The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats
This study compare the regenerative power of SIM and PRF added locally each as a sole filling material on induced bone defect and evaluate the combined effect using PRF loaded with SIM. (Source: Bone)
Source: Bone - September 9, 2018 Category: Orthopaedics Authors: Shereen N. Raafat, Reham M. Amin, Mohey M. Elmazar, Mahmoud M. Kattab, Aiman El-Khatib Tags: Full Length Article Source Type: research
Improved accuracy in the assessment of vertebral cortical thickness by quantitative computed tomography using the Iterative Convolution Optimization (ICON) method
We present an image processing method specifically adopted to thin cortices that substantially improves accuracy.Ten human vertebrae embedded in epoxy resin were imaged using clinical QCT and High-Resolution QCT (HR-QCT) protocols, both acquired on a clinical whole body CT scanner, whereas high resolution peripheral QCT (HR-pQCT) was used as gold standard. (Source: Bone)
Source: Bone - September 8, 2018 Category: Orthopaedics Authors: Timo Damm, Jaime Andr és Peña, Graeme Michael Campbell, Jan Bastgen, Reinhard Barkmann, Claus-Christian Glüer Tags: Full Length Article Source Type: research
Trabecular bone score in adults with cerebral palsy
Bone fragility in cerebral palsy (CP) is secondary to a complex interplay of functional, hormonal, and nutritional factors that affect bone remodelling. A greater understanding of bone microarchitectural changes seen in CP should assist therapeutic decision making. (Source: Bone)
Source: Bone - September 4, 2018 Category: Orthopaedics Authors: A. Trinh, P. Wong, M.C. Fahey, P.R. Ebeling, P.J. Fuller, F. Milat Tags: Full Length Article Source Type: research
PRMT5 inhibition promotes osteogenic differentiation of mesenchymal stromal cells and represses basal interferon stimulated gene expression
Protein arginine methyltransferases (PRMTs) catalyze symmetric and asymmetric methylation on arginine residues of multiple protein targets including histones and have essential roles in organismal development and disease. PRMT5 mediates symmetric di-methylation (sDMA) of arginine 2 (H3R2me2) and arginine 8 on histone 3 (H3R8me2), arginine 3 on histones 2A and 4 (H2A/H4R3me2) as well as several non-histone substrates like Sm proteins. Here, we found that selective inhibition of Prmt5 in mesenchymal stromal cells (MSCs) led to a reduction in colony forming units (CFUs) and increased osteoblast differentiation. (Source: Bone)
Source: Bone - September 3, 2018 Category: Orthopaedics Authors: Satya K. Kota, Coco Roening, Nehal Patel, Savithri B. Kota, Roland Baron Tags: Full Length Article Source Type: research
Comparison of bone turnover markers in peripheral blood and bone marrow aspirate
Bone remodeling takes place in the bone marrow environment. We investigated if levels of bone turnover markers (BTMs) differ between bone marrow and peripheral blood, if the bone marrow is an independent compartment, and how well the measurements in bone marrow correlate with bone mineral density. (Source: Bone)
Source: Bone - August 31, 2018 Category: Orthopaedics Authors: M.J. Ornstrup, T.N. Kj ær, T. Harsløf, N.R. Jørgensen, S.B. Pedersen, B.L. Langdahl Tags: Full Length Article Source Type: research
Low-trauma rib fracture in the elderly: Risk factors and mortality consequence
Low trauma rib fracture (hereinafter, rib fracture) is common in the elderly, but its risk factors and mortality consequence are rarely studied. We sought to define the epidemiology of rib fracture and the association between rib fracture and postfracture mortality. (Source: Bone)
Source: Bone - August 30, 2018 Category: Orthopaedics Authors: Ha T. Mai, Thach S. Tran, Thao P. Ho-Le, Thuy T. Pham, Jacqueline R. Center, John A. Eisman, Tuan V. Nguyen Tags: Full Length Article Source Type: research
Long term time trends in use of medications associated with risk of developing osteoporosis: Nationwide data for Denmark from 1999 to 2016
To evaluate the development in the use of medications associated with an increased risk of developing osteoporosis over the time period from 1999 to 2016. (Source: Bone)
Source: Bone - August 30, 2018 Category: Orthopaedics Authors: M.K. Skj ødt, Y. Ostadahmadli, B. Abrahamsen Tags: Full Length Article Source Type: research
Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method
Clinical and epidemiological findings point to an association between type 2 diabetes (T2D) and osteoporosis. Genome-wide association studies (GWASs) have been fruitful in identifying some loci potentially associated with osteoporosis and T2D respectively. However, the total genetic variance for each of these two diseases and the shared genetic determination between them are largely unknown. The aim of this study was to identify novel genetic variants for osteoporosis and/or T2D. (Source: Bone)
Source: Bone - August 30, 2018 Category: Orthopaedics Authors: Yuan Hu, Li-Jun Tan, Xiang-Ding Chen, Jonathan Greenbaum, Hong-Wen Deng Tags: Full Length Article Source Type: research
Assessing the genetic correlations between early growth parameters and bone mineral density: A polygenic risk score analysis
In this study, we performed a large scale polygenic risk score (PRS) analysis to evaluate the potential impact of early growth parameters on the variations of BMD. (Source: Bone)
Source: Bone - August 30, 2018 Category: Orthopaedics Authors: Xiao Liang, CuiYan Wu, Hongmou Zhao, Li Liu, Yanan Du, Ping Li, Yan Wen, Yan Zhao, Miao Ding, Bolun Cheng, Shiqiang Cheng, Mei Ma, Lu Zhang, Xiong Guo, Hui Shen, Qing Tian, Feng Zhang, Hong-Wen Deng Tags: Full Length Article Source Type: research
Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects
Tissue oxygen (O2) levels vary during development and disease; adaptations to decreased O2 (hypoxia) are mediated by hypoxia-inducible factor (HIF) transcription factors. HIFs are active in the skeleton, and stabilizing HIF- α isoforms cause high bone mass (HBM) phenotypes. A fundamental limitation of previous studies examining the obligate role for HIF-α isoforms in the skeleton involves the persistence of gene deletion as osteolineage cells differentiate into osteocytes. Because osteocytes orchestrate skeletal devel opment and homeostasis, we evaluated the influence of Vhl or Hif1a disruption in osteocytes. (Source: Bone)
Source: Bone - August 30, 2018 Category: Orthopaedics Authors: Gabriela G. Loots, Alexander G. Robling, Jiun C. Chang, Deepa K. Murugesh, Jamila Bajwa, Cameron Carlisle, Jennifer O. Manilay, Alice Wong, Clare E. Yellowley, Damian C. Genetos Tags: Full Length Article Source Type: research
The study of GPX3 methylation in patients with Kashin-Beck Disease and its mechanism in chondrocyte apoptosis
Selenium deficiency is a risk factor for Kashin-Beck Disease (KBD), an endemic osteoarthropathy. Although promoter hypermethylation of glutathione peroxidase 3 (GPX3) (a selenoprotein) has been identified in several cancers, little is known about promoter methylation and expression of GPX3 and their relation to selenium in KBD. The present study was thus conducted to investigate this research question. (Source: Bone)
Source: Bone - August 25, 2018 Category: Orthopaedics Authors: Lixin Han, Xiaoli Yang, Wenyan Sun, Zhaofang Li, Hao Ren, Baorong Li, Rongqiang Zhang, Dandan Zhang, Ziyun Shi, Jifeng Liu, Junling Cao, Jianjun Zhang, Yongmin Xiong Tags: Full Length Article Source Type: research
Women with fracture, unidentified by FRAX, but identified by cortical porosity, have a set of characteristics that contribute to their increased fracture risk beyond high FRAX score and high cortical porosity
The Fracture Risk Assessment Tool (FRAX) is widely used to identify individuals at increased risk for fracture. However, cortical porosity is associated with risk for fracture independent of FRAX and is reported to improve the net reclassification of fracture cases. We wanted to test the hypothesis that women with fracture who are unidentified by high FRAX score, but identified by high cortical porosity, have a set of characteristics that contribute to their fracture risk beyond high FRAX score and high cortical porosity. (Source: Bone)
Source: Bone - August 25, 2018 Category: Orthopaedics Authors: Rita Kral, Marit Osima, Roald Vestgaard, Elin Richardsen, Åshild Bjørnerem Tags: Full Length Article Source Type: research
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Source: Bone - August 24, 2018 Category: Orthopaedics Source Type: research
Energy Metabolism and Bone
For most of the last century of bone research, the skeleton has been studied as a repository for calcium and phosphate ions singularly responsive to hormones that regulate mineral ion homeostasis. Work in the past two decades has changed our view of the skeleton by demonstrating its hormonal connection with other organs of metabolic control. Prominent among the emerging connections are leptin and insulin/insulin-like growth factor pathways, which assume central roles in regulating growth and metabolism in higher organisms. (Source: Bone)
Source: Bone - August 24, 2018 Category: Orthopaedics Authors: Fanxin Long Source Type: research
Magnoflorine with hyaluronic acid gel promotes subchondral bone regeneration and attenuates cartilage degeneration in early osteoarthritis
To investigate efficacy of Chinese medicine magnoflorine combined with hyaluronic acid (HA)-gel in promoting subchondral bone (SCB) regeneration and attenuating cartilage degeneration in early osteoarthritis (OA). (Source: Bone)
Source: Bone - August 24, 2018 Category: Orthopaedics Authors: Zhe Cai, Yu Feng, Chentian Li, Kedi Yang, Tianhao Sun, Lei Xu, Yan Chen, Chun-Hoi Yan, William Weijia Lu, Kwong-Yuen Chiu Tags: Full Length Article Source Type: research
