Influence of voxel size on micro-CT analysis of debris after root canal preparation
Abstract: The aim of this study was to assess the influence of micro-computed tomography (micro-CT) voxel size on the evaluation of debris accumulation after passive ultrasonic irrigation (PUI) in curved root canals prepared with rotary nickel-titanium files. Mesial root canals (n = 24) of mandibular molars with curvature between 25 ° and 35° were prepared using ProDesign Logic 30/.05 (PDL) or HyFlex EDM 25/.08 (HEDM). PUI was performed after root canal preparation of all root canals. The specimens were scanned using high-resolution (5 μ m voxel size) micro-CT imaging before and after experimental procedures. The percen...
Source: Brazilian Oral Research - November 13, 2020 Category: Dentistry Source Type: research
Effect of different factors on patient perception of surgical discomfort in third molar surgery
Abstract: The aim of this study was to evaluate patient perception of surgical discomfort in third molar surgery and the association with clinical variables and polymorphisms associated with the FKBP5, SLC6A4, and COMT genes. This cross-sectional observational study was carried out on 196 participants aged between 18 and 64 years at the Federal University of Paran á in 11 months. The intensity of surgical discomfort was assessed using the QCirDental questionnaire. Data on surgical and individual procedures were also cataloged. The oral health related quality of life was assessed by the Oral Health Impact Profile questionn...
Source: Brazilian Oral Research - November 13, 2020 Category: Dentistry Source Type: research
YouTube™ and oral lichen planus: an appraisal of the educational quality of information
The objective of this study was to analyze the quality of videos on oral lichen planus (OLP) available in YouTube ™ . A cross-sectional analytical study was conducted by searching the video sharing platform YouTube ™ . Videos aimed at clarifying the etiological and clinical characteristics, diagnostic criteria, treatment, and prognosis of OLP were included. A total of 481 videos were retrieved and 37 were included in the study according to the selection criteria established. Most of the videos evaluated (86.5%; n = 32) were produced by independent users. The average reliability was 1.8 and quality assessment classified...
Source: Brazilian Oral Research - November 13, 2020 Category: Dentistry Source Type: research
Endocan (ESM-1) levels in gingival crevicular fluid correlate with ICAM-1 and LFA-1 in periodontitis
This study aims to determine ESM-1 levels in gingival crevicular fluid (GCF) samples from individuals with periodontitis to determine the correlation between the levels of lymphocyte-function-associated antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and clinical findings of periodontitis. This study enrolled 27 individuals diagnosed with Stage III-Grade C generalized periodontitis and 16 individuals as healthy controls. Bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment loss (CAL) were calculated. Enzyme-linked immunosorbent assay (ELISA) test was used for detecting the levels of...
Source: Brazilian Oral Research - November 13, 2020 Category: Dentistry Source Type: research
Management of deep caries lesions with or without pulp involvement in primary teeth: a systematic review and network meta-analysis
Abstract: There is a lack of evidence about the best approach for cavitated caries lesions with the possibility of pulpal involvement in primary teeth. Thus, the present authors aimed to verify the best treatment for deep caries lesions with or without pulp involvement in primary teeth. The search was conducted in MEDLINE/Pubmed and Web of Science databases until May 2020. Studies that compared techniques to manage deep caries lesions with at least 12 months of follow-up were included. The risk of bias was evaluated using the RoB tool. Network meta-analysis and pairwise meta-analyses were conducted considering the treatmen...
Source: Brazilian Oral Research - November 13, 2020 Category: Dentistry Source Type: research
Can kinematics, file diameter, and PUI influence the intracanal decontamination and apical bacterial extrusion?
Abstract: The present study investigated the intracanal decontamination and apical extrusion of bacteria and debris from root canals instrumented with rotary and reciprocating systems (ProDesign Logic or ProDesign R), with different file diameters and using conventional syringe irrigation (CSI) or passive ultrasonic irrigation (PUI). Eighty extracted mandibular premolars were contaminated with Enterococcus faecalis and randomly assigned to eight experimental groups according to the root canal instrumentation and irrigation technique employed (n = 10): G1: Prodesign Logic 25.06; G2: Prodesign R 25.06; G3 and G4 were instrum...
Source: Brazilian Oral Research - November 13, 2020 Category: Dentistry Source Type: research
Association between fixed orthodontic treatment and dental caries: a 1-year longitudinal study
In conclusion, this study showed that individuals undergoing fixed orthodontic therapy for 1 year had a significantly higher incidence and increment of active caries lesions than those without a fixed appliance. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - November 13, 2020 Category: Dentistry Source Type: research
Influence of bone defect position and span in 3-point bending tests: experimental and finite element analysis
Abstract: Three-point bending test is the most common mechanical test used for quantifying the biomechanical quality of bone tissue and bone healing in small animals. However, there is a lack of standardization for evaluation of bone repair by cortical perforation. The aim of this study was to determine the influence of bone defect position in the proximal metaphysis of rat tibias during load application and different span configuration on the three-point bending test outcomes. Cortical defects with 1.6 mm diameter were created at a standardized location on the medial surface of 60 tibias of male Wistar rats. The animals w...
Source: Brazilian Oral Research - November 13, 2020 Category: Dentistry Source Type: research
Risk communication in the context of clinical research
Abstract Physicians and dentists usually make clinical decisions and recommendations without a clear understanding of the meaning of the numbers regarding the accuracy of diagnostic tests and the efficacy of treatments. This critical review aimed to identify problems in the communication of diagnostic test accuracy and treatment benefits and to suggest strategies to improve risk communication in these contexts. Most clinical decisions are taken under uncertainty. Health professionals cannot predict the outcome in one individual patient. This uncertainty invites these professionals to make decisions based on heuristics, whi...
Source: Brazilian Oral Research - August 12, 2020 Category: Dentistry Source Type: research
Clinical trials sponsored by industry and other private organizations
Abstract The present manuscript discussed some relevant aspects related to private sponsored clinical trials in dentistry. For decades, the academy has been the major responsible for research in Brazil. Distant from the trade sector, academic research has not always provided clear benefits to society. A key aspect of making benefits clearer is the process of scientific knowledge transference to decision-makers, which is, in fact, the ground of evidence-based dentistry. Although private sponsoring of clinical research seems to be part of the research progress of the business rates, investment in Brazil is lower than those o...
Source: Brazilian Oral Research - August 12, 2020 Category: Dentistry Source Type: research
How can we associate an economic evaluation with a clinical trial?
Abstract Economic evaluations in Dentistry have been increasing in recent years. They are a relevant contribution if an economic issue exists. Knowing if a new intervention is an efficient way of allocating available (and scarce) resources (the concept of opportunity costs), a well-designed economic evaluation may be helpful. One option is to conduct a trial-based economic analysis, which extracts a considerable board of information from a trial. This approach produces a more controlled result since many sources of variations might be reduced. On the other hand, some aspects could not be predicted directly from the trial o...
Source: Brazilian Oral Research - August 12, 2020 Category: Dentistry Source Type: research
Patient-centered assessments: how can they be used in dental clinical trials?
Abstract Recently, there has been greater interest in adopting a more holistic approach to healthcare. However, this trend should not limit itself merely to the notion that a human being lies behind the mouth being treated. Rather, it should embrace the understanding that this human can actively participate in and contribute to the treatment process. Patient Report Outcome Measures (PROMs) and Patient Report Experience Measures (PREMs) provide means for measuring data from the patient ’ s perspective, and enable health-related feelings and functions to be evaluated. Accordingly, this critical review aims to provide defin...
Source: Brazilian Oral Research - August 12, 2020 Category: Dentistry Source Type: research
Surrogate endpoints: when to use and when not to use? A critical appraisal of current evidences
Abstract Clinical research needs to formulate a question, which must be answered by obeying ethical precepts with well-defined inclusion/exclusion criteria and approval of the study on platforms of ethical appreciation and clinical trial records. In comparing the results or clinically relevant outcomes should be prioritized in the study of techniques, products, inputs, drugs and therapies. However, it is not always possible to use long study drawings, with many participants, and with many costs, then look for study designs with surrogate outcomes, usually a shorter path, with less sample size and considerably lower costs t...
Source: Brazilian Oral Research - August 12, 2020 Category: Dentistry Source Type: research
Clinically relevant outcomes in dental clinical trials: challenges and proposals
Abstract The impact of clinical trials on patient care depends on the outcomes that they evaluate. In Dentistry, many trials use outcomes that are important to clinicians, but not to the patients. Thus, the aim of the present manuscript is to present an overview of the limitations, challenges, and proposals on the use of clinically relevant outcomes (CRO) in dental trials. Clinically relevant outcomes are variables that directly measure how the patient feels, functions, or survives. Some CROs, such as tooth loss, implant failure, and restorations failure require many years to occur and the number of events is low. The adop...
Source: Brazilian Oral Research - August 12, 2020 Category: Dentistry Source Type: research
Practice based research in dentistry: an alternative to deal with clinical questions
In conclusion, this review sought to present PBR studies as alternative designs to answer clinical questions, but not replacing randomized clinical trials. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - August 12, 2020 Category: Dentistry Source Type: research
