Periodontal disease and its impact on general health in Latin America: LAOHA Consensus Meeting Report
Abstract: Periodontal diseases are considered a worldwide public health problem, owing to their high prevalence in developed and developing countries. Periodontitis may lead to tooth loss, which can impact oral health-related quality of life. Gingivitis and periodontitis have been extensively studied regarding their etiopathogenesis, epidemiology, prevention and treatment outcomes. However, most of these aspects are studied and discussed globally, which may hamper a clear interpretation of the findings and the design of effective plans of action for specific regions or populations. For example, in Latin America, epidemiolo...
Source: Brazilian Oral Research - April 10, 2020 Category: Dentistry Source Type: research

Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis
Abstract: Gingivitis and periodontitis are associated with a negative impact on Oral Health Related Quality of Life (OHRQoL), exerting a significant influence on aspects related to the patients' function and esthetics. Periodontitis has been associated with several systemic conditions, including adverse pregnancy outcomes, cardiovascular diseases, type 2 diabetes mellitus (DM), respiratory disorders, fatal pneumonia in hemodialysis patients, chronic renal disease and metabolic syndrome. The aim of this paper was to review the results of different periodontal treatments and their impacts on patients' OHRQoL and systemic hea...
Source: Brazilian Oral Research - April 10, 2020 Category: Dentistry Source Type: research

Strategies for the prevention of periodontal disease and its impact on general health in Latin America. Section III: Prevention
In conclusion, the relations between periodontal diseases, caries, healthy lifestyles and NCD's offer an ideal opportunity to change Latin American prevention strategies at both the individual level and population levels. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - April 10, 2020 Category: Dentistry Source Type: research

Periodontal disease and its impact on general health in Latin America. Section I: Introduction part I
Abstract: A high level of general and oral health are invaluable assets, a factor not always considered a basic human right for their better life quality. The mouth is a critical point of contact with the external environment, which is established when we talk, chew, swallow and when food digestion begins. From a perspective of the human condition, the mouth is crucial for the integration of sound, social appearance of the individual, and is one of the fundamental components of overall health. Therefore, not having an adequate level of oral health affects self-esteem, quality of life and people's general well-being. (Sourc...
Source: Brazilian Oral Research - April 10, 2020 Category: Dentistry Source Type: research

Periodontal disease and its impact on general health in Latin America. Section II: Introduction part II
Abstract: The epidemiological data on gingivitis and periodontitis in Latin America are scarce, as the majority of the Latin American studies have analyzed probing depth instead of clinical attachment loss. Reported data have shown high variations in results between different Latin American countries, with the main causes of these differences being the clinical case definition and methodological strategies used. In general, data have revealed that the prevalence of periodontal disease is higher in Latin Americans than in populations in the USA or Europe. Regarding its relations with other diseases and conditions, some Lati...
Source: Brazilian Oral Research - April 10, 2020 Category: Dentistry Source Type: research

Periodontal disease and its impact on general health in Latin America. Section IV: Diagnosis
Abstract: The art of diagnosis is of great importance in the management of any disease. This includes preventive and therapeutic strategies. To make an accurate and effective diagnosis, knowledge about the health-disease process is fundamental. This paper reviews the important aspects for periodontal diagnosis in a contemporary approach, and endeavors to establish challenges for improving periodontal diagnosis, especially in Latin America. Considering that contemporary periodontal diagnosis should be based on knowledge of the etiopathogenesis of periodontal diseases, this paper highlights that the recently proposed classif...
Source: Brazilian Oral Research - April 10, 2020 Category: Dentistry Source Type: research

Periodontal disease and its impact in Latin America
(Source: Brazilian Oral Research)
Source: Brazilian Oral Research - April 10, 2020 Category: Dentistry Source Type: research

Phenotype changes of oral epithelial stem cells after in vitro culture
Abstract The aim of our study was to isolate populations of keratinocyte stem cells based on the expression of cell surface markers and to investigate whether the culture could affect their phenotype. keratinocytes from human oral mucosa were sorted based on the expression of the epithelial stem cell markers p75NTR and CD71. We also examined the co-expression of other epithelial stem markers such as integrins β 1 and α 6 and their stem cell-like proprieties in in vitro assays. Three passages after being sorted by MACS, more than 93% of the p75NTR+ve cells lost the expression of p75NTR, while 5.46% of the p75NTR-...
Source: Brazilian Oral Research - April 6, 2020 Category: Dentistry Source Type: research

Advanced carcinoma of the oropharynx: survival analysis comparing two treatment modalities
The objective of the present study was to evaluate overall and disease-free survival rates of patients with advanced oropharynx squamous cell carcinoma, comparing surgery + radiotherapy with chemotherapy + radiotherapy. Medical records of patients were reviewed. Previously treated tumors were excluded. Clinical, demographic and microscopic information was collected, and p16 staining was performed. Kaplan-Meier survival curves were plotted. Forty-seven cases were included, 41 men and 6 women, having a mean age of 56.3 years. Most patients were smokers (85.1%) and consumed alcohol (74.5%). Patients were stage III (21.3%) or ...
Source: Brazilian Oral Research - April 6, 2020 Category: Dentistry Source Type: research

Systematic review of the effect of probiotics on experimental gingivitis in humans
Abstract: Probiotic therapy is a viable alternative to chlorhexidine, a widely used antiseptic in dentistry that produces significant adverse effects. This systematic review aimed to analyze the effects of probiotics on experimental gingivitis in humans. Two independent reviewers conducted a comprehensive literature search until March 2019. Randomized clinical trials and controlled clinical trials were selected. Outcome data were extracted and critically analyzed. A total of five articles were included in the qualitative synthesis. No meta-analysis could be conducted due to the heterogeneity of the selected studies. The us...
Source: Brazilian Oral Research - March 31, 2020 Category: Dentistry Source Type: research

Upregulation of IL-10 expression inhibits the proliferation of human periodontal ligament stem cells
This study aimed to investigate the involvement of microRNA-466l in periodontitis and to explore the possible interaction between IL-10 and microRNA-466l. PDLSCs were obtained from periodontitis-affected teeth and healthy control teeth. The expression of microRNA-466l and IL-10 mRNA was measured in PDLSCs using RT-qPCR. The proliferation ability of PDLSCs was analyzed using CCK-8 assays. Overexpression of microRNA-466l in a PDLSC cell line was established using two different types of PDLSCs, and the effect of microRNA-466l overexpression on IL-10 expression and cell proliferation were detected by western blot and CCK-8 ass...
Source: Brazilian Oral Research - March 27, 2020 Category: Dentistry Source Type: research

Access to oral healthcare services of adolescents of a large-size municipality in northeastern Brazil
Abstract: The aim of this study was to describe and evaluate access to oral health services among adolescents enrolled in public schools of Campina Grande, Para íba, Brazil, a large-size municipality in the Northeast of Brazil. An observational, descriptive, analytical, quantitative, and cross-sectional study was carried out through a school survey, in which four validated questionnaires were applied to 438 adolescents aged 12 to 19 years. Data were proces sed using the SPSS statistical software version 20.0, with bivariate analysis and multivariate analysis through Poisson regression. About 90.9% of adolescents rep...
Source: Brazilian Oral Research - March 27, 2020 Category: Dentistry Source Type: research

Effect of ethanol-wet bonding on porosity and retention of fiberglass post to root dentin
Abstract: This in vitro study aimed to assess the effects of different pretreatments used to adapt glass-fiber posts cemented to root canals with different resin cements, regarding porosity percentage and bond strength. Twelve bovine incisor roots were prepared with Largo drills. After post space preparation, the specimens were randomized into two types of pretreatment groups (n = 3): water-wet bonding and ethanol-wet bonding. After the post were cemented, the roots were stored in 100% humidity at room temperature for 7 days. The samples were scanned by microcomputed tomography (micro-CT). Images were reconstructed by NRec...
Source: Brazilian Oral Research - March 27, 2020 Category: Dentistry Source Type: research

Psychometric properties of Health Literacy in Dentistry scale in an elderly Brazilian population
In conclusion, HeLD-14 was shown to be a reliable and valid instrument to measure oral health literacy in elderly Brazilian participants. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - March 16, 2020 Category: Dentistry Source Type: research

Association of gender, oral habits, and poor sleep quality with possible sleep bruxism in schoolchildren
Abstract The aim of this study was to verify the oral habits, symptoms, and characteristics of some children aged 8 to 10 years that could be associated with possible sleep bruxism. A cross-sectional study was performed. Questionnaires were sent to parents to obtain information on sex, age, school shift, sleep quality, parents ’ perception of children ’ s behavior, and children ’ s oral habits (nail biting, object biting, and lip biting), and symptoms such as headache or earache. In addition, parents reported the frequency of sleep bruxism (no day to 7 days a week). Descriptive analysis and multinomial lo...
Source: Brazilian Oral Research - March 16, 2020 Category: Dentistry Source Type: research

Hydrofluoric acid concentration, time and use of phosphoric acid on the bond strength of feldspathic ceramics
The objective of this study was to evaluate the influence of hydrofluoric acid (HF) concentration, etching time, and application of phosphoric acid (PA) followed by neutralization with sodium bicarbonate on the bond strength between a feldspar ceramic and resin cement. Thus, 80 blocks (10 x 12 x 2 mm) of glass ceramic (VM - Vita Mark II - Vita Zahnfabrik) were made and randomly assigned to eight groups (n = 10) according to the factors: HF concentration (5 and 10%), etching time (60 and 120 s), and use of phosphoric acid (PA) (with and without). According to the experimental group, 37% PA (Condac, FGM) was applied after HF...
Source: Brazilian Oral Research - March 16, 2020 Category: Dentistry Source Type: research

System dynamics modeling for tooth decay treatment in Brazilian children
Abstract Prevention and health promotion are considered important strategies to control oral diseases. Dental caries is preventable disease and remains the most common chronic disease that affects mainly low income children and still considered the main cause of tooth loss in adulthood in Brazil. The aim of this study is to present a System Dynamics model (SDM) specifically developed with the Stella Architect software to estimate the cost and clinical hours required to control the evolution of dental caries in preschool children in Maring á, Brazil. Two main strategies to control caries were considered in the model:...
Source: Brazilian Oral Research - February 27, 2020 Category: Dentistry Source Type: research

Prevalence of horizontal alveolar changes in edentulous patients: a retrospective tomographic study
Abstract Horizontal bone loss after tooth extraction is a common finding that demands bone reconstruction in various cases. The aim of this study was to assess the horizontal alveolar status in partially and completely edentulous patients using cone-beam computed tomography (CBCT). In total, 1516 CBCT scans of 1404 adult patients were analyzed. Assessment of the images was performed in accordance with the previously published horizontal alveolar change (HAC) classification, which categorizes horizontal bone defects into four classes: HAC 1, HAC 2, HAC 3 and HAC 4 (from the least severe to the most severe condition). Analys...
Source: Brazilian Oral Research - February 27, 2020 Category: Dentistry Source Type: research

Characteristics of neutrophil extracellular traps in patients with periodontitis and gingivitis
Abstract We sought to compare the characteristics and clinical significance of neutrophil extracellular traps in gingival samples from patients with periodontitis and those with gingivitis. The clinical indexes of gingival samples from patients with periodontitis and gingivitis were measured; the expression of TNF-alpha and IL-8 was measured by real-time fluorescent quantitative PCR; and the expression of TLR-8 and MMP-9 was measured by western blotting assays. Chemotaxis, phagocytosis and phagocytic activity of neutrophils were measured. Compared with the healthy group, the expression of TNF- α and IL-8 in the perio...
Source: Brazilian Oral Research - February 27, 2020 Category: Dentistry Source Type: research

Impact of teleconsultations on the conduct of oral health teams in the Telehealth Brazil Networks Programme
Abstract Telehealth has been applied in the Unified Health System (SUS) as a tool for qualifying professionals and improving the healthcare provided to the population served by the system. The aim of the present study was to evaluate the impact of teleconsultations on the qualifications of the clinical approach of the oral health teams involved in primary health care (PHC) in the state of Rio Grande do Sul under the Telehealth Brazil Networks Programme. The sample population of the study was composed of 285 dentists and 132 oral health assistants belonging to the Family Health Teams. A chi-square test was used to investiga...
Source: Brazilian Oral Research - February 27, 2020 Category: Dentistry Source Type: research

Impact of history of periodontitis on gene expression of bone-related factors in young patients
Abstract Although dental implants and bone regenerative procedures are important approaches for the reestablishment of esthetics and function in young patients with a history of generalized aggressive periodontitis (GAP), no predictable outcomes have been reported, and the host osteo-immunoinflammatory response may play a relevant role in this context. In view of the lack of molecular investigations into the bone tissue condition of young patients with periodontitis, the aim of this study was to evaluate the gene expression of bone-related factors in this population. Bone biopsies were obtained from the posterior mandible ...
Source: Brazilian Oral Research - February 18, 2020 Category: Dentistry Source Type: research

Effect of ScLL and 15d-PGJ2 on viability and cytokine release in LPS-stimulated fibroblasts: an in vitro study
This study evaluated the effect of a cyclopentenone-type PG, 15-Deoxy- Δ 12,14-PG J2 (15d-PGJ2), and lectin (ScLL) on the viability of human gingival fibroblasts (HGFs), and on IL-6 and TGF β -1 release by these fibroblasts, stimulated with lipopolysaccharide (LPS). HGFs were stimulated with LPS 10 μ g/ml and treated with 15d-PGJ2 1 and 2 μ g/ml, and ScLL 2 and 5 μ g/ml, for 1 and 3h, and then evaluated for viability by MTT assay. Supernatant was collected to detect IL-6 and TGF β -1 release, by ELISA. Positive control was cells kept in Dulbecco ’ s Modified Eagle ’ s Medium, and negati...
Source: Brazilian Oral Research - February 18, 2020 Category: Dentistry Source Type: research

Erratum: Does low-cost GIC have the same survival rate as high-viscosity GIC in atraumatic restorative treatments? A RCT. Braz Oral Res. 2019;33:e125.
In this study, we used Pam2CSK4 (PAM2), a synthetic molecule that mimics bacterial lipoprotein, to investigate the effects of lipoproteins on periodontitis in mice. C57BL/6 male mice were randomly divided into three experimental groups: 1) Negative control group: animals received vehicle injection; 2) Positive control group: animals received injection of Escherichia coli lipopolysaccharide (LPS); 3) PAM2 group: animals received PAM2 injection. All the injections were performed bilaterally every other day into the palatal mucosa between first and second molars. After twenty-four days, the animals were euthanized to assess a...
Source: Brazilian Oral Research - February 10, 2020 Category: Dentistry Source Type: research

Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice
In this study, we used Pam2CSK4 (PAM2), a synthetic molecule that mimics bacterial lipoprotein, to investigate the effects of lipoproteins on periodontitis in mice. C57BL/6 male mice were randomly divided into three experimental groups: 1) Negative control group: animals received vehicle injection; 2) Positive control group: animals received injection of Escherichia coli lipopolysaccharide (LPS); 3) PAM2 group: animals received PAM2 injection. All the injections were performed bilaterally every other day into the palatal mucosa between first and second molars. After twenty-four days, the animals were euthanized to assess a...
Source: Brazilian Oral Research - February 10, 2020 Category: Dentistry Source Type: research

Expression profile of salivary micro RNA-21 and 31 in oral potentially malignant disorders
Abstract Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36 healthy participants as controls and in 36 patients who were newly diagnosed as OPMD having four different lesions including leucoplakia, oral sub mucous fibrosis (OSMF) 궱 , oral lichen planus, and (OSMF) 궱 with leucoplakia. The samples were also classified as non-dysplastic, or with mild, moderate, and severe dysplasia according to their hist...
Source: Brazilian Oral Research - February 10, 2020 Category: Dentistry Source Type: research

Dental caries experience and associated factors in 12-year-old-children: a population based-study
This study aimed to assess the dental caries experience and associated factors among 12-year-old children in the state of S ão Paulo, Brazil. A cross-sectional population-based study was conducted with data obtained from 415 cities, including a total of 26,325 schoolchildren who were included by the double-stage cluster technique, by lot and by systematic sampling. The statistical model included data from the São Paulo Oral Health Survey (SBSP 2015), the Human Development Index (HDI) and the Social Vulnerability Index (SVI). A theoretical-conceptual model categorized the variables into three blocks, namely, c...
Source: Brazilian Oral Research - February 7, 2020 Category: Dentistry Source Type: research

Effect of the sense of coherence and associated factors in the quality of life of head and neck cancer patients
Abstract The sense of coherence (SOC) is a measure of global orientation regarding the ability of individuals to cope with stressful situations. The aim of the present study was to evaluate the association between SOC and quality of life (QoL) and clinical and sociodemographic characteristics among survivors of oral, oropharynx, hypopharynx, or larynx cancer. A cross-sectional study was conducted with 90 cancer patients in follow up at the Santa Maria University Hospital in southern Brazil who had completed conformal 3D radiotherapy at least three months earlier. QoL was assessed using the University of Washington Quality ...
Source: Brazilian Oral Research - February 7, 2020 Category: Dentistry Source Type: research

Effects of restraint stress and high-fat diet on osseointegration of titanium implants: an experimental study
This study aimed to investigate the effects of chronic restraint stress (RS) and a high-fat diet (HFD) on the osseointegration of titanium implants in a rat model. After the surgical insertion of titanium implants into the metaphysis of the tibial bone, the rats were randomly divided into four equal groups (n = 8 each): control (CNT), restraint stress (RS), high-fat diet (HFD), and restraint stress plus high fat diet (RS-HFD). CNT: Rats received no further treatment during the 92-day experimental period. RS: Stress was applied to the rats beginning from two days after the implant surgery for one hour per day for the first ...
Source: Brazilian Oral Research - February 7, 2020 Category: Dentistry Source Type: research

Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes
Abstract The aim of this study was to assess the influence of cyclosporine administration on the repair of critical-sized calvaria defects (CSDs) in rat calvaria filled with diverse biomaterials. Sixty animals were divided into two groups: the control (CTR) group (saline solution) and the cyclosporine (CCP) group (cyclosporine, 10 mg/kg/day). These medications were administered daily by gavage, beginning 15 days before the surgical procedure and lasting until the day the animals were euthanized. A CSD (5 mm Ø) was made in the calvaria of each animal, which was allocated to one of 3 subgroups, according to the biomat...
Source: Brazilian Oral Research - February 7, 2020 Category: Dentistry Source Type: research

Smad1/5 signal transduction regulates the ameloblastic differentiation of induced pluripotent stem cells
Abstract Induced pluripotent stem (iPS) cells could be induced into ameloblast-like cells by ameloblasts serum-free conditioned medium (ASF-CM), and bone morphogenetic proteins (BMPs) might be essential during the regulation of this process. The present study investigates the signal transduction that regulates the ameloblastic differentiation of iPS cells induced by ASF-CM. Mouse iPS cells were characterized and then cultured for 14 days in epithelial cell medium (control) or ASF-CM. Bone morphogenetic protein receptor II (BMPR-II) siRNA, inhibitor of Smad1/5 phosphorylation activated by activin receptor-like kinase (ALK) ...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research

The effect of ionizing radiation on properties of fluoride-releasing restorative materials
Abstract The purpose of this study was to evaluate the effect of ionizing radiation from high energy X-ray on fluoride release, surface roughness, flexural strength, and surface chemical composition of the materials. The study groups comprised five different restorative materials: Beautifil II, GCP Glass Fill, Amalgomer CR, Zirconomer, and Fuji IX GP. Twenty disk-shaped specimens (8x2 mm) for fluoride release and 20 bar-shaped specimens (25 x 2x 2 mm) for flexural strength were prepared from each material. Each material group was divided into two subgroups: irradiated (IR) and non-irradiated (Non-IR). The specimens from IR...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research

Microstructural and mechanical analysis of two CAD-CAM lithium disilicate glass-reinforced ceramics
Abstract The aim of this study was to analyze the structural, morphological and mechanical properties of two different lithium disilicate glass-reinforced ceramics for CAD-CAM systems (IPS e.max CAD and Rosetta SM). Five methodologies were used for both ceramics: microstructure (n = 2) was analyzed using x-ray diffraction (XRD); morphological properties (n = 2) were analyzed by scanning electron microscopy (SEM), with and without hydrofluoric etching; porosity (n = 3) was assessed using 3D micro-computed tomography (micro-CT); flexural strength was measured (n =1 0) using the three-point bending test; and bond strength was...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research

Esthetic perception of facial profile changes after extraction and nonextraction Class II treatment
Abstract This retrospective study evaluated facial profile pleasantness determined by two protocols of Class II treatment. The sample comprised facial profile silhouettes obtained retrospectively from the pretreatment (T1) and posttreatment (T2) cephalograms of 60 patients (42 males and 18 females) divided into two groups. One group of 30 patients (mean age of 12.84 years) was treated with the extraction of maxillary first premolars (mean treatment time of 2.7 years), and the other group of 30 patients (mean age of 12.81 years) was treated with a mandibular advancement appliance (Forsus) (mean treatment time of 2.49 years)...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research

Adhesive resistance of a copaiba oil-based dentin biomodifier
This study analyzed the effect of prior application of copaiba oil (CO) emulsions as a dentin cleaning substance on microleakage and microtensile adhesive strength. Twenty-five premolars and sixty-four molars were used for microleakage and microtensile assays. For the microleakage assays, specimens with standard class V cavities were divided (n = 5), according to the tested CO emulsions: CO10%X, CO10%Y, and CO10%Z, as well as chlorhexidine 2% (CHX) and distilled water (DW), as positive and negative controls, respectively. Restorations were performed using the Adper Single Bond ® and/or Clearfil SE Bond® systems. Ce...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research

Does the implant-abutment interface interfere on marginal bone loss? A systematic review and meta-analysis
The objective of this systematic review was to compare the conical internal connection (IC) with the external hexagonal connection (EH) on the occurrence of marginal bone loss ( Δ MBL). Different databases were used to carry out the selection of the elected studies. The studies were judged according to the risk of bias as “ high ” , “ low ” and “ unclear ” risk. For the meta-analysis we included only studies that could extract the data of Δ MBL, survival rate (SR) and probing depth (PD). No statistically significant differences were found for Δ MBL data at one, three- a...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

The impact of maintenance on peri-implant health
Abstract Most of the literature evaluating dental implants focuses on implant survival, which is a limited proxy for the successful rehabilitation of patients with missing teeth. Success should include not only survival but also lack of mechanical, biological, and esthetics problems. A comprehensive review of local and systemic risk factors prior to implant placement will allow the tailoring of treatment planning and maintenance protocols to the patient ’ s profile in order to achieve longitudinal success of the therapy. This review discusses the role of controlling different risk factors and prevention/treatment of ...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Treatment of peri-implant soft tissue defects: a narrative review
Abstract Soft tissue defects around dental implants, such as papilla or volume loss, peri-implant recession and alterations of the ridge color and/or texture, lead to esthetic and functional complaints. Treatments of these defects in implants are more demanding than in teeth because peri-implant tissue exhibits different anatomical and histological characteristics. This narrative review discusses the proposed treatments for soft tissue defects around implants in the current literature. Several clinical and pre-clinical studies addressed methods to augment the quantity of the peri-implant keratinized mucosa. Autogenous graf...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

New strategies and developments for peri-implant disease
We present novel treatment for infection control and biological rationale of additional use of guided bone regeneration, with an illustrative explanation of the treatments presented with two cases. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Implant-based factor as possible risk for peri-implantitis
In conclusion, further evidences are required to a better understanding of the influence of implant-based factors in the occurrence of peri-implantitis. Large population-based studies including concomitant analyses of implant- and patient-based factors are required to provide strong evidence of a possible association with peri-implantitis in a higher probability. The identification of these factors is essential for the establishment of strategies to prevent peri-implantitis. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Host response and peri-implantitis
Abstract Considering the absence of predictable and effective therapeutic interventions for the treatment of peri-implantitis, scientific evidence concerning the host response profile around dental implants could be important for providing in the future a wider preventive and/or therapeutic window for this peri-implant lesion, indicating biomarkers that provide quantifiable measure of response to peri-implant therapy. Moreover, a better knowledge of pattern of host osteo-immunoinflammatory modulation in the presence of peri-implantitis could either benefit the early diagnostic of the disease or to cooperate to prognostic i...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

An umbrella review on the effects of diabetes on implant failure and peri-implant diseases
Abstract The aim of this review is to summarize the evidence on associations between diabetes mellitus (DM) and complications around dental implants. Electronic database searches of MEDLINE, EMBASE, JBI Database of Systematic Reviews and Implementation Reports, Cochrane Database of Systematic Reviews and the PROSPERO register were performed from 1990 up to and including May 2018, using MeSH terms and other keywords. Systematic reviews and meta-analyses investigating the associations of DM and implant complications (failure, survival, bone loss, peri-implant diseases, and post-surgery infection) were eligible. The quality o...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Does traumatic occlusal forces lead to peri-implant bone loss? A systematic review
Abstract Observational studies have indicated that crestal bone level changes at implants are typically associated with clinical signs of inflammation, but still mechanical overload has been described as possible factor leading to hard – tissue deficiencies at implant sites without mucosal inflammation. The aim of this paper was systematically review the literature regarding the possible effect of traumatic occlusal forces on the peri-implant bone levels. Literature search was conducted using PubMed, Scielo and Lilacs, including the following terms: oral OR dental AND implant$ AND (load OR overload OR excessive load ...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Prevalence of peri-implant diseases – a critical review on the current evidence
In conclusion, it can be stated that a wide range for reporting the prevalence of peri-implantitis can be found and no real estimation of the global burden of the disease can be made. Applying accurate case definitions for peri-implantitis is the most important factor for reporting the prevalence and should be strictly followed in future reports. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Microbiological and clinical effects of adjunctive systemic metronidazole and amoxicillin in the non-surgical treatment of peri-implantitis: 1 year follow-up
Abstract The aim of this study was to evaluate the effects of adjunct systemic antibiotic treatment with metronidazole (MTZ) and amoxicillin (AMX) in patients receiving non-surgical subgingival debridement (NSD) for peri-implantitis. Forty subjects presenting with at least one implant with severe peri-implantitis were randomized into an experimental group [treated with NSD plus MTZ (400 mg) and AMX (500 mg) three times a day for 14 days] and a control group treated with NSD plus placebo. Clinical parameters and submucosal biofilm profiles were evaluated up to 1 year post-treatment. Overall, both treatments improved clinica...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

A prospective case series on surgical treatment of circumferential and semi-circumferential defects due to peri-implantitis
Abstract Different surgical treatment strategies for peri-implantitis with the use of graft material and membranes have been suggested without any longitudinal remarkable success rate. The present preliminary study was aimed to analyze a new clinical approach based on the disinfection of the implant connection, the disinfection of the implant surface and GBR approach in the treatment of circumferential and semi-circumferential bony defect resulting from peri-implantitis. Six consecutive patients were selected for the present study. After removal of factors that could potentially influence peri-implant pathology, the prosth...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Additive manufacturing of titanium alloy could modify the pathogenic microbial profile: an in vitro study
Abstract Additive manufacturing (AM) is an emerging process for biomaterials and medical devices. Direct Laser Metal Sintering (DLMS) is an AM technique used to fabricate Ti – 6Al – 4V implant materials with enhanced surface-related properties compared with wrought samples; thus, this technique could influence microbial adsorption and colonization. Therefore, this in vitro study was conducted to evaluate the impact of different implant production processes on microbial adhesion of periodontal pathogens. Titanium discs produced using two different processes — conventional and AM — were divided into t...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Does subgingival bacterial colonization differ between implants and teeth? A systematic review
Abstract The aim was of this study was to determine the current weight of evidence for the existence of specific differences between the microbiota of healthy teeth and healthy implants, or of teeth with periodontitis and implants with peri-implantitis. A systematic review was conducted according to the PRISMA statement. The MEDLINE, EMBASE and Cochrane databases were searched up to February 2018 for studies comparing microbiological data of biofilm samples collected from healthy teeth and implants or from teeth with periodontitis and implants with peri-implantitis. The weight of evidence was defined in three categories (s...
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Peri-implantitis as a “burden” disease
(Source: Brazilian Oral Research)
Source: Brazilian Oral Research - October 1, 2019 Category: Dentistry Source Type: research

Comparison of apical periodontitis repair in endodontic treatment with calcium hydroxide-dressing and aPDT
This study evaluated the effect of antimicrobial photodynamic therapy (aPDT) on the endodontic treatment of apical periodontitis (AP). AP was induced in 48 premolars of 6 dogs. After biomechanical preparation, the teeth were divided into 4 groups: Calcium-Hydroxide (CH)/120d and CH/180d: root canals filled with CH-based dressing for 15 days before obturation; aPDT/120d and aPDT/180d: conditioning with phenothiazine photosensitizer (10 mg/mL) for 1 minute and irradiation with diode laser in the same session as obturation. Root filling was performed with AH Plus sealer. After the experimental periods, animals were euthanized...
Source: Brazilian Oral Research - September 26, 2019 Category: Dentistry Source Type: research

Impact of smoking on gingival inflammation in representative samples of three South American cities
In conclusion, the occurrence of clinically detectable gingival inflammation was lower in heavy smokers than light and moderate smokers. Older age, diabetes, and visible plaque emerged as risk indicators of gingivitis. Plaque and gingival indices are significantly associated regardless of the smoking status. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - September 17, 2019 Category: Dentistry Source Type: research