Mean Bone Material Strength Index Values for Women are Lower Than Those for Men: Data from a Single Geographical Location
AbstractBone material strength index (BMSi) values are obtained using impact microindentation, which assesses the ability of bone to resist indentation. Differences in BMSi between men and women are unclear, and to date, BMSi sex differences have not been compared for individuals from the same population. Therefore, we compared BMSi values for men and women drawn from the same geographical location in Australia. Participants (n = 220) were from the Geelong Osteoporosis Study. BMSi was measured, following international published guidelines, using an OsteoProbe for participants at recent follow-up phases (women 2022–2...
Source: Calcified Tissue International - September 4, 2023 Category: Orthopaedics Source Type: research
Circulating Osteocalcin Fractions are Associated with Vascular Calcification and Mortality in Chronic Hemodialysis Patients
ConclusionsIn patients undergoing chronic hemodialysis, plasma %cOC positively correlated with vascular calcification and exhibited a U-shaped correlation with PTH. Furthermore, a higher plasma %cOC was associated with increased mortality. These findings suggest that plasma %cOC may serve as a biomarker for CKD-MBD and a predictor of clinical outcomes in chronic hemodialysis patients. (Source: Calcified Tissue International)
Source: Calcified Tissue International - September 4, 2023 Category: Orthopaedics Source Type: research
Associations of Dietary Anthocyanidins Intake with Bone Health in Children: A Cross-Sectional Study
ConclusionsHigher dietary intake of total anthocyanidins and cyanidins were associated with higher BMC and BMD in Chinese children. (Source: Calcified Tissue International)
Source: Calcified Tissue International - September 1, 2023 Category: Orthopaedics Source Type: research
Association of Immune Cell Subsets with Incident Hip Fracture: The Cardiovascular Health Study
In this study, we aimed to evaluate the association of innate and adaptive immune cell subsets in peripheral blood mononuclear cells (PBMCs) with hip fracture. To conduct this study, we used data from the Cardiovascular Health Study (CHS), a U.S. multicenter observational cohort of community-dwelling men and women aged ≥ 65 years. Twenty-five immune cell phenotypes were measured by flow cytometry from cryopreserved PBMCs of CHS participants collected in 1998–1999. The natural killer (NK), γδ T, T helper 17 (Th17), and differentiated/senescent CD4+CD28− T cell subsets were pre-specified as primary subsets of interes...
Source: Calcified Tissue International - August 31, 2023 Category: Orthopaedics Source Type: research
Bone Mineral Density During and After Lactation: A Comparison of African American and Caucasian Women
AbstractDuring lactation, changes in maternal calcium metabolism are necessary to provide adequate calcium for newborn skeletal development. The calcium in milk is derived from the maternal skeleton through a process thought to be mediated by the actions of parathyroid hormone-related protein (PTHrP) in combination with decreased circulating estrogen concentrations. After weaning, bone lost during lactation is rapidly regained. Most studies of bone metabolism in lactating women have been performed in Caucasian subjects. There are well-documented differences between African American (AA) and Caucasian (C) bone metabolism, i...
Source: Calcified Tissue International - August 28, 2023 Category: Orthopaedics Source Type: research
Reductions in Motor Unit Firing are Associated with Clinically Meaningful Leg Extensor Weakness in Older Adults
AbstractWeakness, one of the key characteristics of sarcopenia, is a significant risk factor for functional limitations and disability in older adults. It has long been suspected that reductions in motor unit firing rates (MUFRs) are one of the mechanistic causes of age-related weakness. However, prior work has not investigated the extent to which MUFR is associated with clinically meaningful weakness in older adults. Forty-three community-dwelling older adults (mean: 75.4 ± 7.4 years; 46.5% female) and 24 young adults (mean: 22.0 ± 1.8 years; 58.3% female) performed torque matching tasks at varying submaximal...
Source: Calcified Tissue International - August 21, 2023 Category: Orthopaedics Source Type: research
D3Creatine Dilution as a Direct, Non-invasive and Accurate Measurement of Muscle Mass for Aging Research
AbstractInitial definitions of sarcopenia included the age-associated loss of skeletal muscle mass that was presumed to be associated with late-life reduced functional capacity, disability and loss of independence. Because no method for determination of muscle mass was available for large cohort studies of aging men and women, lean body mass determined by dual X-ray absorptiometry or bioelectrical impedance was used as a surrogate measure of muscle mass. The data from these studies showed either no or a poor relationship between LBM and functional capacity and health related outcomes, leading to the conclusion of many that...
Source: Calcified Tissue International - August 18, 2023 Category: Orthopaedics Source Type: research
Comparison of Bone Quality Among Winter Endurance Athletes with and Without Risk Factors for Relative Energy Deficiency in Sport (REDs): A Cross-Sectional Study
The objective of this study was to investigate differences in bone quality in winter endurance athletes classified as either low-risk versus at-risk for REDs. Forty-four participants were recruited (M = 18; F = 26). Bone quality was assessed at the distal radius and tibia using high resolution peripheral quantitative computed tomography (HR-pQCT), and at the hip and spine using dual X-ray absorptiometry (DXA). Finite element analysis was used to estimate bone strength. Participants were grouped using modified criteria from the REDs Clinical Assessment Tool Version 1. Fourteen participants (M = 3; F = 11), ...
Source: Calcified Tissue International - August 14, 2023 Category: Orthopaedics Source Type: research
