Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases
CONCLUSIONSThe 3 classical UOC cell types are identifiable on FNA, making cytologic diagnosis possible if considered in the differential. A PDAC component is often also observed. The survival advantage of UOC over pure PDAC appears to be negated by FNA and requires further investigation. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - April 3, 2017 Category: Pathology Authors: Michelle D. Reid, Takashi Muraki, Kim HooKim, Bahar Memis, Rondell P. Graham, Daniela Allende, Jiaqi Shi, David F. Schaeffer, Remmi Singh, Olca Basturk, Volkan Adsay Tags: Original Article Source Type: research
Three ‐year risk of high‐grade CIN for women aged 30 years or older who undergo baseline Pap cytology and HPV co‐screening
CONCLUSIONSPap cytology and HPV cotesting are valuable for stratifying CIN‐3 risk. Pap cytology and HPV co‐screening at a 3‐year screening interval appears to carry a low risk of CIN‐3 for women who have a baseline Pap‐/HPV‐ cotesting result. Cancer (Cancer Cytopathol) 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - April 1, 2017 Category: Pathology Authors: Ming Guo, Abha Khanna, Jianping Wang, Marilyn A. Dawlett, Teresa L. Kologinczak, Genevieve R. Lyons, Roland L. Bassett, Nour Sneige, Yun Gong, Therese B. Bevers Tags: Original Article Source Type: research
Why is digital pathology in cytopathology lagging behind surgical pathology?
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - April 1, 2017 Category: Pathology Authors: Matthew G. Hanna, Liron Pantanowitz Tags: Help Desk Source Type: research
Programmed death ‐ligand 1 immunohistochemistry testing for non‐small cell lung cancer in practice
Given the recent approval by the US Food and Drug Administration of an anti‐programmed cell death protein 1 agent as a first‐line therapy for patients with advanced non‐small cell lung cancer, programmed death‐ligand 1 (PD‐L1) immunohistochemistry (IHC) testing has become routine in pathology laboratories in the United States. Each pathology laboratory needs to select a PD‐L1 IHC assay among the multiple assays available, conduct appropriate optimization and validation processes, and pay close attention to appropriate preanalytical tissue handling and the selection of optimal tissue samples. See also pages 000...
Source: Cancer Cytopathology - April 1, 2017 Category: Pathology Authors: Mari Mino ‐Kenudson Tags: Commentary Source Type: research
miR ‐130A as a diagnostic marker to differentiate malignant mesothelioma from lung adenocarcinoma in pleural effusion cytology
CONCLUSIONSThe diagnostic performances of miR‐130a expression analysis and IHC appear to be similar. miR‐130a quantification could be used reliably as second‐level diagnostic tool to differentiate MM from lung AdC in pleural effusion cytology, mainly in those cases with ambiguous or negative IHC. Further validation is needed. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - April 1, 2017 Category: Pathology Authors: Rocco Cappellesso, Marco Galasso, Lorenzo Nicol è, Paolo Dabrilli, Stefano Volinia, Ambrogio Fassina Tags: Original Article Source Type: research
Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics
CONCLUSIONSAlthough diagnosing HS with FNA alone is extremely challenging, the presence of pleomorphic and epithelioid large cells with binucleation and/or multinucleation in an inflammatory background should prompt the diagnosis of HS with judicious use of confirmatory histiocytic lineage markers. The detection of recurrent KMT2D/MLL2 alterations implicates epigenetic regulation in the pathogenesis of HS and supports the notion of transdifferentiation from a genetically similar but phenotypically distinct tumor of a different lineage. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - April 1, 2017 Category: Pathology Authors: Yin P. Hung, Scott B. Lovitch, Xiaohua Qian Tags: Original Article Source Type: research
Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?
CONCLUSIONSAlthough oncocytosis demonstrates some overlap with Warthin tumor and oncocytoma, it lacks the diagnostic findings specific to oncocytic salivary gland malignancies such as salivary duct carcinoma, acinic cell carcinoma, mammary analog secretory carcinoma, and mucoepidermoid carcinoma. Despite current limitations in the understanding of oncocytic salivary gland lesions, the presence of a paucicellular specimen comprised of small groups of oncocytic cells should raise the possibility of oncocytosis in the differential diagnosis and can favor it in elderly patients with multiple salivary nodules. Cancer (Cancer Cy...
Source: Cancer Cytopathology - April 1, 2017 Category: Pathology Authors: Lisa M. Rooper, Mine Onenerk, Momin T. Siddiqui, William C. Faquin, Justin A. Bishop, Syed Z. Ali Tags: Original Article Source Type: research
A scientific skirmish over supplements
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 13, 2017 Category: Pathology Authors: Bryn Nelson, David B. Kaminsky Tags: CytoSource Source Type: research
Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 13, 2017 Category: Pathology Tags: Issue Information Source Type: research
Accuracy of next ‐generation sequencing for the identification of clinically relevant variants in cytology smears in lung adenocarcinoma
CONCLUSIONSThe data show a significantly higher likelihood of successful NGS with cytologic smears with more than 100 tumor cells. There was a trend for a higher NGS success rate with Pap smears versus DQ smears. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 7, 2017 Category: Pathology Authors: Jordan E. Baum, Pan Zhang, Rana S. Hoda, Brian Geraghty, Hanna Rennert, Navneet Narula, Helen D. Fernandes Tags: Original Article Source Type: research
Adequacy criteria for thyroid FNA evaluated by ThinPrep slides only
CONCLUSIONSIn thyroid FNA examined with TP only, lowering the adequacy threshold and eliminating the requirement of 6 groups of at least 10 cells did not significantly affect test performance if cytological features associated with malignancy were absent. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 1, 2017 Category: Pathology Authors: Marina Vivero, Andrew A. Renshaw, Jeffrey F. Krane Tags: Original Article Source Type: research
Columnar cell variant of papillary thyroid carcinoma: Cytomorphological characteristics of 11 cases with histological correlation and literature review
CONCLUSIONSAlthough PTC‐CCV may demonstrate features that overlap with those of the classic variant of PTC, hypercellular smears with papillary structures covered by cells with pseudostratified nuclei that show a paucity of nuclear pseudoinclusions and grooves should alert the cytopathologist to the possibility of this diagnosis. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 1, 2017 Category: Pathology Authors: Massimo Bongiovanni, Maxime Mermod, Sule Canberk, Chiara Saglietti, Gerasimos P. Sykiotis, Marc Pusztaszeri, Moira Ragazzi, Luca Mazzucchelli, Luca Giovanella, Simonetta Piana Tags: Original Article Source Type: research
Alternative lengthening of telomeres and ATRX/DAXX loss can be reliably detected in FNAs of pancreatic neuroendocrine tumors
CONCLUSIONSBoth ALT and loss of ATRX/DAXX can be accurately performed on FNA specimens with adequate material. Because ALT is a fundamental mechanism of pathogenesis, the ability to determine ALT in small biospecimens has implications for the design of clinical trials. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 1, 2017 Category: Pathology Authors: Christopher J. VandenBussche, Derek B. Allison, Mindy K. Graham, Vivek Charu, Anne Marie Lennon, Christopher L. Wolfgang, Ralph H. Hruban, Christopher M. Heaphy Tags: Original Article Source Type: research
Biobanking and cytopathology: Challenges and opportunities from a Brazilian perspective
Fine‐needle aspiration specimens are a valuable resource for health research, but their use in routine biobanking remains limited. To stimulate the creation of biobanks of fine‐needle aspiration‐derived samples, cytopathologists should play a central role in the discussion of the issues specific to this activity. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 1, 2017 Category: Pathology Authors: Antonio Hugo J.F.M. Campos, Dirce Maria Carraro, Fernando Augusto Soares Tags: Commentary Source Type: research
Agreement between cytotechnologists and cytopathologists as a new measure of cytopathologist performance in gynecologic cytology
CONCLUSIONSLaboratories can use this κ to determine when CP levels of agreement with CTs depart from those of their peers. Adding this to established metrics can give a more nuanced impression of CP performance. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 1, 2017 Category: Pathology Authors: Andrew M. Quinn, Abu T. Minhajuddin, Linda S. Hynan, Joan S. Reisch, Edmund S. Cibas Tags: Original Article Source Type: research
