The Potential Roles of Transacylation in Intracellular Lipolysis and Related Qssa Approximations
Bull Math Biol. 2023 Aug 6;85(9):82. doi: 10.1007/s11538-023-01188-7.ABSTRACTFatty acids (FAs) are crucial energy metabolites, signalling molecules, and membrane building blocks for a wide range of organisms. Adipose triglyceride lipase (ATGL) is the first and presumingly most crucial regulator of FA release from triacylglycerols (TGs) stored within cytosolic lipid droplets. However, besides the function of releasing FAs by hydrolysing TGs into diacylglycerols (DGs), ATGL also promotes the transacylation reaction of two DG molecules into one TG and one monoacylglycerol molecule. To date, it is unknown whether DG transacyla...
Source: Bulletin of Mathematical Biology - August 6, 2023 Category: Bioinformatics Authors: J án Eliaš Klemens Fellner Peter Hofer Monika Oberer Renate Schreiber Rudolf Zechner Source Type: research

Mathematical Derivation of Wave Propagation Properties in Hierarchical Neural Networks with Predictive Coding Feedback Dynamics
Bull Math Biol. 2023 Jul 28;85(9):80. doi: 10.1007/s11538-023-01186-9.ABSTRACTSensory perception (e.g., vision) relies on a hierarchy of cortical areas, in which neural activity propagates in both directions, to convey information not only about sensory inputs but also about cognitive states, expectations and predictions. At the macroscopic scale, neurophysiological experiments have described the corresponding neural signals as both forward and backward-travelling waves, sometimes with characteristic oscillatory signatures. It remains unclear, however, how such activity patterns relate to specific functional properties of ...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Gr égory Faye Guilhem Fouilh é Rufin VanRullen Source Type: research

Temporal Pattern of the Emergence of a Mutant Virus Escaping Cross-Immunity and Stochastic Extinction Within a Host
In this study, we examine the effect of escaping the immune reaction of the host. Based on a continuous-time branching process with time-dependent rates, we conclude the chance for a mutant strain to be established [Formula: see text] decreases with time [Formula: see text] since the wild-type infection when the mutant is produced. The number of novel mutants that can escape extinction risk has a peak soon after the wild-type infection. The number of novel escape mutations produced per patient in the early phase of host infection is small both for very strong and very weak immune responses, and it attains its maximum value...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Rena Hayashi Yoh Iwasa Source Type: research

Mathematical Derivation of Wave Propagation Properties in Hierarchical Neural Networks with Predictive Coding Feedback Dynamics
Bull Math Biol. 2023 Jul 28;85(9):80. doi: 10.1007/s11538-023-01186-9.ABSTRACTSensory perception (e.g., vision) relies on a hierarchy of cortical areas, in which neural activity propagates in both directions, to convey information not only about sensory inputs but also about cognitive states, expectations and predictions. At the macroscopic scale, neurophysiological experiments have described the corresponding neural signals as both forward and backward-travelling waves, sometimes with characteristic oscillatory signatures. It remains unclear, however, how such activity patterns relate to specific functional properties of ...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Gr égory Faye Guilhem Fouilh é Rufin VanRullen Source Type: research

Temporal Pattern of the Emergence of a Mutant Virus Escaping Cross-Immunity and Stochastic Extinction Within a Host
In this study, we examine the effect of escaping the immune reaction of the host. Based on a continuous-time branching process with time-dependent rates, we conclude the chance for a mutant strain to be established [Formula: see text] decreases with time [Formula: see text] since the wild-type infection when the mutant is produced. The number of novel mutants that can escape extinction risk has a peak soon after the wild-type infection. The number of novel escape mutations produced per patient in the early phase of host infection is small both for very strong and very weak immune responses, and it attains its maximum value...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Rena Hayashi Yoh Iwasa Source Type: research

Mathematical Derivation of Wave Propagation Properties in Hierarchical Neural Networks with Predictive Coding Feedback Dynamics
Bull Math Biol. 2023 Jul 28;85(9):80. doi: 10.1007/s11538-023-01186-9.ABSTRACTSensory perception (e.g., vision) relies on a hierarchy of cortical areas, in which neural activity propagates in both directions, to convey information not only about sensory inputs but also about cognitive states, expectations and predictions. At the macroscopic scale, neurophysiological experiments have described the corresponding neural signals as both forward and backward-travelling waves, sometimes with characteristic oscillatory signatures. It remains unclear, however, how such activity patterns relate to specific functional properties of ...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Gr égory Faye Guilhem Fouilh é Rufin VanRullen Source Type: research

Temporal Pattern of the Emergence of a Mutant Virus Escaping Cross-Immunity and Stochastic Extinction Within a Host
In this study, we examine the effect of escaping the immune reaction of the host. Based on a continuous-time branching process with time-dependent rates, we conclude the chance for a mutant strain to be established [Formula: see text] decreases with time [Formula: see text] since the wild-type infection when the mutant is produced. The number of novel mutants that can escape extinction risk has a peak soon after the wild-type infection. The number of novel escape mutations produced per patient in the early phase of host infection is small both for very strong and very weak immune responses, and it attains its maximum value...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Rena Hayashi Yoh Iwasa Source Type: research

Mathematical Derivation of Wave Propagation Properties in Hierarchical Neural Networks with Predictive Coding Feedback Dynamics
Bull Math Biol. 2023 Jul 28;85(9):80. doi: 10.1007/s11538-023-01186-9.ABSTRACTSensory perception (e.g., vision) relies on a hierarchy of cortical areas, in which neural activity propagates in both directions, to convey information not only about sensory inputs but also about cognitive states, expectations and predictions. At the macroscopic scale, neurophysiological experiments have described the corresponding neural signals as both forward and backward-travelling waves, sometimes with characteristic oscillatory signatures. It remains unclear, however, how such activity patterns relate to specific functional properties of ...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Gr égory Faye Guilhem Fouilh é Rufin VanRullen Source Type: research

Temporal Pattern of the Emergence of a Mutant Virus Escaping Cross-Immunity and Stochastic Extinction Within a Host
In this study, we examine the effect of escaping the immune reaction of the host. Based on a continuous-time branching process with time-dependent rates, we conclude the chance for a mutant strain to be established [Formula: see text] decreases with time [Formula: see text] since the wild-type infection when the mutant is produced. The number of novel mutants that can escape extinction risk has a peak soon after the wild-type infection. The number of novel escape mutations produced per patient in the early phase of host infection is small both for very strong and very weak immune responses, and it attains its maximum value...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Rena Hayashi Yoh Iwasa Source Type: research

Mathematical Derivation of Wave Propagation Properties in Hierarchical Neural Networks with Predictive Coding Feedback Dynamics
Bull Math Biol. 2023 Jul 28;85(9):80. doi: 10.1007/s11538-023-01186-9.ABSTRACTSensory perception (e.g., vision) relies on a hierarchy of cortical areas, in which neural activity propagates in both directions, to convey information not only about sensory inputs but also about cognitive states, expectations and predictions. At the macroscopic scale, neurophysiological experiments have described the corresponding neural signals as both forward and backward-travelling waves, sometimes with characteristic oscillatory signatures. It remains unclear, however, how such activity patterns relate to specific functional properties of ...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Gr égory Faye Guilhem Fouilh é Rufin VanRullen Source Type: research

Temporal Pattern of the Emergence of a Mutant Virus Escaping Cross-Immunity and Stochastic Extinction Within a Host
In this study, we examine the effect of escaping the immune reaction of the host. Based on a continuous-time branching process with time-dependent rates, we conclude the chance for a mutant strain to be established [Formula: see text] decreases with time [Formula: see text] since the wild-type infection when the mutant is produced. The number of novel mutants that can escape extinction risk has a peak soon after the wild-type infection. The number of novel escape mutations produced per patient in the early phase of host infection is small both for very strong and very weak immune responses, and it attains its maximum value...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Rena Hayashi Yoh Iwasa Source Type: research

Mathematical Derivation of Wave Propagation Properties in Hierarchical Neural Networks with Predictive Coding Feedback Dynamics
Bull Math Biol. 2023 Jul 28;85(9):80. doi: 10.1007/s11538-023-01186-9.ABSTRACTSensory perception (e.g., vision) relies on a hierarchy of cortical areas, in which neural activity propagates in both directions, to convey information not only about sensory inputs but also about cognitive states, expectations and predictions. At the macroscopic scale, neurophysiological experiments have described the corresponding neural signals as both forward and backward-travelling waves, sometimes with characteristic oscillatory signatures. It remains unclear, however, how such activity patterns relate to specific functional properties of ...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Gr égory Faye Guilhem Fouilh é Rufin VanRullen Source Type: research

Temporal Pattern of the Emergence of a Mutant Virus Escaping Cross-Immunity and Stochastic Extinction Within a Host
In this study, we examine the effect of escaping the immune reaction of the host. Based on a continuous-time branching process with time-dependent rates, we conclude the chance for a mutant strain to be established [Formula: see text] decreases with time [Formula: see text] since the wild-type infection when the mutant is produced. The number of novel mutants that can escape extinction risk has a peak soon after the wild-type infection. The number of novel escape mutations produced per patient in the early phase of host infection is small both for very strong and very weak immune responses, and it attains its maximum value...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Rena Hayashi Yoh Iwasa Source Type: research

Mathematical Derivation of Wave Propagation Properties in Hierarchical Neural Networks with Predictive Coding Feedback Dynamics
Bull Math Biol. 2023 Jul 28;85(9):80. doi: 10.1007/s11538-023-01186-9.ABSTRACTSensory perception (e.g., vision) relies on a hierarchy of cortical areas, in which neural activity propagates in both directions, to convey information not only about sensory inputs but also about cognitive states, expectations and predictions. At the macroscopic scale, neurophysiological experiments have described the corresponding neural signals as both forward and backward-travelling waves, sometimes with characteristic oscillatory signatures. It remains unclear, however, how such activity patterns relate to specific functional properties of ...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Gr égory Faye Guilhem Fouilh é Rufin VanRullen Source Type: research

Temporal Pattern of the Emergence of a Mutant Virus Escaping Cross-Immunity and Stochastic Extinction Within a Host
In this study, we examine the effect of escaping the immune reaction of the host. Based on a continuous-time branching process with time-dependent rates, we conclude the chance for a mutant strain to be established [Formula: see text] decreases with time [Formula: see text] since the wild-type infection when the mutant is produced. The number of novel mutants that can escape extinction risk has a peak soon after the wild-type infection. The number of novel escape mutations produced per patient in the early phase of host infection is small both for very strong and very weak immune responses, and it attains its maximum value...
Source: Bulletin of Mathematical Biology - July 28, 2023 Category: Bioinformatics Authors: Rena Hayashi Yoh Iwasa Source Type: research