The effect of age in patients with acquired aplastic anaemia treated with immunosuppressive therapy: comparison of Adolescents and Young Adults with children and older adults
This study confirms that age is a prognostic factor in AA patients treated with IST. However, AYA patients have a similar outcome to children in terms of response rate and survival. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Aur élie Cabannes‐Hamy,
Nicolas Boissel,
Régis Peffault De Latour,
Etienne Lengliné,
Thierry Leblanc,
Flore S. Fontbrune,
Emmanuel Raffoux,
Marie Robin,
Aliénor Xhaard,
André Baruchel,
Gérard Socié,
Nathalie Dhédin Tags: Research Paper Source Type: research
The role of transplantation in Hodgkin lymphoma
SummaryAutologous stem cell transplantation is the standard salvage strategy for young and fit patients with Hodgkin lymphoma failing induction therapy, and is effective in nearly 50% of cases. The quality of response at transplantation is the most relevant prognostic aspect, as patients in complete response can obtain better outcomes. Therefore, first ‐line salvage treatments applied before transplantation need to produce high quality responses without excessive myelotoxicity and without affecting peripheral blood stem cell mobilisation. In this sense, the incorporation of new agents active in Hodgkin lymphoma, such as ...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Alessandro Broccoli,
Pier Luigi Zinzani Tags: Review Source Type: research
The treatment of older Hodgkin lymphoma patients
SummaryThe outcome of patients with Hodgkin lymphoma (HL) has dramatically improved over the past decades and continues to improve with the development of novel targeted therapies, such as the immunoconjugate brentuximab vedotin and the checkpoint inhibitors nivolumab and pembrolizumab. Moreover, with the use of response ‐adapted strategies using positron‐emission‐tomography (PET), the overall intensity of treatment for most patients can be reduced, resulting in less acute and late toxicity. However, these advances are mainly restricted to younger patients, as advances in patients above the age of 60 years (‘ olde...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Boris B öll,
Helen Görgen Tags: Review Source Type: research
Mutational profile and haematological response to iron chelation in myelodysplastic syndromes (MDS)
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Emiliano Fabiani,
Chiara Calabrese,
Pasquale Niscola,
Enrico Balleari,
Alfredo Molteni,
Carlo Finelli,
Giulia Falconi,
Susanna Fenu,
Luana Fianchi,
Marianna Criscuolo,
Flavia Salvi,
Serena Lavorgna,
Francesco Buccisano,
Luca Maurillo,
France Tags: Correspondence Source Type: research
High HFE mutation incidence in idiopathic erythrocytosis
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: B énédicte Burlet,
Valentin Bourgeois,
Céline Buriller,
Bernard Aral,
Fabrice Airaud,
Céline Garrec,
Stéphane Bézieau,
Betty Gardie,
François Girodon Tags: Correspondence Source Type: research
The incidence of symptomatic osteonecrosis after allogeneic haematopoietic stem cell transplantation in children with acute lymphoblastic leukaemia – controversy on dexamethasone as a risk factor
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Reo Tanoshima,
Bruce C. Carleton Tags: Correspondence Source Type: research
Dose ‐limiting stomatitis associated with ibrutinib therapy: a case series
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Emmanuelle Vigarios,
Marie Beylot ‐Barry,
Marie‐Hélène Jegou,
Luice Oberic,
Loïc Ysebaert,
Vincent Sibaud Tags: Correspondence Source Type: research
Cell ‐of‐origin in diffuse large B‐cell lymphoma: findings from the UK's population‐based Haematological Malignancy Research Network
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Daniel Painter,
Sharon Barrans,
Stuart Lacy,
Alexandra Smith,
Simon Crouch,
David Westhead,
Chulin Sha,
Russell Patmore,
Reuben Tooze,
Cathy Burton,
Eve Roman Tags: Correspondence Source Type: research
Current treatment paradigms for advanced stage Hodgkin lymphoma
SummaryThe treatment of advanced classical Hodgkin Lymphoma (cHL) has evolved over the last 50 years with a progressive improvement in long term cure rates in patients up to the age of 60 years. However, a minority of these survivors experience severe morbidity and mortality resulting from intensive chemotherapy and radiotherapy, leading to a drive to de‐escalate treatment without compro mising survival. The early identification of patients with chemoresistant disease by functional imaging allows the modulation of therapy and an efficient means to test new agents in those most in need of more effective therapy. The ou...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Jemma Longley,
Peter W. M. Johnson Tags: Review Source Type: research
The effect on lymphocyte subsets of decreasing/stopping tyrosine kinase inhibitor therapy in chronic myeloid leukaemia: data from the DESTINY trial
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Gemma M. Austin,
Katy Knight,
Joanne Bell,
Anthony Carter,
Earnest Heartin,
David Watson,
Letizia Foroni,
Stephen E. Christmas,
Fotios Polydoros,
Richard E. Clark Tags: Correspondence Source Type: research
A rare complication of bone marrow aspiration and trephine biopsy: Staphylococcus aureus osteomyelitis and septicaemia
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Muhammad Khakwani,
Swathy Srinath,
Guy Pratt,
Paul Moss Tags: Images in Haematology Source Type: research
Granular B ‐lineage acute lymphoblastic leukaemia mimicking acute myeloid leukaemia
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Juan Zhang,
Mingyong Li,
Yuan He Tags: images in haematology Source Type: research
Understanding how older age drives decision ‐making and outcome in Immune Thrombocytopenia. A single centre study on 465 adult patients
SummaryWe analysed the impact of older age on the management of immune thrombocytopenia (ITP) in 465 adult patients diagnosed between 1995 and 2017 and followed at our institution for a minimum of 12 months. Over a follow‐up of 4248 patient‐years, front‐line corticosteroids therapy was required in 334 patients (71·8%), mainly (85·3%) within 1 year from diagnosis. Need for first‐, second‐ and third‐line therapy was comparable in younger and older (age ≥65 years,n = 154) patients. Older patients presented more frequently with severe haemorrhages, started therapy with a higher platelet count and received...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Francesca Palandri,
Lucia Catani,
Giuseppe Auteri,
Daniela Bartoletti,
Sofia Fatica,
Alessio Fusco,
Maria L. Bacchi Reggiani,
Michele Cavo,
Nicola Vianelli Tags: Research Paper Source Type: research
MYD88 p.(L265P) detection on cell ‐free DNA in liquid biopsies of patients with primary central nervous system lymphoma
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Laura S. Hiemcke ‐Jiwa,
Roos J. Leguit,
Tom J. Snijders,
Jacoline E. C. Bromberg,
Stefan Nierkens,
N. Mehdi Jiwa,
Monique C. Minnema,
Manon M. H. Huibers Tags: Correspondence Source Type: research
Mesenchymal stem cells gene signature in high ‐risk myeloma bone marrow linked to suppression of distinct IGFBP2‐expressing small adipocytes
SummaryRecent studies suggest that multiple myeloma (MM) induces proliferation and expansion of bone marrow (BM) mesenchymal stem cells (MSCs), but others showed that MM cells induce MSC senescence. To clarify the interaction between MM and MSCs, we exploited our established MSC gene signature to identify gene expression changes in myeloma MSCs and associated functional differences. Single MSCs from patients with MM had changes in expression of genes associated with cellular proliferation and senescence and a higher proportion of senescent cells and lower proliferative potential than those from age ‐matched healthy donor...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Syed J. Mehdi,
Sarah K. Johnson,
Joshua Epstein,
Maurizio Zangari,
Pingping Qu,
Antje Hoering,
Frits Rhee,
Carolina Schinke,
Sharmilan Thanendrarajan,
Bart Barlogie,
Faith E. Davies,
Gareth J. Morgan,
Shmuel Yaccoby Tags: Research Paper Source Type: research
