Transcriptomic Analysis in Liquid Biopsy Identifies Circulating PCTAIRE-1 mRNA as a Biomarker in NSCLC
Conclusion: Circulating mRNA can be profiled with the DASL assay. From the profile, PCTAIRE-1 RNA in the plasma we discovered as a novel diagnostic/prognostic biomarker and an indicator of poor survival in NSCLC patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2019 Category: Cancer & Oncology Authors: CHANG, J. W.-C., SHIH, C.-L., WANG, C.-L., LUO, J.-D., WANG, C.-W., HSIEH, J.-J., YU, C.-J., CHIOU, C.-C. Tags: Article Source Type: research
BRD4-Regulated Molecular Targets in Mantle Cell Lymphoma: Insights into Targeted Therapeutic Approach
Conclusion: Concomitant targeting multiple BRD4-regulated molecules may constitute a rational therapeutic strategy for MCL. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2019 Category: Cancer & Oncology Authors: TSUKAMOTO, T., NAKAHATA, S., SATO, R., KANAI, A., NAKANO, M., CHINEN, Y., MAEGAWA-MATSUI, S., MATSUMURA-KIMOTO, Y., TAKIMOTO-SHIMOMURA, T., MIZUNO, Y., KUWAHARA-OTA, S., KAWAJI, Y., TANIWAKI, M., INABA, T., TASHIRO, K., MORISHITA, K., KURODA, J. Tags: Article Source Type: research
Therapeutic Efficacy Evaluation of Pegylated Liposome Encapsulated With Vinorelbine Plus 111In Repeated Treatments in Human Colorectal Carcinoma With Multimodalities of Molecular Imaging
Conclusion: The tumors in NOD/SCID mice bearing HT-29/tk-luc xenografts were significantly suppressed by 111In-VNB-liposomes. The study proposed repeated treatments with a novel liposome-mediated radiochemotherapy and validation of therapeutic efficacy via imaging. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2019 Category: Cancer & Oncology Authors: CHIEN, Y.-C., CHOU, Y.-H., WANG, W.-H., CHEN, J. C.-H., CHANG, W.-S., TSAI, C.-W., BAU, D.-T., HWANG, J.-J. Tags: Article Source Type: research
Increased Expression of Gremlin1 Promotes Proliferation and Epithelial Mesenchymal Transition in Gastric Cancer Cells and Correlates With Poor Prognosis of Patients With Gastric Cancer
Conclusion: Increased GREM1 expression in GCs is associated with disease progression and poor prognosis in which EMT, angiogenesis and lymphangiogenesis are likely involved. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2019 Category: Cancer & Oncology Authors: SUN, Z., CAI, S., LIU, C., CUI, Y., JI, J., JIANG, W. G., YE, L. Tags: Article Source Type: research
Chromosome Translocation t(14;21)(q11;q22) Activates Both OLIG1 and OLIG2 in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis
Conclusion: The translocation t(14;21)(q11;q22) occurs in some pediatric T-cell lymphoblastic malignancies. Activation of both OLIG1 and OLIG2 by t(14;21)(q11;q22) in T-lymphoblasts and the ensuing deregulation of thousands of genes could explain the highly malignant disease and resistance to treatment that has characterized this small group of patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2019 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., JOHANNSDOTTIR, I. M. R., ANDERSEN, K., HOLTH, A., BEISKE, K., HEIM, S. Tags: Article Source Type: research
PPAR{gamma} Agonist Pioglitazone in Combination With Cisplatinum Arrests a Chemotherapy-resistant Osteosarcoma PDOX Model
Conclusion: These results suggest that combining PIO along with CDDP could be an effective treatment strategy for osteosarcoma and has important clinical potential for patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2019 Category: Cancer & Oncology Authors: HIGUCHI, T., YAMAMOTO, J., SUGISAWA, N., TASHIRO, Y., NISHINO, H., YAMAMOTO, N., HAYASHI, K., KIMURA, H., MIWA, S., IGARASHI, K., BOUVET, M., SINGH, S. R., TSUCHIYA, H., HOFFMAN, R. M. Tags: Article Source Type: research
TRAF6-Mediated Inflammatory Cytokines Secretion in LPS-induced Colorectal Cancer Cells Is Regulated by miR-140
Conclusion: miR-140 regulates inflammatory cytokine secretion of LPS-induced colorectal cancer cells by targeting TRAF6. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2019 Category: Cancer & Oncology Authors: ZHU, G., LIN, C., CHENG, Z., WANG, Q., HOFFMAN, R. M., SINGH, S. R., HUANG, Y., ZHENG, W., YANG, S., YE, J. Tags: Article Source Type: research
MicroRNAs Involved in Metastasis of Hepatocellular Carcinoma: Target Candidates, Functionality and Efficacy in Animal Models and Prognostic Relevance
We describe miRs which mediate or repress HCC metastasis in mouse xenograft models. We discuss 18 metastasis-promoting miRs and 35 metastasis-inhibiting miRs according to the criteria as outlined. Six of the metastasis-promoting miRs (miR-29a, -219-5p, -331-3p, 425-5p, -487a and -1247-3p) are associated with unfavourable clinical prognosis. Another set of six down-regulated miRs (miR-101, -129-3p, -137, -149, -503, and -630) correlate with a worse clinical prognosis. We discuss the corresponding metastasis-related targets as well as their potential as therapeutic modalities for treatment of HCC-related metastasis. A subset...
Source: Cancer Genomics and Proteomics - December 26, 2019 Category: Cancer & Oncology Authors: WEIDLE, U. H., SCHMID, D., BIRZELE, F., BRINKMANN, U. Tags: Article Source Type: research
Index
(Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Tags: Index Source Type: research
DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency
Conclusion: A complex circuitry between retinoic acid signaling, SWI/SNF components, pluripotency factors including Oct4, Sox2 and Nanog and cell cycle regulators was identified. It is suggested that the DNA replication inhibitor geminin plays a central role in this circuitry. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: TSANIRAS, S. C., DELINASIOS, G. J., PETROPOULOS, M., PANAGOPOULOS, A., ANAGNOSTOPOULOS, A. K., VILLIOU, M., VLACHAKIS, D., BRAVOU, V., STATHOPOULOS, G. T., TARAVIRAS, S. Tags: Article Source Type: research
Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis
Conclusion: These DEPs can potentially be used as biomarkers for the diagnosis of liver metastasis and they may provide a new strategy for developing anti-metastatic liver drugs in colon cancer patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: KIM, E.-K., SONG, M.-J., JUNG, Y., LEE, W.-S., JANG, H. H. Tags: Article Source Type: research
The Activity of Immune Checkpoint Inhibition in KRAS Mutated Non-small Cell Lung Cancer: A Single Centre Experience
Conclusion: Our data suggest that KRAS mutation is predictive of a superior response to immunotherapy. Furthermore, the lack of response of STK11 and KRAS co-mutated NSCLC patients to ICIs, is indeed negated by an additional TP53 mutation. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: TORRALVO, J., FRIEDLAENDER, A., ACHARD, V., ADDEO, A. Tags: Article Source Type: research
Proteomic Profile of Sorafenib Resistance in Hepatocellular Carcinoma; GRP78 Expression Is Associated With Inferior Response to Sorafenib
Conclusion: GRP78 can be a predictive biomarker in HCC patients treated with sorafenib. Strategies designed to inhibit the GRP78-related pathway may overcome sorafenib resistance. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: FENG, Y.-H., TUNG, C.-L., SU, Y.-C., TSAO, C.-J., WU, T.-F. Tags: Article Source Type: research
Genetic Characterization of Myoid Hamartoma of the Breast
Conclusion: Myoid hamartoma of the breast may be pathogenetically related to benign connective tissue tumors with HMGA2 rearrangements, such as pulmonary hamartomas, lipomas, myolipomas, and leiomyomas. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., ANDERSEN, H. K., PEDERSEN, T. D., LOMO, J., LUND-IVERSEN, M., MICCI, F., HEIM, S. Tags: Article Source Type: research
Loss of Both USP10 and p14ARF Protein Expression Is an Independent Prognostic Biomarker for Poor Prognosis in Patients With Epithelial Ovarian Cancer
Conclusion: Decreased expression of USP10 or combined USP10/p14ARF decreased expression is a strong indicator of poor prognosis in patients with ovarian cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: HAN, G. H., CHAY, D. B., YI, J. M., CHO, H., CHUNG, J.-Y., KIM, J.-H. Tags: Article Source Type: research
