Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls
Conclusions:
Our findings support truncating variants in PALB2 as high-penetrance breast cancer susceptibility alleles, and suggest that a common missense variant may also lead to a low level of increased breast cancer risk. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 19, 2015 Category: Cancer & Oncology Authors: Ella ThompsonKylie GorringeSimone RowleyMichelle Wong-BrownSimone McInernyNa LiAlison TrainerLisa DevereuxMaria DoyleJason LiRichard LupatMartin DelatyckiGillian MitchellPaul JamesRodney ScottIan CampbellLifePool Investigators Source Type: research
Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers
Conclusion:
This study provides mechanistic insight as to how obesity enhances the proliferation and metastasis of breast cancer cells; specifically, obASC-derived leptin contributes to the aggressiveness of breast cancer in obese women. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 19, 2015 Category: Cancer & Oncology Authors: Amy StrongJason OhlsteinBrandi BiagasLyndsay RhodesDorothy PeiH. TuckerClaire LlamasAnnie BowlesMaria DutreilShijia ZhangJeffrey GimbleMatthew BurowBruce Bunnell Source Type: research
Expression of truncated human epidermal growth factor receptor 2 on circulating tumor cells of breast cancer patients
Conclusions:
p95HER2-positive CTCs can be detected in both early and metastatic breast cancer patients. Their incidence is increased in the metastatic setting and their presence is associated with poor survival. Longitudinal studies during anti-HER2 treatment are required to determine the clinical relevance of p95HER2-expressing CTCs. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 19, 2015 Category: Cancer & Oncology Authors: Galatea KallergiSofia AgelakiMaria PapadakiDimitris NasiasAlexios MatikasDimitris MavroudisVassilis Georgoulias Source Type: research
A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density
IntroductionMammographic density is an established breast cancer risk factor with a strong genetic component and can be increased in women using menopausal hormone therapy (MHT). Here, we aimed to identify genetic variants that may modify the association between MHT use and mammographic density.
Methods:
The study comprised 6,298 postmenopausal women from the Mayo Mammography Health Study and nine studies included in the Breast Cancer Association Consortium. We selected for evaluation 1327 single nucleotide polymorphisms (SNPs) showing the lowest P-values for interaction (P
...
Source: Breast Cancer Research - August 16, 2015 Category: Cancer & Oncology Authors: Anja RudolphPeter FaschingSabine BehrensUrsula EilberManjeet BollaQin WangDeborah ThompsonKamila CzeneJudith BrandJingmei LiChristopher ScottV. PankratzKathleen BrandtEmily HallbergJanet OlsonAdam LeeMatthias BeckmannArif EkiciLothar HaeberleGertraud Mask Source Type: research
Chromosomal copy number alterations for associations of ductal carcinoma in situ with invasive breast cancer
Conclusions:
CNAs have the potential to improve the identification of high-risk DCIS, defined by presence of concurrent IBC. Expanding and validating this approach in both additional cross-sectional and longitudinal cohorts may enable improved risk stratification and risk-appropriate treatment in DCIS. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 13, 2015 Category: Cancer & Oncology Authors: Anosheh AfghahiErna ForgóAya MitaniManisha DesaiSushama VarmaTina SetoJoseph RigdonKristin JensenMegan TroxellScarlett GomezAmar DasAndrew BeckAllison KurianRobert West Source Type: research
Decoding breast cancer tissue–stroma interactions using species-specific sequencing
Conclusions:
In conclusion, the data show that the S
3
technology allows for faithful recording of transcriptomic changes when human and mouse cells are intermixed and that it can be applied to address a broad spectrum of research questions. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 13, 2015 Category: Cancer & Oncology Authors: Indira ChivukulaDaniel RamsköldHelena StorvallCharlotte AnderbergShaobo JinVeronika MamaevaCecilia SahlgrenKristian PietrasRickard SandbergUrban Lendahl Source Type: research
Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women
IntroductionAlcohol consumption may promote aromatization of androgens to estrogens, which may partly explain the observations linking alcohol consumption to higher breast cancer risk. Whether alcohol consumption is associated with endogenous estrogen levels, and mammographic density phenotypes in premenopausal women remains unclear.
Methods:
Alcohol consumption was collected by self-report and interview, using semi quantitative food frequency questionnaires, and a food diary during seven days of a menstrual cycle among 202 premenopausal women, participating in the Energy Balance and Breast Cancer Aspects (EBBA) study I. E...
Source: Breast Cancer Research - August 7, 2015 Category: Cancer & Oncology Authors: Hanne FrydenbergVidar FloteIne LarssonEmily BarrettAnne-Sofie FurbergGiske UrsinTom WilsgaardPeter EllisonAnne McTiernanAnette HjartåkerGrazyna JasienskaInger Thune Source Type: research
The molecular landscape of premenopausal breast cancer
Conclusion:
Together these data suggest that ER+ preM tumors have distinct molecular characteristics compared to ER+ postM tumors, particularly with respect to integrin/laminin and EGFR signaling, which may represent therapeutic targets in this subgroup of breast cancers. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 7, 2015 Category: Cancer & Oncology Authors: Serena LiaoRyan HartmaierKandace McGuireShannon PuhallaSoumya LuthraUma ChandranTianzhou MaRohit BhargavaFrancesmary ModugnoNancy DavidsonSteve BenzAdrian LeeGeorge TsengSteffi Oesterreich Source Type: research
Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence
Conclusion:
There is no compelling evidence that any clinically available insulin analogue (Aspart, Determir, Glargine, Glulisine or Lispro), nor human insulin increases breast cancer risk. Overall, the data suggests that insulin treatment is not involved in breast tumour initiation, but might induce breast tumour progression by up regulating mitogenic signalling pathways. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 5, 2015 Category: Cancer & Oncology Authors: Heleen BronsveldBas ter BraakØystein KarlstadPeter VestergaardJakob Starup-LindeMarloes BazelierMarie De BruinAnthonius de BoerChristine SiezenBob van de WaterJan van der LaanMarjanka Schmidt Source Type: research
Human breast cancer cells educate macrophages toward the M2 activation status
IntroductionThe immune system plays a major role in cancer progression. In solid tumors, 5-40 % of the tumor mass consists of tumor-associated macrophages (TAMs) and there is usually a correlation between the number of TAMs and poor prognosis, depending on the tumor type. TAMs usually resemble M2 macrophages. Unlike M1-macrophages which have pro-inflammatory and anti-cancer functions, M2-macrophages are immunosuppressive, contribute to the matrix-remodeling, and hence favor tumor growth. The role of TAMs is not fully understood in breast cancer progression.
Methods:
Macrophage infiltration (CD68) and activation status (HLA...
Source: Breast Cancer Research - August 5, 2015 Category: Cancer & Oncology Authors: Sofia SousaRégis BrionMinnamaija LintunenPauliina KronqvistJouko SandholmJukka MönkkönenPirkko-Liisa Kellokumpu-LehtinenSusanna LauttiaOlli TynninenHeikki JoensuuDominique HeymannJorma Määttä Source Type: research
Contralateral breast cancer can represent a metastatic spread of the first primary tumor: determination of clonal relationship between contralateral breast cancers using next-generation whole genome sequencing
Whole genome sequencing was used to differentiate metastatic from second primary tumors in contralateral breast cancer patients: a distinction with clinical implications for treatment and prognosis. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 5, 2015 Category: Cancer & Oncology Authors: Sara AlknerMan-Hung TangChristian BruefferMalin DahlgrenYilun ChenEleonor OlssonChristof WinterSara BakerAnna EhingerLisa RydénLao SaalMårten FernöSofia Gruvberger-Saal Source Type: research
Lobular breast cancer - the most common special subtype or a most special common subtype?
Lobular breast cancer is not only the second most common breast cancer subtype, known for decades, but also a tumour entity that still poses many unresolved questions. These include questions about the targets and cooperation partners of E-cadherin, the best model systems for translational research, and the best tools for detection, surveillance and therapy. Leading experts review the molecular and cellular bases, the model systems, the histopathology and profiling approaches, risk factors, imaging tools and therapeutic options for lobular breast cancer. (Source: Breast Cancer Research)
Source: Breast Cancer Research - July 28, 2015 Category: Cancer & Oncology Authors: Ulrich Lehmann Source Type: research
Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells
Conclusions:
We propose that these mitogenic classifier genes can be used to test the mitogenic potential of novel insulin analogues as well as other alternative molecules with an anticipated affinity for the IGF1R. (Source: Breast Cancer Research)
Source: Breast Cancer Research - July 19, 2015 Category: Cancer & Oncology Authors: Bas ter BraakSteven WinkEsmee KoedootChantal PontChristine SiezenJan van der LaanBob van de Water Source Type: research
Body fatness during childhood and adolescence and breast density in young women: a prospective analysis
IntroductionOverweight and obesity in childhood and adolescence are associated with reduced breast cancer risk, independent of adult body mass index (BMI). These associations may be mediated through breast density.
Methods:
We prospectively examined associations of early life body fatness with adult breast density measured by MRI in 182 women in the Dietary Intervention Study in Children (DISC) who were ages 25–29 at follow-up. Height, weight, and other factors were measured at baseline (ages 8–10) and annual clinic visits through adolescence. We used linear mixed-effects models to quantify associations of percent brea...
Source: Breast Cancer Research - July 16, 2015 Category: Cancer & Oncology Authors: Kimberly BertrandHeather BaerE. OravCatherine KlifaJohn ShepherdLinda Van HornLinda SnetselaarVictor StevensNola HyltonJoanne Dorgan Source Type: research
Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL
No description available (Source: Breast Cancer Research)
Source: Breast Cancer Research - July 16, 2015 Category: Cancer & Oncology Authors: Luke PiggottNader OmidvarSalvador Martí PérezRhiannon FrenchMatthias EberlRichard Clarkson Source Type: research
