Brazilian Journal of Medical and Biological Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Periodontitis and osteoporosis: a two-sample Mendelian randomization analysis
Braz J Med Biol Res. 2024 Mar 18;57:e12951. doi: 10.1590/1414-431X2024e12951. eCollection 2024.ABSTRACTThe incidences of periodontitis and osteoporosis are rising worldwide. Observational studies have shown that periodontitis is associated with increased risk of osteoporosis. We performed a Mendelian randomization (MR) study to genetically investigate the causality of periodontitis on osteoporosis. We explored the causal effect of periodontitis on osteoporosis by MR analysis. A total of 9 single nucleotide polymorphisms (SNP) were related to periodontitis. The primary approach in this MR analysis was the inverse variance-w...
Source: Brazilian Journal of Medical and Biological Research - March 21, 2024 Category: Research Authors: Jiale Wu Lihui Yao Yuchen Liu ShuaiShuai Zhang Kan Wang Source Type: research

Temporal evolution of postsurgical bone repair in a rabbit model: A [99mTc]Tc-MDP scintigraphic study
This study used bone scintigraphy to evaluate osteogenesis secondary to osteotomy in a preclinical model of New Zealand rabbits. For this purpose, we conducted a longitudinal, prospective, case-control study in which scintigraphic variables were measured in both the right forearm (case-operated) and the left forearm (control - non-operated). The study sample consisted of 10 rabbits subjected to osteotomy, followed by a 12-week postoperative evaluation period, divided into six imaging stages at 1, 2, 3, 4, 8, and 12 weeks. We observed that the operated forearm showed significantly higher external radiation than the control ...
Source: Brazilian Journal of Medical and Biological Research - March 21, 2024 Category: Research Authors: A Yoneda K J C C de Lacerda L Alexandre-Santos E N Itikawa P Louzada-Junior L Wichert-Ana Source Type: research

Serum autophagy-related gene 5 level in stroke patients: correlation with CD4+ T cells and cognition impairment during a 3-year follow-up
This study aimed to explore the correlation of serum ATG5 with CD4+ T cells and cognition impairment in stroke patients. Peripheral blood was collected from 180 stroke patients for serum ATG5 and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cell detection via enzyme-linked immunosorbent assays and flow cytometry. The Mini-Mental State Examination (MMSE) scale was completed at enrollment, year (Y)1, Y2, and Y3 in stroke patients. Serum ATG5 was also measured in 50 healthy controls (HCs). Serum ATG5 was elevated in stroke patients compared to HCs (P<0.001) and was positively correlated to Th2 cells (P=0.022), Th17 ...
Source: Brazilian Journal of Medical and Biological Research - March 21, 2024 Category: Research Authors: Juanjuan Qu Linxia Wu Meng Zhang Minchen Kan Huimin Chen Yanqing Shi Shuangyu Wang Xiaohua Wang Fan Chen Source Type: research

Upregulation of PGC-1 α expression by pioglitazone mediates prevention of sepsis-induced acute lung injury
This study aimed to investigate the role of the PGC-1α agonist pioglitazone (PGZ) in modulating sepsis-induced ALI. A mouse model of sepsis-induced ALI was established using cecal ligation and puncture (CLP). An in vitro model was created by stimulating MH-S cells with lipopolysaccharide (LPS). qRT-PCR was used to measure mRNA levels of M1 markers iNOS and MHC-II and M2 markers Arg1 and CD206 to evaluate macrophage polarization. Western blotting detected expression of peroxisome proliferator-activated receptor gamma (PPARγ) PGC-1α, and mitochondrial biogenesis proteins NRF1, NRF2, and mtTFA. To assess mitochondrial cont...
Source: Brazilian Journal of Medical and Biological Research - March 21, 2024 Category: Research Authors: Jing Tang Wenzhu Dong Dan Wang Qin Deng Honggang Guo Guibao Xiao Source Type: research

Silencing of matrix metalloprotease-12 delays the progression of castration-resistant prostate cancer by regulating autophagy and lipolysis
In this study, we observed the effect of MMP-12 on the progression of CRPC and further explored its potential mechanism of action. High levels of MMP-12 were observed in patients with CRPC. We therefore developed cell co-culture and mouse models to study the function of MMP-12. Silencing MMP-12 in CRPC cells disrupted lipid utilization and autophagy marker expression via the CD36/CPT1 and P62/LC3 pathways, respectively, leading to reduced CRPC cell migration and invasion. Moreover, animal experiments confirmed that MMP-12-knockdown CRPC xenograft tumors exhibited reduced tumor growth, and the mechanisms involved the promot...
Source: Brazilian Journal of Medical and Biological Research - March 21, 2024 Category: Research Authors: Xiaoyu Zheng Xiaoqin Xie Wei Wang Liang Wang Bing Tan Source Type: research

Stimulation of mouse hematopoietic stem cells by angiogenin and DNA preparations
Braz J Med Biol Res. 2024 Mar 4;57:e13072. doi: 10.1590/1414-431X2024e13072. eCollection 2024.ABSTRACTImmature hematopoietic progenitors are a constant source for renewal of hemocyte populations and the basic component of the tissue and cell repair apparatus. A unique property of these cells of internalizing extracellular double-stranded DNA has been previously shown. The leukostimulatory effect demonstrated in our pioneering studies was considered to be due to the feature of this cell. In the present research, we have analyzed the effects of DNA genome reconstructor preparation (DNAgr), DNAmix, and human recombinant angio...
Source: Brazilian Journal of Medical and Biological Research - March 7, 2024 Category: Research Authors: E A Potter E V Dolgova A S Proskurina V S Ruzanova Y R Efremov S S Kirikovich S G Oshikhmina A L Mamaev O S Taranov A S Bryukhovetskiy L U Grivtsova N A Kolchanov A A Ostanin E R Chernykh S S Bogachev Source Type: research

Wearable near-infrared spectroscopy: reliability and sensitivity among different endurance cycling exercise intensities
Braz J Med Biol Res. 2024 Mar 4;57:e13102. doi: 10.1590/1414-431X2024e13102. eCollection 2024.ABSTRACTThe present study investigated the reliability and sensitivity of a wearable near-infrared spectroscopy (wNIRS) device in moderate and heavy exercise intensity domains. On three separate days, eleven males performed an incremental test to exhaustion, and in the following visits, four submaximal constant-load bouts (i.e., test and retest) were performed in the moderate-intensity domain (100 and 130 W) and heavy-intensity domain (160 and 190 W). The local tissue oxygen saturation index (SmO2) and pulmonary oxygen uptake (V̇...
Source: Brazilian Journal of Medical and Biological Research - March 7, 2024 Category: Research Authors: J S Hasegawa R A Azevedo A C Silveira A E Lima-Silva R Bertuzzi Source Type: research

Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and myocardial ischemia responses of patients with HFpEF or HFmrEF
Braz J Med Biol Res. 2024 Mar 4;57:e13174. doi: 10.1590/1414-431X2024e13174. eCollection 2024.ABSTRACTThere's limited evidence of the potential benefits of cardiopulmonary and metabolic rehabilitation (CPMR) in patients with heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) and coronary artery disease (CAD). The aim of this study was to investigate the impact of CPMR on the myocardial ischemia response (MIR), exercise-induced arrhythmias (EIA), New York Heart Association (NYHA) functional class, heart rate recovery (HRR), Borg CR10 perceived symptoms, and the SF-36 physical...
Source: Brazilian Journal of Medical and Biological Research - March 7, 2024 Category: Research Authors: C A C Hossri F C Araujo B G Baldi R Otterstetter V R Uemoto C R R Carvalho L E Mastrocola A L P Albuquerque Source Type: research

Phospholipase D regulates ferroptosis signal transduction in mouse spleen hypoxia response
This study aimed to establish a hypoxia animal model. Combined transcriptomic and proteomic analyses showed that 95 predicted target genes (proteins) were significantly differentially expressed under hypoxic conditions. Key genes in phospholipase D and ferroptosis pathways under hypoxic exposure were identified by combining Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis techniques. Gene set enrichment analysis (GSEA) showed that the differential gene sets of the phospholipase D and ferroptosis signaling pathways were upregulated in the high-altitude hypoxia group. The genes in the...
Source: Brazilian Journal of Medical and Biological Research - March 7, 2024 Category: Research Authors: Jiayang Wang Ying Hu Yuzhen Xu Qifu Long Cunlin Gu Chaoqun Tang Ru Wang Sheng Yong Source Type: research