Should one go for individual- or group-level brain parcellations? A deep-phenotyping benchmark
Brain Struct Funct. 2023 Nov 27. doi: 10.1007/s00429-023-02723-x. Online ahead of print.ABSTRACTThe analysis and understanding of brain characteristics often require considering region-level information rather than voxel-sampled data. Subject-specific parcellations have been put forward in recent years, as they can adapt to individual brain organization and thus offer more accurate individual summaries than standard atlases. However, the price to pay for adaptability is the lack of group-level consistency of the data representation. Here, we investigate whether the good representations brought by individualized models are ...
Source: Brain Structure and Function - November 27, 2023 Category: Neuroscience Authors: Bertrand Thirion Himanshu Aggarwal Ana Fernanda Ponce Ana Lu ísa Pinho Alexis Thual Source Type: research
Should one go for individual- or group-level brain parcellations? A deep-phenotyping benchmark
Brain Struct Funct. 2023 Nov 27. doi: 10.1007/s00429-023-02723-x. Online ahead of print.ABSTRACTThe analysis and understanding of brain characteristics often require considering region-level information rather than voxel-sampled data. Subject-specific parcellations have been put forward in recent years, as they can adapt to individual brain organization and thus offer more accurate individual summaries than standard atlases. However, the price to pay for adaptability is the lack of group-level consistency of the data representation. Here, we investigate whether the good representations brought by individualized models are ...
Source: Brain Structure and Function - November 27, 2023 Category: Neuroscience Authors: Bertrand Thirion Himanshu Aggarwal Ana Fernanda Ponce Ana Lu ísa Pinho Alexis Thual Source Type: research
Should one go for individual- or group-level brain parcellations? A deep-phenotyping benchmark
Brain Struct Funct. 2023 Nov 27. doi: 10.1007/s00429-023-02723-x. Online ahead of print.ABSTRACTThe analysis and understanding of brain characteristics often require considering region-level information rather than voxel-sampled data. Subject-specific parcellations have been put forward in recent years, as they can adapt to individual brain organization and thus offer more accurate individual summaries than standard atlases. However, the price to pay for adaptability is the lack of group-level consistency of the data representation. Here, we investigate whether the good representations brought by individualized models are ...
Source: Brain Structure and Function - November 27, 2023 Category: Neuroscience Authors: Bertrand Thirion Himanshu Aggarwal Ana Fernanda Ponce Ana Lu ísa Pinho Alexis Thual Source Type: research
Selective vulnerability of motor neuron types and functional groups to degeneration in amyotrophic lateral sclerosis: review of the neurobiological mechanisms and functional correlates
Brain Struct Funct. 2023 Nov 24. doi: 10.1007/s00429-023-02728-6. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterised by a progressive loss of motor neurons controlling voluntary muscle activity. The disease manifests through a variety of motor dysfunctions related to the extent of damage and loss of neurons at different anatomical locations. Despite extensive research, it remains unclear why some motor neurons are especially susceptible to the disease, while others are affected less or even spared. In this article, we review the neurobiological mechanisms,...
Source: Brain Structure and Function - November 24, 2023 Category: Neuroscience Authors: Saak V Ovsepian Valerie B O'Leary Salvador Martinez Source Type: research
Selective vulnerability of motor neuron types and functional groups to degeneration in amyotrophic lateral sclerosis: review of the neurobiological mechanisms and functional correlates
Brain Struct Funct. 2023 Nov 24. doi: 10.1007/s00429-023-02728-6. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterised by a progressive loss of motor neurons controlling voluntary muscle activity. The disease manifests through a variety of motor dysfunctions related to the extent of damage and loss of neurons at different anatomical locations. Despite extensive research, it remains unclear why some motor neurons are especially susceptible to the disease, while others are affected less or even spared. In this article, we review the neurobiological mechanisms,...
Source: Brain Structure and Function - November 24, 2023 Category: Neuroscience Authors: Saak V Ovsepian Valerie B O'Leary Salvador Martinez Source Type: research
Selective vulnerability of motor neuron types and functional groups to degeneration in amyotrophic lateral sclerosis: review of the neurobiological mechanisms and functional correlates
Brain Struct Funct. 2023 Nov 24. doi: 10.1007/s00429-023-02728-6. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterised by a progressive loss of motor neurons controlling voluntary muscle activity. The disease manifests through a variety of motor dysfunctions related to the extent of damage and loss of neurons at different anatomical locations. Despite extensive research, it remains unclear why some motor neurons are especially susceptible to the disease, while others are affected less or even spared. In this article, we review the neurobiological mechanisms,...
Source: Brain Structure and Function - November 24, 2023 Category: Neuroscience Authors: Saak V Ovsepian Valerie B O'Leary Salvador Martinez Source Type: research
Childhood development of brain white matter myelin: a longitudinal T1w/T2w-ratio study
Brain Struct Funct. 2023 Nov 20. doi: 10.1007/s00429-023-02718-8. Online ahead of print.ABSTRACTMyelination of human brain white matter (WM) continues into adulthood following birth, facilitating connection within and between brain networks. In vivo MRI studies using diffusion weighted imaging (DWI) suggest microstructural properties of brain WM increase over childhood and adolescence. Although DWI metrics, such as fractional anisotropy (FA), could reflect axonal myelination, they are not specific to myelin and could also represent other elements of WM microstructure, for example, fibre architecture, axon diameter and cell...
Source: Brain Structure and Function - November 20, 2023 Category: Neuroscience Authors: Lillian M Dipnall Joseph Y M Yang Jian Chen Ian Fuelscher Jeffrey M Craig Timothy J Silk Source Type: research
Childhood development of brain white matter myelin: a longitudinal T1w/T2w-ratio study
Brain Struct Funct. 2023 Nov 20. doi: 10.1007/s00429-023-02718-8. Online ahead of print.ABSTRACTMyelination of human brain white matter (WM) continues into adulthood following birth, facilitating connection within and between brain networks. In vivo MRI studies using diffusion weighted imaging (DWI) suggest microstructural properties of brain WM increase over childhood and adolescence. Although DWI metrics, such as fractional anisotropy (FA), could reflect axonal myelination, they are not specific to myelin and could also represent other elements of WM microstructure, for example, fibre architecture, axon diameter and cell...
Source: Brain Structure and Function - November 20, 2023 Category: Neuroscience Authors: Lillian M Dipnall Joseph Y M Yang Jian Chen Ian Fuelscher Jeffrey M Craig Timothy J Silk Source Type: research
Childhood development of brain white matter myelin: a longitudinal T1w/T2w-ratio study
Brain Struct Funct. 2023 Nov 20. doi: 10.1007/s00429-023-02718-8. Online ahead of print.ABSTRACTMyelination of human brain white matter (WM) continues into adulthood following birth, facilitating connection within and between brain networks. In vivo MRI studies using diffusion weighted imaging (DWI) suggest microstructural properties of brain WM increase over childhood and adolescence. Although DWI metrics, such as fractional anisotropy (FA), could reflect axonal myelination, they are not specific to myelin and could also represent other elements of WM microstructure, for example, fibre architecture, axon diameter and cell...
Source: Brain Structure and Function - November 20, 2023 Category: Neuroscience Authors: Lillian M Dipnall Joseph Y M Yang Jian Chen Ian Fuelscher Jeffrey M Craig Timothy J Silk Source Type: research
Childhood development of brain white matter myelin: a longitudinal T1w/T2w-ratio study
Brain Struct Funct. 2023 Nov 20. doi: 10.1007/s00429-023-02718-8. Online ahead of print.ABSTRACTMyelination of human brain white matter (WM) continues into adulthood following birth, facilitating connection within and between brain networks. In vivo MRI studies using diffusion weighted imaging (DWI) suggest microstructural properties of brain WM increase over childhood and adolescence. Although DWI metrics, such as fractional anisotropy (FA), could reflect axonal myelination, they are not specific to myelin and could also represent other elements of WM microstructure, for example, fibre architecture, axon diameter and cell...
Source: Brain Structure and Function - November 20, 2023 Category: Neuroscience Authors: Lillian M Dipnall Joseph Y M Yang Jian Chen Ian Fuelscher Jeffrey M Craig Timothy J Silk Source Type: research
Altered functional brain networks in coronary heart disease: independent component analysis and graph theoretical analysis
This study aimed to explore the association of CHD with functional connectivity and topological properties of brain networks. A total of 27 patients with CHD and 44 healthy controls (HCs) participated in this study and underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Intra- and internetwork functional connectivity alterations were explored using independent component analysis in CHD patients. Furthermore, graph theoretical analysis was adopted to assess abnormalities in small-world properties and network efficiency metrics of brain networks. Compared to HCs, CHD patients exhibited increased f...
Source: Brain Structure and Function - November 9, 2023 Category: Neuroscience Authors: Simin Lin Puyeh Wu Shaoyin Duan Qianni Du Shujia Guo Zhishang Chen Naiming Wu Xiaoyan Chen Ting Xie Yi Han Hengyu Zhao Source Type: research
Neonatal olfactory bulbectomy causes dendritic spine retraction in dorsal hippocampal CA3 neurons in female rats and spatial learning deficits in male rats
The objective of the present study was to evaluate learning and memory capacity and dendritic spine density in dorsal hippocampal CA3 neurons. Seven-day-old male and female Wistar rats were subjected to nOBX by suction, we included an intact group as a control (CON) and a sham-operated group (SHAM), too. Spatial learning and memory were measured at 56 days of age using a Morris water maze. A different cohort of experimental groups was used to measure dendritic spine density by Golgi-Cox impregnation. Male rats with nOBX showed a pronounced spatial learning deficit than female rats. Also, there was a significant decrease in...
Source: Brain Structure and Function - November 9, 2023 Category: Neuroscience Authors: H éctor De La Luz Torres Paola Rojas P érez Adriana Berenice Silva G ómez Source Type: research
Altered functional brain networks in coronary heart disease: independent component analysis and graph theoretical analysis
This study aimed to explore the association of CHD with functional connectivity and topological properties of brain networks. A total of 27 patients with CHD and 44 healthy controls (HCs) participated in this study and underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Intra- and internetwork functional connectivity alterations were explored using independent component analysis in CHD patients. Furthermore, graph theoretical analysis was adopted to assess abnormalities in small-world properties and network efficiency metrics of brain networks. Compared to HCs, CHD patients exhibited increased f...
Source: Brain Structure and Function - November 9, 2023 Category: Neuroscience Authors: Simin Lin Puyeh Wu Shaoyin Duan Qianni Du Shujia Guo Zhishang Chen Naiming Wu Xiaoyan Chen Ting Xie Yi Han Hengyu Zhao Source Type: research
Neonatal olfactory bulbectomy causes dendritic spine retraction in dorsal hippocampal CA3 neurons in female rats and spatial learning deficits in male rats
The objective of the present study was to evaluate learning and memory capacity and dendritic spine density in dorsal hippocampal CA3 neurons. Seven-day-old male and female Wistar rats were subjected to nOBX by suction, we included an intact group as a control (CON) and a sham-operated group (SHAM), too. Spatial learning and memory were measured at 56 days of age using a Morris water maze. A different cohort of experimental groups was used to measure dendritic spine density by Golgi-Cox impregnation. Male rats with nOBX showed a pronounced spatial learning deficit than female rats. Also, there was a significant decrease in...
Source: Brain Structure and Function - November 9, 2023 Category: Neuroscience Authors: H éctor De La Luz Torres Paola Rojas P érez Adriana Berenice Silva G ómez Source Type: research
Altered functional brain networks in coronary heart disease: independent component analysis and graph theoretical analysis
This study aimed to explore the association of CHD with functional connectivity and topological properties of brain networks. A total of 27 patients with CHD and 44 healthy controls (HCs) participated in this study and underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Intra- and internetwork functional connectivity alterations were explored using independent component analysis in CHD patients. Furthermore, graph theoretical analysis was adopted to assess abnormalities in small-world properties and network efficiency metrics of brain networks. Compared to HCs, CHD patients exhibited increased f...
Source: Brain Structure and Function - November 9, 2023 Category: Neuroscience Authors: Simin Lin Puyeh Wu Shaoyin Duan Qianni Du Shujia Guo Zhishang Chen Naiming Wu Xiaoyan Chen Ting Xie Yi Han Hengyu Zhao Source Type: research
