Progress and potential: the Cancer Moonshot
Publication date: Available online 6 May 2021Source: Cancer CellAuthor(s): Norman E. Sharpless, Dinah S. Singer (Source: Cancer Cell)
Source: Cancer Cell - May 7, 2021 Category: Cancer & Oncology Source Type: research

Seeing the forest for the trees—single-cell atlases link CD8+ T cells and macrophages to disease progression and treatment response in kidney cancer
Publication date: Available online 15 April 2021Source: Cancer CellAuthor(s): Mei Yee Koh, Nicolas Sayegh, Neeraj Agarwal (Source: Cancer Cell)
Source: Cancer Cell - May 4, 2021 Category: Cancer & Oncology Source Type: research

Evaluation of TMB as a predictive biomarker in patients with solid cancers treated with anti-PD-1/CTLA-4 combination immunotherapy
Publication date: Available online 29 April 2021Source: Cancer CellAuthor(s): Oliver Klein, Damien Kee, Ben Markman, Matteo S. Carlino, Craig Underhill, Jodie Palmer, Daniel Power, Jonathan Cebon, Andreas Behren (Source: Cancer Cell)
Source: Cancer Cell - May 1, 2021 Category: Cancer & Oncology Source Type: research

Evolutionary switch in expression of key markers between mouse and human leads to mis-assignment of cell types in developing adrenal medulla
Publication date: Available online 29 April 2021Source: Cancer CellAuthor(s): Polina Kameneva, Artem V.Artemov, Maria Eleni Kastriti, Erik Sundström, Peter V. Kharchenko, Igor Adameyko (Source: Cancer Cell)
Source: Cancer Cell - May 1, 2021 Category: Cancer & Oncology Source Type: research

José Baselga (1959–2021)
Publication date: Available online 29 April 2021Source: Cancer CellAuthor(s): Pau Castel, Eneda Toska, Neil Vasan, Emiliano Cocco, Maurizio Scaltriti (Source: Cancer Cell)
Source: Cancer Cell - May 1, 2021 Category: Cancer & Oncology Source Type: research

STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma
Publication date: Available online 29 April 2021Source: Cancer CellAuthor(s): Didier Surdez, Sakina Zaidi, Sandrine Grossetête, Karine Laud-Duval, Anna Sole Ferre, Lieke Mous, Thomas Vourc'h, Franck Tirode, Gaelle Pierron, Virginie Raynal, Sylvain Baulande, Erika Brunet, Véronique Hill, Olivier Delattre (Source: Cancer Cell)
Source: Cancer Cell - May 1, 2021 Category: Cancer & Oncology Source Type: research

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
Publication date: Available online 29 April 2021Source: Cancer CellAuthor(s): Silvia Affo, Ajay Nair, Francesco Brundu, Aashreya Ravichandra, Sonakshi Bhattacharjee, Michitaka Matsuda, LiKang Chin, Aveline Filliol, Wen Wen, Xinhua Song, Aubrianna Decker, Jeremy Worley, Jorge Matias Caviglia, Lexing Yu, Deqi Yin, Yoshinobu Saito, Thomas Savage, Rebecca G. Wells, Matthias Mack, Lars Zender (Source: Cancer Cell)
Source: Cancer Cell - May 1, 2021 Category: Cancer & Oncology Source Type: research

Artificial intelligence for clinical oncology
Publication date: Available online 29 April 2021Source: Cancer CellAuthor(s): Benjamin H. Kann, Ahmed Hosny, Hugo J.W.L. Aerts (Source: Cancer Cell)
Source: Cancer Cell - May 1, 2021 Category: Cancer & Oncology Source Type: research

Targeting cell-cycle machinery in cancer
Publication date: Available online 22 April 2021Source: Cancer CellAuthor(s): Jan M. Suski, Marcin Braun, Vladislav Strmiska, Piotr Sicinski (Source: Cancer Cell)
Source: Cancer Cell - April 23, 2021 Category: Cancer & Oncology Source Type: research

Bacteria break barrier to promote metastasis
Publication date: Available online 22 April 2021Source: Cancer CellAuthor(s): Yoshitaka Murota, Christian Jobin (Source: Cancer Cell)
Source: Cancer Cell - April 23, 2021 Category: Cancer & Oncology Source Type: research

Seeing the forest for the trees—single-cell atlases link CD8+T cells and macrophages to disease progression and treatment response in kidney cancer
Publication date: Available online 15 April 2021Source: Cancer CellAuthor(s): Mei Yee Koh, Nicolas Sayegh, Neeraj Agarwal (Source: Cancer Cell)
Source: Cancer Cell - April 16, 2021 Category: Cancer & Oncology Source Type: research

Care without a compass: including patients with cancer in COVID-19 studies
Publication date: Available online 15 April 2021Source: Cancer CellAuthor(s): Christopher R. Friese, Toni K. Choueiri, Narjust Duma, Dimitrios Farmakiotis, Petros Grivas, Brian I. Rini, Dimpy P. Shah, Michael A. Thompson, Steven A. Pergam, Sanjay Mishra, Jeremy L. Warner (Source: Cancer Cell)
Source: Cancer Cell - April 16, 2021 Category: Cancer & Oncology Source Type: research

Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
Publication date: Available online 15 April 2021Source: Cancer CellAuthor(s): Chirag Krishna, Renzo G. DiNatale, Fengshen Kuo, Raghvendra M. Srivastava, Lynda Vuong, Diego Chowell, Sounak Gupta, Chad Vanderbilt, Tanaya A. Purohit, Ming Liu, Emily Kansler, Briana G. Nixon, Ying-Bei Chen, Vladimir Makarov, Kyle A. Blum, Kyrollis Attalla, Stanley Weng, Michael L. Salmans, Mahdi Golkaram, Li Liu (Source: Cancer Cell)
Source: Cancer Cell - April 16, 2021 Category: Cancer & Oncology Source Type: research

Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
Publication date: 12 April 2021Source: Cancer Cell, Volume 39, Issue 4Author(s): Anish Thomas, Nobuyuki Takahashi, Vinodh N. Rajapakse, Xiaohu Zhang, Yilun Sun, Michele Ceribelli, Kelli M. Wilson, Yang Zhang, Erin Beck, Linda Sciuto, Samantha Nichols, Brian Elenbaas, Janusz Puc, Heike Dahmen, Astrid Zimmermann, Jillian Varonin, Christopher W. Schultz, Sehyun Kim, Hirity Shimellis, Parth Desai (Source: Cancer Cell)
Source: Cancer Cell - April 13, 2021 Category: Cancer & Oncology Source Type: research

Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription
Publication date: Available online 8 April 2021Source: Cancer CellAuthor(s): Yanfen Zhu, Amit D. Gujar, Chee-Hong Wong, Harianto Tjong, Chew Yee Ngan, Liang Gong, Yi-An Chen, Hoon Kim, Jihe Liu, Meihong Li, Adam Mil-Homens, Rahul Maurya, Chris Kuhlberg, Fanyue Sun, Eunhee Yi, Ana C. deCarvalho, Yijun Ruan, Roel G.W. Verhaak, Chia-Lin Wei (Source: Cancer Cell)
Source: Cancer Cell - April 10, 2021 Category: Cancer & Oncology Source Type: research