Prostate Cancer Survivorship Essentials for men with prostate cancer on androgen deprivation therapy: protocol for a randomised controlled trial of a tele-based nurse-led survivorship care intervention (PCEssentials Hormone Therapy Study)
Introduction
Androgen deprivation therapy (ADT) is commonly used to treat men with locally advanced or metastatic prostate cancer. Men receiving ADT experience numerous side effects and frequently report unmet supportive care needs. An essential part of quality cancer care is survivorship care. To date, an optimal effective approach to survivorship care for men with prostate cancer on ADT has not been described. This protocol describes a randomised trial of tele-based nurse-led survivorship that addresses this knowledge gap: (1) determine the effectiveness of a nurse-led survivorship care intervention (PCEssentials), relat...
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Green, A., Newton, R. U., Smith, D. P., Tuffaha, H., Galvao, D. A., Heathcote, P., Patel, M. I., Christie, D., Egger, S., Sara, S. A., Heneka, N., Chambers, S. K., Dunn, J. Tags: Open access, Oncology Source Type: research
Association of the triglyceride-glucose index with severity of coronary stenosis and in-hospital mortality in patients with acute ST elevation myocardial infarction after percutaneous coronary intervention: a multicentre retrospective analysis cohort study
Conclusions
The TyG index was associated with the severity of coronary stenosis and all-cause in-hospital mortality in patients with STEMI, which may help physicians precisely risk-stratify patients and implement individualised treatment. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Lu, X., Lin, X., Cai, Y., Zhang, X., Meng, H., Chen, W., Yu, P., Chen, X. Tags: Open access, Cardiovascular medicine Source Type: research
Defining the hidden burden of disease in rural communities in Bangladesh, Cambodia and Thailand: a cross-sectional household health survey protocol
This study protocol has been approved by the Oxford Tropical Research Ethics Committee, National Research Ethics Committee of Bangladesh Medical Research Council, the Cambodian National Ethics Committee for Health Research, the Chiang Rai Provincial Public Health Research Ethical Committee. The results will be disseminated via the local health authorities and partners, peer-reviewed journals and conference presentations.
Trial registration number
NCT05389540. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Zhang, M., Htun, N. S. N., Islam, S., Sen, A., Islam, A., Neogi, A. K., Tripura, R., Dysoley, L., Perrone, C., Chew, R., Batty, E. M., Thongpiam, W., Wongsantichon, J., Menggred, C., Zaman, S. I., Waithira, N., Blacksell, S., Liverani, M., Lee, S., Maude, Tags: Open access, Epidemiology Source Type: research
Association between immune-inflammatory indexes and lower urinary tract symptoms: an analysis of cross-sectional data from the US National Health and Nutrition Examination Survey (2005-2008)
Conclusions
This study indicated that high levels of immune-inflammatory markers were associated with an increased risk of clinical LUTS. The combination of CRP with SIRI, NLR and dNLR, respectively, showed a stronger positive correlation with clinical LUTS compared with any single index. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Liu, W., Wang, J., Wang, M., Ding, X., Wang, M., Liu, M. Tags: Open access, Urology Source Type: research
Effects of haemodiafiltration or haemofiltration compared with haemodialysis on prognosis in patients with end-stage renal disease: protocol an updated systematic review and meta-analysis of randomised trials with trial sequential analysis
Introduction
Haemodialysis is the most common treatment option for patients with life-sustaining end-stage kidney disease (ESKD). In recent years, haemodiafiltration or haemofiltration has been widely used in patients with ESKD, and there are still conflicting findings as to whether both are superior to traditional haemodialysis. This systematic review and meta-analysis were designed to determine whether haemodiafiltration or haemofiltration is more effective than haemodialysis in reducing all-cause mortality risk in patients with ESKD.
Methods and analysis
We will perform a systematic PubMed, Embase, Cochrane Central Reg...
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Zhang, F., Liao, J., Bai, Y., Zhang, Z., Huang, L., Zhong, Y. Tags: Open access, Renal medicine Source Type: research
Return of participant-level clinical trial results to participants: pilot of a simplified centralised approach
Conclusions
This pilot study demonstrates an innovative, cost-effective, centralised and labour conservative approach to return of participant-level and aggregate data to participants in studies. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Hoffman, E., Gaglianone, S., Ketema, R., Tu, W., Peay, H., Clemens, P., Dang, U., Conklin, L. Tags: Open access, Ethics Source Type: research
Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study
Conclusion
We discovered that higher PP independently correlated with pre-DM risk in this study of Chinese participants. The connection between PP and incident pre-DM was also non-linear. High PP levels were related to a higher risk of pre-DM when PP was above 29 mm Hg.
Article focus
Our study investigated the relationship between PP and incident pre-DM in a secondary retrospective cohort of Chinese participants. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Cao, C., Han, Y., Hu, H., He, Y., Luo, J. Tags: Open access, Diabetes and Endocrinology Source Type: research
Longitudinal association of sleep duration with possible sarcopenia: evidence from CHARLS
Conclusions
Short sleep duration was a potential risk factor for possible sarcopenia and low handgrip strength. The improvement of sleep duration should be considered a target in early preventive and administrative strategies against the development of handgrip strength decline and further reduced the occurrence of sarcopenia. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Lv, X., Peng, W., Jia, B., Lin, P., Yang, Z. Tags: Open access, Public health Source Type: research
Comparing blastocyst euploid rates between the progestin-primed and gonadotrophin-releasing hormone antagonist protocols in aneuploidy genetic testing: a randomised trial protocol
This study aims to compare the euploidy rate of blastocysts following the PPOS protocol and the gonadotropin-releasing hormone antagonist protocol in women undergoing preimplantation genetic testing for aneuploidy (PGT-A).
Methods/analysis
This is a randomised trial. A total of 400 women undergoing PGT-A will be enrolled and randomised according to a computer-generated randomisation list to either (1) the antagonist group: an antagonist given once daily from day 6 of ovarian stimulation till the day of the ovulation trigger; or (2) the PPOS group: dydrogesterone from the first day of ovarian stimulation till the day of ov...
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Li, H., Yu, M., Zhang, W., Chen, J., Chen, H., Lu, X., Li, L., Ng, E. H. Y., Sun, X. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Prepregnancy body mass index and other risk factors for early-onset and late-onset haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome: a population-based retrospective cohort study in British Columbia, Canada
Conclusions
Prepregnancy BMI is positively associated with HELLP syndrome and the association is stronger with early-onset HELLP syndrome. Associations with early-onset and late-onset HELLP syndrome differed for some risk factors, suggesting possible differences in aetiological mechanisms. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Wang, L. Q., Bone, J. N., Muraca, G. M., Razaz, N., Joseph, K. S., Lisonkova, S. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Tailored anticoagulant treatment after a first venous thromboembolism: protocol of the Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study - cohort-based randomised controlled trial
Introduction
Patients with a first venous thromboembolism (VTE) are at risk of recurrence. Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes at the cost of an increased risk of bleeding. It is still uncertain whether patients with an intermediate recurrence risk or with a high recurrence and high bleeding risk will benefit from extended anticoagulant treatment, and whether a strategy where anticoagulant duration is tailored on the predicted risks of rVTE and bleeding can improve outcomes. The aim of the Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study is to evaluate the out...
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Burggraaf-van Delft, J. L. I., van Rein, N., Bemelmans, R. H. H., van den Berg, J.-W. K., Bruggeman, C. Y., Cloos-van Balen, M., Coppens, M., Eefting, M., Ende-Verhaar, Y., van Es, N., van Guldener, C., de Jong, W. K., Kleijwegt, F., Koster, T., Kroon, C. Tags: Open access, Cardiovascular medicine Source Type: research
Prospective validity of a clinical prediction rule for response to non-surgical multidisciplinary management of knee osteoarthritis in tertiary care: a multisite prospective longitudinal study
Conclusions
The knee osteoarthritis clinical nomogram prediction tool may have capacity to identify patients at risk of poor response to non-surgical management. Further work is required to determine the implications for service delivery, feasibility and impact of implementing the nomogram in clinical practice. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Window, P., Raymer, M., McPhail, S. M., Vicenzino, B., Hislop, A., Vallini, A., Elwell, B., O'Gorman, H., Phillips, B., Wake, A., Cush, A., McCaskill, S., Garsden, L., Dillon, M., McLennan, A., O'Leary, S. Tags: Open access, Rehabilitation medicine Source Type: research
Motivation and associated factors of health development army in the implementation of health extension packages in Northwest Ethiopia: a cross-sectional study
Conclusion
The proportion of motivation among health development army members was low. To increase the motivation of health development army members in the implementation of the health extension package, measures or strategies may consider targeting members who live in rural areas, are older than 30 years, have less than 4 years of work experience, report low job satisfaction, have low community support, do not have supportive supervision and are not recognised. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Tesfa, H., Getahun, F. A., Alemu, Y. M. Tags: Open access, Public health Source Type: research
Psychoeducational interventions for people living with chronic communicable disease: a systematic review
Conclusion
The findings of this review highlight potential benefits of psychoeducation but indicate more robust clinical trials will be required to examine their effectiveness and elucidate the mechanisms by which they best operate. Future interventions incorporating a broader focus on resilience enhancement and coping skills specific to stigmatisation could more comprehensively serve the needs of adults living with chronic communicable disease, particularly with HIV. The role of peer support in group psychoeducation merits further exploration.
PROSPERO registration number
CRD42021243058. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Burke, A., Davoren, M. P., Arensman, E., Harrington, J. M. Tags: Open access, Public health Source Type: research
Characteristics of constipation screening and assessment tools: a scoping review protocol
Introduction
Constipation is a common and significant burden on individuals and healthcare systems. Accurate assessment of constipation severity and symptom improvement are vital aspects of caring for patients with constipation. Therefore, nurses and allied healthcare professionals should possess knowledge regarding the characteristics of constipation assessment tools (ie, aim, scope, definition of constipation, content, structure, mode, administration time and context of use). However, existing reviews summarising characteristics of tools have been restricted to chronic constipation and self-reported measures. Furthermore...
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Odgaard, L., Rasmussen, A. A., Feo, R., Kristensen, P. K. Tags: Open access, Gastroenterology and hepatology Source Type: research
