Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention
Publication date: 16 September 2019Source: Cancer Cell, Volume 36, Issue 3Author(s): Tracy O'Connor, Xiaolan Zhou, Jan Kosla, Arlind Adili, Maria Garcia Beccaria, Elena Kotsiliti, Dominik Pfister, Anna-Lena Johlke, Ankit Sinha, Roman Sankowski, Markus Schick, Richard Lewis, Nikolaos Dokalis, Bastian Seubert, Bastian Höchst, Donato Inverso, Danijela Heide, Wenlong Zhang, Petra Weihrich, Katrin ManskeSummaryHow lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated cell-adh...
Source: Cancer Cell - September 17, 2019 Category: Cancer & Oncology Source Type: research
Passenger Hotspot Mutations in Cancer
Publication date: 16 September 2019Source: Cancer Cell, Volume 36, Issue 3Author(s): Julian M. Hess, Andre Bernards, Jaegil Kim, Mendy Miller, Amaro Taylor-Weiner, Nicholas J. Haradhvala, Michael S. Lawrence, Gad GetzSummaryCurrent statistical models for assessing hotspot significance do not properly account for variation in site-specific mutability, thereby yielding many false-positives. We thus (i) detail a Log-normal-Poisson (LNP) background model that accounts for this variability in a manner consistent with models of mutagenesis; (ii) use it to show that passenger hotspots arise from all common mutational processes; a...
Source: Cancer Cell - September 17, 2019 Category: Cancer & Oncology Source Type: research
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
Publication date: 16 September 2019Source: Cancer Cell, Volume 36, Issue 3Author(s): Rene Jackstadt, Sander R. van Hooff, Joshua D. Leach, Xabier Cortes-Lavaud, Jeroen O. Lohuis, Rachel A. Ridgway, Valérie M. Wouters, Jatin Roper, Timothy J. Kendall, Campbell S. Roxburgh, Paul G. Horgan, Colin Nixon, Craig Nourse, Matthias Gunzer, William Clark, Ann Hedley, Omer H. Yilmaz, Mamunur Rashid, Peter Bailey, Andrew V. BiankinSummaryThe metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal epithelium leads to...
Source: Cancer Cell - September 17, 2019 Category: Cancer & Oncology Source Type: research
UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis
Publication date: 16 September 2019Source: Cancer Cell, Volume 36, Issue 3Author(s): Laurence Wurth, Panagiotis Papasaikas, David Olmeda, Nadine Bley, Guadalupe T. Calvo, Santiago Guerrero, Daniela Cerezo-Wallis, Javier Martinez-Useros, María García-Fernández, Stefan Hüttelmaier, Maria S. Soengas, Fátima Gebauer (Source: Cancer Cell)
Source: Cancer Cell - September 17, 2019 Category: Cancer & Oncology Source Type: research
Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas
Publication date: 16 September 2019Source: Cancer Cell, Volume 36, Issue 3Author(s): Brian Krug, Nicolas De Jay, Ashot S. Harutyunyan, Shriya Deshmukh, Dylan M. Marchione, Paul Guilhamon, Kelsey C. Bertrand, Leonie G. Mikael, Melissa K. McConechy, Carol C.L. Chen, Sima Khazaei, Robert F. Koncar, Sameer Agnihotri, Damien Faury, Benjamin Ellezam, Alexander G. Weil, Josie Ursini-Siegel, Daniel D. De Carvalho, Peter B. Dirks, Peter W. Lewis (Source: Cancer Cell)
Source: Cancer Cell - September 17, 2019 Category: Cancer & Oncology Source Type: research
