Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel Ultrasound Bone Stiffness: Analyses from the General Population and Patients Evaluated for Osteoporosis
AbstractOsteoporosis, a complex chronic disease with increasing prevalence, is characterised by reduced bone mineral density (BMD) and increased fracture risk. The high heritability of BMD suggests substantial impact of the individual genetic disposition on bone phenotypes and the development of osteoporosis. In the past years, genome-wide association studies (GWAS) identified hundreds of genetic variants associated with BMD or osteoporosis. Here, we analysed 1103 single nucleotide polymorphisms (SNPs), previously identified as associated with estimated BMD (eBMD) in the UK Biobank. We assessed whether these SNPs are relat...
Source: Calcified Tissue International - October 13, 2023 Category: Orthopaedics Source Type: research
Clinical Features, Incidence and Treatment Outcome in Pregnancy-Associated Osteoporosis: A Single-Centre Experience over Two Decades
AbstractPregnancy-associated osteoporosis (PAO) is a rare syndrome which typically presents with vertebral fractures during pregnancy or lactation. The medical records of sixteen patients with PAO who presented to a specialist clinic at the Western General Hospital in Edinburgh over a 20-year period were reviewed to evaluate the mode of presentation, potential risk factors and response to treatment. The most common presentation was back pain occurring in 13/16 (81.2%) individuals due to multiple vertebral fractures. The diagnosis was usually made postpartum and in 12/16 individuals (75.0%), PAO presented during the woman â...
Source: Calcified Tissue International - October 11, 2023 Category: Orthopaedics Source Type: research
Bone Microarchitecture and Volumetric Mineral Density Assessed by HR-pQCT in Patients with 21- and 17 α-Hydroxylase Deficiency
AbstractDue to disturbances in hormones and long-term glucocorticoid replacement therapy (GRT), congenital adrenocortical hyperplasia (CAH) patients are at risk of impaired bone structure and metabolism. This cross-sectional, case –control study aims to investigate for the first time bone microarchitecture features in 21-hydroxylase deficiency (21OHD;N = 38) and 17α-hydroxylase deficiency (17OHD;N = 16) patients using high-resolution peripheral quantitative computed tomography (HR-pQCT) by matching the same sex and similar age [21OHD vs. control: 29.5 (24.0–34.3) vs. 29.6 (25.9–35.2) years; 17OHD vs. control...
Source: Calcified Tissue International - October 9, 2023 Category: Orthopaedics Source Type: research
The Effect of Effervescent and Buffered Alendronate Compared to Conventional Alendronate on Markers of Bone Turnover: A Randomized Non-inferiority Trial
In conclusion, suppression of BTMs was not significantly different between the groups but formal non-inferiority could not be establish ed. (Source: Calcified Tissue International)
Source: Calcified Tissue International - October 6, 2023 Category: Orthopaedics Source Type: research
Impact of EASO/ESPEN-Defined Sarcopenic Obesity Following a Technology-Based Weight Loss Intervention
ConclusionsThe potential lack of significant differences in weight loss or physical function between older adults with and without sarcopenic obesity participating in a weight loss intervention may suggest that well-designed, multicomponent interventions can lead to similar outcomes irrespective of sarcopenia status in persons with obesity. Fully powered randomized clinical trials are critically needed to confirm these preliminary results. (Source: Calcified Tissue International)
Source: Calcified Tissue International - September 27, 2023 Category: Orthopaedics Source Type: research
Monotropein Protects Mesenchymal Stem Cells from Lipopolysaccharide-Induced Impairments and Promotes Fracture Healing in an Ovariectomized Mouse Model
This study aimed to observe the in vitro effects of Monotropein on osteogenic differentiation of lipopolysaccharide treated bone marrow mesenchymal stem cells (bMSCs), and the in vivo effects of local application of Monotropein on bone fracture healing in ovariectomized mice. Lipopolysaccharide was used to set up the inflammatory model in bMSCs, which were treated by Monotropein. Molecular docking analysis was performed to evaluate the potential interaction between Monotropein and p65. Transverse fractures of middle tibias were established in ovariectomized mice, and Monotropein was locally applied to the fracture site usi...
Source: Calcified Tissue International - September 25, 2023 Category: Orthopaedics Source Type: research
Genetic Screening of ZNF687 and PFN1 in a Paget ’s Disease of Bone Cohort Indicates an Important Role for the Nuclear Localization Signal of ZNF687
In conclusion, our findings support the involvement of genetic variation inZNF687 in the pathogenesis of classical PDB, thereby expanding its mutational spectrum. (Source: Calcified Tissue International)
Source: Calcified Tissue International - September 20, 2023 Category: Orthopaedics Source Type: research
High Circulating FGF-23 and Its Relationship with Severity of Spinal Involvement in Diffuse Idiopathic Skeletal Hyperostosis
AbstractThe primary objective of this study was to determine the role of fibroblast growth factor 23 (FGF-23) in the pathogenesis of diffuse idiopathic skeletal hyperostosis (DISH). A total of 61 patients with DISH and 61 age- and sex-matched control patients without DISH were included in this study. The serum FGF-23, creatinine, inorganic phosphate, calcium, albumin, albumin-adjusted calcium and alkaline phosphatase, and C-reactive protein were assessed in both groups. Based on the extent of ossification, DISH group was further divided into T-DISH and L-DISH subgroups. Data were comparatively analyzed between DISH and Non...
Source: Calcified Tissue International - September 19, 2023 Category: Orthopaedics Source Type: research
