Synthesis and its biological activity of carboxymethyl hemicellulose p-hydroxybenzoate (P-CMHC)
Carbohydr Res. 2023 Oct 12;534:108972. doi: 10.1016/j.carres.2023.108972. Online ahead of print.ABSTRACTHemicellulose extracted from ecalyptus APMP pulping waste liquor and undergoes etherification modification to produce carboxymethyl hemicellulose (CMHC). Subsequently, CMHC undergoes esterification reaction with p-hydroxybenzoic acid to synthesize a novel polysaccharide-based preservative known as carboxymethyl hemicellulose p-hydroxybenzoate (P-CMHC). The synthesis conditions of P-CMHC were optimized using the response surface methodology, resulting in an optimal esterification condition that achieved a degree of substi...
Source: Carbohydrate Research - October 18, 2023 Category: Genetics & Stem Cells Authors: Ting Chen Haitang Liu Shunxi Song Sheng Qiang Yongzhen An Jie Li Jing Liu Beibei Chen Lin Chen Fufeng Liu Rui Liu Xue Jiang Xiaoyuan Liao Source Type: research

Click chemistry inspired facile one-pot synthesis of mannosyl triazoles and their hemagglutination inhibitory properties: The effect of alkyl chain spacer length between the triazole and phthalimide moieties in the aglycone backbone
Carbohydr Res. 2023 Oct 4;534:108965. doi: 10.1016/j.carres.2023.108965. Online ahead of print.ABSTRACTAn efficient one-pot synthesis of a new series of mannosyl triazoles has been achieved through CuAAC reaction where the alkyl chain spacer between the phthalimide moiety and the triazole ring in the aglycone backbone is varied from one methylene to six methylene units. The target compounds were evaluated in terms of their inhibitory potency against FimH using hemagglutination inhibition (HAI) assay. It was found that the length of four methylene units was the optimum for the fitting/binding of the compound to FimH as exem...
Source: Carbohydrate Research - October 18, 2023 Category: Genetics & Stem Cells Authors: Hussein Al-Mughaid Younis Jaradat Maha Khazaaleh Ibrahim Al-Taani Source Type: research

Synthesis and its biological activity of carboxymethyl hemicellulose p-hydroxybenzoate (P-CMHC)
Carbohydr Res. 2023 Oct 12;534:108972. doi: 10.1016/j.carres.2023.108972. Online ahead of print.ABSTRACTHemicellulose extracted from ecalyptus APMP pulping waste liquor and undergoes etherification modification to produce carboxymethyl hemicellulose (CMHC). Subsequently, CMHC undergoes esterification reaction with p-hydroxybenzoic acid to synthesize a novel polysaccharide-based preservative known as carboxymethyl hemicellulose p-hydroxybenzoate (P-CMHC). The synthesis conditions of P-CMHC were optimized using the response surface methodology, resulting in an optimal esterification condition that achieved a degree of substi...
Source: Carbohydrate Research - October 18, 2023 Category: Genetics & Stem Cells Authors: Ting Chen Haitang Liu Shunxi Song Sheng Qiang Yongzhen An Jie Li Jing Liu Beibei Chen Lin Chen Fufeng Liu Rui Liu Xue Jiang Xiaoyuan Liao Source Type: research

Click chemistry inspired facile one-pot synthesis of mannosyl triazoles and their hemagglutination inhibitory properties: The effect of alkyl chain spacer length between the triazole and phthalimide moieties in the aglycone backbone
Carbohydr Res. 2023 Oct 4;534:108965. doi: 10.1016/j.carres.2023.108965. Online ahead of print.ABSTRACTAn efficient one-pot synthesis of a new series of mannosyl triazoles has been achieved through CuAAC reaction where the alkyl chain spacer between the phthalimide moiety and the triazole ring in the aglycone backbone is varied from one methylene to six methylene units. The target compounds were evaluated in terms of their inhibitory potency against FimH using hemagglutination inhibition (HAI) assay. It was found that the length of four methylene units was the optimum for the fitting/binding of the compound to FimH as exem...
Source: Carbohydrate Research - October 18, 2023 Category: Genetics & Stem Cells Authors: Hussein Al-Mughaid Younis Jaradat Maha Khazaaleh Ibrahim Al-Taani Source Type: research

Synthesis and its biological activity of carboxymethyl hemicellulose p-hydroxybenzoate (P-CMHC)
Carbohydr Res. 2023 Oct 12;534:108972. doi: 10.1016/j.carres.2023.108972. Online ahead of print.ABSTRACTHemicellulose extracted from ecalyptus APMP pulping waste liquor and undergoes etherification modification to produce carboxymethyl hemicellulose (CMHC). Subsequently, CMHC undergoes esterification reaction with p-hydroxybenzoic acid to synthesize a novel polysaccharide-based preservative known as carboxymethyl hemicellulose p-hydroxybenzoate (P-CMHC). The synthesis conditions of P-CMHC were optimized using the response surface methodology, resulting in an optimal esterification condition that achieved a degree of substi...
Source: Carbohydrate Research - October 18, 2023 Category: Genetics & Stem Cells Authors: Ting Chen Haitang Liu Shunxi Song Sheng Qiang Yongzhen An Jie Li Jing Liu Beibei Chen Lin Chen Fufeng Liu Rui Liu Xue Jiang Xiaoyuan Liao Source Type: research

Click chemistry inspired facile one-pot synthesis of mannosyl triazoles and their hemagglutination inhibitory properties: The effect of alkyl chain spacer length between the triazole and phthalimide moieties in the aglycone backbone
Carbohydr Res. 2023 Oct 4;534:108965. doi: 10.1016/j.carres.2023.108965. Online ahead of print.ABSTRACTAn efficient one-pot synthesis of a new series of mannosyl triazoles has been achieved through CuAAC reaction where the alkyl chain spacer between the phthalimide moiety and the triazole ring in the aglycone backbone is varied from one methylene to six methylene units. The target compounds were evaluated in terms of their inhibitory potency against FimH using hemagglutination inhibition (HAI) assay. It was found that the length of four methylene units was the optimum for the fitting/binding of the compound to FimH as exem...
Source: Carbohydrate Research - October 18, 2023 Category: Genetics & Stem Cells Authors: Hussein Al-Mughaid Younis Jaradat Maha Khazaaleh Ibrahim Al-Taani Source Type: research

An alternative route for tricyclic quinazolinone-iminosugars and their glucosidase inhibitory activities
Carbohydr Res. 2023 Oct 11;534:108967. doi: 10.1016/j.carres.2023.108967. Online ahead of print.ABSTRACTA series of novel tricyclic quinazolinone-iminosugars 5 and their derivatives 7 were obtained from the tosylated sugars by three steps. Firstly, the reaction of the isopropylidene protected sugar tosylate 1 and o-aminobenzylamine 2 generated the precursor tricyclic quinazolin-iminosuar 3, which was then oxidized by KMnO4 to produce the corresponding quinazolinone 4. Finally, removal of the isopropylidene group yielded the target tricyclic quinazolinone iminosugars 5. In addition, quinazolinone-iminosugars 4ac, 4bc and 4c...
Source: Carbohydrate Research - October 16, 2023 Category: Genetics & Stem Cells Authors: Jie Li Xiaoyan Huang Likai Zhou Song Xie Lulu Su Chao Wei Xiaoliu Li Hua Chen Source Type: research

Fabrication of a reusable electrochemical platform based on acid-responsive host-guest interaction with β- cyclodextrin
Carbohydr Res. 2023 Oct 12;534:108966. doi: 10.1016/j.carres.2023.108966. Online ahead of print.ABSTRACTA reusable electrochemical glassy carbon electrode (GCE) platform based on the acid-responsive host-guest interaction between β-cyclodextrin (β-CD) and benzimidazole (BM) derivatives was developed. The β-CD can specifically recognize the BM derivative through the acid -responsive host-guest interaction. The electrode was first modified by eletrografting to immobilize a diamine linker (Boc-EDA), resulting in GCEBoc-EDA in which one amine was used for covalent immobilization to the electrode and another Boc protected am...
Source: Carbohydrate Research - October 16, 2023 Category: Genetics & Stem Cells Authors: Wun Liang Zhi-Jia Chen Chian-Hui Lai Source Type: research

An alternative route for tricyclic quinazolinone-iminosugars and their glucosidase inhibitory activities
Carbohydr Res. 2023 Oct 11;534:108967. doi: 10.1016/j.carres.2023.108967. Online ahead of print.ABSTRACTA series of novel tricyclic quinazolinone-iminosugars 5 and their derivatives 7 were obtained from the tosylated sugars by three steps. Firstly, the reaction of the isopropylidene protected sugar tosylate 1 and o-aminobenzylamine 2 generated the precursor tricyclic quinazolin-iminosuar 3, which was then oxidized by KMnO4 to produce the corresponding quinazolinone 4. Finally, removal of the isopropylidene group yielded the target tricyclic quinazolinone iminosugars 5. In addition, quinazolinone-iminosugars 4ac, 4bc and 4c...
Source: Carbohydrate Research - October 16, 2023 Category: Genetics & Stem Cells Authors: Jie Li Xiaoyan Huang Likai Zhou Song Xie Lulu Su Chao Wei Xiaoliu Li Hua Chen Source Type: research

Fabrication of a reusable electrochemical platform based on acid-responsive host-guest interaction with β- cyclodextrin
Carbohydr Res. 2023 Oct 12;534:108966. doi: 10.1016/j.carres.2023.108966. Online ahead of print.ABSTRACTA reusable electrochemical glassy carbon electrode (GCE) platform based on the acid-responsive host-guest interaction between β-cyclodextrin (β-CD) and benzimidazole (BM) derivatives was developed. The β-CD can specifically recognize the BM derivative through the acid -responsive host-guest interaction. The electrode was first modified by eletrografting to immobilize a diamine linker (Boc-EDA), resulting in GCEBoc-EDA in which one amine was used for covalent immobilization to the electrode and another Boc protected am...
Source: Carbohydrate Research - October 16, 2023 Category: Genetics & Stem Cells Authors: Wun Liang Zhi-Jia Chen Chian-Hui Lai Source Type: research

α-d-(1 → 3)-graft-(1 → 6)-glucan: Comb-like polysaccharide synthesized in vitro with α-1,3/1,6-glucosyltransferase L from Streptococcus salivarius
Carbohydr Res. 2023 Oct 5;534:108969. doi: 10.1016/j.carres.2023.108969. Online ahead of print.ABSTRACTWe demonstrated that a unique polysaccharide with extremely high molecular weight can be easily obtained via a low-cost, mild reaction in a water medium from sucrose, a photosynthetic product. α-1,3/1,6-Glucosyltransferase L (GtfL) from Streptococcus salivarius produced water-insoluble α-d-glucan from sucrose at 37 °C. Gel permeation chromatography revealed the molecular weight was extremely high; the weight-average molecular weight values were more than 1,000,000 irrespective of the substrate concentration. The Smith ...
Source: Carbohydrate Research - October 15, 2023 Category: Genetics & Stem Cells Authors: Ryosuke Kusumi Shinichi Asai Qinfeng He Kayoko Kobayashi Satoshi Kimura Makoto Yoshida Masahisa Wada Source Type: research

α-d-(1 → 3)-graft-(1 → 6)-glucan: Comb-like polysaccharide synthesized in vitro with α-1,3/1,6-glucosyltransferase L from Streptococcus salivarius
Carbohydr Res. 2023 Oct 5;534:108969. doi: 10.1016/j.carres.2023.108969. Online ahead of print.ABSTRACTWe demonstrated that a unique polysaccharide with extremely high molecular weight can be easily obtained via a low-cost, mild reaction in a water medium from sucrose, a photosynthetic product. α-1,3/1,6-Glucosyltransferase L (GtfL) from Streptococcus salivarius produced water-insoluble α-d-glucan from sucrose at 37 °C. Gel permeation chromatography revealed the molecular weight was extremely high; the weight-average molecular weight values were more than 1,000,000 irrespective of the substrate concentration. The Smith ...
Source: Carbohydrate Research - October 15, 2023 Category: Genetics & Stem Cells Authors: Ryosuke Kusumi Shinichi Asai Qinfeng He Kayoko Kobayashi Satoshi Kimura Makoto Yoshida Masahisa Wada Source Type: research

Editorial
Carbohydr Res. 2023 Oct 5:108968. doi: 10.1016/j.carres.2023.108968. Online ahead of print.NO ABSTRACTPMID:37816657 | DOI:10.1016/j.carres.2023.108968 (Source: Carbohydrate Research)
Source: Carbohydrate Research - October 10, 2023 Category: Genetics & Stem Cells Authors: Toshiki Nokami Source Type: research

Editorial
Carbohydr Res. 2023 Oct 5:108968. doi: 10.1016/j.carres.2023.108968. Online ahead of print.NO ABSTRACTPMID:37816657 | DOI:10.1016/j.carres.2023.108968 (Source: Carbohydrate Research)
Source: Carbohydrate Research - October 10, 2023 Category: Genetics & Stem Cells Authors: Toshiki Nokami Source Type: research

Editorial
Carbohydr Res. 2023 Oct 5:108968. doi: 10.1016/j.carres.2023.108968. Online ahead of print.NO ABSTRACTPMID:37816657 | DOI:10.1016/j.carres.2023.108968 (Source: Carbohydrate Research)
Source: Carbohydrate Research - October 10, 2023 Category: Genetics & Stem Cells Authors: Toshiki Nokami Source Type: research