Left in the dark at the end of life
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 14, 2018 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research

Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - March 14, 2018 Category: Pathology Tags: Issue Information Source Type: research

Our 2017 Cancer Cytopathology Young Investigator
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 16, 2018 Category: Pathology Authors: Celeste N. Powers Tags: A Note from the Editor Source Type: research

Bracing for disaster
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 16, 2018 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research

Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 16, 2018 Category: Pathology Tags: Issue Information Source Type: research

Well differentiated grade 3 pancreatic neuroendocrine tumors compared with related neoplasms: A morphologic study
BACKGROUNDPancreatic neuroendocrine neoplasms with a Ki‐67 labeling index greater than 20% were reclassified in 2017 by the World Health Organization into well differentiated (WD) and poorly differentiated grade 3 neuroendocrine carcinoma (NEC). The authors describe the cytologic features of grade 3 WD pancreatic neuroendocrine neoplasms compared with grade 2 neoplasms and NEC. METHODSFine‐needle aspirates from 65 pancreatic neuroendocrine neoplasms were reviewed, and their cytomorphologic features were compared across grade 2, WD grade 3, and PD small cell type (PD‐S), large cell type (PD‐L), and type not otherwis...
Source: Cancer Cytopathology - February 16, 2018 Category: Pathology Authors: Carlie S. Sigel, Vitor Werneck Krauss Silva, Michelle D. Reid, David Chhieng, Olca Basturk, Keith M. Sigel, Tanisha D. Daniel, David S. Klimstra, Laura H. Tang Tags: Original Article Source Type: research

Reply to FNA biopsy in grading pancreatic neuroendocrine tumors: Methodological issues regarding diagnostic value
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 12, 2018 Category: Pathology Authors: Xiaofei Wang Tags: Correspondence Source Type: research

Cytologic ‐histologic correlation of programmed death‐ligand 1 immunohistochemistry in lung carcinomas
CONCLUSIONSTumor PD‐L1 IHC positivity in cytology specimens appears to correlate strongly with results obtained from matching surgical specimens. PD‐L1 IHC in ICs within cytology specimens does not reflect results in matched surgical specimens and should not be used in clinical decision making. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 5, 2018 Category: Pathology Authors: Eleanor Russell ‐Goldman, Sasha Kravets, Suzanne E. Dahlberg, Lynette M. Sholl, Marina Vivero Tags: Original Article Source Type: research

Programmed death ligand 1 testing in non –small cell lung carcinoma cytology cell block and aspirate smear preparations
CONCLUSIONSThe results show that NSCLC cytology samples evaluated for PD‐L1 have high concordance with paired core‐needle biopsy samples and can be used for assessing PD‐L1 expression. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 1, 2018 Category: Pathology Authors: Bryce Noll, Wei ‐Lien Wang, Yun Gong, Jun Zhao, Neda Kalhor, Victor Prieto, Gregg Staerkel, Sinchita Roy‐Chowdhuri Tags: Original Article Source Type: research

Different qualifiers of AUS/FLUS thyroid FNA have distinct BRAF, RAS, RET/PTC, and PAX8/PPARg alterations
BACKGROUNDThe Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine‐needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphological subcategorization based on atypia qualifiers and molecular testing could improve malignancy risk stratification of AUS/FLUS patients, this study assessed the correlation between these qualifiers and the molecular alterations commonly harbored by thyroid neoplasms. METHODSA total of 162 AUS/FLUS cases wer...
Source: Cancer Cytopathology - February 1, 2018 Category: Pathology Authors: Claudio Bellevicine, Roberta Sgariglia, Ilaria Migliatico, Elena Vigliar, Melania D'Anna, Maria Antonia Nacchio, Nicola Serra, Umberto Malapelle, Massimo Bongiovanni, Giancarlo Troncone Tags: Original Article Source Type: research

Detection of ROS1 ‐positive non‐small cell lung cancer on cytological specimens using immunocytochemistry
CONCLUSIONSROS1 ICC is an accurate method for the detection of ROS1 rearrangements in NSCLC. Given the high costs and technical challenges of FISH and the rarity of ROS1 rearrangements, ICC is rapid and therefore well suited as a screening method. Cases with equivocal or positive findings on ICC can be confirmed by FISH or molecular tests. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 1, 2018 Category: Pathology Authors: Tatjana Vlajnic, Spasenija Savic, Audrey Barascud, Betty Baschiera, Michel Bihl, Bruno Grilli, Michelle Herzog, Julien Rebetez, Lukas Bubendorf Tags: Original Article Source Type: research

All ‐in‐one: The dream and reality of molecular cytopathology testing on routine lung cancer smears
If cytopathologists are used to dedicating 1 or more fine‐needle aspiration passes to prepare a tumor‐representative cell block, the testing laboratory may strongly rely on anaplastic lymphoma kinase (ALK), ROS proto‐oncogene 1, receptor tyrosine kinase (ROS1), and programmed death‐ligand 1 (PD‐L1) immunocytochemistry assays. Conversely, when sample procurement and diagnostic interpretation are based primarily on smeared material, cytopathologists should promote, in conjunction with the molecular team, ALK and ROS1 RNA‐based testing approaches on smears, saving the cell block only for PD‐L1 staining. See also...
Source: Cancer Cytopathology - January 24, 2018 Category: Pathology Authors: Giancarlo Troncone Tags: Editorial Source Type: research

Expression of microRNAs in the ascites of patients with peritoneal carcinomatosis and peritonitis
CONCLUSIONSThe data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA‐based molecular approach for the differential diagnosis of PCA. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 23, 2018 Category: Pathology Authors: Philipp Schindler, Juozas Kupcinskas, Simonas Juzenas, Jurgita Skieceviciene, Violeta Salteniene, Christian Schulz, Jochen Weigt, Peter Malfertheiner, Alexander Link Tags: Original Article Source Type: research

The risk of malignancy of atypical urothelial cells of undetermined significance in patients treated with chemohyperthermia or electromotive drug administration
CONCLUSIONSIn the urine samples from patients treated with EMDA/MMC or C‐HT/MMC, a diagnosis of SHGUC could be made even on degenerated urothelial cells when considering cellular degeneration as a “physiological” consequence of the treatment that involves either normal or neoplastic cells. Cancer (Cancer Cytopathol) 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 23, 2018 Category: Pathology Authors: Francesco Pierconti, Esther Diana Rossi, Patrizia Straccia, Guido Fadda, Luigi Maria Larocca, Pier Francesco Bassi, Emilio Sacco, Giovanni Schinzari Tags: Original Article Source Type: research

When words matter: A “suspicious” urinary tract cytology diagnosis improves patient follow‐up among nonurologists
BACKGROUNDUrinary tract cytology (UTC) specimens diagnosed using high‐risk indeterminate categories such as “atypical urothelial cells, cannot exclude high‐grade urothelial carcinoma” (AUC‐H) or “suspicious for high‐grade urothelial carcinoma” (SHGUC) have a high rate of detection of high‐grade urothelial carcinoma on subsequent biopsy. Although urologists are familiar with such terminology, it is unclear whether patients receive appropriate follow‐up when UTC is ordered by nonurologists. In the current study, the authors investigated whether the use of AUC‐H versus SHGUC altered patie...
Source: Cancer Cytopathology - January 23, 2018 Category: Pathology Authors: J. Judd Fite, Dorothy L. Rosenthal, Christopher J. VandenBussche Tags: Original Article Source Type: research

Clipping cancer with CRISPR
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 12, 2018 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research

Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 12, 2018 Category: Pathology Tags: Issue Information Source Type: research

Orthopedia homeobox is preferentially expressed in typical carcinoids of the lung
CONCLUSIONSOTP is specific for LCs because well‐differentiated nonlung NETs are negative for OTP. OTP preferentially stains TCs over ACs. In well‐differentiated NETs, OTP staining is highly specific for LCs, and in combination with a low Ki‐67 index, it suggests a pulmonary TC. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 9, 2018 Category: Pathology Authors: Krisztina Z. Hanley, Zachary J. Dureau, Cynthia Cohen, Dong M. Shin, Taofeek K. Owonikoko, Gabriel L. Sica Tags: Original Article Source Type: research

Advanced practitioner in anatomic pathology: The time has come
Appropriately trained cytotechnologists have been shown to have the skills necessary to safely assist the pathologist in nontraditional tasks. These advanced‐level individuals may be necessary to stem the leakage of traditional pathology services to other specialties or even prevent them from not being done at all. The time has arrived to move this concept forward.See also pages 000‐000. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 9, 2018 Category: Pathology Authors: Brenda J. Sweeney, David C. Wilbur Tags: Editorial Source Type: research

FNA biopsy in grading pancreatic neuroendocrine tumors: Methodological issues regarding diagnostic value
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 1, 2018 Category: Pathology Authors: Siamak Sabour, Fatemeh Hadavand, Somayeh Derakhshan Tags: Correspondence Source Type: research

The impact of noninvasive follicular thyroid neoplasm with papillary ‐like nuclear features on the rate of malignancy for atypia of undetermined significance subcategories
The objective of this study was to evaluate the impact of this change on the rate of malignancy (ROM) for subcategories of an atypia of undetermined significance (AUS) diagnosis on fine‐needle aspiration (FNA) cytology. METHODSConsecutive thyroid FNAs interpreted as AUS over a period of 4 years were retrospectively analyzed. The ROM for AUS subcategories, including atypia of undetermined significance with nuclear atypia (AUS‐N), atypia of undetermined significance with a microfollicular pattern (AUS‐F), atypia of undetermined significance with nuclear atypia and a microfollicular pattern (AUS‐N/F), atypia of undete...
Source: Cancer Cytopathology - January 1, 2018 Category: Pathology Authors: Jen ‐Fan Hang, William H. Westra, Amy G. Zhou, David S. Cooper, Syed Z. Ali Tags: Original Article Source Type: research

Use of the 22C3 anti –programmed death ligand 1 antibody to determine programmed death ligand 1 expression in cytology samples obtained from non–small cell lung cancer patients
BACKGROUNDPembrolizumab monotherapy is a standard‐of‐care treatment for the first‐ and second‐line treatment of advanced non–small cell lung cancer with programmed death ligand 1 (PD‐L1) tumor proportion score (TPS) values ≥ 50% and ≥ 1%, respectively. PD‐L1 testing with the PD‐L1 immunohistochemistry (IHC) 22C3 pharmDx companion assay has been validated on tumor tissue with the Dako Autostainer Link 48 (ASL48). 22C3 anti–PD‐L1 antibody–based laboratory‐developed tests (LDTs) compatible with other autostainers and cytology samples are essential to suppor...
Source: Cancer Cytopathology - January 1, 2018 Category: Pathology Authors: Marius Ilie, Jonathan Juco, Lingkang Huang, Veronique Hofman, Shirin Khambata ‐Ford, Paul Hofman Tags: Original Article Source Type: research

Pancreatic cyst biopsy: Improvement in diagnosis with micro forceps biopsy
Clinician's Corner represents the opinions and views of the author and does not reflect any policy or opinion of the American Cancer Society, Cancer Cytopathology, or Wiley unless this is clearly specified. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 1, 2018 Category: Pathology Authors: Omer Basar Tags: Clinician's Corner Source Type: research

SOX10/keratin dual ‐color immunohistochemistry: An effective first‐line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens
CONCLUSIONSSOX10/keratin dual‐color IHC appears to be an effective, sensitive, and specific test to distinguish between melanoma, sarcoma, and carcinoma. This approach can identify melanoma, prioritize additional studies, and limit the number of markers needed to workup an epithelioid malignant neoplasm, thereby potentially reducing costs and preserving valuable tissue for ancillary studies with which to guide therapy. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 1, 2018 Category: Pathology Authors: Jeffrey K. Mito, James R. Conner, Jason L. Hornick, Edmund S. Cibas, Xiaohua Qian Tags: Original Article Source Type: research

Simultaneous detection of single ‐nucleotide variant, deletion/insertion, and fusion in lung and thyroid carcinoma using cytology specimen and an RNA‐based next‐generation sequencing assay
CONCLUSIONSCytology preparations can be a reliable source for the detection of both DNA and RNA aberrations. The ability to simultaneously detect multiple types of genomic variants is crucial for patients with advanced cancer and maximizes the usefulness of cytology specimens. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 1, 2018 Category: Pathology Authors: Natalya V. Guseva, Omar Jaber, Aaron A. Stence, Krishnaveni Sompallae, Amani Bashir, Ramakrishna Sompallae, Aaron D. Bossler, Chris S. Jensen, Deqin Ma Tags: Original Article Source Type: research

Insulinoma ‐associated protein 1 is a sensitive and specific marker of neuroendocrine lung neoplasms in cytology specimens
CONCLUSIONSINSM1 can be used in cytopathology cell blocks, and it is sensitive and highly specific for neuroendocrine lung tumors. INSM1 staining in cytology cell blocks correlates well with surgical pathology specimens. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 1, 2018 Category: Pathology Authors: Erika E. Doxtader, Sanjay Mukhopadhyay Tags: Original Article Source Type: research

Innovative case ‐writing software can engage millennials in learning pathology topics
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - January 1, 2018 Category: Pathology Authors: Vania Zayat Tags: Bridging the Gap Source Type: research

Thank you to reviewers 2017
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - December 15, 2017 Category: Pathology Tags: Information Item Source Type: research

When religion opens the door
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - December 15, 2017 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research

Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - December 15, 2017 Category: Pathology Tags: Issue Information Source Type: research

Cytotechnologists as coinvestigators in anatomical pathology research
CONCLUSIONSThe collaboration of cytotechnologists and pathologists in research can improve the quality of effort and increase satisfaction and productivity. Cancer Cytopathol 2018. © 2018 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - December 1, 2017 Category: Pathology Authors: Karla J. Kopp, Marie R. Passow, Kristina M. Del Rosario, Michael R. Christensen, John W. O ’Shaughnessy, Mary K. Bartholet, Mary E. Francis, Thomas J. Flotte Tags: Original Article Source Type: research

Implementing The Paris System for Reporting Urinary Cytology results in a decrease in the rate of the “atypical” category and an increase in its prediction of subsequent high‐grade urothelial carcinoma
BACKGROUNDIn the current study, the authors evaluated the impact of implementing The Paris System for Reporting Urinary Cytology (PSRUC) on the prevalence of various cytological categories and their association with a subsequent diagnosis of high‐grade urothelial carcinoma (HGUC). METHODSA comparative study was conducted over the 6‐month period before PSRUC implementation (2013), including 1653 patients and 2371 specimens versus a 6‐month period after implementation of the PSRUC (2016), including 1478 patients and 2392 specimens. The following cytological categories were correlated with the subsequent biopsy result w...
Source: Cancer Cytopathology - December 1, 2017 Category: Pathology Authors: Yujing Wang, Manon Auger, Yonca Kanber, Derin Caglar, Fadi Brimo Tags: Original Article Source Type: research

The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA
CONCLUSIONSThe PRKD1 E710D hotspot mutation is highly specific for identifying PAC on FNA among cases of ACC and PA, whereas the sensitivity is only modest. Alternative PRKD1 mutations exclude PAC, and are more suggestive of ACC. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - December 1, 2017 Category: Pathology Authors: Simon Andreasen, Linea Cecilie Melchior, Katalin Kiss, Justin Avery Bishop, Estrid H øgdall, Morten Grauslund, Irene Wessel, Preben Homøe, Tina Klitmøller Agander Tags: Original Article Source Type: research

The diagnostic value of FNA biopsy in grading pancreatic neuroendocrine tumors
CONCLUSIONSThe current results exhibit good correlation between FNA grade and final grade on surgical resection specimens using Ki‐67 index, even in samples with less than the recommended total cell count. Therefore, grading of PNETs on FNA with the Ki‐67 proliferation index should be assessed and is a practical parameter to report to clinicians. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - December 1, 2017 Category: Pathology Authors: Lisa Laskiewicz, Sarah Jamshed, Yuna Gong, Sanaz Ainechi, Jennifer LaFemina, Xiaofei Wang Tags: Original Article Source Type: research

Process mapping: A cornerstone of quality improvement
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - November 22, 2017 Category: Pathology Authors: Yael K. Heher, Yigu Chen Tags: QA Q & Source Type: research

Reply to Application of the Milan system for reporting risk stratification in salivary gland cytopathology
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - November 22, 2017 Category: Pathology Authors: Manish Rohilla, Nalini Gupta, Priya Singh, Arvind Rajwanshi Tags: Correspondence Source Type: research

When medicine and religion do not mix
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - November 14, 2017 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research

Issue Information
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - November 14, 2017 Category: Pathology Tags: Issue Information Source Type: research

Biomarkers for immune checkpoint inhibitors: The importance of tumor topography and the challenges to cytopathology
The recent emergence of immune checkpoint inhibitors for cancer therapy has created much excitement among cancer patients, drug and diagnostic developers, and health care professionals. This is due largely to the dramatic and sustained responses among some advanced cancers that were previously refractory to therapy. Unfortunately, these responses are difficult to predict, so the goal of the right drug for the right patient at the right time remains elusive. This is in part due to the complexity of the tumor immune microenvironment and its role in drug efficacy. The application of biomarkers to pathologic specimens to predi...
Source: Cancer Cytopathology - November 13, 2017 Category: Pathology Authors: Douglas P. Clark Tags: Review Article Source Type: research

GATA3 differential expression in neuroblastoma and nephroblastoma
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - November 13, 2017 Category: Pathology Authors: Jerzy Klijanienko, Martial Caly, Paul Fr énaux, Jan Klos Tags: Correspondence Source Type: research

Reply to GATA3 differential expression in neuroblastoma and nephroblastoma
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - November 13, 2017 Category: Pathology Authors: Austin Blackburn Wiles, Celeste N. Powers, Steven Christopher Smith Tags: Correspondence Source Type: research

Imaging modalities for the detection of distant metastases in breast cancer patients diagnosed in the 1970s and 1990s: Does it make any sense?
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - November 6, 2017 Category: Pathology Authors: Kadri Altundag Tags: Correspondence Source Type: research

Self ‐clotting method improves cell block preparation
CONCLUSIONSThe results of the current study demonstrate that the self‐clotting method is superior to the conventional needle wash method for FNA samples. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - November 1, 2017 Category: Pathology Authors: Yan Shi, Jeanine Chiaffarano, Melissa Yee ‐Chang, Tamar C. Brandler, Paul Elgert, Allen Leung, Xiao‐Jun Wei, Joan Cangiarella, Aylin Simsir, Wei Sun Tags: Original Article Source Type: research

Application of the Milan system for reporting risk stratification in salivary gland cytopathology
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - November 1, 2017 Category: Pathology Authors: Marc Pusztaszeri, Zubair Baloch, Philippe Vielh, William C. Faquin Tags: Correspondence Source Type: research

High ‐grade urothelial carcinoma in urine cytology with jet black and smooth or glassy chromatin
CONCLUSIONSMalignant urothelial cells in urine cytology with jet black chromatin are common and can be diagnosed as “positive for malignancy” based on their irregular nuclear outline, increased cellularity (≥50 abnormal cells), and frequent necrosis. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 26, 2017 Category: Pathology Authors: Andrew A. Renshaw, Edwin W. Gould Tags: Original Article Source Type: research

The utility of adaptive eLearning in cervical cytopathology education
CONCLUSIONSOverall, the modules were viewed positively by participants. Adaptive eLearning modules can provide an engaging and effective adjunct to traditional teaching methods in cervical cytopathology. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 20, 2017 Category: Pathology Authors: T. Danielle Samulski, Laura A. Taylor, Teresa La, Chelsea R. Mehr, Cindy M. McGrath, Roseann I. Wu Tags: Original Article Source Type: research

Programmed death ‐ligand 1 testing of lung cancer cytology specimens obtained with bronchoscopy
CONCLUSIONSBronchoscopically obtained cytology needle–based samples are adequate for PD‐L1 testing in patients with NSCLC. There was no difference noted between different needle sizes with regard to adequacy for PD‐L1 testing. These findings are relevant for clinicians caring for patients with lung cancer because a vast majority of patients with advanced NSCLC are diagnosed by bronchoscopic needle‐based techniques using a variety of commercially available needles. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 20, 2017 Category: Pathology Authors: Sean P. Stoy, Lauren Rosen, Jeffrey Mueller, Septimiu Murgu Tags: Original Article Source Type: research

Histological outcomes of anal high ‐grade cytopredictions
This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12‐month period. METHODSThe Study of the Prevention of Anal Cancer is a 3‐year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old. For each participant with a baseline cytological abnormality, the worst histology was recorded at the baseline high‐resolution anoscopy and at 6 and 12 months. PPVs for a histological high‐grade squamous intraepithelial lesion (HSIL) diagnosis were calculated for each level of baseline cy...
Source: Cancer Cytopathology - October 20, 2017 Category: Pathology Authors: Jennifer Margaret Roberts, Fengyi Jin, Isobel Mary Poynten, Carmella Law, David James Templeton, Julia Kathleen Thurloe, Suzanne Marie Garland, Andrew Edwin Grulich, Annabelle Farnsworth, Richard John Hillman, Tags: Original Article Source Type: research

A combination of MTAP and BAP1 immunohistochemistry in pleural effusion cytology for the diagnosis of mesothelioma
CONCLUSIONSA combination of MTAP and BAP1 IHC in cell blocks from pleural effusions appears to be a reliable and useful method for differentiating MPM cells from RMC and can be used in the routine diagnosis of MPM. Cancer Cytopathol 2017. © 2017 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 20, 2017 Category: Pathology Authors: Yoshiaki Kinoshita, Tomoyuki Hida, Makoto Hamasaki, Shinji Matsumoto, Ayuko Sato, Tohru Tsujimura, Kunimitsu Kawahara, Kenzo Hiroshima, Yoshinao Oda, Kazuki Nabeshima Tags: Original Article Source Type: research

Chasing bubbles for cancer diagnostics
(Source: Cancer Cytopathology)
Source: Cancer Cytopathology - October 16, 2017 Category: Pathology Authors: Bryn Nelson Tags: CytoSource Source Type: research