Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion
Conclusion:
BCL9 is a molecular driver of DCIS invasive progression and may predispose to the development of basal like invasive breast cancers. As such, BCL9 has the potential to serve as a biomarker of high risk DCIS and as a therapeutic target for prevention of IDC. (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 17, 2015 Category: Cancer & Oncology Authors: Hanan ElsarrajYan HongKelli ValdezWhitney MichaelsMarcus HookWilliam SmithJeremy ChienJason HerschkowitzMelissa TroesterMoriah BeckMarc InciardiJason GatewoodLisa MayTherese CusickMarilee McGinnessLawrence RicciFang FanOssama TawfikJeffrey MarksJennifer K Source Type: research
Erratum to: Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells
No description available (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 16, 2015 Category: Cancer & Oncology Authors: Stephanie VerbekeElodie RichardElodie MonceauXenia SchmidtBenoit RousseauValerie VelascoDavid BernardHerve BonnefoiGaetan MacGroganRichard Iggo Source Type: research
Applicability of HIN-1, MGMT and RASSF1A promoter methylation as biomarkers for detecting field cancerization in breast cancer
IntroductionIt has been shown in some articles that genetic and epigenetic abnormalities cannot only be found in tumor tissues but also in adjacent regions that appear histologically normal. This phenomenon is metaphorically called field cancerization or field defect. Field cancerization is regarded as clinically significant because it is assumed to be an important factor in local recurrence of cancer. As the field showing these molecular abnormalities may not be removed completely by surgery, these changes might lead to neoplasms and subsequent transformation to a tumor. We aimed to investigate the applicability of the me...
Source: Breast Cancer Research - September 14, 2015 Category: Cancer & Oncology Authors: Melanie SpitzwieserElisabeth HolzweberGeorg PfeilerStefan HackerMargit Cichna-Markl Source Type: research
A hypoxic ticket to the bone metastatic niche
Hypoxia is a well-characterized driver of aggressive cancer phenotypes, including metastasis. Accumulating evidence suggests that, in addition to having local effects, the consequences of tumour hypoxia can be systemic, leading to the formation of pre-metastatic niches that can later foster metastatic colonization in distant organs. Recent findings have demonstrated that such niches can also form in the bone, possibly revealing new avenues for therapeutic intervention. (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 4, 2015 Category: Cancer & Oncology Authors: Sakari Vanharanta Source Type: research
Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer
Conclusion:
The HOXC11 target gene, PSAP, is an AR activator which facilitates adaptation to a more invasive phenotype in vitro. These findings have particular relevance to the development of resistance to AI therapy which is an emerging clinical issue. PSAP is a secreted biomarker which has potential in identifying patients failing to exhibit sustained response to hormonal treatment. (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 4, 2015 Category: Cancer & Oncology Authors: Azlena AliLaura CreeveyYuan HaoDamian McCartanPeadar O¿GaoraArnold HillLeonie YoungMarie McIlroy Source Type: research
Prognostic significance of tumor-infiltrating CD8 + and FOXP3 + lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study
Conclusions:
This is the first study to demonstrate that high CD8
+
TIL and a high CD8/FOXP3 ratio in residual tumors and increment of these parameters following NAC and accurately predict improved prognosis in TNBC patients with non-pathological complete response following NAC. These parameters could serve as a surrogate one for adjuvant treatment in patients with residual disease in the neoadjuvant setting. (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 4, 2015 Category: Cancer & Oncology Authors: Minoru MiyashitaHironobu SasanoKentaro TamakiHisashi HirakawaYayoi TakahashiSaki NakagawaGou WatanabeHiroshi TadaAkihiko SuzukiNoriaki OhuchiTakanori Ishida Source Type: research
The seventh ENBDC workshop on methods in mammary gland development and cancer
The seventh annual meeting of the European Network of Breast Development and Cancer Laboratories, held in Weggis, Switzerland, in April 2015, was focused on techniques for the study of normal and cancer stem cells, cell fate decisions, cancer initiation and progression. (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 2, 2015 Category: Cancer & Oncology Authors: Marina GlukhovaNancy HynesMaria VivancoRenée van AmerongenRobert ClarkeMohamed Bentires-Alj Source Type: research
Effect of weight loss, with or without exercise, on body composition and sex hormones in postmenopausal women: the SHAPE-2 trial
Results from the SHAPE-2 trial show the importance of physical activity as a positive intervention to decrease breast cancer risk. (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 2, 2015 Category: Cancer & Oncology Authors: Willemijn van GemertAlbertine SchuitJob van der PalenAnne MayJolein IestraHarriet WittinkPetra PeetersEvelyn Monninkhof Source Type: research
Bisphosphonates as anticancer agents in early breast cancer: preclinical and clinical evidence
Bisphosphonates (BPs) are approved as standard therapy in breast cancer for the treatment of bone metastases, since they were demonstrated to reduce the prevalence of skeletal-related events including fractures and hypercalcemia. In the adjuvant setting, BPs can be given to prevent and treat tumor therapy-induced bone loss in premenopausal and postmenopausal women and, owing to their beneficial effect on bone turnover, have also been evaluated for prevention of bone metastases occurrence. In this article we will review the mechanisms through which BPs have been demonstrated to prevent premetastatic niche formation and cell...
Source: Breast Cancer Research - September 2, 2015 Category: Cancer & Oncology Authors: Daniele SantiniLuciano StumboChiara SpotoLoretta D¿OnofrioFrancesco PantanoMichele IulianiMarco fioramontiAlice ZoccoliGiulia RibelliVladimir VirzìBruno VincenziGiuseppe Tonini Source Type: research
Breast bruises and breast cancer
No description available (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 27, 2015 Category: Cancer & Oncology Authors: Nancy Krieger Source Type: research
Preliminary evaluation of the publicly available Laboratory for Breast Radiodensity Assessment (LIBRA) software tool: comparison of fully automated area and volumetric density measures in a case–control study with digital mammography
Conclusions:
Our study suggests that new automated density measures may ultimately augment the current standard breast cancer risk factors. In addition, the ability to fully automate density estimation with digital mammography, particularly through the use of publically available breast density estimation software, could accelerate the translation of density reporting in routine breast cancer screening and surveillance protocols and facilitate broader research into the use of breast density as a risk factor for breast cancer. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 25, 2015 Category: Cancer & Oncology Authors: Brad KellerJinbo ChenDania DayeEmily ConantDespina Kontos Source Type: research
Breast cancer tumour growth modelling for studying the association of body size with tumour growth rate and symptomatic detection using case-control data
Conclusions:
The times at which tumours will be symptomatically detected may vary substantially between women with different breast sizes. The proposed tumour growth model represents a novel and useful approach for quantifying the effects of breast cancer risk factors on tumour growth and detection. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 21, 2015 Category: Cancer & Oncology Authors: Linda AbrahamssonKamila CzenePer HallKeith Humphreys Source Type: research
Micro-anatomical quantitative optical imaging: toward automated assessment of breast tissues
Automated classification of breast lesions from confocal images is a step towards breast cancer diagnosis from fresh tissue samples at the point of care. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 20, 2015 Category: Cancer & Oncology Authors: Jessica DobbsJenna MuellerSavitri KrishnamurthyDongsuk ShinHenry KuererWei YangNirmala RamanujamRebecca Richards-Kortum Source Type: research
Assessing breast cancer cell lines as tumour models by comparison of mRNA expression profiles
Conclusions:
This study demonstrates that many of the differences between breast cancer cell lines and tumours are due to the absence of stromal and immune components in vitro. Hence, extra precautions should be taken when modelling extracellular proteins in vitro. The specific differences discovered emphasize the importance of choosing an appropriate model for each research question. (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 20, 2015 Category: Cancer & Oncology Authors: Krista VincentScott FindlayLynne Postovit Source Type: research
Lack of epidermal growth factor receptor (EGFR)-activating mutations in triple-negative breast cancer in China
No description available (Source: Breast Cancer Research)
Source: Breast Cancer Research - August 20, 2015 Category: Cancer & Oncology Authors: Wen-Ming CaoYun GaoXiao-Jia Wang Source Type: research
