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Birth Rates after Adolescent and Young Adult Cancer in North Carolina, 2000-2014
Each year, >45,000 U.S. women are diagnosed with cancer during adolescence and young adulthood (AYA), defined by the National Cancer Institute as ages 15–39 years. ASCO first published guidelines on fertility counseling and preservation for cancer patients in 2006. Few studies have assessed birth rates after cancer among AYAs. We identified women with an incident cancer diagnosis at ages 15–39 during 2000–2013 in the North Carolina Cancer Registry. Cancer records were linked with statewide birth certificates through 2014 using a probabilistic algorithm. Hazard ratios (HR) and 95% confidence intervals (...
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Nichols, H., Anderson, C., Black, K., Engel, S., Mersereau, J. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

Using Global Metabolomics to Identify Novel Biomarkers of Treatment-Associated Cognitive Impairment in Pediatric Acute Lymphoblastic Leukemia
Conclusion: We identified several novel CSF biomarkers of treatment-related cognitive impairment among pediatric ALL patients. These findings may translate to clinical improvements in the management of cognitive outcomes by introducing the opportunity to deliver targeted interventions to high-risk patients prior to detectable or irreversible cognitive impairment. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Brown, A., Rodgers, C., Taylor, O., Moore, I., Hooke, M., Pan, W., Hockenberry, M., Scheurer, M., Lupo, P. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

Decreasing Trends in Cervical Cancer Incidence among Young Women (15-34 Years) in the United States during the Human Papillomavirus (HPV) Vaccine Era
Conclusion: A significance decrease in the incidence of cervical cancer during the vaccine era among young females 15–24 years may indicate early effects of HPV vaccination. Further research is needed to confirm this trend. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Guo, F., Cofie, L., Berenson, A. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

Health System-Based HPV Vaccine Reminders: Randomized Trial Results
Conclusion: Reminder calls after an outreach letter led to more timely vaccine initiation and overall completion. Reminders beyond the initial letter and reminder call did not appear to impact vaccine series completion. The program was acceptable to parents, though there was low uptake of SMS reminders. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Henrikson, N., Zhu, W., Nguyen, M., Baba, L., Berthoud, H., Hofstetter, A. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

Effect of Diindolylmethane on Estrogen-related Hormones, Metabolites and Tamoxifen Metabolism: Results of a Randomized, Placebo-controlled Trial
Conclusions In this first large study of DIM in the setting of breast cancer chemoprevention, a favorable shift in estrogen metabolism and SHBG was demonstrated. However, the reduction in tamoxifen metabolites raises concern regarding the potential interaction between DIM and tamoxifen, an area in need of continued research. Impact Given the widespread and generally unsupported use of dietary supplementation by breast cancer survivors, these data will help to inform the use of DIM as a dietary supplement for breast cancer patients receiving tamoxifen. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Thomson, C., Chow, S., Roe, D., Wertheim, B., Chalasani, P., Altbach, M., Thompson, P., Stopek, A., Maskaranic, G. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

Long-term Adherence to Colorectal Cancer Screening; 5-Year Results from the Systems of Support to Increase Colorectal Cancer Screening Trial
Conclusions: An organized mail and phone program led to increased CRC screening adherence over 5 years, mainly because of regular fecal testing uptake. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Green, B., Anderson, M., Chubak, J., Fuller, S., Meenan, R., Vernon, S. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

Pilot-Testing a Survivorship Needs Assessment Planning Tool for Head and Neck Cancer Survivors and Caregivers
The purpose of this study was to develop and pilot-test a tablet-based survivorship needs assessment planning (SNAP) tool to assess head and neck cancer (HNC) survivor and caregiver needs after treatment and generate tailored care plans. We recruited survivors completing treatment <24 months ago, and their caregivers. Participants completed baseline surveys, a clinic session with SNAP assessments (symptoms, unmet needs, behaviors) and care plan delivery, and 6-week follow-up surveys. We tracked intervention delivery/acceptability and used paired t-tests to explore changes in psychosocial factors over time. We enrolled 2...
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Sterba, K., Zapka, J., Armeson, K., Garris, T., Scallion, M., Day, T. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

Explaining Disparities in Ovarian Cancer Incidence Rates between Women of African and European Ancestry: The Role of Genetic Factors
Non-Hispanic White (NHW) women are at higher risk of ovarian cancer than African-American (AA) women. Approximately 30% of the difference in age-adjusted invasive epithelial ovarian cancer incidence rates (AAIR) between the two groups can be explained by differing oophorectomy rates and the prevalence of non-genetic risk and protective factors. Our purpose was to determine how much of the remaining difference in AAIRs could be explained by varying allele frequencies between NHWs and AAs for 18 genome-wide significant common susceptibility variants for ovarian cancer. Using data on 13,385 cases and 24,875 controls from the ...
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Mullins, M., Mukherjee, B., Wu, A., Pike, M., Pharoah, P., Berchuck, A., Pearce, C., on behalf of the OCAC Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

Decision Support and Navigation to Increase Colorectal Cancer Screening among Hispanic Primary Care Patients
Conclusions. A decision support and navigation intervention significantly increased CRC screening adherence among Hispanic primary care patients. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Myers, R., Stello, B., Daskalakis, C., Sifri, R., DiCarlo, M., Johnson, M., Gonzalez, E., Hegarty, S., Rivera, A., Gordis-Molina, L., Shaak, K., Quinn, A., Careyva, B., Anderson-Ortiz, R. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

Effective Cancer Risk Communication to Prevent Disparities in the Era of Precision Medicine
As genetics and genomics become part of mainstream Medicine, these advances have the potential to reduce or exacerbate health disparities. Gaps in effective communication (where all parties share the same meaning) are widely recognized as a major contributor to health disparities. The purpose of this study was to examine cancer genetic counselor-patient communication, to assess its effectiveness from the patient perspective, and to pilot intervention strategies to improve it. We used multiple inductive methods, including standard ethnographic techniques to systematically observe and audio-record genetic counseling sessions...
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Joseph, G., Pasick, R., Schillinger, D., Luce, J., Cheng, J., Guerra, C. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research

The History of a Name: The American Society for Preventive Oncology Renames Its Highest Honor the Joseph F. Fraumeni, Jr., Distinguished Achievement Award
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Newcomb, P. A., Hsing, A. B., Bondy, M. L., Neugut, A. I. Tags: ASPO Report Source Type: research

Long-term Exposure to Fine Particulate Matter and Breast Cancer Incidence in the Danish Nurse Cohort Study
Conclusions: Air pollution is not associated with breast cancer risk. Impact: Exposure to air pollution in adulthood does not increase the risk of breast cancer, but more data on the effects of early exposure, before first birth, are needed. Cancer Epidemiol Biomarkers Prev; 26(3); 428–30. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Andersen, Z. J., Ravnskjaer, L., Andersen, K. K., Loft, S., Brandt, J., Becker, T., Ketzel, M., Hertel, O., Lynge, E., Bräuner, E. V. Tags: Null Results in Brief Source Type: research

Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer
Conclusions: We found no statistically significant associations between inherited chromosomally integrated HHV-6 and breast cancer in women. Impact: These results do not provide evidence to suggest that iciHHV-6 is a risk factor for breast cancer. Cancer Epidemiol Biomarkers Prev; 26(3); 425–7. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Gravel, A., Dubuc, I., Brooks-Wilson, A., Aronson, K. J., Simard, J., Velasquez-Garcia, H. A., Spinelli, J. J., Flamand, L. Tags: Null Results in Brief Source Type: research

Urinary Melatonin in Relation to Postmenopausal Breast Cancer Risk According to Melatonin 1 Receptor Status
Conclusions: Higher urinary melatonin levels were associated with reduced breast cancer risk in this cohort of postmenopausal women, and the association was not modified by MT1R subtype. Impact: Urinary melatonin levels appear to predict the risk of breast cancer in postmenopausal women. However, future research should evaluate these associations with longer-term follow-up and among premenopausal women. Cancer Epidemiol Biomarkers Prev; 26(3); 413–9. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Devore, E. E., Warner, E. T., Eliassen, A. H., Brown, S. B., Beck, A. H., Hankinson, S. E., Schernhammer, E. S. Tags: Research Articles Source Type: research

Impact of a False-Positive Screening Mammogram on Subsequent Screening Behavior and Stage at Breast Cancer Diagnosis
Conclusions: Women with a FP mammogram were more likely to delay their subsequent screening compared with women with a TN mammogram. Impact: A prior FP experience may subsequently increase the 4-year cumulative risk of late stage at diagnosis. Cancer Epidemiol Biomarkers Prev; 26(3); 397–403. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Dabbous, F. M., Dolecek, T. A., Berbaum, M. L., Friedewald, S. M., Summerfelt, W. T., Hoskins, K., Rauscher, G. H. Tags: Research Articles Source Type: research