PP06   Presentation Time: 5:15 PM
NIBB has potential advantages over other APBI techniques by delivering highly conformal radiation with minimal collateral dose to the heart and lung compared with external beam techniques, but unlike other brachytherapy techniques NIBB is non-invasive. Previous data has shown encouraging clinical outcomes using a 10-fraction regimen. To improve efficiency, convenience, and cost, reduction in fraction number is desirable. A prospective phase II trial was initiated to evaluate NIBB APBI delivered in 5 fractions. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Jaroslaw Hepel, Kara L. Leonard, Catheryn M. Yashar, John P. Einck, Sandra J. Sha, Thomas A. DiPetrillo, Doreen L. Wiggins, Theresa A. Graves, David A. Edmonson, Jennifer S. Gass, Mark J. Rivard, Br UOG, David E. Wazer Source Type: research

Thursday, June 22, 20234:30 PM - 5:30 PMPSOR01 Presentation Time: 4:30 PM
While advancements in the field of custom 3D-printed HDR brachytherapy applicators have allowed for creative and economical solutions to many clinical issues, they have also introduced additional challenges. One such challenge arises when the curvature of the custom applicator path is too tight, causing the HDR source to fail its clearance check. We designed, printed, and validated two small phantoms capable of testing the minimum curvature radius (MCR) of an institution's HDR afterloader. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Alek K. Rapchak, Matthew Maynard, Daniel McDonald, William Godwin, Sean Roles, Christopher Mart, Joseph Winiecki, Austin Skinner, Jean L. Peng Tags: Scientific Session: Physics Snap Orals I Source Type: research

PSOR02   Presentation Time: 4:35 PM
In LDR brachytherapy, limited options are available for treatment planning systems using model-based dose calculation algorithms (MBDCAs). The delay in the clinical implementation of MBDCAs in LDR brachytherapy is mainly due to the lack of accessible and reliable MBDCAs in clinical contexts. The aim of this work is to deploy eb_gui, a user-friendly Monte Carlo (MC) MBDCA for LDR brachytherapy, and ensure its consistency across multiple Canadian centres. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Samuel Ouellet, Narjes Moghadam, Claire Zhang, Dakota McKeown, Mojtaba Hoseini-Ghahfarokhi, Éric Vigneault, Juanita Crook, Felipe Castro, Joana E. Cygler, Marie-Claude Lavallée, Jean-François Carrier, Michelle Hilts, Rowan M. Thomson, Luc Beaulieu Source Type: research

PSOR03   Presentation Time: 4:40 PM
Current preclinical in vitro brachytherapy studies predominantly rely on low dose rate, orthovoltage x −ray irradiators which lack the dosimetric characteristics of clinical irradiators. A 3D−printed platform for performing in vitro tissue culture studies using a clinical HDR brachytherapy afterloader was designed to allow variable distances between the HDR source and the cells to vary the dose r ate resulting in clinically relevant dose distributions. The platform allows for maximization of the instantaneous dose rate in order to investigate radiobiological response in regions of high dose rates proximal to the 192Ir ...
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Aaron Silvus, Thomas R. Mazur, Sreekrishna Goddu, Jacqueline E. Zoberi, Stephanie Markovina, Michael B. Altman Source Type: research

PSOR04   Presentation Time: 4:45 PM
The use of high dose rate brachytherapy (HDR BT) either as monotherapy, or in combination with external beam radiotherapy (EBRT) is a proven technique in the treatment of prostate cancer. The high dose gradients inherent within HDR BT make it an ideal technique for dose escalation, however the same dose gradients also make HDR BT susceptible to dosimetric errors. Treatment verification is therefore imperative, to ensure correct dose delivery in HDR BT of the prostate. One method of performing treatment verification is in-vivo source tracking (IVST), in which the position of the BT source is tracked in real time as it deliv...
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Joel Poder, Dylan Koprivec, Dean Cutajar, Andrew Howie, Joseph Bucci, Anatoly Rosenfeld Source Type: research

PSOR05   Presentation Time: 4:50 PM
3D-printed implants and applicators for brachytherapy (BT), and the evolution of “dose paintings” techniques that better cover the geometry of tumors, open several avenues to improve BT accuracy.1 However, complex-shaped devices represent dosimetry challenges that could be tackled better by dosimetric gels rather than by conventional technologies (ion chambers, TLDs, or radi ographic films)2. Gels as such based on methacrylic acid (MAA; “MAGIC”), are well established, flexible in their preparation, and have provided stable dose distributions for high-energy external beam radiotherapy. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Mahdokht Akbari Taemeh, Baljeet Seniwal, Theophraste Theophraste, Solange Landreville, Marc-Andr é Fortin Source Type: research

PSOR07   Presentation Time: 5:00 PM
In this study, we present a novel simultaneous dwell-time and 4-pi catheter angle optimization algorithm for HDR prostate treatment. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Catherine Holly Frank, Pavitra Ramesh, Qihui Lyu, Dan Ruan, Sang-June Park, Ke Sheng Source Type: research

PSOR08   Presentation Time: 5:05 PM
Patients that undergo treatment for head and neck cancer and then recur with local node or cancer can potentially be treated using a combination of tumor resection and implanted cesium-131 seeds to treat the tumor margins. The number of seeds ordered and their subsequent strengths are always based on a TG-43 dose calculation as is the final patient-specific dose distribution which is reconstructed using a post-implant CT scan and localization of the implanted seeds. The heterogeneous anatomy of the head and neck can diminish the accuracy of TG-43 based dose calculations which assume that the surrounding anatomy is entirely...
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Vimal Kirti Desai, Reza Taleei Source Type: research

PSOR09   Presentation Time: 5:10 PM
Retrospective review of HDR prostate boost cases to quantitatively assess the dosimetric impact of the needle material, i.e., plastic and Stainless Steel (SS). (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Ileana Iftimia, Howard Hsu Source Type: research

PSOR10   Presentation Time: 5:15 PM
The purpose of this study was to develop and test a device that can selectively highlight needle locations and improve their ultrasound (US) conspicuity during high-dose rate (HDR) prostate brachytherapy. Brachytherapy needles are notoriously difficult to digitize in the setting of poor US signal and imaging artifacts, which results in inaccurate digital reconstructions, decreased tumor control, and increased normal tissue toxicity. This work describes prototype vibrational devices for color VISION (Vibrationally Induced Shimmering for Identifying an Object's Nature) that generate a high contrast color-Doppler (CD) signal ...
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Justine Marie Dupere, Eric E. Brost, Matthew E. Hainy, Matthew W. Urban, Christine U. Lee, Bradley J. Stish, Christopher L. Deufel Source Type: research

PSOR11   Presentation Time: 5:20 PM
Electromagnetic tracking (EMT) can be used to reconstruct the 3D geometry of implants used in interstitial gynecological (GYN) brachytherapy, but it does not share the same reference frame (RF) as the patient's medical image. This work validates the use of a tandem and ring (T&R) GYN applicator and its 3D model counterpart from a treatment planning system (TPS), to register the RF of an EMT-enabled brachytherapy afterloader with the RF of a CT scan image-set of a rigid phantom. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Isaac Neri Gomez Sarmiento, Daline Tho, Christopher D ürrbeck, Wim de Jager, Denis Laurendeau, Luc Beaulieu Source Type: research

PSOR12   Presentation Time: 5:25 PM
Radiobiological indices provide an estimate of the biological effect of treatment instead of tracking only dosimetric surrogate such as dose-volume histograms (DVH) and related dosimetric parameters. The purpose of this work is to evaluate the use of radiobiological criteria as a mean to generate high-dose-rate (HDR) brachytherapy plans for the treatment of prostate cancer within a multi-criteria optimization (MCO) algorithm and to compare them with current plans selected solely based on physical dose criteria. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Charles Iorio-Duval, C édric Bélanger, Luc Beaulieu Source Type: research

Friday, June 23, 202310:00 AM - 11:00 AMPP01 Presentation Time: 10:00 AM
Brachytherapy treatment planning for cervical cancer is performed real-time while patients are sedated and requires expertise to optimally tailor the radiation to patients ’ anatomy. While numerous tools have been developed to increase the efficiency of treatment planning, these methods have not achieved widespread adoption. As a result, many centers are still performing treatment planning manually, which can take 95 minutes on average1. The goal of this work was to automate treatment planning for both intracavitary and hybrid interstitial brachytherapy of cervical cancer using a single neural network model for dose pred...
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Sandra Meyers, Lance C. Moore, Karoline Kallis, Nuno Vasconcelos, Kelly Kisling, Dominique Rash, Catheryn M. Yashar, Jyoti Mayadev, Kevin L. Moore Tags: Scientific Session: GYN Proffered Papers II Source Type: research

PP02   Presentation Time: 10:09 AM
To prospectively evaluate the visibility (quantitatively and qualitatively) of interstitial needles in cervical cancer patients with combined intracavitary/interstitial (IC/IS) applications using transrectal ultrasound images (TRUS). (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Johannes Knoth, Alina Sturdza, Alexandru Zaharie, Aleksandra Winkler, Hannes Sperrer, Joachim Widder, Nicole Eder-Nesvacil, Christian Kirisits, Maximilian Schmid Source Type: research

PP03   Presentation Time: 10:18 AM
Optimally placing interstitial needles for interstitial only gynecologic brachytherapy requires time and expertise. Individualized vaginal templates to guide needles to dosimetrically beneficial positions could simplify interstitial procedures, decrease procedure time, improve needle distribution and optimize dosimetry. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Elizabeth Kidd, Thomas Niedermayr Source Type: research