SF-deferoxamine, a bone-seeking angiogenic drug, prevents bone loss in estrogen-deficient mice
Deferoxamine (DFO) possesses a good chelating capability and is therefore used for the clinical treatment of ion deposition diseases. Increasing evidence shows that DFO can inhibit the activity of proline hydroxylase (PHD) by chelating iron, resulting in hypoxia-induced factor (HIF) signaling activation and angiogenesis promotion. However, clinical evidence indicates that a high concentration of DFO could be biotoxic due to its enrichment in related organs. Thus, we established a new compound by conjugating DFO with the bone-seeking agent iminodiacetic acid (IDA); the new agent is called SF-DFO, and we verified its promoti...
Source: Bone - October 30, 2018 Category: Orthopaedics Authors: Changjun Guo, Kai Yang, Yufei Yan, Dongming Yan, Yifan Cheng, Xueming Yan, Niandong Qian, Qi Zhou, Bo Chen, Min Jiang, Hanbing Zhou, Changwei Li, Fei Wang, Jin Qi, Xiangyang Xu, Lianfu Deng Tags: Full Length Article Source Type: research
Bone collagen network integrity and transverse fracture toughness of human cortical bone
In this study, we tested whether early observations that a strong correlation between bone collagen integrity measured by thermomechanical methods and work to fracture exist in a more general and heterogeneous sampling of the population. (Source: Bone)
Source: Bone - October 27, 2018 Category: Orthopaedics Authors: Thomas L. Willett, Daniel Y. Dapaah, Sasidhar Uppuganti, Mathilde Granke, Jeffry S. Nyman Tags: Full Length Article Source Type: research
Response to letter to the editor: The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats
Successful graft incorporation is defined as the ability of the graft and surrounding tissue to function and maintain mechanical integrity [1]. (Source: Bone)
Source: Bone - October 26, 2018 Category: Orthopaedics Authors: Shereen Nader Raafat Tags: Correspondence Source Type: research
Induction of Lrp5 HBM-causing mutations in Cathepsin-K expressing cells alters bone metabolism
High-bone-mass (HBM)-causing missense mutations in the low density lipoprotein receptor-related protein-5 (Lrp5) are associated with increased osteoanabolic action and protection from disuse- and ovariectomy-induced osteopenia. These mutations (e.g., A214V and G171V) confer resistance to endogenous secreted Lrp5/6 inhibitors, such as sclerostin (SOST) and Dickkopf homolog-1 (DKK1). Cells in the osteoblast lineage are responsive to canonical Wnt stimulation, but recent work has indicated that osteoclasts exhibit both indirect and direct responsiveness to canonical Wnt. (Source: Bone)
Source: Bone - October 25, 2018 Category: Orthopaedics Authors: Kyung Shin Kang, Jung Min Hong, Daniel J. Horan, Kyung-Eun Lim, Whitney A. Bullock, Angela Bruzzaniti, Steven Hann, Matthew L. Warman, Alexander G. Robling Tags: Full Length Article Source Type: research
Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis
Vertebrate teeth are attached to the jawbones using a variety of methods but in mammals, a fibrous connection is the norm. This fibrous periodontal ligament (PDL) allows teeth to move in the jawbones in response to natural eruptive forces, mastication, and orthodontic tooth movement. In some disease states the PDL either calcifies or is replaced by a mineralized tissue and the result is ankylosis, where the tooth is fused to the alveolar bone. To understand how the PDL maintains this fibrous state we examined a strain of mice in which tooth movement is arrested. (Source: Bone)
Source: Bone - October 25, 2018 Category: Orthopaedics Authors: Yan Wu, Xue Yuan, Kristy C. Perez, Sydnee Hyman, Liao Wang, Gretel Pellegrini, Benjamin Salmon, Teresita Bellido, Jill A. Helms Tags: Full Length Article Source Type: research
Letter to the editor: The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats
In this study, the authors compared the regenerative effect of platelet-rich fibrin (PRF) and simvastatin as a filli ng material to induce bone healing. They did a great job in the experimental design and result assessment. But their preparation method of PRF may be controversial. (Source: Bone)
Source: Bone - October 24, 2018 Category: Orthopaedics Authors: Panxi Yu, Xiaonan Yang, Zuoliang Qi Tags: Correspondence Source Type: research
Bone mineral density response rates are greater in patients treated with abaloparatide compared with those treated with placebo or teriparatide: Results from the ACTIVE phase 3 trial
Abaloparatide is a 34 –amino acid peptide that selectively binds to the RG conformation of the parathyroid hormone receptor type 1. It was developed for the treatment of women with postmenopausal osteoporosis at high risk of fracture. In ACTIVE, an 18-month phase 3 study (NCT01343004), abaloparatide increased bone mine ral density (BMD), decreased the risk of vertebral and nonvertebral fractures compared with placebo, and decreased the risk of major osteoporotic fractures compared with placebo and teriparatide. (Source: Bone)
Source: Bone - October 22, 2018 Category: Orthopaedics Authors: P.D. Miller, G. Hattersley, E. Lau, L.A. Fitzpatrick, A.G. Harris, G.C. Williams, M.-Y. Hu, B.J. Riis, L. Russo, C. Christiansen Tags: Full Length Article Source Type: research
Editorial Board / Barcode
(Source: Bone)
Source: Bone - October 21, 2018 Category: Orthopaedics Source Type: research
Frequency and duration of vigorous physical activity bouts are associated with adolescent boys' bone mineral status: A cross-sectional study
Vigorous physical activity (VPA) has been proven to promote osteogenesis in adolescents; however the specifics of the optimal pattern of frequency and duration of VPA are unknown. The main goal of the present study was to analyze the associations of different length of VPA bouts with bone health. (Source: Bone)
Source: Bone - October 21, 2018 Category: Orthopaedics Authors: Jorge Marin-Puyalto, Jarek M äestu, Alba Gómez-Cabello, Evelin Lätt, Liina Remmel, Priit Purge, German Vicente-Rodríguez, Jaak Jürimäe Tags: Full Length Article Source Type: research
Administration of teriparatide for four years cyclically compared to two years daily in treatment na ïve and alendronate treated women
We evaluated if equivalent doses of TPTD given cyclically over 4-years could increase BMD>2-years of daily TPTD in 2 cohorts of women; previously untreated (Rx-Na ïve) and women previously treated with ALN (ALN-Rx). (Source: Bone)
Source: Bone - October 21, 2018 Category: Orthopaedics Authors: Felicia Cosman, Jeri W. Nieves, Catherine Roimisher, Simon Neubort, Donald J. McMahon, David W. Dempster, Robert Lindsay Tags: Full Length Article Source Type: research
Abaloparatide, a novel osteoanabolic PTHrP analog, increases cortical and trabecular bone mass and architecture in orchiectomized rats by increasing bone formation without increasing bone resorption
Male osteoporosis can occur with advanced age and with hypogonadism, with increased bone resorption and/or inadequate bone formation contributing to reduced bone mass and increased fracture risk. Abaloparatide is a selective PTH receptor agonist that increases bone formation and bone mass in postmenopausal women with osteoporosis and in estrogen-deficient animals. The current study evaluated the effects of abaloparatide in orchiectomized (ORX) rats, a model of male osteoporosis. Four-month-old Sprague-Dawley rats underwent ORX or sham surgery; 8 weeks later the ORX groups exhibited relative osteopenia vs sham controls, ...
Source: Bone - October 18, 2018 Category: Orthopaedics Authors: Heidi Chandler, Beate Lanske, Aurore Varela, Martin Guillot, Marilyne Boyer, Jeffrey Brown, Allen Pierce, Michael Ominsky, Bruce Mitlak, Roland Baron, Paul Kostenuik, Gary Hattersley Tags: Full Length Article Source Type: research
Tissue nonspecific alkaline phosphatase promotes calvarial progenitor cell cycle progression and cytokinesis via Erk1,2
Bone growth is dependent upon the presence of self-renewing progenitor cell populations. While the contribution of Tissue Nonspecific Alkaline Phosphatase (TNAP) enzyme activity in promoting bone mineralization when expressed in differentiated bone forming cells is well understood, little is known regarding the role of TNAP in bone progenitor cells. We previously found diminished proliferation in the calvarial MC3T3E1 cell line upon suppression of TNAP by shRNA, and in calvarial cells and tissues of TNAP −/− mice. (Source: Bone)
Source: Bone - October 17, 2018 Category: Orthopaedics Authors: Hwa Kyung Nam, Iva Vesela, Erica Siismets, Nan E. Hatch Tags: Full Length Article Source Type: research
QCT of the femur: Comparison between QCTPro CTXA and MIAF Femur
In this study we compared two analysis software options, QCTPro CTXA and MIAF-Femur, using CT scans of the semi-anthropometric European Proximal Femur Phantom (EPFP) and in vivo data from 130 Chinese elderly men and women aged 60 –80 years.Integral (Int), cortical (Cort) and trabecular (Trab) vBMD, volume, and BMC of the femur neck (FN), trochanter (TR), inter-trochanter (IT), and total hip (TH) VOIs were compared. (Source: Bone)
Source: Bone - October 17, 2018 Category: Orthopaedics Authors: Ling Wang, Oleg Museyko, Yongbin Su, Keenan Brown, Ruopei Yang, Yong Zhang, Yangyang Duanmu, Zhe Guo, Wei Zhang, Dong Yan, Xiaoguang Cheng, Klaus Engelke Tags: Full Length Article Source Type: research
Systemic bone loss, impaired osteogenic activity and type I muscle fiber atrophy in mice with elastase-induced pulmonary emphysema: Establishment of a COPD-related osteoporosis mouse model
Although it is suggested that chronic obstructive pulmonary disease (COPD) and bone are related, almost all of the pathological mechanisms of COPD-related osteoporosis remain unknown. There is a mouse model showing a deterioration of bone quality after cigarette smoke exposure; however, in smoking exposure models, various factors exist that affect bone metabolism, such as smoking and body weight loss (muscle and fat mass loss). We considered it appropriate to use an elastase-induced emphysema model to exclude factors influencing bone metabolism and to investigate the influence of pulmonary emphysema on bone metabolism. (Source: Bone)
Source: Bone - October 17, 2018 Category: Orthopaedics Authors: Manabu Tsukamoto, Toshiharu Mori, Ke-Yong Wang, Yasuaki Okada, Hokuto Fukuda, Keisuke Naito, Yoshiaki Yamanaka, Ken Sabanai, Eiichiro Nakamura, Kazuhiro Yatera, Akinori Sakai Tags: Full Length Article Source Type: research
Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate
This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45 mL of vehicle (VEH and VEH/aPDT) or 0.45 mL of zoledronate (ZOL and ZOL/aPDT) every three days for seven weeks. After three weeks of treatment, the first lower left molar was extracted. VEH/aPDT and ZOL/aPDT were submitted to aPDT on the extraction site at 0, 2 and 4 days postoperatively. (Source: Bone)
Source: Bone - October 16, 2018 Category: Orthopaedics Authors: Edilson Ervolino, Cristian Statkievicz, Luan Felipe Toro, Jo ão Martins de Mello-Neto, Thamires Priscila Cavazana, João Paulo Mardegan Issa, Rita Cássia Menegati Dornelles, Juliano Milanezi de Almeida, Maria José Hitomi Nagata, Roberta Okamoto, Cláud Tags: Full Length Article Source Type: research
