SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia
SummaryAlteration in RNA splicing is implicated in carcinogenesis and progression. Mutations in spliceosome genes and alternative splicing of other genes have been noted in chronic lymphocytic leukaemia (CLL), a common B cell malignancy with heterogeneous outcomes. We previously demonstrated that differences in the amount of SET oncoprotein (a physiological inhibitor of the serine/threonine phosphatase, PP2A) is associated with clinical aggressiveness in patients with CLL. It is unknown if alternative splicing of gene transcripts regulating kinases and phosphatases affects disease pathobiology and CLL progression. We show ...
Source: British Journal of Haematology - November 15, 2018 Category: Hematology Authors: Danielle M. Brander,
Daphne R. Friedman,
Alicia D. Volkheimer,
Dale J. Christensen,
Laura Z. Rassenti,
Thomas J. Kipps,
Eross Guadalupe,
Youwei Chen,
Dadong Zhang,
Xi Wang,
Carter Davis,
Kouros Owzar,
J. Brice Weinberg Tags: Research Paper Source Type: research
Utility of the DASH score after unprovoked venous thromboembolism; a single centre study
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 15, 2018 Category: Hematology Authors: Stephen MacDonald,
Rajani Chengal,
Anida Hanxhiu,
Emily Symington,
Karen Sheares,
Martin Besser,
Will Thomas Tags: Correspondence Source Type: research
Interim FDG ‐PET does not predict outcome in advanced‐stage Hodgkin lymphoma patients treated with BEACOPP
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 14, 2018 Category: Hematology Authors: Hugo J. A. Adams,
Thomas C. Kwee Tags: Correspondence Source Type: research
Sickle cell screening in Europe: the time has come
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 14, 2018 Category: Hematology Authors: Lisa M. Shook,
Russell E. Ware Tags: Editorial Comment Source Type: research
Circulating dendritic cells deficiencies as a new biomarker in classical Hodgkin lymphoma
In conclusion, DCs may contribute to the disturbed immunological interplay typical of cHL, prompting a further evaluation of their value as a potential new biomarker. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 13, 2018 Category: Hematology Authors: Domenico Galati,
Serena Zanotta,
Gaetano Corazzelli,
Dario Bruzzese,
Gaetana Capobianco,
Emanuela Morelli,
Manuela Arcamone,
Rosaria De Filippi,
Antonio Pinto Tags: Research Paper Source Type: research
Hepatitis E virus infection after haploidentical haematopoietic stem cell transplantation: incidence and clinical course
In conclusion, HEV infection is a rare but serious complication after haplo‐HSCT. We recommend screening of HEV in haplo‐HSCT. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 13, 2018 Category: Hematology Authors: Fei ‐Fei Tang,
Xiao‐Dong Mo,
Yu Wang,
Chen‐Hua Yan,
Yu‐Hong Chen,
Huan Chen,
Wei Han,
Ying‐Jun Chang,
Hai‐Ying Zhang,
Yan‐Di Xie,
Hui Ma,
Lai Wei,
Lan‐Ping Xu,
Xiao‐Jun Huang,
Xiao‐Hui Zhang Tags: Research Paper Source Type: research
A guideline for the management of specific situations in polycythaemia vera and secondary erythrocytosis
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 13, 2018 Category: Hematology Authors: Mary F. F. McMullin,
Adam J. Mead,
Sahra Ali,
Catherine Cargo,
Frederick Chen,
Joanne Ewing,
Mamta Garg,
Anna Godfrey,
Steven Knapper,
Donal P. McLornan,
Jyoti Nangalia,
Mallika Sekhar,
Frances Wadelin,
Claire N. Harrison,
on behalf of the B Tags: Guideline Source Type: research
Acute promyelocytic leukaemia with increased basophils
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 13, 2018 Category: Hematology Authors: Juan Zhang,
Mingyong Li,
Yuan He Tags: Images in Haematology Source Type: research
Issue Information
British Journal of Haematology, Volume 183, Issue 3, Page 331-341, November 2018. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 12, 2018 Category: Hematology Tags: Issue Information Source Type: research
Incidence and risk factors for clinical neurodegenerative Langerhans cell histiocytosis: a longitudinal cohort study
AbstractNeurodegenerative (ND) complications in Langerhans cell histiocytosis (LCH) are a late ‐onset but dramatic sequelae for which incidence and risk factors are not well defined. Based on a national prospective registry of paediatric LCH patients, we determined the incidence rate of clinical ND LCH (cND‐LCH) and analysed risk factors, taking into account disease extent and molecular c haracteristics. Among 1897 LCH patients, 36 (1·9%) were diagnosed with a cND‐LCH. The 10‐year cumulative incidence of cND‐LCH was 4·1%. cND‐LCH typically affected patients previously treated for a multisystem, risk organ–n...
Source: British Journal of Haematology - November 12, 2018 Category: Hematology Authors: S ébastien Héritier,
Mohamed‐Aziz Barkaoui,
Jean Miron,
Caroline Thomas,
Despina Moshous,
Anne Lambilliotte,
Françoise Mazingue,
Kamila Kebaili,
Eric Jeziorski,
Geneviève Plat,
Nathalie Aladjidi,
Hélène Pacquement,
Claire Galambrun,
L Tags: Research Paper Source Type: research
Elevated fetal haemoglobin levels are associated with decreased incidence of retinopathy in adults with sickle cell disease
SummaryAmong the many vascular complications of sickle cell disease (SCD), retinopathy is the most prevalent and represents a leading cause of blindness. Hydroxycarbamide therapy ameliorates many symptoms of SCD, and high fetal haemoglobin (HbF) levels have been shown to protect against the development of retinopathy in children with HbSS. Its effect on adults with SCD, who are at a much higher risk of developing retinopathy, has not been studied. We aimed to investigate the effect of hydroxycarbamide use and HbF level on sickle cell retinopathy development in adults. We performed a retrospective cross ‐sectional study a...
Source: British Journal of Haematology - November 12, 2018 Category: Hematology Authors: Umar K. Mian,
Joyce Tang,
Ana P. M. Allende,
Moonseong Heo,
Nicole Bernstein,
Leena Vattappally,
Daniel Schoenfeld,
Caterina P. Minniti Tags: Research Paper Source Type: research
Prognostic impact of trisomy 21 in follicular lymphoma
In conclusion, the presence of trisomy 21 was an independent risk factor for in FL. Chromosomal analysis of FL patients at diagnosis can provide useful information about their expected survival. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 12, 2018 Category: Hematology Authors: Takeki Mitsui,
Akihiko Yokohama,
Hiromi Koiso,
Akio Saito,
Kohtaro Toyama,
Hiroaki Shimizu,
Takuma Ishizaki,
Hiroyuki Irisawa,
Makiko Takizawa,
Takayuki Saitoh,
Kayoko Murayama,
Morio Matsumoto,
Hiroshi Handa,
Junko Hirato,
Masaru Kojima,
H Tags: Research Paper Source Type: research
The translational science of hodgkin lymphoma
SummaryHodgkin Lymphoma (HL) is an unusual B‐cell lymphoma because the malignant cells exist as a minority population in a densely cellular microenvironment. The microenvironment is comprised predominately of inflammatory and immune cells with fibrosis in some cases. There are multiple dysregulated signalling pathways that sustain HL within this microenvironment, such as the Nuclear factor ‐κB and Janus kinase/signal transducers and activators of transcription pathways. Advances in genomic medicine have enabled a better characterisation of the rare tumour cells and improved our understanding of the signalling mechanis...
Source: British Journal of Haematology - November 12, 2018 Category: Hematology Authors: Melita Cirillo,
Sarah Reinke,
Wolfram Klapper,
Sven Borchmann Tags: Review Source Type: research
Waldenstr öm macroglobulinaemia terminating in acute lymphoblastic leukaemia after treatment with fludarabine
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Chen Tian,
Yong Yu,
Yizhuo Zhang Tags: Images in Haematology Source Type: research
Updated 2018 NICE guidance on venous thromboembolism – does evidence from root cause analysis of hospital‐associated thrombosis support the additional investment required?
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Nicola McQuaid,
Peter Davies,
Tamara Everington Tags: Correspondence Source Type: research
