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Studying propofol-induced cardioprotection: from mechanism to clinical phenomenon and back again
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 4, 2016 Category: Anesthesiology Source Type: research

Fetal descending aortic flow and heart rate monitoring with transesophageal echocardiography during maternal cardiac surgery
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 4, 2016 Category: Anesthesiology Source Type: research

A systematic review of transthoracic and transesophageal echocardiography in non-cardiac surgery: implications for point-of-care ultrasound education in the operating room
Conclusion In this systematic review examining the use of TTE or TEE in non-cardiac surgery, the most frequent diagnoses were valvulopathy, low LVEF, hypovolemia, PE, SWMAs, and RV failure. This information should be used to inform evidence-based curricula for POCU in anesthesiology. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 4, 2016 Category: Anesthesiology Source Type: research

Perioperative genomics: coming soon to (operating) theatres near you
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 4, 2016 Category: Anesthesiology Source Type: research

Novel techniques for increasing the size of the radial artery during ultrasound-guided cannulation
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 4, 2016 Category: Anesthesiology Source Type: research

Erratum to: Extracranial contamination in the INVOS 5100C versus the FORE-SIGHT ELITE cerebral oximeter: a prospective observational crossover study in volunteers
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 4, 2016 Category: Anesthesiology Source Type: research

Atlas of Functional Anatomy for Regional Anesthesia and Pain Medicine
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 4, 2016 Category: Anesthesiology Source Type: research

Severe spinal and chest deformity secondary to neurofibromatosis
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - March 4, 2016 Category: Anesthesiology Source Type: research

Stoelting’s Pharmacology & Physiology in Anesthetic Practice—5 th Edition
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 13, 2016 Category: Anesthesiology Source Type: research

Ketamine as an adjunct to patient-controlled analgesia: why, for whom, and how much?
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 13, 2016 Category: Anesthesiology Source Type: research

Cardiac and Critical Care Ultrasonography
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 13, 2016 Category: Anesthesiology Source Type: research

Post-traumatic giant occipital pseudomeningocele
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 13, 2016 Category: Anesthesiology Source Type: research

Video imaging of arytenoid prolapse
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 13, 2016 Category: Anesthesiology Source Type: research

Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study
Conclusion The results suggest a contribution of IL1β in modulating susceptibility to postoperative QTc prolongation after cardiac surgery. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 8, 2016 Category: Anesthesiology Source Type: research

Prewarming neurosurgical patients to minimize hypotension on induction of anesthesia: a randomized trial
Abstract Purpose Prewarming prior to surgery is effective in preventing perioperative hypothermia. There is a paucity of evidence, however, regarding the hemodynamic effects of prewarming. We hypothesized that the nadir mean arterial pressure during anesthesia induction would be higher after prewarming than after no prewarming. Methods We randomized 32 patients prior to elective neurosurgery to receive either one hour of forced-air convective warming at 46°C or routine care (full body blanket with convective warmer attached but not turned on). All pa...
Source: Canadian Journal of Anesthesia - February 8, 2016 Category: Anesthesiology Source Type: research

Medical cannabis: considerations for the anesthesiologist and pain physician
Conclusion The science of medical cannabis and the need for education of healthcare professionals and patients require continued effort. Although cannabinoids work to decrease pain, there is still a need to confirm these beneficial effects clinically and to exploit them with acceptable benefit-to-risk ratios. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 5, 2016 Category: Anesthesiology Source Type: research

Perioperative management and oncological outcomes following radical cystectomy for bladder cancer: a matched retrospective cohort study
Abstract Purpose The immune system plays an important role in tumour progression. Systemic opioids are immunosuppressive; thus, theoretically they may promote tumour spread. Our primary aim was to test the hypothesis that general anesthesia (GA) with spinal analgesia (SA) in patients with bladder cancer undergoing radical cystectomy (RC) will both reduce systemic opioid use and improve oncological outcomes. Since blood transfusions also induce immunosuppression, a secondary aim was to evaluate the effect of perioperative transfusions on oncological outcomes. Metho...
Source: Canadian Journal of Anesthesia - February 5, 2016 Category: Anesthesiology Source Type: research

Cerebral tissue oxygen saturation values in volunteers and patients in the lateral decubitus and beach chair positions: a prospective observational study
The objective of this study was to describe changes in cerebral tissue oxygen saturation (SctO2) due to changes in body position in healthy volunteers and in patients undergoing surgery under general anesthesia in the beach chair position (BCP) and lateral decubitus position (LDP). Methods In this prospective observational study, SctO2 was measured in 85 awake volunteers serially positioned every 15 min, beginning with the supine position (SP) and followed by the beach chair, supine, and lateral decubitus positions. Cerebral tissue oxygen saturation was also measured supine and in ei...
Source: Canadian Journal of Anesthesia - February 4, 2016 Category: Anesthesiology Source Type: research

Frequency and characteristics of healthcare visits associated with chronic pain: results from a population-based Canadian study
Conclusion Interventions aimed at reducing healthcare costs for chronic pain should target individuals living with multiple chronic conditions. Research is needed to develop and test interventions that focus on the needs of these groups. Identifying the risk factors for high healthcare use and improving self-management may reduce healthcare visits. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 3, 2016 Category: Anesthesiology Source Type: research

Epidural analgesia does not increase the rate of inpatient falls after major upper abdominal and thoracic surgery: a retrospective case-control study
Abstract Purpose Postoperative epidural analgesia for major upper abdominal and thoracic surgery can provide significant benefits, including superior analgesia and reduced pulmonary dysfunction. Nevertheless, epidural analgesia may also be associated with decreased muscle strength, sympathetic tone, and proprioception that could possibly contribute to falls. The purpose of this retrospective case-control study was to search a large national database in order to investigate the possible relationship between postoperative epidural analgesia and the rate of inpatient falls. ...
Source: Canadian Journal of Anesthesia - February 2, 2016 Category: Anesthesiology Source Type: research

Falling after epidural analgesia: lessons from obstetric anesthesia
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 1, 2016 Category: Anesthesiology Source Type: research

The effect of sevoflurane versus desflurane on postoperative catheter-related bladder discomfort in patients undergoing transurethral excision of a bladder tumour: a randomized controlled trial
Conclusions As a maintenance agent of general anesthesia, sevoflurane reduced the incidence of early postoperative CRBD in patients undergoing TURBT when compared with desflurane. The protocol for this clinical trial was registered at ClinicalTrials.gov (NCT02096224). (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 1, 2016 Category: Anesthesiology Source Type: research

A “VL tube” for endotracheal intubation using video laryngoscopy
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 29, 2016 Category: Anesthesiology Source Type: research

Dexmedetomidine during total knee arthroplasty performed under spinal anesthesia decreases opioid use: a randomized-controlled trial
Abstract Background It remains unclear whether the opioid-sparing effects of dexmedetomidine seen in patients undergoing general anesthesia are reproducible in patients undergoing spinal anesthesia. We hypothesized that the administration of intravenous dexmedetomidine for sedation during total knee arthroplasty under spinal anesthesia would decrease postoperative morphine consumption in the first 24 hr following surgery. Methods We conducted this prospective double-blind randomized-controlled trial in 40 patients (American Society of Anesthesiologists p...
Source: Canadian Journal of Anesthesia - January 29, 2016 Category: Anesthesiology Source Type: research

Successful inter-hospital transfer for extracorporeal membrane oxygenation after an amniotic fluid embolism induced cardiac arrest
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 29, 2016 Category: Anesthesiology Source Type: research

Ultrasonography-guided penile block for adult penile surgery
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 28, 2016 Category: Anesthesiology Source Type: research

Definitive airway management in emergency department patients with a King laryngeal tube™ in place: a simple and safe approach
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 25, 2016 Category: Anesthesiology Source Type: research

In reply: Definitive airway management in emergency department patients with a King laryngeal tube™ in place: a simple and safe approach
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 25, 2016 Category: Anesthesiology Source Type: research

Life-Changing Medical Invention: Build a Successful Enterprise and a New World
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 22, 2016 Category: Anesthesiology Source Type: research

In reply: Anesthesia research training: preparing for the future of our specialty
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 21, 2016 Category: Anesthesiology Source Type: research

Anesthetic depth and long-term survival: an update
Conclusions The available evidence on anesthetic depth and long-term survival is inconclusive. Randomized controlled trials with carefully controlled arterial blood pressure are required. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 20, 2016 Category: Anesthesiology Source Type: research

Perioperative stroke
Conclusions Perioperative stroke carries a significant clinical burden. The incidence of perioperative stroke may be higher than previously recognized, and there are diverse pathophysiologic mechanisms. There are many opportunities for further investigation of the pathophysiology, prevention, and management of perioperative stroke. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 20, 2016 Category: Anesthesiology Source Type: research

Preclinical neuroprotective actions of xenon and possible implications for human therapeutics: a narrative review
Conclusion According to the evidence to date, the neuroprotective efficacy of xenon in preclinical models and its safety in clinical anesthesia set the stage for the launch of randomized clinical trials to determine whether these encouraging neuroprotective findings can be translated into clinical utility. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 20, 2016 Category: Anesthesiology Source Type: research

Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis?
Conclusions Current laboratory research suggests that perioperative interventions may impact recurrence or metastasis through effects on cancer cell signalling, the immune response, or modulation of the neuroendocrine stress response. Further evidence is awaited from prospective randomized-controlled trials. Meanwhile, with limited data upon which to make strong recommendations, anesthesiologists should seek optimal anesthesia and analgesia for their patients based on individual risk-benefit analysis and best available evidence on outcomes other than cancer recurrence. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 20, 2016 Category: Anesthesiology Source Type: research

Depth of anesthesia causality dilemmas: the next generation
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 20, 2016 Category: Anesthesiology Source Type: research

Optimum brightness of a new light-emitting diode lightwand device in a cadaveric model – a pilot study
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 20, 2016 Category: Anesthesiology Source Type: research

Anesthesia research training: preparing for the future of our speciality
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 20, 2016 Category: Anesthesiology Source Type: research

Tracheal obstruction in a child with a posterior mediastinal mass
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 19, 2016 Category: Anesthesiology Source Type: research

A retrospective review of pediatric difficult airways: once easy, not always easy
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 14, 2016 Category: Anesthesiology Source Type: research

Tympanic membrane rupture during robotic-assisted laparoscopic prostatectomy
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 12, 2016 Category: Anesthesiology Source Type: research

Failed caudal block due to physiologic changes associated with a cerebrospinal fluid leak: a case report
Conclusions The possible mechanism of this failed caudal block was high systemic absorption of anesthetic given the epidural venous plexus engorgement thus leaving less anesthetic acting within the CSF and on the exiting spinal nerves. Decreased CSF flow in the thecal sac might also have contributed, as might dilution of the remaining local anesthetic caused by large amounts of leaking CSF within the epidural space. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 12, 2016 Category: Anesthesiology Source Type: research

Standardizing endpoints in perioperative research
Abstract Measuring patient-relevant, clinically important, and valid outcomes is fundamental to the delivery of high-quality clinical care and to the innovation and development of such care through research. As surgical innovations become more complex and the burden of age and comorbidities in the surgical patient population continues to increase, understanding the benefits and harms of surgical interventions becomes ever more important. Nevertheless, we can understand only what we can adequately describe. Truly collaborative decision-making, delivery of safe effective care, and on-going quality improvement are al...
Source: Canadian Journal of Anesthesia - January 7, 2016 Category: Anesthesiology Source Type: research

Management of acute epiglottitis in an infant with a family history of malignant hyperthermia
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 7, 2016 Category: Anesthesiology Source Type: research

Physician-assisted death in Canada: an imminent reality
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 6, 2016 Category: Anesthesiology Source Type: research

Physician-assisted death and the anesthesiologist
Abstract Although physician-assisted death (PAD) is established in certain countries, the legality and ethics of this issue have been debated for decades in Canada. The Supreme Court of Canada has now settled the issue of legality nationally, and as a result of the decision in Carter v. Canada, PAD (which includes both physician-assisted suicide and euthanasia) will become legal on February 6, 2016. It is difficult to predict the potential demand for PAD in Canada. This paper highlights other countries’ experiences with PAD in order to shed light on this question and to forecast issues that Canadian phy...
Source: Canadian Journal of Anesthesia - January 6, 2016 Category: Anesthesiology Source Type: research

Lessons learned from physician participation in lethal injection: Is Carter v. Canada a death knell for medical self-regulation?
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 6, 2016 Category: Anesthesiology Source Type: research

Cervical spine tuberculosis and airway compromise
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 6, 2016 Category: Anesthesiology Source Type: research

Brokering trust: estimating the cost of physician-assisted death
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 5, 2016 Category: Anesthesiology Source Type: research

Pediatric Atlas of Ultrasound- and Nerve Stimulation-Guided Regional Anesthesia
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 4, 2016 Category: Anesthesiology Source Type: research

The known knowns and known unknowns of chronic pain
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 4, 2016 Category: Anesthesiology Source Type: research