Differential use of medical versus surgical androgen deprivation therapy for patients with metastatic prostate cancer
CONCLUSIONSRace/ethnicity, neighborhood SES, and insurance status appear to be significantly associated with receipt of surgical ADT. Future research will need to characterize other differences in initial treatments among men with advanced prostate cancer based on race/ethnicity and aim to better understand what factors drive the association between surgical ADT among men of Hispanic origin or those from areas with low neighborhood SES. (Source: Cancer)
Source: Cancer - November 16, 2018 Category: Cancer & Oncology Authors: Hala T. Borno, Daphne Y. Lichtensztajn, Scarlett L. Gomez, Nynikka R. Palmer, Charles J. Ryan Tags: Original Article Source Type: research

Reply to Annual Report to the Nation on the Status of Cancer, Part II: Recent changes in prostate cancer trends and disease characteristics
Cancer, EarlyView. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Serban Negoita, Angela Mariotto, Vicki Benard, Betsy A. Kohler, Ahmedin Jemal, Lynne Penberthy Tags: Correspondence Source Type: research

A phase 2 trial of abiraterone acetate without glucocorticoids for men with metastatic castration ‐resistant prostate cancer
ConclusionsTreatment with abiraterone acetate without steroids is feasible, although clinically significant adverse events can occur in a minority of patients. The use of abiraterone acetate without prednisone should be balanced with the potential for toxicity and requires close monitoring. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Rana R. McKay, Lillian Werner, Susanna J. Jacobus, Alexandra Jones, Elahe A. Mostaghel, Brett T. Marck, Atish D. Choudhury, Mark M. Pomerantz, Christopher J. Sweeney, Susan F. Slovin, Michael J. Morris, Philip W. Kantoff, Mary ‐Ellen Taplin Tags: Original Article Source Type: research

Annual Report to the Nation on the Status of Cancer, Part II: Recent changes in prostate cancer trends and disease characteristics
Cancer, EarlyView. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Susan J. Curry, Alex H. Krist, Douglas K. Owens Tags: Correspondence Source Type: research

Ethical considerations about emergent surgical hospitalizations in patients with advanced cancer
Cancer, EarlyView. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Katherine C. Lee, Zara Cooper Tags: Cancer Case Conundrums Source Type: research

Regional differences in gallbladder cancer pathogenesis: Insights from a multi ‐institutional comparison of tumor mutations
ConclusionsDifferences in clinicopathologic variables suggest the possibility of distinct GBCA pathogenesis in Japanese patients, which may be supported by differences in mutation pattern. Among all centers,SMAD4 mutations were detected in approximately one ‐third of patients and may represent a converging factor associated with worse survival. The majority of patients carried mutations in actionable gene targets, which may inform the design of future trials. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Raja R. Narayan, John M. Creasy, Debra A. Goldman, Mithat G önen, Cyriac Kandoth, Ritika Kundra, David B. Solit, Gokce Askan, David S. Klimstra, Olca Basturk, Peter J. Allen, Vinod P. Balachandran, Michael I. D’Angelica, Ronald P. DeMatteo Tags: Original Article Source Type: research

Does race predict the development of metastases in men who receive androgen ‐deprivation therapy for a biochemical recurrence after radical prostatectomy?
ConclusionsAmong veterans who received ADT post ‐BCR after RP, race was not a predictor of metastases or other adverse outcomes. The current findings suggest that research efforts to understand racial differences in prostate cancer biology should focus on early stages of the disease (ie, closer to the time of diagnosis). (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Adriana C. Vidal, Lauren E. Howard, Amanda De Hoedt, Christopher J. Kane, Martha K. Terris, William J. Aronson, Matthew R. Cooperberg, Christopher L. Amling, Stanislav Lechpammer, Scott C. Flanders, Stephen J. Freedland Tags: Original Article Source Type: research

Reply to Annual Report to the Nation on the Status of Cancer, Part II: Recent changes in prostate cancer trends and disease characteristics
Cancer, EarlyView. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Serban Negoita, Angela Mariotto, Vicki Benard, Betsy A. Kohler, Ahmedin Jemal, Lynne Penberthy Tags: Correspondence Source Type: research

A phase 2 trial of abiraterone acetate without glucocorticoids for men with metastatic castration ‐resistant prostate cancer
ConclusionsTreatment with abiraterone acetate without steroids is feasible, although clinically significant adverse events can occur in a minority of patients. The use of abiraterone acetate without prednisone should be balanced with the potential for toxicity and requires close monitoring. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Rana R. McKay, Lillian Werner, Susanna J. Jacobus, Alexandra Jones, Elahe A. Mostaghel, Brett T. Marck, Atish D. Choudhury, Mark M. Pomerantz, Christopher J. Sweeney, Susan F. Slovin, Michael J. Morris, Philip W. Kantoff, Mary ‐Ellen Taplin Tags: Original Article Source Type: research

Annual Report to the Nation on the Status of Cancer, Part II: Recent changes in prostate cancer trends and disease characteristics
Cancer, EarlyView. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Susan J. Curry, Alex H. Krist, Douglas K. Owens Tags: Correspondence Source Type: research

Ethical considerations about emergent surgical hospitalizations in patients with advanced cancer
Cancer, EarlyView. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Katherine C. Lee, Zara Cooper Tags: Cancer Case Conundrums Source Type: research

Regional differences in gallbladder cancer pathogenesis: Insights from a multi ‐institutional comparison of tumor mutations
ConclusionsDifferences in clinicopathologic variables suggest the possibility of distinct GBCA pathogenesis in Japanese patients, which may be supported by differences in mutation pattern. Among all centers,SMAD4 mutations were detected in approximately one ‐third of patients and may represent a converging factor associated with worse survival. The majority of patients carried mutations in actionable gene targets, which may inform the design of future trials. (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Raja R. Narayan, John M. Creasy, Debra A. Goldman, Mithat G önen, Cyriac Kandoth, Ritika Kundra, David B. Solit, Gokce Askan, David S. Klimstra, Olca Basturk, Peter J. Allen, Vinod P. Balachandran, Michael I. D’Angelica, Ronald P. DeMatteo Tags: Original Article Source Type: research

Does race predict the development of metastases in men who receive androgen ‐deprivation therapy for a biochemical recurrence after radical prostatectomy?
ConclusionsAmong veterans who received ADT post ‐BCR after RP, race was not a predictor of metastases or other adverse outcomes. The current findings suggest that research efforts to understand racial differences in prostate cancer biology should focus on early stages of the disease (ie, closer to the time of diagnosis). (Source: Cancer)
Source: Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Adriana C. Vidal, Lauren E. Howard, Amanda De Hoedt, Christopher J. Kane, Martha K. Terris, William J. Aronson, Matthew R. Cooperberg, Christopher L. Amling, Stanislav Lechpammer, Scott C. Flanders, Stephen J. Freedland Tags: Original Article Source Type: research

Iron overload in patients with myelodysplastic syndromes: An updated overview
Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by a broad clinical spectrum related to ineffective hematopoiesis leading to unilineage or multilineage cytopenias, with a high propensity for transformation to acute myeloid leukemia. Iron overload has been recently identified as one of the important conditions complicating the management of these diverse disorders. The accumulation of iron is mainly related to chronic transfusions; however, evidence suggests a possible role for ineffective erythropoiesis and increased intestinal absorption of iron, re...
Source: Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Nour M. Moukalled, Fuad A. El Rassi, Sally N. Temraz, Ali T. Taher Tags: Review Article Source Type: research

Gut microbiota ‐immune‐brain interactions in chemotherapy‐associated behavioral comorbidities
Increasing scientific attention is focused on the gut ‐brain axis, including the ability of the gastrointestinal (GI) tract to modulate central nervous system function. Changes in the intestinal microbiome can influence affective‐like behavior, cognitive performance, fatigue, and sleep in rodents and humans. Patients with cancer who are receiving c hemotherapy experience similar negative behavioral changes and concurrent GI symptoms. These chemotherapy comorbidities can be long‐lasting and may reduce patients' quality of life and motivation to comply with treatment. This review summarizes the clinical and preclinical...
Source: Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Kelley R. Jordan, Brett R. Loman, Michael T. Bailey, Leah M. Pyter Tags: Review Article Source Type: research