Reference Intervals for Bone Impact Microindentation in Healthy Adults: A Multi-Centre International Study
This study provides healthy reference data that can be used to calculate T- and Z-scores for BMSi and assist in determining the utility of BMSi in fracture prediction. These data will be useful for positioning individuals within the population and for identifying those with BMSi at the extremes of the population. (Source: Calcified Tissue International)
Source: Calcified Tissue International - February 2, 2023 Category: Orthopaedics Source Type: research
Periosteal Bone Formation Varies with Age in Periostin Null Mice
The objective of this study was to examine the function of periostin in maintaining bone mass and tissue strength across different ages. In periostin null mice (Postn −/−), periosteal bone formation was significantly reduced in young (3 months) and adult mice (9 months). The lack of bone formation resulted in reduced bone mass and ultimate strength. Conversely, periosteal bone formation increased at advanced ages in 18-month-old Postn−/− mice. The increas e in periosteal mineralization at advanced ages coincides with increased expression of vitronectin and osteopontin. Periosteal progenitors from Postn−/− mice ...
Source: Calcified Tissue International - February 2, 2023 Category: Orthopaedics Source Type: research
Reference Intervals for Bone Impact Microindentation in Healthy Adults: A Multi-Centre International Study
This study provides healthy reference data that can be used to calculate T- and Z-scores for BMSi and assist in determining the utility of BMSi in fracture prediction. These data will be useful for positioning individuals within the population and for identifying those with BMSi at the extremes of the population. (Source: Calcified Tissue International)
Source: Calcified Tissue International - February 2, 2023 Category: Orthopaedics Source Type: research
New Emerging Biomarkers for Bone Disease: Sclerostin and Dickkopf-1 (DKK1)
AbstractA healthy skeleton depends on a continuous renewal and maintenance of the bone tissue. The process of bone remodeling is highly controlled and consists of a fine-tuned balance between bone formation and bone resorption. Biochemical markers of bone turnover are already in use for monitoring diseases and treatment involving the skeletal system, but novel biomarkers reflecting specific biological processes in bone and interacting tissues may prove useful for diagnostic, prognostic, and monitoring purposes. The Wnt-signaling pathway is one of the most important pathways controlling bone metabolism and consequently the ...
Source: Calcified Tissue International - February 1, 2023 Category: Orthopaedics Source Type: research
Alkaline Phosphatases: Biochemistry, Functions, and Measurement
AbstractAlkaline phosphatases (ALPs) are a group of isoenzymes, situated on the external layer of the cell membrane; they catalyze the hydrolysis of organic phosphate esters present in the extracellular space. Zinc and magnesium are significant co-factors for the biological activity of these enzymes. Although ALPs are available in various body tissues and have distinct physiochemical properties, they are true isoenzymes since they catalyze a similar reaction. In the liver, ALP is cytosolic and present in the canalicular membrane of the hepatocytes. ALPs are available in placenta, ileal mucosa, kidney, bone, and liver. Howe...
Source: Calcified Tissue International - February 1, 2023 Category: Orthopaedics Source Type: research
