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Transcriptional Response of < em > Burkholderia cenocepacia < /em > H111 to Severe Zinc Starvation
Br J Biomed Sci. 2023 Sep 26;80:11597. doi: 10.3389/bjbs.2023.11597. eCollection 2023.ABSTRACTBurkholderia cenocepacia is an opportunistic pathogen that is primarily associated with severe respiratory infections in people with cystic fibrosis. These bacteria have significant intrinsic resistance to antimicrobial therapy, and there is a need for more effective treatments. Bacterial zinc uptake and homeostasis systems are attractive targets for new drugs, yet our understanding of how bacteria acquire and utilise zinc remains incomplete. Here we have used RNA-sequencing and differential gene expression analysis to investigate...
Source: British Journal of Biomedical Science - October 12, 2023 Category: Laboratory Medicine Authors: James Paul Barnett Source Type: research

The Use of CD200 in the Differential Diagnosis of B-Cell Lymphoproliferative Disorders
Conclusion: CD200 has an important role in differentiating CLL from MCL, HCL has a consistent bright expression of CD200. By adding CD200 to the combinations of markers in routine testing panel, Immunophenotyping by flow cytometry can be an effective tool in the diagnosis of B-LPDs especially in cases with atypical immunophenotyping pattern. Our result support that CD200 can be added to routine testing panel as it is useful in differentiating them.PMID:37822353 | PMC:PMC10563807 | DOI:10.3389/bjbs.2023.11573 (Source: British Journal of Biomedical Science)
Source: British Journal of Biomedical Science - October 12, 2023 Category: Laboratory Medicine Authors: Hanaan Kareem Al-Zubaidi Stephen F ôn Hughes Source Type: research

Evaluation of a New Mordant Based Haematoxylin Dye (Haematoxylin X) for Use in Clinical Pathology
In this study, the performance of this new haematoxylin (Haematoxylin X) was compared against some commonly utilised alum-based haematoxylins (Carazzi's, Harris' and Mayer's) when used as a part of formalin-fixed paraffin embedded (FFPE) tissue, special stains, immunohistochemical counterstaining and frozen section (Mohs procedure) staining procedures. FFPE sections of different tissue types and frozen skin tissues were sectioned and stained with each haematoxylin subtype to allow for a direct comparison of staining quality. The slides were independently evaluated microscopically by two assessors. A combined score was gene...
Source: British Journal of Biomedical Science - October 11, 2023 Category: Laboratory Medicine Authors: J A Gabriel C D'Amico U Kosgodage J Satoc N Haine S Willis G E Orchard Source Type: research

Authentic Pathology Specimen Reception: A Valuable Resource for Developing Biomedical Science Student Competencies and Employability
Conclusion: This study highlights simulation-based learning as a tool to develop core Biomedical Science knowledge, build student graduate capital, and ensure the preparedness of students for post-graduation employment.PMID:37818106 | PMC:PMC10561093 | DOI:10.3389/bjbs.2023.11731 (Source: British Journal of Biomedical Science)
Source: British Journal of Biomedical Science - October 11, 2023 Category: Laboratory Medicine Authors: T Hussain S Namvar M Jones Source Type: research

Comparability and Stability of Serum Creatinine Concentration in Capillary and Venous Blood
Conclusion: It is believed that this is the first published study to determine if self-collected capillary blood sampling is an acceptable alternative to venous sampling for the measurement of serum creatinine concentration; our data indicates that there is no significant difference in results from unspun venous and capillary blood stored at room temperature for at least 3 days compared to venous blood tested on the same day of collection.PMID:37753533 | PMC:PMC10519179 | DOI:10.3389/bjbs.2023.11402 (Source: British Journal of Biomedical Science)
Source: British Journal of Biomedical Science - September 27, 2023 Category: Laboratory Medicine Authors: Timothy Woolley Emma Rutter Macarena Staudenmaier Source Type: research