50 ‐year‐old man with a falcine mass
(Source: Brain Pathology)
Source: Brain Pathology - April 17, 2017 Category: Neurology Authors: A. Tauziede ‐Espariat, H. Adle‐Biassette, A. Simonneau, J.M. Guinebretiere, M. Polivka Tags: CASES OF THE MONTH Source Type: research
A 19 ‐year‐old male with a well‐demarcated parieto‐occipital mass
(Source: Brain Pathology)
Source: Brain Pathology - April 17, 2017 Category: Neurology Authors: Aur élie Beaufrère, Mathilde Fouet, Onorina Bruno, Dominique Cazals‐Hatem, Stéphane Goutagny Tags: CASES OF THE MONTH Source Type: research
Nasopharyngeal tumor developing in a 36 ‐year‐old man following radiation for a childhood meningioma
(Source: Brain Pathology)
Source: Brain Pathology - April 17, 2017 Category: Neurology Authors: Marwah M. Abdulkader, Isaac C. Wu, James C. Miller, Don ‐John Summerlin, Eyas M. Hattab Tags: CASES OF THE MONTH Source Type: research
61 ‐year‐old man with chronic expansile sellar mass
(Source: Brain Pathology)
Source: Brain Pathology - April 17, 2017 Category: Neurology Authors: Negar Khanlou, Randy Tashjian, Hrayr K. Shahinian, Harry V. Vinters Tags: CASES OF THE MONTH Source Type: research
Proteomics in pediatric cystic craniopharyngioma
Abstract
Adamantinomatous craniopharyngioma (ACP) is still often burdened by a poor prognosis in children as far as the risk of recurrence and the quality of life are concerned. Therefore, many efforts are now dedicated to investigate the molecular characteristics of this tumor aiming at finding new therapeutic options. ACP is prevalently a cystic lesion so that an increasing number of researches are focused on the analysis of its cystic content. In the present article, the main results of the current proteomic analysis (PA) on the ACP fluid are summarized. Both “bottom‐up” and “top‐down” approaches have been u...
Source: Brain Pathology - April 17, 2017 Category: Neurology Authors: Luca Massimi, Claudia Martelli, Massimo Caldarelli, Massimo Castagnola, Claudia Desiderio Tags: MINI ‐SYMPOSIUM: ADAMANTINOMATOUS CRANIOPHARYNGIOMA AND XANTHOMATOUS LESIONS OF THE SELLA Source Type: research
Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology
Abstract
Adamantinomatous craniopharyngioma (ACP) is the commonest tumor of the sellar region in childhood. Two genetically engineered mouse models have been developed and are giving valuable insights into ACP biology. These models have identified novel pathways activated in tumors, revealed an important function of paracrine signalling and extended conventional theories about the role of organ‐specific stem cells in tumorigenesis. In this review, we summarize these mouse models, what has been learnt, their limitations and open questions for future research. We then discussed how these mouse models may be used to test no...
Source: Brain Pathology - April 17, 2017 Category: Neurology Authors: John Richard Apps, Juan Pedro Martinez ‐Barbera Tags: MINI ‐SYMPOSIUM: ADAMANTINOMATOUS CRANIOPHARYNGIOMA AND XANTHOMATOUS LESIONS OF THE SELLA Source Type: research
Models of human adamantinomatous craniopharyngioma tissue: Steps toward an effective adjuvant treatment
Abstract
Even though ACP is a benign tumor, treatment is challenging because of the tumor's eloquent location. Today, with the exception of surgical intervention and irradiation, further treatment options are limited. However, ongoing molecular research in this field provides insights into the pathways involved in ACP pathogenesis and reveal a plethora of druggable targets. In the next step, appropriate models are essential to identify the most suitable and effective substances for clinical practice. Primary cell cultures in low passages provide a proper and rapid tool for initial drug potency testing. The patient‐derive...
Source: Brain Pathology - April 17, 2017 Category: Neurology Authors: Annett H ölsken, Rolf Buslei Tags: MINI ‐SYMPOSIUM: ADAMANTINOMATOUS CRANIOPHARYNGIOMA AND XANTHOMATOUS LESIONS OF THE SELLA Source Type: research
Adamantinomatous craniopharyngioma and xanthomatous lesions of the sella
(Source: Brain Pathology)
Source: Brain Pathology - April 17, 2017 Category: Neurology Authors: Todd C. Hankinson, B.K. Kleinschmidt ‐DeMasters Tags: MINI ‐SYMPOSIUM: ADAMANTINOMATOUS CRANIOPHARYNGIOMA AND XANTHOMATOUS LESIONS OF THE SELLA Source Type: research
Issue Information
(Source: Brain Pathology)
Source: Brain Pathology - April 17, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Intracranial myxoid mesenchymal tumors with EWSR1 –CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity?
We present three pediatric patients with intracranial EWSR1‐rearranged myxoid mesenchymal neoplasm and provide a molecular genetic characterization of these tumors. Clinical histories and imaging results were reviewed. Histology, immunohistochemistry, EWSR1, FUS, NR4A3 fluorescence in situ hybridization (FISH), and next‐generation sequencing (NGS) were performed. A 12‐year‐old male (case 1), 14‐year‐old female (case 2), and 18‐year‐old male (case 3), presented with headaches, emesis, and seizures, respectively. The magnetic resonance images demonstrated tumors abutting the dura (cases 1 and 3) and in the th...
Source: Brain Pathology - April 11, 2017 Category: Neurology Authors: Tejus A. Bale, Angelica Oviedo, Harry Kozakewich, Caterina Giannini, Phani K. Davineni, Keith Ligon, Sanda Alexandrescu Tags: Research Article Source Type: research
Transcriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - April 6, 2017 Category: Neurology Source Type: research
---
Brain Pathology, Ahead of Print. (Source: Brain Pathology)
Source: Brain Pathology - April 6, 2017 Category: Neurology Source Type: research
Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit
Brain Pathology,Volume 28, Issue 2, Page 143-154, March 2018. (Source: Brain Pathology)
Source: Brain Pathology - April 5, 2017 Category: Neurology Source Type: research
---
Brain Pathology,Volume 28, Issue 2, Page 143-154, March 2018. (Source: Brain Pathology)
Source: Brain Pathology - April 5, 2017 Category: Neurology Source Type: research
Overlapping but distinct TDP ‐43 and tau pathologic patterns in aged hippocampi
Brain Pathology,Volume 28, Issue 2, Page 264-273, March 2018. (Source: Brain Pathology)
Source: Brain Pathology - March 9, 2017 Category: Neurology Source Type: research
