Prophylactic tranexamic acid in Cesarean delivery: an updated meta-analysis with a trial sequential analysis
CONCLUSION: Prophylactic TXA administration for parturients undergoing Cesarean delivery significantly reduced blood loss, without increasing adverse events, supporting its use as a safe and effective strategy for reducing PPH in this population.STUDY REGISTRATION: PROSPERO (CRD42023422188); first submitted 27 April 2023.PMID:38453797 | DOI:10.1007/s12630-024-02715-3 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 7, 2024 Category: Anesthesiology Authors: Henrique Provinciatto Maria E Barbalho Pedro M da C âmara Isabelle B Donadon Luiza M Fonseca Marina S Bertani Alice D Marinho Eduardo Sirena Alexandre Provinciatto Sara Amaral Source Type: research

Simulation-based medical education in Canadian anesthesiology academic institutions: a national survey
CONCLUSION: Large variability exists in the delivery of SBME in Canadian anesthesiology residency simulation programs, in part because of differences in financial/human resources and educational content. Future studies should explore whether training and patient outcomes differ between SBME programs and, if so, whether additional standardization is warranted.PMID:38453798 | DOI:10.1007/s12630-024-02720-6 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 7, 2024 Category: Anesthesiology Authors: Yuqi Gu Marshall Tenenbein Linda Korz Jason W Busse Michelle Chiu Source Type: research

Critical Care Canada Forum 2023 Abstracts
Can J Anaesth. 2024 Mar 7. doi: 10.1007/s12630-024-02727-z. Online ahead of print.NO ABSTRACTPMID:38453796 | DOI:10.1007/s12630-024-02727-z (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 7, 2024 Category: Anesthesiology Source Type: research

Prophylactic tranexamic acid in Cesarean delivery: an updated meta-analysis with a trial sequential analysis
CONCLUSION: Prophylactic TXA administration for parturients undergoing Cesarean delivery significantly reduced blood loss, without increasing adverse events, supporting its use as a safe and effective strategy for reducing PPH in this population.STUDY REGISTRATION: PROSPERO (CRD42023422188); first submitted 27 April 2023.PMID:38453797 | DOI:10.1007/s12630-024-02715-3 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 7, 2024 Category: Anesthesiology Authors: Henrique Provinciatto Maria E Barbalho Pedro M da C âmara Isabelle B Donadon Luiza M Fonseca Marina S Bertani Alice D Marinho Eduardo Sirena Alexandre Provinciatto Sara Amaral Source Type: research

Simulation-based medical education in Canadian anesthesiology academic institutions: a national survey
CONCLUSION: Large variability exists in the delivery of SBME in Canadian anesthesiology residency simulation programs, in part because of differences in financial/human resources and educational content. Future studies should explore whether training and patient outcomes differ between SBME programs and, if so, whether additional standardization is warranted.PMID:38453798 | DOI:10.1007/s12630-024-02720-6 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 7, 2024 Category: Anesthesiology Authors: Yuqi Gu Marshall Tenenbein Linda Korz Jason W Busse Michelle Chiu Source Type: research

Superficial parasternal intercostal plane blocks in cardiac surgery: a systematic review and meta-analysis
CONCLUSION: The literature suggests a potential benefit of using superficial parasternal blocks to improve acute postoperative pain control after cardiac surgery via midline sternotomy. Future studies specifying dosing regimens and adjuncts are required.STUDY REGISTRATION: PROSPERO (CRD42022306914); first submitted 22 March 2022.PMID:38443735 | DOI:10.1007/s12630-024-02726-0 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 5, 2024 Category: Anesthesiology Authors: Matthew J Cameron Justin Long Kenneth Kardash Stephen S Yang Source Type: research

Superficial parasternal intercostal plane blocks in cardiac surgery: a systematic review and meta-analysis
CONCLUSION: The literature suggests a potential benefit of using superficial parasternal blocks to improve acute postoperative pain control after cardiac surgery via midline sternotomy. Future studies specifying dosing regimens and adjuncts are required.STUDY REGISTRATION: PROSPERO (CRD42022306914); first submitted 22 March 2022.PMID:38443735 | DOI:10.1007/s12630-024-02726-0 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 5, 2024 Category: Anesthesiology Authors: Matthew J Cameron Justin Long Kenneth Kardash Stephen S Yang Source Type: research

Superficial parasternal intercostal plane blocks in cardiac surgery: a systematic review and meta-analysis
CONCLUSION: The literature suggests a potential benefit of using superficial parasternal blocks to improve acute postoperative pain control after cardiac surgery via midline sternotomy. Future studies specifying dosing regimens and adjuncts are required.STUDY REGISTRATION: PROSPERO (CRD42022306914); first submitted 22 March 2022.PMID:38443735 | DOI:10.1007/s12630-024-02726-0 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 5, 2024 Category: Anesthesiology Authors: Matthew J Cameron Justin Long Kenneth Kardash Stephen S Yang Source Type: research

The 90% effective dose of intrathecal hyperbaric bupivacaine for Cesarean delivery under combined spinal-epidural anesthesia in parturients with super obesity: an up-down sequential allocation study
CONCLUSION: The estimated ED90 of hyperbaric bupivacaine with fentanyl and morphine in parturients with super obesity undergoing Cesarean delivery under CSE was approximately 11.5 mg.STUDY REGISTRATION: ClinicalTrials.gov (NCT03781388); first submitted 18 December 2018.PMID:38438681 | DOI:10.1007/s12630-024-02705-5 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 4, 2024 Category: Anesthesiology Authors: Hon Sen Tan Matthew E Fuller Emily Z Barney Olga I Diomede Riley A Landreth Trung Pham Samantha M Rubright Liliane Ernst Ashraf S Habib Source Type: research

Definitions of major bleeding for predicting mortality in critically ill adult patients who survived 24 hours while supported with peripheral veno-arterial extracorporeal membrane oxygenation for cardiogenic shock: a comparative historical cohort study
CONCLUSION: Extracorporeal Life Support Organization-serious bleeding and BARC ≥ type 2 are relevant definitions of major bleeding regarding their association with mortality in critically ill patients who survived the first 24 hr while supported with pVA-ECMO for cardiogenic shock.STUDY REGISTRATION: CERAR (IRB 00010254-2022-050, Paris, France); first submitted on 18 April 2022.PMID:38438682 | DOI:10.1007/s12630-024-02704-6 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 4, 2024 Category: Anesthesiology Authors: Mouhamed D Moussa J érôme Soquet Emmanuel Robin Julien Labreuche Natacha Rousse Antoine Rauch Valentin Loobuyck Guillaume Leroy Thibault Duburcq Guillaume Gantois Xavier Leroy Slimane Ait-Ouarab Antoine Lamer Lise Thellier Oliver Lukowiak Guillaume Schu Source Type: research

Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis
CONCLUSION: Cholinesterase activities may be relevant prognostic markers for the occurrence of SAE and mortality in the ICU in patients with viral sepsis.STUDY REGISTRATION: This study constitutes an analysis of data from the ongoing studies ICROS (NCT03620409, first submitted 15 May 2018) and ICROVID (DRKS00024162, first submitted 9 February 2021).PMID:38429621 | DOI:10.1007/s12630-024-02692-7 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 1, 2024 Category: Anesthesiology Authors: Charles Neu Ricardo Esper Treml Philipp Baumbach Markus Engelmann Claudius Gebhardt Juliane G ötze Sina M Coldewey Source Type: research

Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis
CONCLUSION: Cholinesterase activities may be relevant prognostic markers for the occurrence of SAE and mortality in the ICU in patients with viral sepsis.STUDY REGISTRATION: This study constitutes an analysis of data from the ongoing studies ICROS (NCT03620409, first submitted 15 May 2018) and ICROVID (DRKS00024162, first submitted 9 February 2021).PMID:38429621 | DOI:10.1007/s12630-024-02692-7 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 1, 2024 Category: Anesthesiology Authors: Charles Neu Ricardo Esper Treml Philipp Baumbach Markus Engelmann Claudius Gebhardt Juliane G ötze Sina M Coldewey Source Type: research

Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis
CONCLUSION: Cholinesterase activities may be relevant prognostic markers for the occurrence of SAE and mortality in the ICU in patients with viral sepsis.STUDY REGISTRATION: This study constitutes an analysis of data from the ongoing studies ICROS (NCT03620409, first submitted 15 May 2018) and ICROVID (DRKS00024162, first submitted 9 February 2021).PMID:38429621 | DOI:10.1007/s12630-024-02692-7 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 1, 2024 Category: Anesthesiology Authors: Charles Neu Ricardo Esper Treml Philipp Baumbach Markus Engelmann Claudius Gebhardt Juliane G ötze Sina M Coldewey Source Type: research

Association of chronic poststernotomy pain and health-related quality of life: a prospective cohort study
CONCLUSION: Chronic poststernotomy pain still affects patient recovery at six and 12 months after cardiac surgery. The severity of that pain is poorly correlated with patients' quality of life.STUDY REGISTRATION: www.osf.io ( https://osf.io/52rsw ); registered 14 May 2022.PMID:38424390 | DOI:10.1007/s12630-024-02706-4 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - February 29, 2024 Category: Anesthesiology Authors: Terri Sun Mikayla Fan Defen Peng Lauren Li Alyson Ree Alana M Flexman Ainsley M Sutherland Stephan K W Schwarz Tim Ting Han Jen Cynthia H Yarnold Source Type: research

Association of chronic poststernotomy pain and health-related quality of life: a prospective cohort study
CONCLUSION: Chronic poststernotomy pain still affects patient recovery at six and 12 months after cardiac surgery. The severity of that pain is poorly correlated with patients' quality of life.STUDY REGISTRATION: www.osf.io ( https://osf.io/52rsw ); registered 14 May 2022.PMID:38424390 | DOI:10.1007/s12630-024-02706-4 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - February 29, 2024 Category: Anesthesiology Authors: Terri Sun Mikayla Fan Defen Peng Lauren Li Alyson Ree Alana M Flexman Ainsley M Sutherland Stephan K W Schwarz Tim Ting Han Jen Cynthia H Yarnold Source Type: research