Influenza, Pneumococcal, Hepatitis B and Herpes Zoster Vaccinations
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Nadira Husein, Ashen Chetty (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Diabetes and Mental Health
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): David J. Robinson, Michael Coons, Heidi Haensel, Michael Vallis, Jean-François Yale (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Weight Management in Diabetes
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Sean Wharton, Sue D. Pedersen, David C.W. Lau, Arya M. Sharma (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

In-Hospital Management of Diabetes
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Janine Malcolm, Ilana Halperin, David B. Miller, Sarah Moore, Kara A. Nerenberg, Vincent Woo, Catherine H. Yu (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Hyperglycemic Emergencies in Adults
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Jeannette Goguen, Jeremy Gilbert (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Hypoglycemia
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Jean-François Yale, Breay Paty, Peter A. Senior (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Pharmacologic Glycemic Management of Type 2 Diabetes in Adults
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Lorraine Lipscombe, Gillian Booth, Sonia Butalia, Kaberi Dasgupta, Dean T. Eurich, Ronald Goldenberg, Nadia Khan, Lori MacCallum, Baiju R. Shah, Scot Simpson (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Glycemic Management in Adults With Type 1 Diabetes
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Angela McGibbon, Lenley Adams, Karen Ingersoll, Tina Kader, Barna Tugwell (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Nutrition Therapy
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): John L. Sievenpiper, Catherine B. Chan, Paula D. Dworatzek, Catherine Freeze, Sandra L. Williams (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Physical Activity and Diabetes
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Ronald J. Sigal, Marni J. Armstrong, Simon L. Bacon, Normand G. Boulé, Kaberi Dasgupta, Glen P. Kenny, Michael C. Riddell (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Monitoring Glycemic Control
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Lori D. Berard, Rick Siemens, Vincent Woo (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Self-Management Education and Support
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Diana Sherifali, Lori D. Berard, Enza Gucciardi, Barbara MacDonald, Gail MacNeill (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Organization of Diabetes Care
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Maureen Clement, Pierre Filteau, Betty Harvey, Susie Jin, Tessa Laubscher, Geetha Mukerji, Diana Sherifali (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Reducing the Risk of Developing Diabetes
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Ally P.H. Prebtani, Harpreet S. Bajaj, Ronald Goldenberg, Yvonne Mullan (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Screening for Diabetes in Adults
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Jean-Marie Ekoe, Ronald Goldenberg, Pamela Katz (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Zubin Punthakee, Ronald Goldenberg, Pamela Katz (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Methods
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 Author(s): Diana Sherifali, Doreen Rabi, Robyn L. Houlden (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Note to Readers
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

2018 Clinical Practice Guidelines Committees
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Supplement 1 (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 10, 2018 Category: Endocrinology Source Type: research

Effect of Biochanin a on Retina Level of VEGF, TNF-a and IL-1B in STZ Induced Diabetic Rats
Conclusion Administration of BCA can improve and postpone retinopathy, by lowering blood sugar, suppressing inflammation via decreasing TNF-α and IL-1β, and reducing angiogenesis via decreasing VEGF in the retinal tissues. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 4, 2018 Category: Endocrinology Source Type: research

Dipeptidyl Peptidase-4 Inhibitor, Vildagliptin, Improves Trabecular Bone Mineral Density and Microstructure in Obese, Insulin-Resistant, Pre-diabetic Rats
Conclusions Vildagliptin had a beneficial effect on the bone of obese insulin-resistant rats with prediabetes, particularly at the trabecular site. Such benefit probably results from enhanced bone formation rather than from suppressed bone resorption. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 30, 2018 Category: Endocrinology Source Type: research

Assessing the Levels of L-Carnitine and Total Antioxidant Capacity in Newly Diagnosed and Long-Standing Type II Diabetes
Conclusions According to the effect of reduced LC level on the metabolic profile of long-standing type II diabetes, setting of the LC content value to prevent diabetes through the use of effective drugs or nutrition therapy containing LC can be useful in managing diabetes. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 30, 2018 Category: Endocrinology Source Type: research

Placental Expression of Glucose Transporter Proteins in Pregnancies Complicated by Gestational and Pregestational Diabetes Mellitus
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Paweł Jan Stanirowski, Dariusz Szukiewicz, Monika Pazura-Turowska, Włodzimierz Sawicki, Krzysztof Cendrowski Gestational diabetes mellitus and pregestational diabetes mellitus constitute carbohydrate metabolism disorders, which, if not diagnosed and adequately treated, lead to serious and often life-threatening pregnancy complications. According to a recently formulated hypothesis, some diabetes-related complications, such as fetal macrosomia, may be the result of disturbances in the transplacental transport of nutrients&mdas...
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Single-Pill Combinations in the Treatment of Hypertension in Adults: Beyond Convenience
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Benoit Imbeault, Michel Vallée Adequate blood pressure control in patients with hypertension remains the pillar of cardiovascular-event prevention. Smoking cessation, reduced dietary salt intake, physical exercise and weight loss contribute to better blood pressure control and reduced cardiovascular morbidity, but alone, they are often insufficient in doing so, and their success is highly dependent on individual patient motivation. Pharmacologic therapy, thus, remains necessary for most patients, and our conception of th...
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Nonpharmacological Interventions in the Management of Hypertension in the Adult Population With Type 2 Diabetes Mellitus
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Patricia Urrico This review discusses nonpharmacological interventions for the management of hypertension in people with diabetes. Interventions that focus on controlling weight, reducing salt intake, eating according to the Dietary Approaches to Stop Hypertension guidelines, partaking in regular physical activity, ceasing smoking and self-measuring of blood pressure can lower blood pressure in the population with diabetes. Other positive outcomes resulting from these lifestyle changes are improved glycemia levels and cardiac f...
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Hypertension in Adults With Type 2 Diabetes: A Review of Blood Pressure Measurement Methods, Targets and Therapy
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Lyne Cloutier, Maxime Lamarre-Cliche Hypertension occurs in more than two-thirds of patients with type 2 diabetes. In a retrospective analysis of a Framingham cohort, high blood pressure was associated with a 72% increase in the risk for all-cause death and a 57% increment in the risk for any cardiovascular disease event, making hypertension the strongest driver of cardiovascular outcomes in individuals with diabetes. One of the key aspects of hypertension management is the correct measurement of blood pressure; various types o...
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Low Hepcidin in Type 2 Diabetes Mellitus: Examining the Molecular Links and Their Clinical Implications
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Driton Vela, Ramadan B. Sopi, Mitko Mladenov The relationship between iron and glucose metabolism has been evidenced strongly, but the molecular mediation of this connection is just being revealed. The discovery of hepcidin as the prime controller of iron metabolism has paved the way for understanding the main actors behind this mediation. Recent data suggest that insulin therapy and probably other diabetes drugs can influence hepcidin production, thus influencing the iron load in cells. Correcting iron load through hepcidin ex...
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Resistant Hypertension in Adults With Type 1 or 2 Diabetes: A Structured Diagnostic Approach
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Philip A. McFarlane People with diabetes often have difficulty reaching their blood pressure targets and are labelled as having resistant hypertension. Clinicians often move quickly to screen such people for secondary causes of hypertension; however, such causes are rare, and resistant hypertension usually has other explanations that are significantly more common. By using a structured approach to resistant hypertension, clinicians can assist patients to reach their target blood pressure levels. Step 1 is to determine out-of-of...
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Thresholds and Targets for Hypertension Management in Adults With Type 2 Diabetes Should Remain at 130/80  mmHg: What's the Evidence?
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Niharika Shahi, Sheldon W. Tobe Hypertension and diabetes are common comorbidities and are both modifiable risk factors for cardiovascular disease and death. Lowering blood pressure reduces target organ damage and prevents cardiovascular disease outcomes. The harmonized Canadian clinical practice guidelines for managing hypertension in people with diabetes provides health-behaviour advice and medical therapy recommendations for a threshold blood pressure of 130/80 mmHg and above and to target blood pressure to below 130/...
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Adherence to Guidelines for Inpatient Pharmacologic Management of Type 2 Diabetes in Adults and Glycemic Outcomes
Conclusions Adherence to guidelines for inpatient type 2 diabetes management is good and may be greater with more training. Hyperglycemia was more common in patients who did not receive guideline-based care. Hypoglycemia was uncommon and did not appear to be more common in the guideline-adherent group, although numbers were small. These results may alleviate physicians' fear that providing adequate insulin to hospitalized patients may cause hypoglycemia. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Associations Between Sleep Habits and Dysglycemia in Adults in the United States: A Cross-Sectional Analysis
Conclusions Between 7 and 8 hours of sleep and fair/poor sleep quality were associated with optimal A1C levels, while sleeping for fewer or more hours appeared to increase dysglycemia, without adjustment for covariates. These relationships were attenuated following multivariable adjustment. Future research is necessary to refine our understanding of the sleep/glycemic-control relationship to provide a context for the clinical significance of these findings for longer-term A1C control in adults with diabetes. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Anti-Inflammatory, Antiapoptotic and Proproliferative Effects of Vitis vinifera Seed Ethanolic Extract in the Liver of Streptozotocin-Nicotinamide-Induced Type 2 Diabetes in Male Rats
Conclusions The anti-inflammatory, anti-apoptotic and pro-proliferative effects of VVSEE could account for its hepatoprotective actions in diabetes. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Blood Pressure Management in Adults With Type 2 Diabetes: Insights From the Diabetes Mellitus Status in Canada (DM-SCAN) Survey
Conclusions Only about one-third of patients with diabetes achieved the target BP of below 130/80 mmHg. Patients with BP 130/80 mmHg or higher were also less likely to achieve optimal guideline-recommended glycated hemoglobin and low-density lipoprotein-cholesterol targets. Improved comprehensive management of all risk factors in patients with diabetes is warranted. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

The Divergent Cardiovascular Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Type 1 Receptor Blockers in Adult Patients With Type 2 Diabetes Mellitus
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Martin H. Strauss, Alistair S. Hall The renin angiotensin aldosterone system (RAAS) plays a central role in the pathophysiology of hypertension and vascular disease. Angiotensin-converting enzyme inhibitors (ACEi's) suppress angiotensin II (ANG II) concentrations, whereas angiotensin II type 1 (AT1) receptor blockers (ARBs) block the binding of ANG II to AT1 receptors. ACEi's and ARBs are both effective antihypertensive agents and produce similar risk reductions for stroke, a blood pressure-dependent phenomenon. ACEi's also red...
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Angiotensin-Converting Enzyme Inhibitors vs. Angiotensin Receptor Blockers for the Treatment of Hypertension in Adults With Type 2 Diabetes: Why We Favour Angiotensin Receptor Blockers
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Thomas A. Mavrakanas, Mark L. Lipman Cardiovascular disease is the principal cause of morbidity and mortality in patients with diabetes mellitus. The incidence or progression of kidney disease is also common in these patients. Several clinical trials have established the efficacy of angiotensin receptor blockers for the prevention of adverse cardiovascular and renal outcomes in this population and are summarized in this review article. Head-to-head comparison of angiotensin receptor blockers with angiotensin-converting enzyme i...
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Response to the Letter to the Editor From Dr. Kawada, “Predictors of Serum Adiponectin in Patients With Prediabetes and Type 2 Diabetes”
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Anindita Banerjee, Vineet Kumar Khemka (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Top 10 Reviewers for 2017
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Diabetes and Hypertension: The Low and High Points
Publication date: April 2018 Source:Canadian Journal of Diabetes, Volume 42, Issue 2 Author(s): Luc Trudeau, Jeremy Gilbert (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 28, 2018 Category: Endocrinology Source Type: research

Improving Glycemic Control in Adults and Children with Type 1 Diabetes with the Use of Smart-Phone Based Mobile Applications: a Systematic Review
Conclusion This study highlights the need for larger and longer studies to explore the efficacy of apps in T1DM in optimizing outcomes, the populations that would benefit most from these tools, and the resources needed to support mobile-apps plus text-messaging / feedback system. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 27, 2018 Category: Endocrinology Source Type: research

Association between Elevated C-Reactive Protein Levels and Prediabetes, Particularly Impaired Glucose Tolerance
Conclusions Elevated serum CRP levels are associated with prediabetes, particularly impaired glucose tolerance. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 20, 2018 Category: Endocrinology Source Type: research

Copeptin and Estimated Insulin Sensitivity in Adults with and Without Type 1 Diabetes: CACTI Study
Conclusion Copeptin does not correlate with markers of IR in T1DM, but strongly correlates in non-T1DM. Thus, elevated vasopressin activity and IR appear to be independent risk factors for vascular complications in T1DM. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 15, 2018 Category: Endocrinology Source Type: research

Optimal HbA1c Cut-Off Point for Diagnosis of Type 2 Diabetes in Iranian Adults
Conclusion The findings suggest the necessity of determining the HbA1c cut-offs for detecting diabetes or prediabetes in each region population. This also suggests that the combination of these HbA1c cut-offs with fasting blood glucose levels are required to determine diabetes and prediabetes more accurately. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 13, 2018 Category: Endocrinology Source Type: research

Targeted Glycemic Control for Patients with Type 2 Diabetes Mellitus in the Acute Care Setting
Publication date: Available online 8 February 2018 Source:Canadian Journal of Diabetes Author(s): Ali Pourmand, Maryann Mazer-Amirshahi, Amy Caggiula, Aria Nawab, Christopher Payette, Samuel Johnson Diabetes mellitus and complications arising from the disease are a leading cause of morbidity and mortality worldwide. With increasing prevalence over the last 50 years, and an estimated 20% of healthcare spending dedicated to the disease, diabetes is considered by many to be a true public health emergency. Several protocols and management options exist to maximize glycemic control in the ambulatory setting, but the optimal gl...
Source: Canadian Journal of Diabetes - March 10, 2018 Category: Endocrinology Source Type: research

Results From a Feasibility Study of Square-Stepping Exercise in Older Adults with Type 2 Diabetes and a Self-Reported Cognitive Complaint to Improve Global Cognitive Functioning
Conclusions SSE should be evaluated further to improve its feasibility in older adults with T2DM. This study provides preliminary evidence that SSE improves executive function in adults with T2DM and self-reported cognitive complaints. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 7, 2018 Category: Endocrinology Source Type: research

Fear of Falling and Balance Confidence in Older Adults with Type 2 Diabetes Mellitus: a Scoping Review
Publication date: Available online 6 March 2018 Source:Canadian Journal of Diabetes Author(s): Patricia Hewston, Nandini Deshpande Type 2 diabetes mellitus (DM) is highly prevalent in older adults (?65 years of age) and increases fall-risk. Fear of falling and low balance confidence are reported in both fallers and non-fallers, and can potentially be more debilitating than a fall itself. Therefore, the objective of this scoping review was to examine and map the current research evidence of fear of falling and balance confidence in older adults with DM. The search strategy involved a primary search of CINAHL, EMBASE, PubMe...
Source: Canadian Journal of Diabetes - March 7, 2018 Category: Endocrinology Source Type: research

An Update on Hypertension in Children with Type 1 Diabetes
Publication date: Available online 6 March 2018 Source:Canadian Journal of Diabetes Author(s): Mallory L. Downie, Emma Ulrich, Damien G. Noone The prevalence of hypertension in children with T1D is reported to lie between 6-16%. This potentially modifiable cardiovascular risk factor may go undiagnosed and under-treated, particularly in children with T1D. Recent updated Canadian clinical practice guidelines recommend blood pressure screening every 2 years in children with T1D, as well as routine use of ambulatory blood pressure monitoring. Risk factors for hypertension in T1D include poor glycemic control, overweight and o...
Source: Canadian Journal of Diabetes - March 7, 2018 Category: Endocrinology Source Type: research

Re: Natural Health Products and Diabetes: a Practical Review
Publication date: Available online 6 March 2018 Source:Canadian Journal of Diabetes Author(s): Peter Senior (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 7, 2018 Category: Endocrinology Source Type: research

Serum Vit-D and Its Upregulated Protein, Thioredoxin Interacting Protein, are Associated with Β-Cell Dysfunction in Type 1 and Type 2 Diabetic Patients
Conclusions Our data showed that vit-D and TXNIP were associated with different β-cell dysfunction markers indicating the potential abilities of them to predict the β-cell status in diabetes. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 2, 2018 Category: Endocrinology Source Type: research

Accumulation of Advanced Glycation End Products and Subclinical Inflammation in Deep Tissues of Adult Diabetic /Non Diabetic Patients
Conclusions AGEs contents were strongly correlated with each other, and were accompanied with inflammatory cells. Skin AF measurement could provide information about the systemic accumulation of AGEs. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 28, 2018 Category: Endocrinology Source Type: research

Activated Mast Cells Mediate Low-Grade Inflammation in Type 2 Diabetes: IL-37 Could be Beneficial
Publication date: Available online 31 January 2018 Source:Canadian Journal of Diabetes Author(s): Pio Conti, Gianpaolo Ronconi, Spyridon K. Kritas, Alessandro Caraffa, Theoharis C. Theoharides Mast cells (MCs) promote guest immune response against parasites and play a critical role in allergic and inflammatory reactions. Once they have been activated, MCs release high inflammatory compounds that can provoke serious pathological signs that can even lead to death. MCs generate a number of pre-formed, de novo synthesized compounds, and inflammatory cytokine/chemokine synthesis in response to the high affinity (Kd=10-10 M) Ig...
Source: Canadian Journal of Diabetes - February 28, 2018 Category: Endocrinology Source Type: research