ...
Source: Cardiology Clinics - July 9, 2021 Category: Cardiology Authors: Alison Travers, Harrison W. Farber, Mark J. Sarnak Source Type: research

Atrial Fibrillation in Patients with Chronic Kidney Disease
This article discusses an integrated care approach toward the management of patients with AF, including those with CKD. There is an increasing risk of both ischemic stroke and bleeding with progressive deterioration of renal function, complicating the decision of optimal stroke prevention strategies among patients with AF and CKD. The optimal stroke prevention strategy in patients with AF and severe CKD remains uncertain. An individualized approach incorporating stroke and bleeding risk stratification is needed, especially in those with end-stage renal disease. (Source: Cardiology Clinics)
Source: Cardiology Clinics - July 9, 2021 Category: Cardiology Authors: Agnieszka Kotalczyk, Wern Yew Ding, Christopher F. Wong, Anirudh Rao, Dhiraj Gupta, Gregory Y.H. Lip Source Type: research

Approach to Resistant Hypertension from Cardiology and Nephrology Standpoints
This article details an approach to the diagnosis and treatment of resistant hypertension with special consideration for patients with preexisting renal and/or cardiovascular disease. (Source: Cardiology Clinics)
Source: Cardiology Clinics - July 9, 2021 Category: Cardiology Authors: Luke J. Laffin, George L. Bakris Source Type: research

New Antidiabetes Medications and Their Cardiovascular and Renal Benefits
This article reviews the major CVOTs that support the use of these agents, describes the mechanisms of action that lead to their broad cardiorenal benefits, explains current guidelines, and offers prac tical clinical advice to initiate and monitor treatment with these agents. (Source: Cardiology Clinics)
Source: Cardiology Clinics - July 9, 2021 Category: Cardiology Authors: Enrico G. Ferro, Mohamed B. Elshazly, Deepak L. Bhatt Source Type: research