Masculinizing hormone therapy effect on breast tissue: Changes in estrogen and androgen receptors in transgender female-to-male mastectomies
CONCLUSION: Increased androgen exposure is associated with lobular atrophy and gynecomastoid changes in breast parenchyma. Overall, ER and AR are expressed strongly in lobular epithelium in patients with prolonged androgen exposure. Exogenous testosterone does not appear to increase risk for breast cancer. Additional studies are needed to investigate the mechanism responsible for these changes at a cellular level and its role in cancer development.PMID:37951051 | DOI:10.1016/j.breast.2023.103596 (Source: Breast)
Source: Breast - November 11, 2023 Category: Cancer & Oncology Authors: Manita Chaum Sara Grossi Jiaxi Chen Vivian Hu Edward Ray Armando Giuliano Shikha Bose Source Type: research
Masculinizing hormone therapy effect on breast tissue: Changes in estrogen and androgen receptors in transgender female-to-male mastectomies
CONCLUSION: Increased androgen exposure is associated with lobular atrophy and gynecomastoid changes in breast parenchyma. Overall, ER and AR are expressed strongly in lobular epithelium in patients with prolonged androgen exposure. Exogenous testosterone does not appear to increase risk for breast cancer. Additional studies are needed to investigate the mechanism responsible for these changes at a cellular level and its role in cancer development.PMID:37951051 | DOI:10.1016/j.breast.2023.103596 (Source: Breast)
Source: Breast - November 11, 2023 Category: Cancer & Oncology Authors: Manita Chaum Sara Grossi Jiaxi Chen Vivian Hu Edward Ray Armando Giuliano Shikha Bose Source Type: research
Exploring the clinical outcomes and safety profile of inetetamab treatment in metastatic breast cancer patients: A multicenter assessment of a Chinese-origin recombinant Anti-HER2 monoclonal antibody
CONCLUSION: Inetetamab demonstrates effectiveness with a manageable safety profile, offering a promising therapeutic option for HER2-positive breast cancer patients who have shown resistance to prior anti-HER2 treatments.PMID:37944341 | DOI:10.1016/j.breast.2023.103597 (Source: Breast)
Source: Breast - November 9, 2023 Category: Cancer & Oncology Authors: Binliang Liu Ning Xie Can Tian Ronghua Feng Zhe-Yu Hu Jing Li Liping Liu Huawu Xiao Xiaohong Yang Mengsi Zeng Hui Wu Jun Lu Jianxiang Gao Xuming Hu Min Cao Zhengrong Shui Yu Tang Tao Wu Quchang Ouyang Source Type: research
Exploring the clinical outcomes and safety profile of inetetamab treatment in metastatic breast cancer patients: A multicenter assessment of a Chinese-origin recombinant Anti-HER2 monoclonal antibody
CONCLUSION: Inetetamab demonstrates effectiveness with a manageable safety profile, offering a promising therapeutic option for HER2-positive breast cancer patients who have shown resistance to prior anti-HER2 treatments.PMID:37944341 | DOI:10.1016/j.breast.2023.103597 (Source: Breast)
Source: Breast - November 9, 2023 Category: Cancer & Oncology Authors: Binliang Liu Ning Xie Can Tian Ronghua Feng Zhe-Yu Hu Jing Li Liping Liu Huawu Xiao Xiaohong Yang Mengsi Zeng Hui Wu Jun Lu Jianxiang Gao Xuming Hu Min Cao Zhengrong Shui Yu Tang Tao Wu Quchang Ouyang Source Type: research
Exploring the clinical outcomes and safety profile of inetetamab treatment in metastatic breast cancer patients: A multicenter assessment of a Chinese-origin recombinant Anti-HER2 monoclonal antibody
CONCLUSION: Inetetamab demonstrates effectiveness with a manageable safety profile, offering a promising therapeutic option for HER2-positive breast cancer patients who have shown resistance to prior anti-HER2 treatments.PMID:37944341 | DOI:10.1016/j.breast.2023.103597 (Source: Breast)
Source: Breast - November 9, 2023 Category: Cancer & Oncology Authors: Binliang Liu Ning Xie Can Tian Ronghua Feng Zhe-Yu Hu Jing Li Liping Liu Huawu Xiao Xiaohong Yang Mengsi Zeng Hui Wu Jun Lu Jianxiang Gao Xuming Hu Min Cao Zhengrong Shui Yu Tang Tao Wu Quchang Ouyang Source Type: research
Correlation between the CEM imaging characteristics and different molecular subtypes of breast cancer
CONCLUSION: CEM imaging features could distinguish BC molecular subtypes. In particular, TNBC showed oval or round tumor shape, rim enhancement, and swollen axillary lymph nodes, providing insights into the diagnosis and prognosis of TNBC.PMID:37925875 | DOI:10.1016/j.breast.2023.103595 (Source: Breast)
Source: Breast - November 5, 2023 Category: Cancer & Oncology Authors: Na Li Weiyun Gong Yuanzhong Xie Lei Sheng Source Type: research
Correlation between the CEM imaging characteristics and different molecular subtypes of breast cancer
CONCLUSION: CEM imaging features could distinguish BC molecular subtypes. In particular, TNBC showed oval or round tumor shape, rim enhancement, and swollen axillary lymph nodes, providing insights into the diagnosis and prognosis of TNBC.PMID:37925875 | DOI:10.1016/j.breast.2023.103595 (Source: Breast)
Source: Breast - November 5, 2023 Category: Cancer & Oncology Authors: Na Li Weiyun Gong Yuanzhong Xie Lei Sheng Source Type: research
Correlation between the CEM imaging characteristics and different molecular subtypes of breast cancer
CONCLUSION: CEM imaging features could distinguish BC molecular subtypes. In particular, TNBC showed oval or round tumor shape, rim enhancement, and swollen axillary lymph nodes, providing insights into the diagnosis and prognosis of TNBC.PMID:37925875 | DOI:10.1016/j.breast.2023.103595 (Source: Breast)
Source: Breast - November 5, 2023 Category: Cancer & Oncology Authors: Na Li Weiyun Gong Yuanzhong Xie Lei Sheng Source Type: research
Correlation between the CEM imaging characteristics and different molecular subtypes of breast cancer
CONCLUSION: CEM imaging features could distinguish BC molecular subtypes. In particular, TNBC showed oval or round tumor shape, rim enhancement, and swollen axillary lymph nodes, providing insights into the diagnosis and prognosis of TNBC.PMID:37925875 | DOI:10.1016/j.breast.2023.103595 (Source: Breast)
Source: Breast - November 5, 2023 Category: Cancer & Oncology Authors: Na Li Weiyun Gong Yuanzhong Xie Lei Sheng Source Type: research
Benefit of postoperative regional nodal irradiation in patients receiving preoperative systemic therapy with docetaxel/carboplatin/trastuzumab/pertuzumab for HER2-positive breast cancer
CONCLUSION: With a rare incidence of LRR, RNI did not significantly affect LRR or DFS in patients with HER2-positive breast cancer after with PST-TCHP. However, intensive systemic treatment is required for advanced diseases (C/D). Selective de-intensified RNI and intensified systemic treatment should be investigated in future studies.PMID:37924622 | DOI:10.1016/j.breast.2023.103594 (Source: Breast)
Source: Breast - November 4, 2023 Category: Cancer & Oncology Authors: Nalee Kim Ji-Yeon Kim Won Park Won Kyung Cho Tae Gyu Kim Young-Hyuck Im Jin Seok Ahn Jeong Eon Lee Seok Jin Nam Seok Won Kim Jonghan Yu Byung Joo Chae Sei Kyung Lee Jai-Min Ryu Yeon Hee Park Haeyoung Kim Source Type: research
Trends in the pre-operative diagnosis and surgical management of axillary lymph node metastases in women with screen-detected breast cancer
CONCLUSION: Pre-operative confirmation of axillary lymph node metastasis by ultrasound-guided biopsy did not rise despite the increased use of CNB at the expense of less invasive FNAB. A significant reduction in ALND was observed through the years.PMID:37890215 | PMC:PMC10624574 | DOI:10.1016/j.breast.2023.103593 (Source: Breast)
Source: Breast - October 27, 2023 Category: Cancer & Oncology Authors: Lucien E M Duijm Luc J A Strobbe Vivian van Breest Smallenburg Clemence L Op de Coul-Froger Wikke Setz-Pels Willem Vreuls Hermen C van Beek Rob M G van Bommel Adri C Voogd Source Type: research
Trends in the pre-operative diagnosis and surgical management of axillary lymph node metastases in women with screen-detected breast cancer
CONCLUSION: Pre-operative confirmation of axillary lymph node metastasis by ultrasound-guided biopsy did not rise despite the increased use of CNB at the expense of less invasive FNAB. A significant reduction in ALND was observed through the years.PMID:37890215 | DOI:10.1016/j.breast.2023.103593 (Source: Breast)
Source: Breast - October 27, 2023 Category: Cancer & Oncology Authors: Lucien E M Duijm Luc J A Strobbe Vivian van Breest Smallenburg Clemence L Op de Coul-Froger Wikke Setz-Pels Willem Vreuls Hermen C van Beek Rob M G van Bommel Adri C Voogd Source Type: research
Trends in the pre-operative diagnosis and surgical management of axillary lymph node metastases in women with screen-detected breast cancer
CONCLUSION: Pre-operative confirmation of axillary lymph node metastasis by ultrasound-guided biopsy did not rise despite the increased use of CNB at the expense of less invasive FNAB. A significant reduction in ALND was observed through the years.PMID:37890215 | DOI:10.1016/j.breast.2023.103593 (Source: Breast)
Source: Breast - October 27, 2023 Category: Cancer & Oncology Authors: Lucien E M Duijm Luc J A Strobbe Vivian van Breest Smallenburg Clemence L Op de Coul-Froger Wikke Setz-Pels Willem Vreuls Hermen C van Beek Rob M G van Bommel Adri C Voogd Source Type: research
Trends in the pre-operative diagnosis and surgical management of axillary lymph node metastases in women with screen-detected breast cancer
CONCLUSION: Pre-operative confirmation of axillary lymph node metastasis by ultrasound-guided biopsy did not rise despite the increased use of CNB at the expense of less invasive FNAB. A significant reduction in ALND was observed through the years.PMID:37890215 | DOI:10.1016/j.breast.2023.103593 (Source: Breast)
Source: Breast - October 27, 2023 Category: Cancer & Oncology Authors: Lucien E M Duijm Luc J A Strobbe Vivian van Breest Smallenburg Clemence L Op de Coul-Froger Wikke Setz-Pels Willem Vreuls Hermen C van Beek Rob M G van Bommel Adri C Voogd Source Type: research
Trends in the pre-operative diagnosis and surgical management of axillary lymph node metastases in women with screen-detected breast cancer
CONCLUSION: Pre-operative confirmation of axillary lymph node metastasis by ultrasound-guided biopsy did not rise despite the increased use of CNB at the expense of less invasive FNAB. A significant reduction in ALND was observed through the years.PMID:37890215 | DOI:10.1016/j.breast.2023.103593 (Source: Breast)
Source: Breast - October 27, 2023 Category: Cancer & Oncology Authors: Lucien E M Duijm Luc J A Strobbe Vivian van Breest Smallenburg Clemence L Op de Coul-Froger Wikke Setz-Pels Willem Vreuls Hermen C van Beek Rob M G van Bommel Adri C Voogd Source Type: research
