High maternal osteocalcin levels during pregnancy is associated with low birth weight infants: A nested case-control study in China
Low birth weight infants (LBW) are at risk of chronic diseases in later life due to the disorder of energy metabolism during pregnancy. Osteocalcin (OC) has been identified as a hormone that regulate energy metabolism. However, few studies have researched on the associations between maternal serum OC levels and low birth weight infants. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Luyun Wei, Dehao Cao, Xiujuan Zhu, Yu Long, Chaoqun Liu, Shengzhu Huang, Jiarong Tian, Qingzhi Hou, Yaling Huang, Juan Ye, Bangzhu Luo, Ying Luo, Chunmei Liang, Mujun Li, Xiaobo Yang, Zengnan Mo, Jianfeng Xu Tags: Full Length Article Source Type: research
Pulsed electromagnetic fields modulate bone metabolism via RANKL/OPG and Wnt/ β-catenin pathways in women with postmenopausal osteoporosis: A pilot study
Pulsed electromagnetic fields (PEMFs) have been proven to enhance in vitro and in vivo osteogenesis with unknown mechanism. Aim of our study was to explore whether RANKL/OPG and Wnt/ β-Catenin pathways could be involved in bone response to PEMFs in a setting of postmenopausal osteoporotic women.Forty-three women (mean age 62.8 ± 4.5 yr.) were randomized into two groups. The PEMFs group received PEMFs treatment (50 min treatment session/day, 6 treatment sessions/week, f or a total of 25 times), by wearing a specific gilet applied to the trunk and connected to the electromagnetic device (Biosalus, by HSD Srl, Serra...
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Antonino Catalano, Saverio Loddo, Federica Bellone, Carmelo Pecora, Antonino Lasco, Nunziata Morabito Tags: Full Length Article Source Type: research
Dietary sugar intake does not pose any risk of bone loss and non-traumatic fracture and is associated with a decrease in all-cause mortality among Chinese elderly: Finding from an 11-year longitudinal study of Mr. and Ms. OS Hong Kong
The association of dietary sugar intake and skeletal health remains uncertain in the elderly. We aimed to investigate the association of sugar intake with the bone health and mortality of Chinese elderly. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Zhao-min Liu, Shelly Lap Ah. Tse, Bailing Chen, Dicken Chan, Carmen Wong, Jean Woo, Samuel Yeung-shan Wong Tags: Full Length Article Source Type: research
Impact of aging on bone, marrow and their interactions
Hematopoiesis in land dwelling vertebrates and marine mammals occurs within the bone marrow, continually providing mature progeny over the course of an organism's lifetime. This conserved dependency highlights the critical relationship between these two organs, yet the skeletal and hematopoietic systems are often thought of as separate. In fact, data are beginning to show that skeletal disease pathogenesis influences hematopoiesis and viceversa, offering novel opportunities to approach disease affecting bone and blood. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Corey M. Hoffman, Jimin Han, Laura M. Calvi Tags: Review Article Source Type: research
Real-world effectiveness of teriparatide on fracture reduction in patients with osteoporosis and comorbidities or risk factors for fractures: Integrated analysis of 4 prospective observational studies
Teriparatide significantly reduces fracture rates in clinical trials; however, those study populations were relatively restricted and included too few patients to analyze fracture outcomes within clinically important patient subgroups. We assessed fracture outcomes in subgroups of osteoporosis patients from 4 real-world teriparatide observational studies. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Bente L. Langdahl, Stuart Silverman, Saeko Fujiwara, Ken Saag, Nicola Napoli, Satoshi Soen, Hiroyuki Enomoto, Thomas E. Melby, Damon P. Disch, Fernando Marin, John H. Krege Tags: Full Length Article Source Type: research
Serum 25-hydroxyvitamin D and bone mineral density among children and adolescents in a Northwest Chinese city
Although vitamin D is essential for bone health, little is known about prevalence of vitamin D deficiency and low bone mineral density (BMD) among children, especially those in developing countries. It also remains unclear whether serum 25-hydroxyvitamin D [25(OH)D] is associated with BMD among children. We investigated these questions among children and adolescents in Yinchuan (latitude: 38 ° N), Ningxia, an economically underdeveloped province in Northwest China. A total of 1582 children (756 boys and 826 girls), aged 6–18 years, were recruited from schools using the stratified random sampling method in fall 2015. (Source: Bone)
Source: Bone - July 10, 2018 Category: Orthopaedics Authors: Jing Li, Wenqing Ding, Juan Cao, Lijiao Sun, Shanghong Liu, Jianjun Zhang, Haiping Zhao Tags: Full Length Article Source Type: research
Response to R. L. Nevin “Considerations in the repurposing of mefloquine for prevention and treatment of osteoporosis”
The authors would like to thank the reader for his interest in our article and his insightful feedback [1]. All of the points raised are important to take into consideration when looking at the possibility of using mefloquine to treat bone loss in aging. As correctly indicated by Dr. Nevin, the other members of the quinine family of drugs, but not mefloquine, have been used in humans to prevent skeletal complications. Our study was meant to be more of a proof of concept study based on the previous findings that other chloroquines effect bone mass. (Source: Bone)
Source: Bone - July 9, 2018 Category: Orthopaedics Authors: Hannah M. Davis, Rafael Pacheco-Costa, Lilian I. Plotkin Tags: Correspondence Source Type: research
Exploring the potential of tocotrienol from Bixa orellana as a single agent targeting metabolic syndrome and bone loss
This study aimed to investigate the effects of annatto tocotrienol as a single treatment for MetS and osteoporosis in high-carbohydrate high-fat (HCHF) diet-induced MetS animals. Three-month-old male Wistar rats were randomly divided into five groups. The baseline group was euthanized at the onset of the study. (Source: Bone)
Source: Bone - July 7, 2018 Category: Orthopaedics Authors: Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana Tags: Full Length Article Source Type: research
The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study
The diagnostic threshold for osteoporosis, a bone mineral density (BMD) T-score ≤ −2.5, signals an increased risk for fracture. However, most fragility fractures arise among the majority of women with ‘osteopenia’ or ‘normal’ BMD. We hypothesized that a BMD T-score of −2.5, even if not intended as a treatment threshold, paradoxically may create disincentive t o initiating treatment of women with osteopenia or normal BMD at high risk for fracture. From a population-based BMD registry covering the Province of Manitoba, Canada, we identified 3735 untreated women aged ≥ 50 years undergoing BMD screen...
Source: Bone - July 6, 2018 Category: Orthopaedics Authors: William D. Leslie, Ego Seeman, Suzanne N. Morin, Lisa M. Lix, Sumit R. Majumdar Tags: Full Length Article Source Type: research
Divergence from osteoporosis screening guidelines in older breast cancer patients treated with anti-estrogen therapy: A population-based cohort study
This study characterizes patterns and predictors of receiving guideline-recommended bone densitometry (BD) screening at AET initiation. (Source: Bone)
Source: Bone - July 5, 2018 Category: Orthopaedics Authors: David Henault, Tracy Westley, Sinziana Dumitra, Sue-Ling Chang, Richard Kremer, Robyn Tamblyn, Nancy Mayo, Ari N. Meguerditchian Tags: Full Lenght Article Source Type: research
Children with myelomeningocele do not exhibit normal remodeling of tibia roundness with physical development
This study analyzed computed tomography images of the tibia from 77 children with MM and 124 typically developing (TD) children between the ages of 6 and 16 years. (Source: Bone)
Source: Bone - July 4, 2018 Category: Orthopaedics Authors: Kyle P. Chadwick, Nicole M. Mueske, Rachel E. Horenstein, Sandra J. Shefelbine, Tishya A.L. Wren Tags: Full Length Article Source Type: research
Age trajectories of musculoskeletal morbidities in adults with cerebral palsy
Individuals with cerebral palsy (CP) are at an increased risk for age-related morbidities due to functional impairments, maladapted growth, and altered body composition. While musculoskeletal (MSK) deficits are present in children, little is understood about MSK morbidity throughout the lifespan in those with CP. The purpose of this study was to examine the age-related trajectories of MSK morbidity and multimorbidity throughout adulthood in those with CP. (Source: Bone)
Source: Bone - July 4, 2018 Category: Orthopaedics Authors: Daniel G. Whitney, Edward A. Hurvitz, Maureen J. Devlin, Michelle S. Caird, Zachary P. French, Elie C. Ellenberg, Mark D. Peterson Tags: Full Length Article Source Type: research
Sleep disordered breathing and fibroblast growth factor 23 in the Hispanic Community Health Study/Study of Latinos
Preclinical data suggest that hypoxia stimulates fibroblast growth factor 23 (FGF23) transcription and cleavage in osteocytes, resulting in elevated circulating c-terminal (cFGF23) levels but normal intact FGF23 (iFGF23) levels. We conducted a case-control study within the Hispanic Community Health Study/Study of Latinos to investigate whether sleep disordered breathing, as a model of hypoxemia, is independently associated with elevated cFGF23 levels in the general population and with elevated cFGF23 and iFGF23 levels in patients with chronic kidney disease (CKD), in whom FGF23 cleavage may be impaired. (Source: Bone)
Source: Bone - July 3, 2018 Category: Orthopaedics Authors: Rupal Mehta, Xuan Cai, Alexander Hodakowski, Bharat Thyagarajan, Donglin Zeng, Phyllis C. Zee, William Wohlgemuth, Susan Redline, James P. Lash, Myles Wolf, Tamara Isakova Tags: Full Length Article Source Type: research
Considerations in the repurposing of mefloquine for prevention and treatment of osteoporosis
I read with interest the recent paper by Pacheco-Costa and colleagues [1], which demonstrates that the antimalarial drug mefloquine can affect bone formation in a mouse model. The authors note that mefloquine may be able to at least partially reverse the deleterious consequences of aging in bone, suggesting the potential repurposing of this drug for prevention and treatment of osteoporosis. (Source: Bone)
Source: Bone - July 3, 2018 Category: Orthopaedics Authors: Remington L. Nevin Tags: Correspondence Source Type: research
Higher sympathetic activity as a risk factor for skeletal deterioration in pheochromocytoma
Despite the potential biological importance of sympathetic activity in human bone metabolism, its effects on bone microarchitecture, a key determinant of bone quality, has not been thoroughly studied. In the present study, we investigated the lumbar spine trabecular bone score (TBS) as an indicator of skeletal deterioration in pheochromocytoma. Among 620 consecutive patients with newly diagnosed adrenal incidentaloma, 29 with histologically confirmed pheochromocytoma (a catecholamine-secreting neuroendocrine tumor) and 266 with nonfunctional adrenal incidentaloma were defined as cases and controls, respectively. (Source: Bone)
Source: Bone - July 2, 2018 Category: Orthopaedics Authors: Beom-Jun Kim, Mi Kyung Kwak, Jae Seung Kim, Seung Hun Lee, Jung-Min Koh Tags: Full Length Article Source Type: research
