Time to diagnosis and stage of symptomatic colorectal cancer determined by three different sources of information: A population based retrospective study
Conclusion There is no evidence that patients with more advanced CRC have longer TDIs. In fact, we found an inverse relationship between the TDI and CRC stage, an example of the “waiting time paradox”. This association may likely be due to the presence of unmeasured confounders as the stage when symptoms appear or the tumour aggressiveness. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - January 23, 2017 Category: Cancer & Oncology Source Type: research

Incidence, mortality and receptor status of breast cancer in African Caribbean women: Data from the cancer registry of Guadeloupe
Conclusion We found high age-specific incidence rates of breast cancer in women aged 45 to 55 years, which warrants further investigation in our population. However, this population of mainly African descent had good overall survival rates, and data according to subtypes are consistent with those reported internationally. These results may suggest that poorer survival in other African descent populations may not be an inherent feature of the disease but may be amenable to improvement. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - January 22, 2017 Category: Cancer & Oncology Source Type: research

Development of a model to predict the 10-year cumulative risk of second primary cancer among cancer survivors
Conclusion This study provides physicians with a practical estimate to assess the risk of SPC of their patients more accurately. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - January 21, 2017 Category: Cancer & Oncology Source Type: research

Early adulthood body mass index, cumulative smoking, and esophageal adenocarcinoma survival
Conclusions Two key modifiable behaviors, elevated BMI in early adulthood and heavy cumulative smoking history are independently associated with increased mortality risk in two North American cohorts of EAC patients. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - January 13, 2017 Category: Cancer & Oncology Source Type: research

Low-dose aspirin use and survival in breast cancer patients: A nationwide cohort study
Conclusion In this large nationwide study of breast cancer patients, we found little evidence of an association between post-diagnostic low-dose aspirin use and cancer-specific mortality. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - January 13, 2017 Category: Cancer & Oncology Source Type: research

Association between comorbidity and participation in breast and cervical cancer screening: A systematic review and meta-analysis
Conclusion While a definitive conclusion could not be drawn, the results from high quality studies suggest that women with comorbidity are less likely to participate in breast, and possibly cervical, cancer screening. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - January 11, 2017 Category: Cancer & Oncology Source Type: research

The future excess fraction of occupational cancer among those exposed to carcinogens at work in Australia in 2012
Conclusions A significant proportion of future cancers will result from occupational exposures. This estimate is lower than previous estimates in the literature; however, our estimate is not directly comparable to past estimates of the occupational cancer burden because they describe different quantities – future cancers in currently exposed versus current cancers due to past exposures. The results of this study allow us to determine which current occupational exposures are most important, and where to target exposure prevention. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - January 10, 2017 Category: Cancer & Oncology Source Type: research

Disparities in hospitalization outcomes among African-American and White prostate cancer patients
Conclusion There were significant racial differences in outcomes among prostate cancer patients within the inpatient setting, even after accounting for demographic and presentation differences. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - January 4, 2017 Category: Cancer & Oncology Source Type: research

Proton pump inhibitors on pancreatic cancer risk and survival
Conclusions Long-term PPI therapy may be associated with pancreatic cancer risk. While PPI users recently started on treatment had a slightly worse survival, this result likely is from reverse causation. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - January 3, 2017 Category: Cancer & Oncology Source Type: research

Trends of classification, incidence, mortality, and survival of MDS patients in Switzerland between 2001 and 2012
Publication date: February 2017 Source:Cancer Epidemiology, Volume 46 Author(s): Nicolas Bonadies, Anita Feller, Alicia Rovo, Axel Ruefer, Sabine Blum, Bernhard Gerber, Georg Stuessi, Rudolf Benz, Nathan Cantoni, Andreas Holbro, Adrian Schmidt, Thomas Lehmann, C. Matthias Wilk, Volker Arndt Myelodysplastic syndromes (MDS) are emerging disorders of the elderly with an increasing burden on healthcare systems. He we report on the first population-based, epidemiological analysis of patients diagnosed with MDS in Switzerland between 2001 and 2012. The aim of this study was to characterize the extent and limitations of currentl...
Source: Cancer Epidemiology - January 3, 2017 Category: Cancer & Oncology Source Type: research

Body mass index, height and early-onset basal cell carcinoma in a case-control study
Conclusions We found a significant inverse association between BMI and early-onset BCC, but no association between height and BCC. This association was not explained by UV exposures or estrogen-related exposures in women. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - December 28, 2016 Category: Cancer & Oncology Source Type: research

Geographic patterns of change over time in mammography: Differences between Black and White U.S. Medicare enrollees
Publication date: February 2017 Source:Cancer Epidemiology, Volume 46 Author(s): Laura Stiel, Samuel Soret, Susanne Montgomery U.S. Black women have higher breast cancer mortality compared to White women while their rate of ever having a mammogram has become equal to or slightly surpassed that of Whites. We mapped the distribution of change in screening mammography for Black and White female Medicare enrollees ages 67–69 from 2008 to 2012 by hospital referral region across the contiguous U.S., performed cluster analysis to assess spatial autocorrelation, and examined the screening differences between these groups in...
Source: Cancer Epidemiology - December 26, 2016 Category: Cancer & Oncology Source Type: research

Assessment of lead-time bias in estimates of relative survival for breast cancer
We describe a simulation-based framework for studying the lead-time bias due to mammography screening on RSRs of breast cancer based on a natural history model developed in a Swedish setting. We have performed simulations, using this framework, under different assumptions for screening sensitivity and breast cancer survival with the aim of estimating the lead-time bias. Screening every second year among ages 40–75 was introduced assuming that screening had no effect on survival, except for lead-time bias. Relative survival was estimated both with and without screening to enable quantification of the lead-time bias. S...
Source: Cancer Epidemiology - December 25, 2016 Category: Cancer & Oncology Source Type: research

Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics
Conclusions Malignant yolk sac tumors and malignant teratomas exhibited distinct demographic and gestational characteristics; additionally, complications in pregnancy and labor may be brought on by specific histologic subtypes. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - December 23, 2016 Category: Cancer & Oncology Source Type: research

Lower use of prostate specific antigen testing by cigarette smokers —Another possible explanation for the unfavorable prostate cancer (PCA) specific prognosis in smokers?
Publication date: February 2017 Source:Cancer Epidemiology, Volume 46 Author(s): Matthias May, Odilo Maurer, Steffen Lebentrau, Sabine Brookman-May (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - December 22, 2016 Category: Cancer & Oncology Source Type: research

Evaluation of maternal health and labor and delivery conditions as risk factors for childhood leukemias in children with Down syndrome
Publication date: February 2017 Source:Cancer Epidemiology, Volume 46 Author(s): Susan E. Carozza, Harold Bae, Thomas Meath, Adam Branscum, Marit L. Bovbjerg, Peter H. Langlois Children with Down syndrome (DS) have a remarkably high risk of developing leukemia during childhood; the mechanisms driving that risk are not well understood, and no clear prevention strategies exist. We conducted a nested case-control study in a Texas DS birth cohort to investigate possible links between maternal health, labor/delivery conditions, and leukemia risk. For most of the factors studied there was no evidence of an increased risk of tot...
Source: Cancer Epidemiology - December 22, 2016 Category: Cancer & Oncology Source Type: research

Diet and the risk of head-and-neck cancer among never-smokers and smokers in a Chinese population
Conclusions Reduced HNC risks were observed for high fruit and vegetable intake, a finding consistent with the results of previous studies. Processed meat intake was associated with an increased risk. The role of dietary factors in HNC in the East Asian population is similar to that in European populations. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - December 3, 2016 Category: Cancer & Oncology Source Type: research

Prevalence and characteristics of cancer patients receiving care from single vs. multiple institutions
Conclusions Population-based data show that one in six newly diagnosed cancer patients received care from multiple institutions, and differed from patients seen only at a single institution. Cancer care data from single institutions may be incomplete and possibly biased. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - December 3, 2016 Category: Cancer & Oncology Source Type: research

Economic analysis of the Nairobi Cancer Registry: Implications for expanding and enhancing cancer registration in Kenya
Conclusions Stable funding for cancer registry operations is necessary to sustain core registry activities in other to deliver high-quality data, which in turn is necessary to foster evidence-based policies to improve cancer outcomes. As stakeholders look into expanding the Nairobi Cancer Registry into a national program, the cost data provided in this study will help justify the funding required for sustaining and expanding registry activities. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - December 1, 2016 Category: Cancer & Oncology Source Type: research

Uganda experience —Using cost assessment of an established registry to project resources required to expand cancer registration
Conclusion After identifying many differences between KCR and GCR that could potentially affect the cost of registration, our best estimate is that the GCR, though newer and in a rural area, should require fewer resources than the KCR to sustain operations as a stand-alone entity. The optimal structure of the GCR needs to be determined in the future. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 25, 2016 Category: Cancer & Oncology Source Type: research

What explains the differences between centres in the European screening trial? A simulation study
Conclusion The small screening impact in Finland was not explained by the differences in the screening protocols. A possible reason for it was the contamination of and the unexpectedly low PrCa mortality in the Finnish control arm. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 25, 2016 Category: Cancer & Oncology Source Type: research

Evaluating the use of friend or family controls in epidemiologic case-control studies
Conclusion The apparent comparability of neighborhood controls to friend and family controls among respondents in this study suggests that these alternative methods of control identification can serve as a complementary source of eligible controls in epidemiologic case-control studies. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 19, 2016 Category: Cancer & Oncology Source Type: research

Terminate lung cancer (TLC) study —A mixed-methods population approach to increase lung cancer screening awareness and low-dose computed tomography in Eastern Kentucky
This study reports on rates of awareness and screening in intervention regions, as compared to a control region. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 18, 2016 Category: Cancer & Oncology Source Type: research

Economic assessment of integrated cancer and cardiovascular registries: The Barbados experience
Conclusion These findings indicate that there are substantial fixed costs related to management and administration of NCD registries. All registries need management and administration support. When registries are combined, management and administration costs can be shared. We project that registries that can share fixed-cost infrastructure are likely to incur a lower total cost per case. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 17, 2016 Category: Cancer & Oncology Source Type: research

Enrolment of young women attending cervical cancer screening to survey effectiveness of HPV vaccination
Publication date: Available online 12 November 2016 Source:Cancer Epidemiology Author(s): Marc Arbyn, Davy Vanden Broeck, Johannes Bogers, Pierre Van Damme, Marleen Temmerman, Steven Weyers (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 13, 2016 Category: Cancer & Oncology Source Type: research

HR+/Her2- breast cancer in pre-menopausal women: The impact of younger age on clinical characteristics at diagnosis, disease management and survival
Publication date: December 2016 Source:Cancer Epidemiology, Volume 45 Author(s): Marianna De Camargo Cancela, Harry Comber, Linda Sharp Young women (20–39 years-old) with breast cancer are diagnosed with more aggressive tumours and consequently have poorer survival. However, there is an evidence gap as to whether age has an independent effect on survival of pre-menopausal women diagnosed with HR+/Her2- tumours. The aim of this population-based study was to compare characteristics at diagnosis, determinants of treatment and survival in women aged 20–39 and 40–49 years diagnosed with HR+/Her2- tumours. Fro...
Source: Cancer Epidemiology - November 13, 2016 Category: Cancer & Oncology Source Type: research

There is no point in cervical cancer screening below 25 years of age
Publication date: Available online 11 November 2016 Source:Cancer Epidemiology Author(s): Wiebren A.A. Tjalma (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 12, 2016 Category: Cancer & Oncology Source Type: research

Parkinson ’s disease and risk of prostate cancer: A Danish population-based case-control study, 1995–2010
Conclusion Parkinson’s disease was associated with a risk reduction overall (27%), which decreased with increasing duration of Parkinson’s disease. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 11, 2016 Category: Cancer & Oncology Source Type: research

Corrigendum to “European Code against Cancer 4th Edition: Alcohol drinking and cancer‿ [Cancer Epidemiology 39S1 (2015) S67–S74]
Publication date: Available online 4 November 2016 Source:Cancer Epidemiology (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 5, 2016 Category: Cancer & Oncology Source Type: research

Dietary water intake and bladder cancer risk: An Italian case –control study
Publication date: December 2016 Source:Cancer Epidemiology, Volume 45 Author(s): Matteo Di Maso, Cristina Bosetti, Martina Taborelli, Maurizio Montella, Massimo Libra, Antonella Zucchetto, Federica Turati, Maria Parpinel, Eva Negri, Alessandra Tavani, Diego Serraino, Monica Ferraroni, Carlo La Vecchia, Jerry Polesel Previous studies on the relationship between fluid intake and risk of bladder cancer have generally focused on beverages, and results have been inconsistent. We investigated the relationship between water intake and bladder cancer risk, considering water from both beverages and foods. Between 2003 and 2014 we ...
Source: Cancer Epidemiology - November 5, 2016 Category: Cancer & Oncology Source Type: research

Association between family cancer history and risk of pancreatic cancer
Conclusions Our results yield further evidence of increased risk of pancreatic cancer in those with family histories of the disease. We also provide suggestive evidence of an association between family history of melanoma and risk of pancreatic cancer. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 2, 2016 Category: Cancer & Oncology Source Type: research

Breast cancer risk and the interaction between adolescent body size and weight gain in later life: A case-control study
Conclusion In postmenopausal women adolescent leanness was only associated with increased breast cancer risk when excess weight was gained during adulthood. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 1, 2016 Category: Cancer & Oncology Source Type: research

Cancer screening barriers and facilitators for under and never screened populations: A mixed methods study
Conclusions Interventions addressing fear through individual, interpersonal and structural facilitators may increase cancer screening. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 30, 2016 Category: Cancer & Oncology Source Type: research

Estimating the cost of operating cancer registries: Experience in Colombia
Conclusions The detailed economic information presented in this study constitutes a valuable source of activity-based cost data that registries can use to compare operations, assess key factors that lead to differences in cost per case, and identify potential approaches to improve efficiencies. Furthermore, the knowledge gained from studying the Colombian registries can help inform the planning and operations of other registries in the region. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 29, 2016 Category: Cancer & Oncology Source Type: research

Resource requirements for cancer registration in areas with limited resources: Analysis of cost data from four low- and middle-income countries
Conclusion This study estimates the total cost and resources used for cancer registration across several countries in the limited-resource setting, and provides cancer registration stakeholders and registries with opportunities to identify cost savings and efficiency improvements. Our results suggest that cancer registration involve substantial fixed costs and labor, and that partnership with other institutions is critical for the operation and sustainability of cancer registries in limited resource settings. Although we included registries from a variety of limited-resource areas, information from eight registries in four...
Source: Cancer Epidemiology - October 29, 2016 Category: Cancer & Oncology Source Type: research

Tea, coffee, and caffeinated beverage consumption and risk of epithelial ovarian cancers
Conclusion Black tea consumption may be associated with an increased risk epithelial ovarian carcinoma. The excess risk is seen only in the endometrioid histotype but not in serous or clear cell. Further studies are required to confirm these findings and identify the constituents in black tea that may increase the risk. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 29, 2016 Category: Cancer & Oncology Source Type: research

Association between the TCF7L2 polymorphism and colorectal cancer does not differ by diabetes and obesity statuses
This study evaluated the association between polymorphism in a newly identified locus, rs11196172, located in transcription factors 7-like 2 (TCF7L2) and colorectal cancer (CRC) risk according to diabetes and obesity statuses. A study enrolled 6138 CRC patients and 4367 community controls. The adjusted odds ratios (aORs) with age, sex, smoking, and body mass index of the A allele, compared with the G allele, was 1.08 (95% CI 1.01–1.16). The significantly higher risk of CRC with the A allele remained after adjusting for diabetic status (aOR 1.07, 95% CI 1.01–1.15). When stratified by diabetic or obesity status, ...
Source: Cancer Epidemiology - October 29, 2016 Category: Cancer & Oncology Source Type: research

Association of cigarette smoking and microRNA expression in rectal cancer: Insight into tumor phenotype
We examined current smoking, current versus never and former versus never (C/F/N) smoking 1 1 C/F/N smoking: Differential miRNA expression in subjects who were current smokers at time of diagnosis compared to subjects who never smoked, and differential miRNA expression in former smokers compared to those who had never smoked. , and pack-years smoked with miRNA expression in normal mucosa as well as differential miRNA expression between paired normal and carcinoma tissue for colon and rectal tissue to determine associations between smoking and miRNA expression. We adjusted for multiple comparisons using the Benjamini Hochbe...
Source: Cancer Epidemiology - October 29, 2016 Category: Cancer & Oncology Source Type: research

Racial/ethnicity disparities in invasive breast cancer among younger and older women: An analysis using multiple measures of population health
Conclusions The breast cancer disparities between younger NHB compared to NHW women highlight the need for expanded efforts to address these disparities through primary prevention and to improve access to quality healthcare to minority women with breast cancer. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 29, 2016 Category: Cancer & Oncology Source Type: research

The burden of HPV associated cancers in two regions in Nigeria 2012 –2014
Conclusions HPV attributable cancers constitute a substantial cancer burden in Nigerian women, much less so in men. A significant proportion of cancers in Nigerian women would be prevented if strategies such as HPV DNA based screening and HPV vaccination are implemented. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 29, 2016 Category: Cancer & Oncology Source Type: research

Population-based analysis of breast cancer treatment by intrinsic sub-type in Manitoba, Canada
Conclusions Reasons for variability in the prevalence of intrinsic sub-type by region is not fully understood. Manitoba is unique due the stability of the population, completeness of the registry and length of breast cancer screening program. Few true population-based studies grouped by intrinsic sub-type are available. Impact Descriptive epidemiological studies guide future research by identifying factors that can affect treatment, recurrence, and survival. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 29, 2016 Category: Cancer & Oncology Source Type: research

Importance of economic evaluation of cancer registration in the resource limited setting: Laying the groundwork for surveillance systems
Publication date: Available online 15 October 2016 Source:Cancer Epidemiology Author(s): Mona Saraiya, Florence K.L. Tangka, Samira Asma, Lisa C. Richardson (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 16, 2016 Category: Cancer & Oncology Source Type: research

Statin use and survival in colorectal cancer: Results from a population-based cohort study and an updated systematic review and meta-analysis
Conclusion In a Scottish CRC cohort and updated meta-analysis there was some evidence that statin use was associated with improved survival. However, these associations were weak in magnitude and, particularly for post-diagnosis use, varied markedly between studies. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 16, 2016 Category: Cancer & Oncology Source Type: research

Developing and testing a cost data collection instrument for noncommunicable disease registry planning
Conclusion Internal and external registry factors reveal that a single estimate for the cost of registry operations is not feasible; costs will vary on the basis of factors that may be beyond the control of the registries. Some factors, such as data collection approach, can be modified to improve the efficiency of registry operations. These findings will inform both future economic data collection using a web-based tool and cost and cost-effectiveness analyses of registry operations in low- and middle-income countries (LMICs) and other locations with similar characteristics. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 10, 2016 Category: Cancer & Oncology Source Type: research

Economic evaluation of Mumbai and its satellite cancer registries: Implications for expansion of data collection
Conclusion The centralization of fixed-cost activities in Mumbai likely resulted in economies of scale in operating the Mumbai and satellite registries, which, together, report on almost 20,000 cancer cases annually. In middle-income countries like India, where financial resources are limited, the operational framework provided by the Mumbai and satellite registries can serve as a model for other registries looking to expand data collection. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 10, 2016 Category: Cancer & Oncology Source Type: research

Cancer mortality among adolescents and young adults: A historical cohort in a reference institution for cancer treatment in Santa Catarina/South of Brazil 2002 –2013
Conclusions The sample studied with a longer period of time between diagnosis and the start of treatment (access to oncology therapy) and with fewer years in school showed that these factors had important roles in early death from cancer for the observed individuals. This must be considered when planning and identifying risk in young cancer patients in order to lower the impact of the disease on mortality for this age group. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 4, 2016 Category: Cancer & Oncology Source Type: research

Colorectal cancer incidence in 5 Asian countries by subsite: An analysis of Cancer Incidence in Five Continents (1998 –2007)
In conclusion, there was substantial variation in subsite distributions of colorectal cancer in Asian registries and increases in overall incidence of colorectal cancer could be attributed to increases in colon cancer. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 4, 2016 Category: Cancer & Oncology Source Type: research

Black:white disparities in breast cancer mortality in the 50 largest cities in the United States, 2005 –2014
Conclusion This analysis provides updated city-level breast cancer mortality data for Black and White women through 2014, and reveals that in the US and 24 of the 43 largest US cities, Black women continue to die from breast cancer at a higher rate than their White counterparts. Importantly, however, a few cities, Memphis, Boston and Philadelphia, showed a decrease in the Black:White breast cancer mortality disparity between 2005–2009 and 2010–2014. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 3, 2016 Category: Cancer & Oncology Source Type: research

MicroRNA-related polymorphisms and non-Hodgkin lymphoma susceptibility in the Multicenter AIDS Cohort Study
Conclusions This study suggests that a few miRNA-SNPs are associated with AIDS-NHL risk and may modulate miRNA expression. These results support a role for miRNA in AIDS-NHL and may highlight pathways to be targeted for risk stratification or therapeutics. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 2, 2016 Category: Cancer & Oncology Source Type: research

Response to Letter to the Editor: Vitamin D status may help explain racial disparities in breast cancer hospitalization outcomes
Publication date: Available online 30 September 2016 Source:Cancer Epidemiology Author(s): Tomi Akinyemiju, Swati Sakhuja, Neomi Vin-Raviv (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 1, 2016 Category: Cancer & Oncology Source Type: research