Protein arginine methyltransferase 5 promotes lung cancer metastasis via the epigenetic regulation of miR-99 family/FGFR3 signaling
Protein arginine methyltransferase 5 (PRMT5) functions as a tumor initiator to regulate several cancer progressions, such as proliferation and apoptosis, by catalyzing the symmetrical dimethylation (me2s) of arginine residues within targeted molecules. However, the exact role of PRMT5-mediated metastasis in lung cancer is not fully understood. Here, we illustrated its potential effects in lung cancer metastasis in vivo and vitro. PRMT5 was frequently overexpressed in lung tumors, and its expression was positively related to tumor stages, lymphatic metastasis and poor outcome. (Source: Cancer Letters)
Source: Cancer Letters - April 18, 2018 Category: Cancer & Oncology Authors: Pengyu Jing, Nan Zhao, Mingxiang Ye, Yong Zhang, Zhipei Zhang, Jianyong Sun, Zhengxin Wang, Jian Zhang, Zhongping Gu Tags: Original Articles Source Type: research
Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1/2 signalling pathway
Cancer stem cells (CSCs) are a small subpopulation of tumour cells that have been proposed to be responsible for cancer initiation, chemotherapy resistance and cancer recurrence. Shear stress activated cellular signalling is involved in cellular migration, proliferation and differentiation. However, little is known about the effects of shear stress on the migration of liver cancer stem cells (LCSCs). Here, we studied the effects of shear stress that are generated from a parallel plated flow chamber system, on LCSC migration and the activation of focal adhesion kinase (FAK) and extracellular signal regulated kinase1/2 (ERK1...
Source: Cancer Letters - April 17, 2018 Category: Cancer & Oncology Authors: Jinghui Sun, Qing Luo, Lingling Liu, Guanbin Song Tags: Original Articles Source Type: research
Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer
The folate receptor (FR) is a valued target that is highly expressed in various cancers, which will expedite the development of ligand-receptor binding based cancer therapeutics. In the present investigation, through tissue microarray analysis, we report higher levels of folate receptor expression in prostate cancer (PCa) tissue derived from patients, which were minimal in normal tissue. For folate-receptor based targeted therapy of PCa, we generated novel planetary ball milled (PBM) nanoparticles (NPs) encapsulated with resveratrol (RES), and in combination with docetaxel (DTX) and conjugated with folic acid (FA) on the s...
Source: Cancer Letters - April 17, 2018 Category: Cancer & Oncology Authors: Santosh Kumar Singh, James W. Lillard, Rajesh Singh Tags: Original Articles Source Type: research
Title: Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer
The folate receptor (FR) is a valued target that is highly expressed in various cancers, which will expedite the development of ligand-receptor binding based cancer therapeutics. In the present investigation, through tissue microarray analysis, we report higher levels of folate receptor expression in prostate cancer (PCa) tissue derived from patients, which were minimal in normal tissue. For folate-receptor based targeted therapy of PCa, we generated novel planetary ball milled (PBM) nanoparticles (NPs) encapsulated with resveratrol (RES), and in combination with docetaxel (DTX) and conjugated with folic acid (FA) on the s...
Source: Cancer Letters - April 17, 2018 Category: Cancer & Oncology Authors: Santosh Kumar Singh, James W. Lillard, Rajesh Singh Tags: Original Articles Source Type: research
Acetyl-L-carnitine is an anti-angiogenic agent targeting the VEGFR2 and CXCR4 pathways
Carnitines play an important role in the energy exchange in cells, involved in the transport of fatty acids across the inner mitochondrial membrane. L-Acetylcarnitine (ALCAR) is an acetic acid ester of carnitine that has higher bioavailability than carnitine and is considered a fat-burning energizer supplement. We previously found that in serum samples from prostate cancer (PCa) patients, 3 carnitine family members were significantly decreased, suggesting a potential protective role of carnitine against PCa. (Source: Cancer Letters)
Source: Cancer Letters - April 17, 2018 Category: Cancer & Oncology Authors: Denisa Baci, Antonino Bruno, Barbara Bassani, Matilde Tramacere, Lorenzo Mortara, Adriana Albini, Douglas M. Noonan Tags: Original Articles Source Type: research
Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1/2 signalling pathway
Cancer stem cells (CSCs) are a small subpopulation of tumour cells that have been proposed to be responsible for cancer initiation, chemotherapy resistance and cancer recurrence. Shear stress activated cellular signalling is involved in cellular migration, proliferation and differentiation. However, little is known about the effects of shear stress on the migration of liver cancer stem cells (LCSCs). Here, we studied the effects of shear stress that are generated from a parallel plated flow chamber system, on LCSC migration and the activation of focal adhesion kinase (FAK) and extracellular signal regulated kinase1/2 (ERK1...
Source: Cancer Letters - April 17, 2018 Category: Cancer & Oncology Authors: Jinghui Sun, Qing Luo, Lingling Liu, Guanbin Song Tags: Original Articles Source Type: research
Title: Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer
The folate receptor (FR) is a valued target that is highly expressed in various cancers, which will expedite the development of ligand-receptor binding based cancer therapeutics. In the present investigation, through tissue microarray analysis, we report higher levels of folate receptor expression in prostate cancer (PCa) tissue derived from patients, which were minimal in normal tissue. For folate-receptor based targeted therapy of PCa, we generated novel planetary ball milled (PBM) nanoparticles (NPs) encapsulated with resveratrol (RES), and in combination with docetaxel (DTX) and conjugated with folic acid (FA) on the s...
Source: Cancer Letters - April 17, 2018 Category: Cancer & Oncology Authors: Santosh Kumar Singh, James W. Lillard, Rajesh Singh Tags: Original Articles Source Type: research
Acetyl-L-carnitine is an anti-angiogenic agent targeting the VEGFR2 and CXCR4 pathways
Carnitines play an important role in the energy exchange in cells, involved in the transport of fatty acids across the inner mitochondrial membrane. L-Acetylcarnitine (ALCAR) is an acetic acid ester of carnitine that has higher bioavailability than carnitine and is considered a fat-burning energizer supplement. We previously found that in serum samples from prostate cancer (PCa) patients, 3 carnitine family members were significantly decreased, suggesting a potential protective role of carnitine against PCa. (Source: Cancer Letters)
Source: Cancer Letters - April 17, 2018 Category: Cancer & Oncology Authors: Denisa Baci, Antonino Bruno, Barbara Bassani, Matilde Tramacere, Lorenzo Mortara, Adriana Albini, Douglas M. Noonan Tags: Original Articles Source Type: research
The Interplay between Critical Transcription Factors and MicroRNAs in the Control of Normal and Malignant Myelopoiesis
Myelopoiesis is a complex process driven by essential transcription factors, including C/EBP α, PU.1, RUNX1, KLF4 and IRF8. Together, these factors are critical for the control of myeloid progenitor cell expansion and lineage determination in the development of granulocytes and monocytes/macrophages. MicroRNAs (miRNAs) are expressed in a cell type and lineage specific manner. There is incr easing evidence that miRNAs fine-tune the expression of hematopoietic lineage-specific transcription factors and drive the lineage decisions of hematopoietic progenitor cells. (Source: Cancer Letters)
Source: Cancer Letters - April 16, 2018 Category: Cancer & Oncology Authors: Christiaan J. Stavast, Pieter J.M. Leenen, Stefan J. Erkeland Tags: Mini-review Source Type: research
ARID1A ablation leads to multiple drug resistance in ovarian cancer via transcriptional activation of MRP2
Multiple Drug Resistance (MDR) of ovarian cancer is a severe trouble for clinical treatment and always contributes to a bad prognosis. AT-rich interaction domain 1 A (ARID1A) has been recognized as a bona fide tumor suppressor gene in recent years, with the highest mutation rate in ovarian cancer. Previous study illustrated that ARID1A expression is negatively correlated with chemoresistance of ovarian cancer cases. However, the specific role of ARID1A in c hemoresistance of ovarian cancer remains elusive. (Source: Cancer Letters)
Source: Cancer Letters - April 13, 2018 Category: Cancer & Oncology Authors: Qingyu Luo, Xiaowei Wu, Yiping Zhang, Tong Shu, Fang Ding, Hongyan Chen, Pengfei Zhao, Wan Chang, Xiaolin Zhu, Zhihua Liu Tags: Original Articles Source Type: research
miR-195 Potentiates the Efficacy of Microtubule-Targeting Agents in Non-Small Cell Lung Cancer
Microtubule-targeting agents (MTAs) are widely used for the treatment of non-small cell lung cancer (NSCLC). The response rate is only ∼25%, mainly attributable to drug resistance. To identify determinants of resistance in NSCLC, we performed a high-throughput screen using a library of miRNA mimics. Here we report that miR-195 synergizes with MTAs to inhibit the growth of NSCLC cells in vitro, that increased expression of miR-195 sensitizes NSCLC cells to MTAs and that repression of miR-195 confers resistance to MTAs. (Source: Cancer Letters)
Source: Cancer Letters - April 13, 2018 Category: Cancer & Oncology Authors: Xiaojie Yu, Yiqiang Zhang, Xiuye Ma, Alexander Pertsemlidis Tags: Original Articles Source Type: research
Jade family PHD finger 3 (JADE3) increases cancer stem cell-like properties and tumorigenicity in colon cancer
Jade family PHD finger 3 (JADE3) plays a role in inducing histone acetylation during transcription, and is involved in the progression of several human cancers; however, its role in colon cancer remains unclear. Herein, we found that JADE3 was markedly upregulated in colon cancer tissues and significantly correlated with cancer progression, and predicted shorter patient survival. Further, JADE3 was expressed much higher in colon cancer cell lines that are enriched with a stem-like signature. Overexpression of JADE3 increased, while silencing JADE3 reduced cancer stem cell-like traits in colon cancer cells in vitro and in v...
Source: Cancer Letters - April 13, 2018 Category: Cancer & Oncology Authors: Yunting Jian, Meng Wang, Yan Zhang, Ruizhang Ou, Ziyuan Zhu, Yangying Ou, Xiangfu Chen, Xin Liang, Yanqing Ding, Libing Song, Xuehu Xu, Wenting Liao Tags: Original Articles Source Type: research
miR-195 Potentiates the Efficacy of Microtubule-Targeting Agents in Non-Small Cell Lung Cancer
Microtubule-targeting agents (MTAs) are widely used for the treatment of non-small cell lung cancer (NSCLC). The response rate is only ∼25%, mainly attributable to drug resistance. To identify determinants of resistance in NSCLC, we performed a high-throughput screen using a library of miRNA mimics. Here we report that miR-195 synergizes with MTAs to inhibit the growth of NSCLC cells in vitro, that increased expression of miR-195 sensitizes NSCLC cells to MTAs and that repression of miR-195 confers resistance to MTAs. (Source: Cancer Letters)
Source: Cancer Letters - April 13, 2018 Category: Cancer & Oncology Authors: Xiaojie Yu, Yiqiang Zhang, Xiuye Ma, Alexander Pertsemlidis Tags: Original Articles Source Type: research
Jade family PHD finger 3 (JADE3) increases cancer stem cell-like properties and tumorigenicity in colon cancer
Jade family PHD finger 3 (JADE3) plays a role in inducing histone acetylation during transcription, and is involved in the progression of several human cancers; however, its role in colon cancer remains unclear. Herein, we found that JADE3 was markedly upregulated in colon cancer tissues and significantly correlated with cancer progression, and predicted shorter patient survival. Further, JADE3 was expressed much higher in colon cancer cell lines that are enriched with a stem-like signature. Overexpression of JADE3 increased, while silencing JADE3 reduced cancer stem cell-like traits in colon cancer cells in vitro and in v...
Source: Cancer Letters - April 13, 2018 Category: Cancer & Oncology Authors: Yunting Jian, Meng Wang, Yan Zhang, Ruizhang Ou, Ziyuan Zhu, Yangying Ou, Xiangfu Chen, Xin Liang, Yanqing Ding, Libing Song, Xuehu Xu, Wenting Liao Tags: Original Articles Source Type: research
