Breast cancer brain metastases: biology and new clinical perspectives
Because of improvements in the treatment of patients with metastatic breast cancer, the development of brain metastases (BM) has become a major limitation of life expectancy and quality of life for many breast cancer patients. The improvement of management strategies for BM is thus an important clinical challenge, especially among high-risk patients such as human epidermal growth factor receptor 2-positive and triple-negative patients. However, the formation of BM as a multistep process is thus far poorly understood. To grow in the brain, single tumor cells must pass through the tight blood–brain barrier (BBB). The BBB r...
Source: Breast Cancer Research - January 19, 2016 Category: Cancer & Oncology Authors: Isabell WitzelLeticia Oliveira-FerrerKlaus PantelVolkmar MüllerHarriet Wikman Source Type: research
Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer
Conclusions:
Our results demonstrate that WAP-Cre:Pten
f/f
:p53
lox.stop.lox_R270H
mice represent a tractable model to study basal-like breast cancer because unlike p53 deletion, p53
R270H
mutation in the mouse does not skew tumors toward the claudin-low subtype. The WAP-Cre:Pten
f/f
:p53
lox.stop.lox_R270H
mice develop basal-like breast cancer that is enriched in TICs, can readily form lung metastasis, and provides a ...
Source: Breast Cancer Research - January 19, 2016 Category: Cancer & Oncology Authors: Sharon WangJeff LiuDanbi KimAlessandro DattiEldad Zacksenhaus Source Type: research
Breast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state
We report here that breast primary epithelial cells propagated in vitro with WIT medium on Primaria plates express some luminal characteristics, but not a complete luminal lineage phenotype. They undergo a p16-dependent stress-induced senescence (stasis), and the cells that escape stasis finally enter a crisis state with rampant chromosome instability. Chromosome instability in these cells is driven by excessive telomere attrition, as distributions of chromosomes involved in aberrations correlate with the profiles of telomere signal-free ends. Importantly, ectopic expression of the human TERT gene rescued their chromosomal...
Source: Breast Cancer Research - January 13, 2016 Category: Cancer & Oncology Authors: Purificación FeijooMariona TerradasDavid SolerDaniel DomínguezLaura TusellAnna Genescà Source Type: research
Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells
Background:
Developing novel strategies against treatment-resistant triple negative breast cancer (TNBC) cells remains a significant challenge. The ErbB family, including epidermal growth factor receptor (EGFR), plays key roles in metastasis, tumorigenesis, cell proliferation, and drug resistance. Recently, these characteristics have been linked to a small subpopulation of cells classified as cancer stem cells (CSC) which are believed to be responsible for tumor initiation and maintenance. Ixabepilone is a new generation microtubule-stabilizing agent, which has been expected to be more efficacious than conventional taxanes...
Source: Breast Cancer Research - January 12, 2016 Category: Cancer & Oncology Authors: Tomonori TaneiDong ChoiAngel RodriguezDiana LiangLacey DobroleckiMadhumita GhoshMelissa LandisJenny Chang Source Type: research
Increased peri-ductal collagen micro-organization may contribute to raised mammographic density
Conclusions:
These preliminary data suggest that remodelling, and hence stiffening, of the existing stromal collagen microarchitecture promotes high mammographic density within the breast. In turn, this aberrant mechanical environment may trigger neoplasia-associated mechanotransduction pathways within the epithelial cell population. (Source: Breast Cancer Research)
Source: Breast Cancer Research - January 8, 2016 Category: Cancer & Oncology Authors: James McConnellOliver O¿ConnellKeith BrennanLisa WeipingMiles HoweLeena JosephDavid KnightRonan O¿CualainYit LimAngela LeekRachael WaddingtonJane RoganSusan AstleyAshu GandhiCliona KirwanMichael SherrattCharles Streuli Source Type: research
ELF5 isoform expression is tissue-specific and significantly altered in cancer
Conclusions:
Alternative promoter use, conferring differential regulatory responses, is the main mechanism governing ELF5 action rather than differential transcriptional activity of the isoforms. This understanding of expression and function at the isoform level is a vital first step in realizing the potential of transcription factors such as ELF5 as prognostic markers or therapeutic targets in cancer. (Source: Breast Cancer Research)
Source: Breast Cancer Research - January 7, 2016 Category: Cancer & Oncology Authors: Catherine PigginDaniel RodenDavid Gallego-OrtegaHeather LeeSamantha OakesChristopher Ormandy Source Type: research
Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01)
Conclusions:
Absent or diminished expression of IGF-1R after neoadjuvant chemotherapy was associated with a better pathological response. Additionally, we found a SNP (rs2016347) in IGF1R as a potential predictive marker for chemotherapy efficacy in BC patients treated with TAC.Trial registrationClinicalTrials.gov NCT01099436. Registered April 6, 2010. (Source: Breast Cancer Research)
Source: Breast Cancer Research - January 6, 2016 Category: Cancer & Oncology Authors: Stefanie de GrootAyoub CharehbiliHanneke van LaarhovenAntien MooyaartN. Dekker-EnsinkSaskia van de VenLaura JanssenJesse SwenVincent SmitJoan HeijnsLonneke KesselsTahar van der StraatenStefan BöhringerHans GelderblomJacobus van der HoevenHenk-Jan Guchela Source Type: research
Assessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study
Conclusions:
BCI had a strong prognostic effect on RFS in patients with early-stage breast cancer treated with tamoxifen alone or with tamoxifen and octreotide. BCI was prognostic in both LN− and LN+ patients. This retrospective study is an independent validation of the prognostic performance of BCI in a prospective trial. (Source: Breast Cancer Research)
Source: Breast Cancer Research - January 4, 2016 Category: Cancer & Oncology Authors: Dennis SgroiJudy-Anne ChapmanT. Badovinac-CrnjevicElizabeth ZarellaShemeica BinnsYi ZhangCatherine SchnabelMark ErlanderKathleen PritchardLei HanLois ShepherdPaul GossMichael Pollak Source Type: research
“New” metastases are associated with a poorer prognosis than growth of pre-existing metastases in patients with metastatic breast cancer treated with chemotherapy
IntroductionProgression-free survival (PFS) and overall survival (OS) endpoints often only weakly correlate. This analysis investigates how different progression events impact on OS, using data from two phase 3 studies with eribulin in women with advanced/metastatic breast cancer (MBC).
Methods:
In Study 301, 1102 women with ≤2 prior chemotherapies for advanced/MBC were randomized to eribulin mesylate (1.4 mg/m
2
on days 1 and 8 every 21 days) or capecitabine (1.25 g/m
2
twice daily on days 1–14 every 21 days). Study 305/EMBRACE enr...
Source: Breast Cancer Research - December 9, 2015 Category: Cancer & Oncology Authors: Christopher TwelvesJavier CortesPeter KaufmanLouise YelleAhmad AwadaTerri BinderMartin OlivoJames SongJoyce O¿ShaughnessyMaria JoveEdith Perez Source Type: research
HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers
Conclusion:
Our finding that IBC cells are sensitive to HDAC6 inhibition provides a foundation to rapidly develop novel, efficient, and well-tolerated targeted therapy strategies for IBC patients. (Source: Breast Cancer Research)
Source: Breast Cancer Research - December 8, 2015 Category: Cancer & Oncology Authors: Preeti PutchaJiyang YuRuth Rodriguez-BarruecoLaura Saucedo-CuevasPatricia VillagrasaEva Murga-PenasSteven QuayleMin YangVeronica CastroDavid Llobet-NavasDaniel BirnbaumPascal FinettiWendy WoodwardFrançois BertucciMary AlpaughAndrea CalifanoJose Silva Source Type: research
Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers
Conclusions:
These studies highlight the important role of Vps34-mediated autophagy in limiting the anti-tumor response to inhibitors of HER2 or type I PI3K in HER2+ breast cancers. The type III PI3K Vps34 represents a potential therapeutic target to block treatment-induced autophagy and enhance tumor cell killing. (Source: Breast Cancer Research)
Source: Breast Cancer Research - December 4, 2015 Category: Cancer & Oncology Authors: Christian YoungCarlos ArteagaRebecca Cook Source Type: research
Mammographic density adds accuracy to both the Tyrer-Cuzick and Gail breast cancer risk models in a prospective UK screening cohort
Conclusions:
Breast density may be usefully combined with the Tyrer-Cuzick model or the Gail model. (Source: Breast Cancer Research)
Source: Breast Cancer Research - December 1, 2015 Category: Cancer & Oncology Authors: Adam BrentnallElaine HarknessSusan AstleyLouise DonnellyPaula StavrinosSarah SampsonLynne FoxJamie SergeantMichelle HarvieMary WilsonUrsula BeetlesSoujanya GaddeYit LimAnil JainSara BundredNicola BarrValerie ReeceAnthony HowellJack CuzickD. Evans Source Type: research
Longer term effects of the Angelina Jolie effect: increased risk-reducing mastectomy rates in BRCA carriers and other high-risk women
No description available (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 25, 2015 Category: Cancer & Oncology Authors: D. EvansJulie WiselyTara ClancyFiona LallooMary WilsonRichard JohnsonJonathon DuncanLester BarrAshu GandhiAnthony Howell Source Type: research
β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion
Conclusion:
These findings provide insight into conditions that control tumor cell invasion by identifying signaling through β
2
-adrenoceptors as a regulator of invadopodia formation. These findings suggest novel pharmacological strategies for intervention, by using β-blockers to target β
2
-adrenoceptors to limit tumor cell dissemination and metastasis. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 25, 2015 Category: Cancer & Oncology Authors: Sarah CreedCaroline LeMona HassanCindy PonSabine AlboldKeefe ChanMatthew BerginskiZhendong HuangJames BearJ. LaneMichelle HallsDavide FerrariCameron NowellErica Sloan Source Type: research
The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features
Conclusions:
In this study, we identified SSEA4 as highly expressed in a subpopulation of tumor cells resistant to multiple commonly used chemotherapy drugs, as well as ST3GAL2, the rate-limiting enzyme of SSEA4 synthesis, as a predictive marker of poor outcome for breast and ovarian cancer patients undergoing chemotherapy. Both biomarkers and additionally identified regulatory miRNAs may be used to further understand chemoresistance, to stratify patient groups in order to avoid ineffective and painful therapies, and to develop alternative treatment regimens for breast cancer patients. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 25, 2015 Category: Cancer & Oncology Authors: Andrea AloiaEvgeniya PetrovaStefan TomiukUte BisselsOlivier DéasMassimo SainiFranziska ZickgrafSteve WagnerSaskia SpaichMarc SütterlinAndreas SchneeweissManuel ReitbergerSilvia RübergBernhard GerstmayerDavid AgorkuSebastian KnöbelAnnalisa TerranegraMo Source Type: research
