Association between osteoarthritis and cardiovascular disease in elderly in Japan: an administrative claims database analysis
Conclusion
This study confirms the association of KOA with CVD, particularly IHD and stroke, in the Japanese population. The finding that patients with KOA have a higher CVD risk can potentially assist in guiding future treatment strategies. (Source: BMJ Open)
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Uematsu, T., Nojiri, S., Ishijima, M., Nishizaki, Y. Tags: Open access, Geriatric medicine Source Type: research
Efficacy and safety of natural killer cells injection combined with XELOX chemotherapy in postoperative patients with stage III colorectal cancer in China: a prospective randomised controlled clinical trial study protocol
Background
Colorectal cancer (CRC) is the second most frequently diagnosed cancer and the fifth leading cause of cancer-related death in China. However, resistance to multiple chemotherapeutics after surgery leads to failure of the main therapy to CRC. Natural killer (NK) cells are innate cytotoxic lymphocytes that exhibit strong cytotoxic activity against tumour cells. NK cell-based therapy, either alone or in combination with chemotherapy, has achieved favourable results and holds promise for addressing recurrence and metastasis in CRC patients after surgery.
Methods and analysis
This is a prospective, randomised contro...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Geng, S., Yu, X., Yu, S. Tags: Open access, Oncology Source Type: research
Associations between use of diabetes technology and diabetes distress: a Danish cross-sectional survey of adults with type 1 diabetes
Conclusions
Among Danish adults with T1D, the use of IPT was associated with lower levels of DD, while CGM use was associated with higher levels of DD. DD should be addressed when introducing people with T1D to diabetes technology, CGM in particular.
Trial registration number
NCT04311164 (Results). (Source: BMJ Open)
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Lorenzen, J. T., Madsen, K. P., Cleal, B., Joensen, L. E., Norgaard, K., Pedersen-Bjergaard, U., Schmidt, S., Rytter, K., Willaing, I. Tags: Open access, Diabetes and Endocrinology Source Type: research
Behavioural mental health interventions delivered in the emergency department for suicide, overdose and psychosis: a scoping review
Conclusions
A wide range of multicomponent ED-delivered behavioural health interventions for suicidality and opioid use disorder show short-term improvement on primary outcomes such as suicide reattempt. Few studies on non-opioid substances and psychosis are available. (Source: BMJ Open)
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Nugent, S. M., Anderson, J., Young, S. K. Tags: Open access, Emergency medicine Source Type: research
Institutional delivery rate and associated factors among women in rural communities: analysis of the 2017-2018 Bangladesh Demographic and Health Survey
Conclusion
The study revealed that a low proportion of women in rural communities in Bangladesh used institutional delivery. The results of this study should be taken into account by policy-makers and governmental efforts when creating interventions or programmes aimed at increasing institutional delivery in Bangladesh. (Source: BMJ Open)
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Afaya, A., Nesa, M., Akter, J., Lee, T. Tags: Open access, Nursing Source Type: research
Comparison of the effects of ultrasound-guided quadratus lumborum block and erector spinae plane block on postoperative pain in abdominal surgeries: a protocol for systematic review and meta-analysis
Introduction
Ultrasound-guided quadratus lumborum block and erector spinae plane block are widely used for postoperative analgesia in adult patients undergoing abdominal surgeries. This protocol aims to compare the analgesic effects between ultrasound-guided quadratus lumborum block and erector spinae plane block on postoperative pain in abdominal surgeries.
Methods and analysis
Four databases, including PubMed, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL), will be searched. Randomised controlled trials that compared the analgesic effects between ultrasound-guided quadratus lumbo...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Zhang, X., Zhang, D., Wang, X., Wei, Y. Tags: Open access, Anaesthesia Source Type: research
Skeletal muscle relaxants as adjunctive pain control following cardiothoracic surgery: a systematic review protocol
Introduction
Multimodal pain control following cardiothoracic surgery remains a focus in international guidelines. We hypothesise that non-depolarising skeletal muscle relaxants can prove to be a useful adjunct for this population.
Methods/analysis
This systematic review will focus on human adult studies of pain control using muscle relaxants within 1 week following cardiac and thoracic surgery available in PubMed, Cochrane Central, Web of Science and EMBASE. Target studies will have a primary focus on measured effects on quality of pain control and reduction in opioid usage. Studies that include non-depolarising skeletal...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Kabir, S., Whaley, Q., Fernandez, M., Murphy, T. W. Tags: Open access, Surgery Source Type: research
Clinical practice guideline recommendations to improve the mental health of adult trauma patients: protocol for a systematic review
Introduction
Mental disorders are common in adult patients with traumatic injuries. To limit the burden of poor psychological well-being in this population, recognised authorities have issued recommendations through clinical practice guidelines (CPGs). However, the uptake of evidence-based recommendations to improve the mental health of trauma patients has been low until recently. This may be explained by the complexity of optimising mental health practices and interpretating CGPs scope and quality. Our aim is to systematically review CPG mental health recommendations in the context of trauma care and appraise their qualit...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Berube, M., Bradley, N., O'Donnell, M., Stelfox, H. T., Garraway, N., Vasiliadis, H.-M., Turcotte, V., Perreault, M., Menear, M., Archambault, L., Haagsma, J., Provencher, H., Genest, C., Gagnon, M.-A., Bourque, L., Lapierre, A., Khalfi, A., Panenka, W. Tags: Open access, Mental health Source Type: research
Association between body mass index and delirium incidence in critically ill patients: a retrospective cohort study based on the MIMIC-IV Database
Conclusion
BMI was associated with the incidence of delirium. Our results suggested that a BMI higher or lower than obesity grade 1 rather than the healthy weight in critically ill patients increases the risk of delirium incidence. (Source: BMJ Open)
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Fu, J., Zhang, X., Zhang, G., Wei, C., Fu, Q., Gui, X., Ji, Y., Chen, S. Tags: Open access, Intensive care Source Type: research
Correlates of post-traumatic stress disorder among adult residents of conflict-affected communities in Cross River State, Nigeria: a cross-sectional study
Conclusion
A multisectoral approach for creating and routinely arranging mental health interventions and aid programmes aimed at improving social outcomes such as employment, living conditions and social networks for conflict-affected communities is recommended. (Source: BMJ Open)
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Awa, T. M., Ugbe, U. M.-J., Onwusaka, O. C., Abua, E. E., Esu, E. B. Tags: Open access, Mental health Source Type: research
Impact of clinical supervision on the mental health nursing workforce: a scoping review protocol
Introduction
Mental health nurses work in potentially unpredictable, stressful and complex environments that can lead to burn-out and high staff turnover. Clinical supervision is a formal and professional agreement between two or more people that aims to strengthen individuals’ competencies and organisational strengths. Effective clinical supervision has been noted as a method of reducing workplace issues within mental health nursing, but there is not currently a synthesis of evidence in this area. The key objective of this scoping review is to identify, map and analyse the available evidence reporting on the impact ...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: McDonough, J. H., Rhodes, K., Procter, N. Tags: Open access, Nursing Source Type: research
Hidden hunger in patients with type 2 diabetes (T2D) and its effect on glycaemic control: a protocol for systematic review and meta-analysis
Introduction
Hidden hunger or micronutrient deficiencies are quite common in many parts of the world, particularly in the countries of sub-Saharan Africa and South Asia. Micronutrient deficiencies may impact insulin signalling pathways and glucose metabolism, potentially accelerating the onset and development of type 2 diabetes (T2D). This review aims to estimate the prevalence of multiple micronutrient deficiencies among patients with T2D and assess the effect of their deficiency on glycaemic control.
Methodology
The review follows the Cochrane Handbook and PRISMA 2020 guidelines. It includes all eligible studies reporti...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Mangal, D. K., Gautam, D., Pandey, A. K., Shaikh, N., Mishra, S. S., Tolani, H., Sonnathi, Y., Gupta, S. D., Sharma, K. C., Prasad, J., Tewari, R., Anwar, F. Tags: Open access, Diabetes and Endocrinology Source Type: research
Effectiveness of metformin to pregnant women with PCOS to reduce spontaneous abortion and gestational diabetes mellitus: a protocol for an overview of reviews
Introduction
Polycystic ovary syndrome (PCOS) is a globally prevalent endocrinological disorder and has been associated with poor pregnancy outcomes, including a higher rate of gestational diabetes and miscarriage. Metformin is among the drugs investigated to improve the prognosis of pregnant women with PCOS.
Objective
To conduct an overview of systematic reviews examining the effects of metformin versus placebo or no intervention throughout pregnancy among pregnant women with a preconception PCOS diagnosis to reduce the incidence of miscarriage and gestational diabetes.
Methods and analysis
We will perform an overview o...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Nassif, D. S., Januario, B. L., Sousa, B. A., Thabane, L., Abbade, J. F. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Precise infliximab exposure and pharmacodynamic control to achieve deep remission in paediatric Crohns disease (REMODEL-CD): study protocol for a multicentre, open-label, pragmatic clinical trial in the USA
Introduction
The only biologic therapy currently approved to treat moderate to severe Crohn’s disease in children (<18 years old) are those that antagonise tumour necrosis factor-alpha (anti-TNF). Therefore, it is critically important to develop novel strategies that maximise treatment effectiveness in this population. There is growing evidence that rates of sustained corticosteroid-free clinical remission, endoscopic healing and drug durability considerably improve when patients receive early anti-TNF dose optimisations guided by reactive or proactive therapeutic drug monitoring and pharmacodynamic monitoring. In...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Minar, P. P., Colman, R. J., Zhang, N., Mizuno, T., Vinks, A. A. Tags: Open access, Gastroenterology and hepatology Source Type: research
Innovative services in home health nursing: a scoping review protocol
This study will not involve human or animal participants. Data will be sourced from the published literature. To be published, the results of the study will be submitted to an international peer-reviewed, open-access journal as well as scientific meetings on HHN and innovative services research. (Source: BMJ Open)
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Eshghi, F., Pourgholam, N., Kianian, T., Kashani, M., Azami, M. Tags: Open access, Nursing Source Type: research
