Dose-Response Relationship between Inorganic Arsenic Exposure and Lung Cancer among Arseniasis Residents with Low Methylation Capacity
Conclusions: Hypomethylation responses to InAs exposure may dose dependently increase lung cancer occurrence. Impact: The high-risk characteristics observed among those exposed should be considered in future preventive medicine and research on arsenic carcinogenesis. Cancer Epidemiol Biomarkers Prev; 26(5); 756–61. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Hsu, K.-H., Tsui, K.-H., Hsu, L.-I., Chiou, H.-Y., Chen, C.-J. Tags: Research Articles Source Type: research

Initiation, Progression, and Sustained Waterpipe Use: A Nationally Representative Longitudinal Study of U.S. Young Adults
Conclusions: Prevention efforts may be most successful if they target individuals with clear intentions to use WTS and challenge positive attitudes surrounding WTS. Impact: Surveillance of WTS trajectories will help inform health care and policy surrounding this emerging risk behavior among U.S. young adults. Cancer Epidemiol Biomarkers Prev; 26(5); 748–55. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Sidani, J. E., Shensa, A., Naidu, M. R., Yabes, J. G., Primack, B. A. Tags: Research Articles Source Type: research

The Association between Age-Related Macular Degeneration and Renal Cell Carcinoma: A Nested Case-Control Study
Conclusions: Patients with AMD may be at higher risk for RCC. Providers should be aware of this potential link and consider screening for RCC within this population. Impact: Providers should be aware of the potential link between AMD and RCC. Cancer Epidemiol Biomarkers Prev; 26(5); 743–7. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Keizman, D., Yang, Y.-X., Gottfried, M., Dresler, H., Leibovitch, I., Haynes, K., Mamtani, R., Boursi, B. Tags: Research Articles Source Type: research

Years of Life and Productivity Loss from Potentially Avoidable Colorectal Cancer Deaths in U.S. Counties with Lower Educational Attainment (2008-2012)
Conclusions: County-level EA disparities contribute to a large number of potentially avoidable colorectal cancer–related deaths. Increased prevention and improved screening potentially could decrease deaths and help reduce the associated economic burden in lower EA communities. Increased screening could further reduce deaths in all EA groups. Impact: These results estimate the large economic impact of potentially avoidable colorectal cancer–related deaths in economically disadvantaged communities, as measured by lower EA. Cancer Epidemiol Biomarkers Prev; 26(5); 736–42. ©2016 AACR. (Source: Cancer Ep...
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Weir, H. K., Li, C., Henley, S. J., Joseph, D. Tags: Research Articles Source Type: research

Endometrial Cancer Risk Factors, Hormone Receptors, and Mortality Prediction
Conclusions: Obesity may be associated with greater endometrial tumor expression of ER and PR. Adding either marker does not appear to improve mortality prediction beyond the standard predictors. Impact: Body mass index might explain some of the biological variation among endometrial tumors. Cancer Epidemiol Biomarkers Prev; 26(5); 727–35. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Busch, E. L., Crous-Bou, M., Prescott, J., Chen, M. M., Downing, M. J., Rosner, B. A., Mutter, G. L., De Vivo, I. Tags: Research Articles Source Type: research

Perineural Invasion and Risk of Lethal Prostate Cancer
Conclusions: These data support the hypothesis that perineural invasion creates a microenvironment that promotes cancer aggressiveness. Impact: Our findings suggest that PNI should be a standardized component of histopathologic review, and highlights a mechanism underlying prostate cancer metastasis. Cancer Epidemiol Biomarkers Prev; 26(5); 719–26. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Zareba, P., Flavin, R., Isikbay, M., Rider, J. R., Gerke, T. A., Finn, S., Pettersson, A., Giunchi, F., Unger, R. H., Tinianow, A. M., Andersson, S.-O., Andren, O., Fall, K., Fiorentino, M., Mucci, L. A., on behalf of the Transdisciplinary Prostate Cancer Tags: Research Articles Source Type: research

Proteomic Profiling of Serial Prediagnostic Serum Samples for Early Detection of Colon Cancer in the U.S. Military
Conclusions: Proteomic profiles in the year before cancer diagnosis have the potential to discriminate colon cancer patients from controls, and the addition of epidemiologic information may increase the sensitivity and specificity of discrimination. Impact: Our findings indicate the potential value of using serum prediagnostic proteomic biomarkers in combination with epidemiologic data for early detection of colon cancer. Cancer Epidemiol Biomarkers Prev; 26(5); 711–8. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Shao, S., Neely, B. A., Kao, T.-C., Eckhaus, J., Bourgeois, J., Brooks, J., Jones, E. E., Drake, R. R., Zhu, K. Tags: Research Articles Source Type: research

Cytokeratin 7 in Oropharyngeal Squamous Cell Carcinoma: A Junctional Biomarker for Human Papillomavirus-Related Tumors
Conclusions: An association between CK7 and HPV has been demonstrated. CK7-expressing tonsillar crypt cells potentially represent an oropharyngeal subsite susceptible to HPV-related SCC. Impact: Along with the cervix and anorectum, specific oropharyngeal expression of CK7 in a site predisposed to HPV-related tumors may suggest a role for CK7 in the pathogenesis of this subgroup of tumors. Further research is warranted to characterize the association between CK7 and HPV-related head and neck SCC. Cancer Epidemiol Biomarkers Prev; 26(5); 702–10. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Woods, R. S. R., Keegan, H., White, C., Tewari, P., Toner, M., Kennedy, S., O'Regan, E. M., Martin, C. M., Timon, C. V. I., O'Leary, J. J. Tags: Research Articles Source Type: research

The Interaction between Genetic Ancestry and Breast Cancer Risk Factors among Hispanic Women: The Breast Cancer Health Disparities Study
Conclusions: The lower NA ancestry groups were more likely to have the established risk factors, with the exception of BMI. Although the majority of factors were associated with risk in the expected directions among all women, BMI had an inverse association among Hispanics with lower NA ancestry. Impact: These data suggest that the established risk factors are less relevant for breast cancer development among women with more NA ancestry. Cancer Epidemiol Biomarkers Prev; 26(5); 692–701. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Hines, L. M., Sedjo, R. L., Byers, T., John, E. M., Fejerman, L., Stern, M. C., Baumgartner, K. B., Giuliano, A. R., Torres-Mejia, G., Wolff, R. K., Harrall, K. K., Slattery, M. L. Tags: Research Articles Source Type: research

Prospective Study of Ultraviolet Radiation Exposure and Thyroid Cancer Risk in the United States
Conclusions: Recent UVR exposure was associated with a decreased risk of thyroid cancer. This association appeared to be modified by benign thyroid disease and skin complexion. Impact: UVR exposure may be associated with a decreased risk of thyroid cancer. Cancer Epidemiol Biomarkers Prev; 26(5); 684–91. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Zamoiski, R. D., Cahoon, E. K., Freedman, D. M., Linet, M. S., Kitahara, C. M. Tags: Research Articles Source Type: research

Metabolomic Characterization of Hepatocellular Carcinoma in Patients with Liver Cirrhosis for Biomarker Discovery
Conclusions: This study demonstrates the combination of metabolites and clinical covariates as an effective approach for early detection of HCC in patients with liver cirrhosis. Impact: Further investigation of these findings may improve understanding of HCC pathophysiology and possible implication of the metabolites in HCC prevention and diagnosis. Cancer Epidemiol Biomarkers Prev; 26(5); 675–83. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Di Poto, C., Ferrarini, A., Zhao, Y., Varghese, R. S., Tu, C., Zuo, Y., Wang, M., Nezami Ranjbar, M. R., Luo, Y., Zhang, C., Desai, C. S., Shetty, K., Tadesse, M. G., Ressom, H. W. Tags: Research Articles Source Type: research

Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort
This article describes the methods of late toxicity assessment used in the St. Jude Lifetime Cohort Study, a clinically assessed cohort in which data from multiple diagnostic modalities and patient-reported outcomes are ascertained. Cancer Epidemiol Biomarkers Prev; 26(5); 666–74. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Hudson, M. M., Ehrhardt, M. J., Bhakta, N., Baassiri, M., Eissa, H., Chemaitilly, W., Green, D. M., Mulrooney, D. A., Armstrong, G. T., Brinkman, T. M., Klosky, J. L., Krull, K. R., Sabin, N. D., Wilson, C. L., Huang, I.-C., Bass, J. K., Hale, K., Kaste, Tags: Review Source Type: research

Excess Weight as a Risk Factor Common to Many Cancer Sites: Words of Caution when Interpreting Meta-analytic Evidence
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Arnold, M., Renehan, A. G., Colditz, G. A. Tags: Commentary Source Type: research

Highlights of This Issue
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Tags: Highlights Source Type: research

Longitudinal Study of Mammographic Density Measures That Predict Breast Cancer Risk
Conclusions: The mammographic measures that predict breast cancer risk are highly correlated over time. Impact: This has implications for etiologic research and clinical management whereby women at increased risk could be identified at a young age (e.g., early 40s or even younger) and recommended appropriate screening and prevention strategies. Cancer Epidemiol Biomarkers Prev; 26(4); 651–60. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - April 2, 2017 Category: Cancer & Oncology Authors: Krishnan, K., Baglietto, L., Stone, J., Simpson, J. A., Severi, G., Evans, C. F., MacInnis, R. J., Giles, G. G., Apicella, C., Hopper, J. L. Tags: Research Articles Source Type: research