Society news
(Source: Brain Pathology)
Source: Brain Pathology - June 5, 2017 Category: Neurology Tags: SOCIETY NEWS Source Type: research
A 32 ‐Year‐Old Man with Headache and Visual Loss
(Source: Brain Pathology)
Source: Brain Pathology - June 5, 2017 Category: Neurology Authors: Fabio Rogerio, Luciano de Souza Queiroz, Fabiano Reis, Aya Fukuda, Nivaldo Adolfo Silva, Andrei Fernandes Joaquim Tags: CASE OF THE MONTH Source Type: research
19 ‐Year‐Old Male with Headaches and a Possible Seizure
(Source: Brain Pathology)
Source: Brain Pathology - June 5, 2017 Category: Neurology Authors: MacLean P. Nasrallah, Ilya M. Nasrallah, Marisa S. Prelack, Margaret O. Johnson, Travis B. Lewis, Michael Rubenstein, Jane E. Minturn, Arati Desai, Paul Marcotte, Mariarita Santi, Maria Martinez ‐Lage Tags: CASE OF THE MONTH Source Type: research
A 53 ‐Year‐Old Woman with a Subfascial Mass of the Back that Lasted for Years
(Source: Brain Pathology)
Source: Brain Pathology - June 5, 2017 Category: Neurology Authors: Elia Guadagno, Domenico Solari, Gianpiero Iannuzzo, Eduardo Clery, Mararosaria Cervasio, Annarosaria De Chiara, Marialaura Del Basso De Caro Tags: CASE OF THE MONTH Source Type: research
AN 11 ‐Year‐Old Boy with a Leptomeningeal Tumor
(Source: Brain Pathology)
Source: Brain Pathology - June 5, 2017 Category: Neurology Authors: Cyril Habougit, Fabien Forest, Claire Boutet, Catherine Douchet, Jean ‐Louis Stephan, Marie‐Laure Stachowicz, Francois Vassal, Michel Péoc'h Tags: CASE OF THE MONTH Source Type: research
Modeling Parkinson's disease with induced pluripotent stem cells harboring α‐synuclein mutations
Abstract
Parkinson's disease (PD) is a common neurodegenerative condition affecting more than 8 million people worldwide. Although, the majority of PD cases are sporadic in nature, there are a growing number of monogenic mutations identified to cause PD in a highly penetrant manner. Many of these familial mutations give rise to a condition that is clinically and neuropathologically similar, if not identical, to sporadic PD. Mutations in genes such as SNCA cause PD in an autosomal dominant manner and patients have motor and non‐motor symptoms that are typical for sporadic PD. With the advent of reprogramming technology it...
Source: Brain Pathology - June 5, 2017 Category: Neurology Authors: Karamjit Singh Dolt, Fella Hammachi, Tilo Kunath Tags: MINI ‐SYMPOSIUM: USING iPSCs TO UNDERSTAND HUMAN NEUROLOGICAL DISEASE: POTENTIAL AND LIMITATIONS Source Type: research
Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders
Abstract
Neuroscience and Neurobiology have historically been neuron biased, yet up to 40% of the cells in the brain are astrocytes. These cells are heterogeneous and regionally diverse but universally essential for brain homeostasis. Astrocytes regulate synaptic transmission as part of the tripartite synapse, provide metabolic and neurotrophic support, recycle neurotransmitters, modulate blood flow and brain blood barrier permeability and are implicated in the mechanisms of neurodegeneration. Using pluripotent stem cells (PSC), it is now possible to study regionalised human astrocytes in a dish and to model their contribu...
Source: Brain Pathology - June 5, 2017 Category: Neurology Authors: Lucy A. Crompton, Oscar Cordero ‐Llana, Maeve A. Caldwell Tags: MINI ‐SYMPOSIUM: USING iPSCs TO UNDERSTAND HUMAN NEUROLOGICAL DISEASE: POTENTIAL AND LIMITATIONS Source Type: research
Modeling tau pathology in human stem cell derived neurons
Abstract
Tau pathology is a defining characteristic of multiple neurodegenerative disorders including Alzheimer's disease (AD) and Frontotemporal Dementia (FTD) with tau pathology. There is strong evidence from genetics and experimental models to support a central role for tau dysfunction in neuronal death, suggesting tau is a promising therapeutic target for AD and FTD. However, the development of tau pathology can precede symptom onset by several years, so understanding the earliest molecular events in tauopathy is a priority area of research. Induced pluripotent stem cells (iPSC) derived from patients with genetic cause...
Source: Brain Pathology - June 5, 2017 Category: Neurology Authors: Selina Wray Tags: MINI ‐SYMPOSIUM: USING iPSCs TO UNDERSTAND HUMAN NEUROLOGICAL DISEASE: POTENTIAL AND LIMITATIONS Source Type: research
Modeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells
Abstract
C9ORF72 repeat expansion is the most frequent causal genetic mutation giving rise to amyotrophic lateral sclerosis (ALS) and fronto‐temporal dementia (FTD). The relatively recent discovery of the C9ORF72 repeat expansion in 2011 and the complexity of the mutation have meant that animal models that successfully recapitulate human C9ORF72 repeat expansion‐mediated disease are only now emerging. Concurrent advances in the use of patient‐derived induced pluripotent stem cells (iPSCs) to model aspects of neurological disease offers an additional approach for the study of C9ORF72 mutation. This review focuses on t...
Source: Brain Pathology - June 5, 2017 Category: Neurology Authors: Bhuvaneish T. Selvaraj, Matthew R. Livesey, Siddharthan Chandran Tags: MINI ‐SYMPOSIUM: USING iPSCs TO UNDERSTAND HUMAN NEUROLOGICAL DISEASE: POTENTIAL AND LIMITATIONS Source Type: research
Understanding neurodevelopmental disorders using human pluripotent stem cell ‐derived neurons
Abstract
Research into psychiatric disorders has long been hindered by the lack of appropriate models. Induced pluripotent stem cells (iPSCs) offer an unlimited source of patient‐specific cells, which in principle can be differentiated into all disease‐relevant somatic cell types to create in vitro models of the disorder of interest. Here, neuronal differentiation protocols available for this purpose and the current progress on iPSCs‐based models of schizophrenia, autism spectrum disorders and bipolar disorder were reviewed. We also discuss the impact of the recently developed CRISPR/Cas9 genome editing tool in the d...
Source: Brain Pathology - June 5, 2017 Category: Neurology Authors: Claudia Tamburini, Meng Li Tags: MINI ‐SYMPOSIUM: USING iPSCs TO UNDERSTAND HUMAN NEUROLOGICAL DISEASE: POTENTIAL AND LIMITATIONS Source Type: research
Issue Information
(Source: Brain Pathology)
Source: Brain Pathology - June 5, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Pericyte ‐derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - May 31, 2017 Category: Neurology Source Type: research
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Brain Pathology, Ahead of Print. (Source: Brain Pathology)
Source: Brain Pathology - May 31, 2017 Category: Neurology Source Type: research
Rapid amyloid ‐β oligomer and protofibril accumulation in traumatic brain injury
This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - May 29, 2017 Category: Neurology Authors: Sami Abu Hamdeh, Erik Rollman Waara, Christer M öller, Linda Söderberg, Hans Basun, Irina Alafuzoff, Lars Hillered, Lars Lannfelt, Martin Ingelsson, Niklas Marklund Tags: Research Article Source Type: research
