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Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma
CONCLUSION: PIWIL mRNAs are overexpressed in HCC tissue and serum samples, the expression patterns could be valuable molecular markers for HCC, due to their association with age, tumour grade and pattern. To the best of our knowledge, our study is the first to report the expression levels of all PIWIL mRNA and to suggest their remarkable values as diagnostic and prognostic biomarkers, in addition to their correlation to HCC development. Additionally, a therapeutic opportunity might be also suggested through in silico miRNA prediction for HCC and PIWIL genes through DDX4 and miR-124-3p.PMID:38043006 | DOI:10.3233/CBM-230134...
Source: Cancer Biomarkers : Section A of Disease Markers - December 3, 2023 Category: Cancer & Oncology Authors: Gehan Hammad Samah Mamdouh Dina Mohamed Seoudi Mohamed Ismail Seleem Gehan Safwat Rania Hassan Mohamed Source Type: research

Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model
CONCLUSION: Subcutaneous fat index could predict bone metastasis in BC patients. Deep learning multimodal algorithm demonstrates superior performance in assessing bone metastases in BC patients.PMID:38043007 | DOI:10.3233/CBM-230219 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - December 3, 2023 Category: Cancer & Oncology Authors: Shidi Miao Haobo Jia Wenjuan Huang Ke Cheng Wenjin Zhou Ruitao Wang Source Type: research

Correlation between IL3 signaling pathway-related genes and immune checkpoint inhibitor efficacy in patients with renal cell carcinoma
CONCLUSION: The IL3 pathway-related genes can be used as a predictor of the efficacy of ICIs in KIRC. The IL3 pathway-related genes may affect the therapeutic efficacy of ICIs by affecting the expression of immune-related molecules, immune cell infiltration, and the level of immune response pathways.PMID:38043008 | DOI:10.3233/CBM-230226 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - December 3, 2023 Category: Cancer & Oncology Authors: Shuang Hou Tianqi Gu Ying Shi Yushan Huang Jiarong Yao Peng Luo Manming Cao Jian Zhang Anqi Lin Weiliang Zhu Source Type: research

Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression
CONCLUSION: Our data reveal hsa_circ_0000018 as a tumor suppressor in LA that targets the let-7f-5p/FAM96A axis. Our findings enrich the known regulatory network of circRNAs in LA.PMID:38043005 | DOI:10.3233/CBM-230111 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - December 3, 2023 Category: Cancer & Oncology Authors: Qi Li Min Zhao Dan-Dan Hu Jun-Jiao Qin Wei He Source Type: research