Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma
Conclusion: Up-regulation of PNCK expression as well as its association with poor prognosis was demonstrated in HCC. PNCK might be a prognostic biomarker of HCC, and could be a potential candidate therapeutic target. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: CHO, Y. A., CHOI, S., PARK, S., PARK, C.-K., HA, S. Y. Tags: Experimental Studies Source Type: research
The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential
Conclusion: The protective effect of SNP 4 from PCa is lost and modified by tanning potential in African Americans. This finding needs to be verified by larger studies in different ethnic populations. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: BEYENE, D. A., DAREMIPOURAN, M. R., APPREY, V., NAAB, T., KASSIM, O. O., COPELAND, R. L., KANAAN, Y. M. Tags: Experimental Studies Source Type: research
Stem-like Cells from Invasive Breast Carcinoma Cell Line MDA-MB-231 Express a Distinct Set of Eph Receptors and Ephrin Ligands
Conclusion: The up-regulation of transcripts for EPHA8 and its cognate ligand, ephrin-A5, in the stem cells isolated from MDA-MB-231, suggest their involvement in the invasiveness of this cell line. Based on literature reports, we propose the role of EPHA8 and ephrin-A5 in MDA-MB-231 stem cells via the PI3K-AKT-mTOR pathway. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: LUCERO, M., THIND, J., SANDOVAL, J., SENAATI, S., JIMENEZ, B., KANDPAL, R. P. Tags: Experimental Studies Source Type: research
The KDR (VEGFR-2) Genetic Polymorphism Q472H and c-KIT Polymorphism M541L Are Associated With More Aggressive Behaviour in Astrocytic Gliomas
Conclusion: This study highlights the role of single-nucleotide variants (SNVs) that may be considered non-pathogenic and suggests the prognostic significance for survival of KIT rs3822214 and KDR rs1870377 and potential importance in planning new treatment strategies for gliomas. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: ZAMAN, N., DASS, S. S., DU PARCQ, P., MACMAHON, S., GALLAGHER, L., THOMPSON, L., KHORASHAD, J. S., LIMBACK-STANIC, C. Tags: Experimental Studies Source Type: research
Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2
Conclusion: Our results are indicative of an association between GRIK2 and aging of fibroblasts. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: ZHAWAR, V. K., KANDPAL, R. P., ATHWAL, R. S. Tags: Experimental Studies Source Type: research
Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis
Conclusion: Thus, our study suggested the functional interaction of G9a, Dclk1 and Mapk pathway in the Kras-driven pancreatic carcinogenesis. The inhibition of G9a may suppress the initiation of oncogenic Kras-driven pancreatic carcinogenesis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: KATO, H., TATEISHI, K., FUJIWARA, H., IJICHI, H., YAMAMOTO, K., NAKATSUKA, T., KAKIUCHI, M., SANO, M., KUDO, Y., HAYAKAWA, Y., NAKAGAWA, H., TANAKA, Y., OTSUKA, M., HIRATA, Y., TACHIBANA, M., SHINKAI, Y., KOIKE, K. Tags: Experimental Studies Source Type: research
TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer
Conclusion: There is a potential interaction between H4K12ac and TIP60 in heterochromatin or euchromatin in breast tumors. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: IDRISSOU, M., BOISNIER, T., SANCHEZ, A., KHOUFAF, F. Z. H., PENAULT-LLORCA, F., BIGNON, Y.-J., BERNARD-GALLON, D. Tags: Experimental Studies Source Type: research
Differential Proteomic Analysis of Hepatocellular Carcinomas from Ppp2r5d Knockout Mice and Normal (Knockout) Livers
Conclusion: We identified several proteins for further exploration as novel potential HCC biomarkers, and independently underscored the relevance of Ppp2r5d knockout mice as a valuable hepatocarcinogenesis model. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: LAMBRECHT, C., FERREIRA, G. B., OMELLA, J. D., LIBBRECHT, L., DE VOS, R., DERUA, R., MATHIEU, C., OVERBERGH, L., WAELKENS, E., JANSSENS, V. Tags: Experimental Studies Source Type: research
Micro RNAs Promoting Growth and Metastasis in Preclinical In Vivo Models of Subcutaneous Melanoma
During the last years a considerable therapeutic progress in melanoma patients with the RAF V600E mutation via RAF/MEK pathway inhibition and immuno-therapeutic modalities has been witnessed. However, the majority of patients relapse after therapy. Therefore, a deeper understanding of the pathways driving oncogenicity and metastasis of melanoma is of paramount importance. In this review, we summarize microRNAs modulating tumor growth, metastasis, or both, in preclinical melanoma-related in vivo models and possible clinical impact in melanoma patients as modalities and targets for treatment of melanoma. We have identified m...
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: WEIDLE, U. H., AUSLANDER, S., BRINKMANN, U. Tags: Reviews Source Type: research
Erratum
(Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Tags: Erratum Source Type: research
Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of SESN2 Have a Role in Age-related Different Prognoses?
Conclusion: This is the first time that a CNA involving the deletion of the SESN2 gene is associated with papillary thyroid carcinomas, particularly in patients aged 45 years and older, indicating that this deletion would lead to a more malignant and prominent tumoral behavior associated to a worst prognosis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: DE ALMEIDA, D. C. N., DE SOUZA, M. P. C., AMORIM, C. K. N., DA SILVA MAUES, J. H., DO E. SANTO SAGICA, F., MOREIRA-NUNES, C. A., DE OLIVEIRA, E. H. C. Tags: Clinical Studies Source Type: research
Clinicopathological and Molecular Differences Between Gastric-type Mucinous Carcinoma and Usual-type Endocervical Adenocarcinoma of the Uterine Cervix
Conclusion: GMC is associated with more aggressive behavior than UEA. Distinctive p53 and p16 immunostaining patterns enable differential diagnosis. GMC and UEA exhibit genetic heterogeneity with potentially actionable molecular alterations. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: JUNG, H., BAE, G. E., KIM, H. M., KIM, H.-S. Tags: Clinical Studies Source Type: research
hTERT Protein Expression in Cytoplasm and Nucleus and its Association With HPV Infection in Patients With Cervical Cancer
Conclusion: hTERT protein is found in both the nucleus and cytoplasm of patients with cervical cancer and confirm the relationship between the non-methylated status of hTERT promoter and some HPV species as well as the relationship between these species and hTERT protein expression. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: MORENO-ACOSTA, P., MOLANO, M., MORALES, N., ACOSTA, J., GONZALEZ-PRIETO, C., MAYORGA, D., BUITRAGO, L., GAMBOA, O., MEJIA, J. C., CASTRO, J., ROMERO-ROJAS, A., ESPENEL, S., MURRAY, G. L., GARLAND, S. M., VALLARD, A., MAGNE, N. Tags: Clinical Studies Source Type: research
Association of miR-125b, miR-17 and let-7c Dysregulations With Response to Anti-epidermal Growth Factor Receptor Monoclonal Antibodies in Patients With Metastatic Colorectal Cancer
Conclusion: The results show that up-regulation of miR-125b is associated with higher ORR and DCR and longer survival; let-7c up-regulation and miR-17 down-regulation are associated with higher DCR in mCRC patients treated with anti-EGFR mAbs. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: FIALA, O., SOREJS, O., HOSEK, P., LISKA, V., VYCITAL, O., BRUHA, J., KUCERA, R., TOPOLCAN, O., FINEK, J., MACECKOVA, D., PITULE, P. Tags: Clinical Studies Source Type: research
Influence of Concurrent Mutations on Overall Survival in EGFR-mutated Non-small Cell Lung Cancer
Conclusion: Concurrent resistance mutations in genes other than EGFR influenced the outcome of patients with NSCLC, while non-resistance mutations did not alter survival, compared to the absence of co-mutations. This evidence highlights the importance of a careful interpretation of molecular findings. The best treatment options for these patients should be studied in randomized controlled trials. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: CHEVALLIER, M., TSANTOULIS, P., ADDEO, A., FRIEDLAENDER, A. Tags: Clinical Studies Source Type: research
