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Regional citrate anticoagulation in hemodialysis: an observational study of safety, efficacy, and effect on calcium balance during routine care
Conclusions Regional citrate dialysis can be performed safely and effectively using a sparse plasma calcium sampling protocol. The calcium balance induced by this protocol is not different to that seen in standard heparin-anticoagulated dialysis, but in the absence of prospective studies, it is unknown whether this is optimal for patient care. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 19, 2016 Category: Urology & Nephrology Source Type: research

Atypical antipsychotic medications and hyponatremia in older adults: a population-based cohort study
ConclusionsIn this study, the use of an atypical antipsychotic was associated with a modest but statistically significant increase in the 30-day risk of a hospitalization with hyponatremia. The association was less pronounced than that described with other psychotropic drugs. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 11, 2016 Category: Urology & Nephrology Source Type: research

Atypical antipsychotic medications and hyponatremia in older adults: a population-based cohort study
Conclusions In this study, the use of an atypical antipsychotic was associated with a modest but statistically significant increase in the 30-day risk of a hospitalization with hyponatremia. The association was less pronounced than that described with other psychotropic drugs. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 10, 2016 Category: Urology & Nephrology Source Type: research

Validation of administrative database codes for acute kidney injury in kidney transplant recipients
ConclusionsSimilar to the general population, theICD-10 N17x code misses many kidney transplant patients with AKI during their hospitalization. This makes the code unusable for studying the incidence and consequences of AKI in hospitalized kidney transplant patients. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 7, 2016 Category: Urology & Nephrology Source Type: research

Validation of administrative database codes for acute kidney injury in kidney transplant recipients
Conclusions Similar to the general population, the ICD-10 N17x code misses many kidney transplant patients with AKI during their hospitalization. This makes the code unusable for studying the incidence and consequences of AKI in hospitalized kidney transplant patients. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 6, 2016 Category: Urology & Nephrology Source Type: research

Primary care physicians ’ perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study
ConclusionsThis work will inform development of clinical resources and tools for care of older adults with stage 5 CKD, to address barriers and enable facilitators to community-based conservative care. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 4, 2016 Category: Urology & Nephrology Source Type: research

Primary care physicians ’ perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study
Conclusions < /h3 > < p class= " a-plus-plus " > This work will inform development of clinical resources and tools for care of older adults with stage 5 CKD, to address barriers and enable facilitators to community-based conservative care. < /p > < /span > (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 3, 2016 Category: Urology & Nephrology Source Type: research

Primary care physicians’ perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study
Conclusions This work will inform development of clinical resources and tools for care of older adults with stage 5 CKD, to address barriers and enable facilitators to community-based conservative care. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 3, 2016 Category: Urology & Nephrology Source Type: research

Reproducibility of carotid-femoral pulse wave velocity in end-stage renal disease patients: methodological considerations
ConclusionsWeek-to-week measurements of cf-PWV and pulse wave analysis are highly reproducible in ESRD patients prior to hemodialysis treatment. The high reproducibility and minimal test-to-test variations encourage use of cf-PWV to monitor changes in arterial stiffness and the efficacy of interventions in ESRD patients.Trial registrationClinicalTrials.gov,NCT02196610. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 1, 2016 Category: Urology & Nephrology Source Type: research

Reproducibility of carotid-femoral pulse wave velocity in end-stage renal disease patients: methodological considerations
Conclusions Week-to-week measurements of cf-PWV and pulse wave analysis are highly reproducible in ESRD patients prior to hemodialysis treatment. The high reproducibility and minimal test-to-test variations encourage use of cf-PWV to monitor changes in arterial stiffness and the efficacy of interventions in ESRD patients. Trial registration ClinicalTrials.gov, NCT02196610. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - March 31, 2016 Category: Urology & Nephrology Source Type: research

Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review
AbstractPurpose of the reviewUremic pruritus (UP) is a common discomfort of dialysis-dependent end-stage renal disease. Some studies suggest a neuropathic cause of UP. Gabapentin, an anticonvulsant, has shown promising results as an emerging drug to treat this condition.ObjectiveAn updated qualitative systematic review was conducted to evaluate its efficacy and safety in hemodialysis patients.Source of informationOvid MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, and Google Scholar through June 2015 were used as sources of information.PatientsPatients are adult hemodialysis patients r...
Source: Canadian Journal of Kidney Health and Disease - March 28, 2016 Category: Urology & Nephrology Source Type: research

Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review
Abstract Purpose of the review Uremic pruritus (UP) is a common discomfort of dialysis-dependent end-stage renal disease. Some studies suggest a neuropathic cause of UP. Gabapentin, an anticonvulsant, has shown promising results as an emerging drug to treat this condition. Objective An updated qualitative systematic review was conducted to evaluate its efficacy and safety in hemodialysis patients. Source of info...
Source: Canadian Journal of Kidney Health and Disease - March 27, 2016 Category: Urology & Nephrology Source Type: research

The Canadian experience using the expanded criteria donor classification for allocating deceased donor kidneys for transplantation
Conclusions The ECD classification identifies kidneys at increased risk for graft loss in Canadian patients. The performance of more granular measures of donor risk (e.g., Kidney Donor Risk Index) and its impact on organ allocation/utilization in Canadian patients requires further study. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - March 23, 2016 Category: Urology & Nephrology Source Type: research

Comparative effectiveness of home dialysis therapies: a matched cohort study
Conclusions Home daily hemodialysis was associated with lower mortality risk than home peritoneal dialysis. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - March 19, 2016 Category: Urology & Nephrology Source Type: research

Parental attitudes to genetic testing differ by ethnicity and immigration in childhood nephrotic syndrome: a cross-sectional study
Conclusion While majority of parents were interested in genetic testing for their child, immigrants, particularly South Asians and East/Southeast Asians, were more likely to decline genetic testing. Genetic counseling needs to be tailored to address specific concerns in these parental groups to maximize informed decision-making in the clinical setting. Trial registration ClinicalTrials.gov, NCT01605266 (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - March 17, 2016 Category: Urology & Nephrology Source Type: research