Fine ‐needle aspiration versus core needle biopsy: Reconsidering the evidence of superiority
The choice of which invasive procedure to perform for pathologic diagnosis should be a careful analysis of the relative risks and benefits based on data rather than personal taste. Cytopathologists should take an active role in obtaining FNA samples which are adequate for both diagnosis and ancillary testing. This approach optimizes diagnostic accuracy and minimizes morbidity. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 30, 2016 Category: Pathology Authors: Annemieke Zante, Britt ‐Marie Ljung Tags: Commentary Source Type: research
Cytohistologic correlation of recurrent urothelial carcinoma detected in urinary diversion specimens
CONCLUSIONSThe current data demonstrate that abnormal cytology in urinary diversion specimens is rare but, when present, can help to detect recurrent urothelial carcinoma. Careful examination of these specimens is warranted to screen for features of high‐grade urothelial carcinoma among a degenerated cellular and sometimes inflammatory background. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 30, 2016 Category: Pathology Authors: Juan Xing, Somak Roy, Sara E. Monaco, Liron Pantanowitz Tags: Original Article Source Type: research
Young investigator challenge: The morphologic analysis of noninvasive follicular thyroid neoplasm with papillary ‐like nuclear features on liquid‐based cytology: Some insights into their identification
CONCLUSIONSThe majority of NIFTPs appear to be devoid of nuclear pseudoinclusions and papillary structures, thereby allowing the inclusion in the follicular nodule cases. Nuclear size and microfollicular clusters may suggest the discrimination between NIFTPs and I‐FVPCs. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 25, 2016 Category: Pathology Authors: Tommaso Bizzarro, Maurizio Martini, Sara Capodimonti, Patrizia Straccia, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Esther Diana Rossi Tags: Original Article Source Type: research
Test anxiety
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 15, 2016 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research
2016 publication schedule
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 15, 2016 Category: Pathology Tags: Issue Information Source Type: research
Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 15, 2016 Category: Pathology Tags: Issue Information Source Type: research
Cytology smears as excellent starting material for next ‐generation sequencing‐based molecular testing of patients with adenocarcinoma of the lung
CONCLUSIONSThe results of the current study demonstrated the suitability of non‐formalin cytology specimens for the simultaneous NGS testing of lung ADCs using amplicon resequencing panels. These assays allowed for the input of cytological smears equal to concurrent histology or cell blocks and proved to be accurate in the detection of therapeutically actionable somatic mutations and gene rearrangements. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 15, 2016 Category: Pathology Authors: Nadezda P. Velizheva, Markus P. Rechsteiner, Christine E. Wong, Qing Zhong, Matthias R össle, Beata Bode, Holger Moch, Alex Soltermann, Peter J. Wild, Verena Tischler Tags: Original Article Source Type: research
Diagnosis of trichomoniasis in men by urine cytology
CONCLUSIONSThis study is the largest series of Trichomonas infection in men diagnosed by urine cytology in the literature. Most men had no prior diagnosis of trichomoniasis and received specific antibiotic therapy based on their urine cytology results. Urine cytology may represent the initial diagnostic test for Trichomonas in men, and accurate cytologic diagnosis may prevent undesired adverse outcomes for them and their partners. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 15, 2016 Category: Pathology Authors: Erika E. Doxtader, Tarik M. Elsheikh Tags: Original Article Source Type: research
Technical and US regulatory issues in triaging material for the molecular laboratory
Cytology samples offer many advantages for molecular testing, but the devil is in the details. In addition, regulatory issues may end up being the most significant challenge for cytology. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - September 5, 2016 Category: Pathology Authors: Andrew H. Fischer, Lloyd M. Hutchinson Tags: Commentary Source Type: research
Knowledge of the HPV status biases cytotechnologists' interpretation of Pap tests originally diagnosed as negative for intraepithelial lesion or malignancy
CONCLUSIONSA known HPV‐positive status biases cytotechnologists' interpretation of Pap tests, and this results in a higher rate of upgrading to ASCUS or worse; however, it does not improve sensitivity for disease detection. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - August 31, 2016 Category: Pathology Authors: Erika E. Doxtader, Jennifer A. Brainard, Dawn Underwood, Deborah J. Chute Tags: Original Article Source Type: research
Young investigator challenge: Can the Ion AmpliSeq Cancer Hotspot Panel v2 be used for next ‐generation sequencing of thyroid FNA samples?
CONCLUSIONSCHPv2 is a valid option for the molecular evaluation of thyroid FNA specimens by NGS. It is interesting to note that this approach is accurate and effective even when applied to routine cytology samples that usually do not have optimal preanalytical and postsequencing requirements. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - August 31, 2016 Category: Pathology Authors: Claudio Bellevicine, Roberta Sgariglia, Umberto Malapelle, Elena Vigliar, Mariantonia Nacchio, Giuseppe Ciancia, Markus Eszlinger, Ralf Paschke, Giancarlo Troncone Tags: Original Article Source Type: research
Next ‐generation sequencing adds value to the preoperative diagnosis of pancreatic cysts
CONCLUSIONSThe detection of KRAS/GNAS variants improves the identification of mucinous neoplasms. Variants in TP53, SMAD4, CDKN2A, and NOTCH1 support the diagnosis of a high‐risk cyst requiring surgery or additional sampling. Although molecular analysis is not a replacement for cytopathology, it does provide valuable information for accurate preoperative diagnosis, helping to classify mucinous neoplasms and high‐risk cysts that require surgical resection. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - August 31, 2016 Category: Pathology Authors: Matthew W. Rosenbaum, Martin Jones, Jonathan C. Dudley, Long P. Le, A. John Iafrate, Martha B. Pitman Tags: Original Article Source Type: research
Cytomorphology of clear cell papillary renal cell carcinoma
CONCLUSIONSCCPRCC was found to demonstrate cytologic features that when taken together are helpful in diagnosing CCPRCC on FNA smears and TPs. If core needle biopsy specimens or cell blocks are available, an immunohistochemical panel including CK7, CA IX, CD10, and AMACR may help in excluding congeners. This subtype of RCC requires differentiation from clear cell RCC and papillary RCC due to its low‐grade indolent behavior. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - August 31, 2016 Category: Pathology Authors: Xiaoqi Lin Tags: Original Article Source Type: research
Interobserver agreement in the cytologic grading of atypia in neoplastic pancreatic mucinous cysts with the 2 ‐tiered approach
CONCLUSIONSThis study shows that the cytologic recognition of HG dysplasia or worse as HG atypia in pancreatic mucinous cysts has a good degree of interobserver reproducibility among cytopathologists. In contrast, a problematic area with a lack of agreement appears to be the cytologic recognition of LG and IG dysplasia as LG atypia. Additional studies with the development of reproducible criteria and educational tools may help with this challenging distinction. Cancer Cytopathol 2016. © 2016 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - August 14, 2016 Category: Pathology Authors: Abha Goyal, Fadi W. Abdul ‐Karim, Bin Yang, Jinesh B. Patel, Jennifer A. Brainard Tags: Original Article Source Type: research
Gynecologic cytology in Cancer Cytopathology: 20 years of massive change
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - August 11, 2016 Category: Pathology Authors: Terence J. Colgan Tags: Editorial Source Type: research
