Incidence of bloodstream infections: a nationwide surveillance of acute care hospitals in Switzerland 2008-2014
Conclusions The described trends may impact morbidity, mortality and healthcare costs associated with bloodstream infections. (Source: BMJ Open)
Source: BMJ Open - March 20, 2017 Category: Journals (General) Authors: Buetti, N., Atkinson, A., Marschall, J., Kronenberg, A., the Swiss Centre for Antibiotic Resistance (ANRESIS), Auckenthaler, Cherkaoui, Gaia, Dubuis, Egli, Koch, Leib, Luyet, Nordmann, Perreten, Piffaretti, Prod'hom, Schrenzel, Widmer, Zanetti, Zbinden Tags: Open access, Epidemiology, Infectious diseases Research Source Type: research

Prevalence of undiagnosed asymptomatic bacteriuria and associated risk factors during pregnancy: a cross-sectional study at two tertiary centres in Cairo, Egypt
Conclusions The prevalence of ASB seen in pregnant women in 2 tertiary hospitals in Egypt was 10%. E. coli and Klebsiella are the common organisms isolated. The direction of washing genitals and sexual activity significantly influences the risk of ASB. Pregnant women should be screened early for ASB during pregnancy; appropriate treatment should be given for positive cases according to antibiotic sensitivity screening. Cephalexin is likely to be of limited use in this management. (Source: BMJ Open)
Source: BMJ Open - March 20, 2017 Category: Journals (General) Authors: Abdel-Aziz Elzayat, M., Barnett-Vanes, A., Dabour, M. F. E., Cheng, F. Tags: Open access, Public health, Urology, Obgyn Research Source Type: research

Scoping review of potential quality indicators for hip fracture patient care
Conclusions To improve quality of care for patients with hip fracture and create a more efficient healthcare system, mechanisms for the measurement of quality of care across the entire continuum, not just during the acute period, are required. Future research should focus on decreasing the heterogeneity in definitions of quality indicators and the development and implementation of quality indicators for the postacute period. (Source: BMJ Open)
Source: BMJ Open - March 20, 2017 Category: Journals (General) Authors: Pitzul, K. B., Munce, S. E. P., Perrier, L., Beaupre, L., Morin, S. N., McGlasson, R., Jaglal, S. B. Tags: Open access, Evidence based practice, Geriatric medicine, Health policy, Health services research, Rehabilitation medicine Source Type: research

Recruitment and retention of participants in randomised controlled trials: a review of trials funded and published by the United Kingdom Health Technology Assessment Programme
Conclusions There is considerable variation in the consent, recruitment and retention rates in publicly funded RCTs. Investigators should bear this in mind at the planning stage of their study and not be overly optimistic about their recruitment projections. (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Walters, S. J., Bonacho dos Anjos Henriques-Cadby, I., Bortolami, O., Flight, L., Hind, D., Jacques, R. M., Knox, C., Nadin, B., Rothwell, J., Surtees, M., Julious, S. A. Tags: Open access, Health services research, Public health, Research methods Source Type: research

From first symptoms to diagnosis of amyotrophic lateral sclerosis: perspectives of an Irish informal caregiver cohort--a thematic analysis
Conclusions Exploring the perspectives of caregivers from first problem symptoms to diagnosis provides valuable insights into the development of the condition, impediments to its recognition, help-seeking behaviours and interactions with healthcare services. The journey from early symptoms to diagnosis is important for future decision-making, affects readiness for caregiving and could negatively impact on caregiver health and well-being. The early acknowledgement by healthcare professionals of stressors along the journey to diagnosis, and appreciation of their possible impact on caregivers is important. The separate needs ...
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Galvin, M., Gaffney, R., Corr, B., Mays, I., Hardiman, O. Tags: Open access, Health services research, Neurology, Qualitative research Source Type: research

Interventions to improve the self-management support health professionals provide for people with progressive neurological conditions: protocol for a realist synthesis
Introduction Supporting self-management among people with long-term conditions is recognised as an important component of healthcare. Progressive neurological conditions (PNCs), for example, Parkinson's disease and multiple sclerosis are associated with problems such as fatigue and cognitive impairment which may make self-management more challenging. Health professionals may need to develop specific skills in order to provide effective self-management support for these patients. The review aims to develop explanatory theories about how health professional-targeted interventions to improve self-management support provision ...
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Davies, F., Wood, F., Bullock, A., Wallace, C., Edwards, A. Tags: Open access, Medical education and training, Neurology, Patient-centred medicine, Rehabilitation medicine, Research methods Protocol Source Type: research

Design and reliability of a specific instrument to evaluate patient safety for patients with acute myocardial infarction treated in a predefined care track: a retrospective patient record review study in a single tertiary hospital in the Netherlands
Conclusions This study shows that it is possible to develop a reliable method, which can objectively assess process deviations and the occurrence of AEs in a specified population. This method could be a starting point for developing an electronic tracking system for continuous monitoring in strictly predefined care tracks. (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Eindhoven, D. C., Borleffs, C. J. W., Dietz, M. F., Schalij, M. J., Brouwers, C., de Bruijne, M. C. Tags: Open access, Cardiovascular medicine, Research methods Source Type: research

Effect of alcohol consumption and psychosocial stressors on preterm and small-for-gestational-age births in HIV-infected women in South Africa: a cohort study
Objectives Psychosocial stressors such as depression and stress, intimate partner violence (IPV) and alcohol use have been linked to preterm and small-for-gestational-age (SGA) births in general populations. The prevalence of psychosocial stressors and alcohol abuse is high in many HIV-infected (HIV+) populations. Our objective was to evaluate the effects of psychosocial stressors and alcohol abuse on birth outcomes in HIV-infected women. Methods Antenatal depression and non-specific psychological distress, periconception IPV and alcohol consumption were measured during the second trimester among HIV+ women initiating ant...
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Sania, A., Brittain, K., Phillips, T. K., Zerbe, A., Ronan, A., Myer, L., Abrams, E. J. Tags: Open access, Epidemiology, Global health, Mental health, HIV AIDS Research Source Type: research

Cross-sectional survey on defensive practices and defensive behaviours among Israeli psychiatrists
Conclusions This study provides evidence that DP is well established in the routine clinical daily practice of psychiatrists. Further studies are needed to reveal whether DP effectively protects psychiatrists from malpractice suits or, rather, if it impedes providing quality psychiatric care and represents an economic burden that leads to more harm for the patient. (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Reuveni, I., Pelov, I., Reuveni, H., Bonne, O., Canetti, L. Tags: Open access, Medical management, Mental health Research Source Type: research

Innovative public-private partnership to target subsidised antimalarials: a study protocol for a cluster randomised controlled trial to evaluate a community intervention in Western Kenya
This study seeks to evaluate the public health impact of targeted antimalarial subsidies delivered through a partnership between CHVs and the private retail sector. Methods and analysis We are conducting a stratified cluster-randomised controlled trial in Western Kenya where 32 community units were randomly assigned to the intervention or control (usual care) arm. In the intervention arm, CHVs offer free RDT testing to febrile individuals and, conditional on a positive test result, a voucher to purchase a WHO-qualified artemisinin combination therapy (ACT) at a reduced fixed price in the retail sector. Study outcomes in i...
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Laktabai, J., Lesser, A., Platt, A., Maffioli, E., Mohanan, M., Menya, D., Prudhomme O'Meara, W., Turner, E. L. Tags: Open access, Global health, Health economics, Health services research, Infectious diseases, Research methods Protocol Source Type: research

RCT of the effect of berryfruit polyphenolic cultivar extract in mild steroid-naive asthma: a cross-over, placebo-controlled study
Conclusions In steroid-naïve participants with mild asthma and elevated FeNO, there was no effect of BFPE on FeNO, a biomarker of eosinophilic airways inflammation. Caution is required in the extrapolation of apparent benefit in murine models of lung eosinophilia to clinical efficacy in patients with asthma. Trial registration number ANZCTR: 12613000451707; Results. (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Power, S., Williams, M., Semprini, A., Munro, C., Caswell-Smith, R., Pilcher, J., Holliday, M., Fingleton, J., Harper, J., Hurst, R., Weatherall, M., Beasley, R., Braithwaite, I. Tags: Open access, Pharmacology and therapeutics, Respiratory medicine Research Source Type: research

My Home is My Marae: Kaupapa Maori evaluation of an approach to injury prevention
Conclusions Injury prevention or health promotion approaches that seek to engage with whānau and/or Māori communities would benefit from applying critical success factors of ‘My Home is My Marae’. (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Hayward, B., Lyndon, M., Villa, L., Madell, D., Elliot-Hohepa, A., Le Comte, L. Tags: Open access, Public health, Research methods Source Type: research

Patient-reported outcomes and associations with pleural effusion in outpatients with heart failure: an observational cohort study
Conclusions Our study indicates that patient-reported outcome measures as MLHFQ may be sensitive tools to identify patients with HF at highest risk of symptomatic PLE and that treatment targeting reduction of PLE during follow-up is essential to improvement of QoL and functional capacity of outpatients with HF. Trial registration number NCT01794715; Results (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Gundersen, G. H., Norekval, T. M., Graven, T., Haug, H. H., Skjetne, K., Kleinau, J. O., Gustad, L. T., Dalen, H. Tags: Open access, Cardiovascular medicine, Health services research, Nursing Source Type: research

Patient experience of different regional models of urgent and emergency care: a cross-sectional survey study
Conclusions No consistent relationship was found between the type of urgent and emergency care model in different regions and patient experience. Scale-level data may not offer a useful metric for exploring the impact of system-level service change. (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Foley, C., Droog, E., Boyce, M., Healy, O., Browne, J. Tags: Open access, Emergency medicine, General practice / Family practice, Health services research, Patient-centred medicine Source Type: research

'right@home: a randomised controlled trial of sustained nurse home visiting from pregnancy to child age 2 years, versus usual care, to improve parent care, parent responsivity and the home learning environment at 2 years
This study is approved by the Royal Children's Hospital Human Research Ethics Committees (HREC 32296) and site-specific HRECs. The investigators and sponsor will communicate the trial results to stakeholders, participants, healthcare professionals, the public and other relevant groups via presentations and publications. Trial registration number ISRCTN89962120, pre-results. (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Goldfeld, S., Price, A., Bryson, H., Bruce, T., Mensah, F., Orsini, F., Gold, L., Hiscock, H., Smith, C., Bishop, L., Jackson, D., Kemp, L. Tags: Open access, Health services research, Public health Protocol Source Type: research

Effectiveness of chronic care models for the management of type 2 diabetes mellitus in Europe: a systematic review and meta-analysis
Conclusions Effects of European multifaceted diabetes care patient outcomes are only small. Improvements are somewhat larger for screen-detected and newly diagnosed diabetes patients than for patients with prevalent diabetes. (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Bongaerts, B. W. C., Müssig, K., Wens, J., Lang, C., Schwarz, P., Roden, M., Rathmann, W. Tags: Open access, Health services research, Diabetes and Endocrinology Source Type: research

Investigating skin-to-skin care patterns with extremely preterm infants in the NICU and their effect on early cognitive and communication performance: a retrospective cohort study
This study took place in a level-IV all-referral neonatal intensive care unit in the Midwest USA specialising in the care of extremely preterm infants. Participants Data were collected from the electronic medical records of all extremely preterm infants (gestational age
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Gonya, J., Ray, W. C., Rumpf, R. W., Brock, G. Tags: Open access, Intensive care, Paediatrics Research Source Type: research

Exploring similarities and differences in hospital adverse event rates between Norway and Sweden using Global Trigger Tool
Conclusions The level of patient safety in acute care hospitals, as assessed by GTT, was essentially the same in both countries. The differences between the countries in the rates of several types of AEs provide new incentives for Norwegian and Swedish governing bodies to address patient safety issues. (Source: BMJ Open)
Source: BMJ Open - March 19, 2017 Category: Journals (General) Authors: Deilkas, E. T., Risberg, M. B., Haugen, M., Lindstrom, J. C., Nylen, U., Rutberg, H., Michael, S. Tags: Open access, Health policy, Health services research Source Type: research

Randomised controlled trial comparing ofatumumab to rituximab in children with steroid-dependent and calcineurin inhibitor-dependent idiopathic nephrotic syndrome: study protocol
Introduction Oral steroids induce remission in about 90% of children with idiopathic nephrotic syndrome (INS), which is characterised by severe proteinuria and hypoalbuminaemia. Some children become steroid-dependent (SD) and require addition of calcineurin inhibitors (CNI) to maintain remission. Since these oral agents are toxic, alternative interventions are needed for long-term treatment. The anti-CD20 antibody rituximab has shown promising steroid-sparing properties in clinical trials, but benefits are less convincing in complicated forms of SD-INS. Ofatumumab, a new anti-CD20 antibody with stronger affinity to CD20, m...
Source: BMJ Open - March 16, 2017 Category: Journals (General) Authors: Ravani, P., Bonanni, A., Ghiggeri, G. M. Tags: Open access, Medical management, Paediatrics, Pharmacology and therapeutics, Renal medicine Protocol Source Type: research

Adjunctive clindamycin for cellulitis: a clinical trial comparing flucloxacillin with or without clindamycin for the treatment of limb cellulitis
Conclusions The addition of a short course of clindamycin to flucloxacillin early on in limb cellulitis does not improve outcome. The addition of clindamycin doubles the likelihood of diarrhoea within the first few days. Trial registration number NCT01876628, Results. (Source: BMJ Open)
Source: BMJ Open - March 16, 2017 Category: Journals (General) Authors: Brindle, R., Williams, O. M., Davies, P., Harris, T., Jarman, H., Hay, A. D., Featherstone, P. Tags: Open access, Dermatology, Infectious diseases Research Source Type: research

Protocol for a cluster randomised stepped wedge trial assessing the impact of a community-level hygiene intervention and a water intervention using riverbank filtration technology on diarrhoeal prevalence in India
This study is funded by an Australian National Health and Medical Research Council (NHMRC) project grant. Trial registration number ACTRN12616001286437; pre-results. (Source: BMJ Open)
Source: BMJ Open - March 16, 2017 Category: Journals (General) Authors: McGuinness, S. L., O'Toole, J. E., Boving, T. B., Forbes, A. B., Sinclair, M., Gautam, S. K., Leder, K. Tags: Open access, Epidemiology, Infectious diseases, Public health Protocol Source Type: research

Differences in predictors of permanent work disability between immigrants and natives: a cohort study of adults with sick leave due to common mental disorders
Conclusions Morbidity measured by medication, but not by specialised healthcare, was a stronger predictor for DP in immigrants than in native Swedes, warranting scrutiny of differences in care and treatment in immigrants and native Swedes with CMDs. (Source: BMJ Open)
Source: BMJ Open - March 16, 2017 Category: Journals (General) Authors: Werlen, L., Helgesson, M., Mittendorfer-Rutz, E. Tags: Open access, Epidemiology, Public health Research Source Type: research

Correction
This article has been corrected since it was first published. Several instances of ‘GP’ have been expanded for clarity. The title of reference number 26 has been corrected to ‘The preliminary development and testing of a global trigger tool to detect error and patient harm in primary-care records’. (Source: BMJ Open)
Source: BMJ Open - March 15, 2017 Category: Journals (General) Tags: Open access Correction Source Type: research

Innovative approach for self-management and social welfare of children with cystic fibrosis in Europe: development, validation and implementation of an mHealth tool (MyCyFAPP)
Introduction For the optimal management of children with cystic fibrosis, there are currently no efficient tools for the precise adjustment of pancreatic enzyme replacement therapy, either for advice on appropriate dietary intake or for achieving an optimal nutrition status. Therefore, we aim to develop a mobile application that ensures a successful nutritional therapy in children with cystic fibrosis. Methods and analysis A multidisciplinary team of 12 partners coordinate their efforts in 9 work packages that cover the entire so-called ‘from laboratory to market’ approach by means of an original and innovativ...
Source: BMJ Open - March 15, 2017 Category: Journals (General) Authors: Calvo-Lerma, J., Martinez-Jimenez, C. P., Lazaro-Ramos, J.-P., Andres, A., Crespo-Escobar, P., Stav, E., Schauber, C., Pannese, L., Hulst, J. M., Suarez, L., Colombo, C., Barreto, C., de Boeck, K., Ribes-Koninckx, C., on behalf of MyCyFAPP Tags: Open access, Evidence based practice, Gastroenterology and hepatology, Health informatics, Medical education and training, Medical management, Paediatrics Protocol Source Type: research

Protocol for determining primary healthcare practice characteristics, models of practice and patient accessibility using an exploratory census survey with linkage to administrative data in Nova Scotia, Canada
This study will create a database of all family physicians and primary healthcare nurse practitioners in NS, including information about accessibility and the model of care in which they practice, and will link the survey data to administrative health databases. Methods and analysis 3 census surveys of all family physicians, primary care nurse practitioners (ie, PCPs) and their practices in NS will be conducted. The first will be a telephone survey conducted during typical daytime business hours. At each practice, the person answering the telephone will be asked questions about the practice's accessibility and model of ca...
Source: BMJ Open - March 15, 2017 Category: Journals (General) Authors: Marshall, E. G., Gibson, R. J., Lawson, B., Burge, F. Tags: Open access, General practice / Family practice, Health services research, Research methods Protocol Source Type: research

Pharmacist provided medicines reconciliation within 24 hours of admission and on discharge: a randomised controlled pilot study
Conclusions The results suggest that changes in outcome measures resulting from MR within 24 hours were in the appropriate direction and readmission within 3 months is the most appropriate primary outcome measure. A future study to determine cost-effectiveness of the intervention is feasible and warranted. Trial registration number ISRCTN23949491. (Source: BMJ Open)
Source: BMJ Open - March 15, 2017 Category: Journals (General) Authors: Cadman, B., Wright, D., Bale, A., Barton, G., Desborough, J., Hammad, E. A., Holland, R., Howe, H., Nunney, I., Irvine, L. Tags: Open access, Evidence based practice, Health economics, Health services research, Pharmacology and therapeutics Source Type: research

Financial modelling of femtosecond laser-assisted cataract surgery within the National Health Service using a 'hub and spoke model for the delivery of high-volume cataract surgery
Conclusions The financial viability of FLACS within the NHS is currently precluded by the cost of the PI and the lack of knowledge regarding any gains in operational efficiency. (Source: BMJ Open)
Source: BMJ Open - March 15, 2017 Category: Journals (General) Authors: Roberts, H. W., Ni, M. Z., O'Brart, D. P. S. Tags: Open access, Health economics, Ophthalmology, Surgery Research Source Type: research

Residential proximity to major roads, exposure to fine particulate matter and aortic calcium: the Framingham Heart Study, a cohort study
Conclusions In this cohort from a region with relatively low levels of and variation in PM2.5, there were no strong associations of proximity to a major road or PM2.5 with the presence or extent of aortic calcification, or with AAC progression. (Source: BMJ Open)
Source: BMJ Open - March 15, 2017 Category: Journals (General) Authors: Dorans, K. S., Wilker, E. H., Li, W., Rice, M. B., Ljungman, P. L., Schwartz, J., Coull, B. A., Kloog, I., Koutrakis, P., D'Agostino, R. B., Massaro, J. M., Hoffmann, U., O'Donnell, C. J., Mittleman, M. A. Tags: Open access, Cardiovascular medicine, Epidemiology, Public health Research Source Type: research

Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series
Conclusions A large number of non-pharmacological interventions for BPSD were identified. The majority of the studies had great variation in how the same type of intervention was defined and applied, the follow-up duration, the type of outcome measured, usually with modest sample size. Overall, music therapy and behavioural management techniques were effective for reducing BPSD. (Source: BMJ Open)
Source: BMJ Open - March 15, 2017 Category: Journals (General) Authors: Abraha, I., Rimland, J. M., Trotta, F. M., Dell'Aquila, G., Cruz-Jentoft, A., Petrovic, M., Gudmundsson, A., Soiza, R., O'Mahony, D., Guaita, A., Cherubini, A. Tags: Open access, Geriatric medicine, Mental health, Neurology Research Source Type: research

Fruit and vegetable consumption and psychological distress: cross-sectional and longitudinal analyses based on a large Australian sample
Conclusions Increasing fruit and vegetable consumption may help reduce psychological distress in middle-aged and older adults. However, the association of fruit and vegetable consumption with the incidence of psychological distress requires further investigation, including the possibility of a threshold effect between medium and higher consumption levels. (Source: BMJ Open)
Source: BMJ Open - March 14, 2017 Category: Journals (General) Authors: Nguyen, B., Ding, D., Mihrshahi, S. Tags: Open access, Mental health, Nutrition and metabolism Research Source Type: research

Metabolic syndrome in Finnish women 7 years after a gestational diabetes prevention trial
Conclusions Increased prepregnancy BMI and early GDM diagnosis were the strongest risk factors for developing MeS 7 years postpartum. Overweight and obese women and especially those with early GDM should be monitored and counselled for cardiometabolic risk factors after delivery. (Source: BMJ Open)
Source: BMJ Open - March 14, 2017 Category: Journals (General) Authors: Puhkala, J., Raitanen, J., Kolu, P., Tuominen, P., Husu, P., Luoto, R. Tags: Open access, Nutrition and metabolism, Diabetes and Endocrinology Research Source Type: research

Building a new life in Australia: an analysis of the first wave of the longitudinal study of humanitarian migrants in Australia to assess the association between social integration and self-rated health
Conclusions Using a more comprehensive framework of social integration, we found that greater social integration was associated with better physical and mental health outcomes among HMs. Social integration should be embedded in HMs' resettlement programmes in order to reduce migration-related health inequities. (Source: BMJ Open)
Source: BMJ Open - March 14, 2017 Category: Journals (General) Authors: Chen, W., Ling, L., Renzaho, A. M. N. Tags: Open access, Global health, Public health Research Source Type: research

Incidence, risk factors and clinical outcomes of acute kidney injury associated with scrub typhus: a retrospective study of 510 consecutive patients in South Korea (2001-2013)
This study evaluated the incidence, predictors and prognosis of AKI associated with scrub typhus according to the RIFLE (risk, injury, failure, loss, end-stage kidney disease) criteria. Methods We retrospectively evaluated the medical records of patients diagnosed with scrub typhus from January 2001 to November 2013 in Gyeongsang National University Hospital. Results During the study period, 510 patients were diagnosed with scrub typhus and the incidence of AKI was 35.9%. There were 132 (25.9%) patients at risk, 37 (7.3%) with injury and 14 (2.7%) with failure. In comparison with the non-AKI group, the AKI group was olde...
Source: BMJ Open - March 14, 2017 Category: Journals (General) Authors: Hwang, K., Jang, H. N., Lee, T. W., Cho, H. S., Bae, E., Chang, S.-H., Park, D. J. Tags: Open access, Infectious diseases, Renal medicine Research Source Type: research

Antibiotics for acute respiratory tract infections: a mixed-methods study of patient experiences of non-medical prescriber management
Conclusions NMPs demonstrate an understanding of patient expectations of RTI consultations and use a range of non-antibiotic management strategies, particularly those resembling a patient-centred approach. Overall, patients' expectations were met and prescribers were not unduly influenced by patient expectations for an antibiotic. Patients were satisfied with the consultation, indicating that strategies used by NMPs were acceptable. However, the lower levels of satisfaction among patients who expected but did not receive an antibiotic indicates that although NMPs appear to have strategies for managing RTI consultations, th...
Source: BMJ Open - March 14, 2017 Category: Journals (General) Authors: Courtenay, M., Rowbotham, S., Lim, R., Deslandes, R., Hodson, K., MacLure, K., Peters, S., Stewart, D. Tags: Open access, Communication, Health services research, Nursing, Patient-centred medicine, Respiratory medicine Source Type: research

Collagenase injections for Dupuytren's disease: prospective cohort study assessing 2-year treatment effect durability
Conclusions Two years after collagenase injections for Dupuytren's disease, improvement was maintained in 72% of the treated hands. Complete contracture correction was seen in more than 80% of the MCP but in less than half of the PIP joints. (Source: BMJ Open)
Source: BMJ Open - March 14, 2017 Category: Journals (General) Authors: Lauritzson, A., Atroshi, I. Tags: Open access, Rehabilitation medicine, Surgery Research Source Type: research

Relevance of clerkship characteristics in changing students' interest in family medicine: a questionnaire survey
Conclusions In more than 50% of cases, the clerkship changed the students' interest in FM. Those with decreased interest were more frequently underchallenged. We observed an increase in FM if at least six learning activities were trained. Our findings stress the importance of well-designed FM clerkships. There is a need for standardised educational strategies which enable teaching physicians to operationalise educational requirements. (Source: BMJ Open)
Source: BMJ Open - March 14, 2017 Category: Journals (General) Authors: Herwig, A., Viehmann, A., Thielmann, A., Gesenhues, S., Weltermann, B. Tags: Open access, General practice / Family practice, Medical education and training Research Source Type: research

Alcohol policy changes and 22-year trends in individual alcohol consumption in a Swiss adult population: a 1993-2014 cross-sectional population-based study
Objective Evidence on the impact of legislative changes on individual alcohol consumption is limited. Using an observational study design, we assessed trends in individual alcohol consumption of a Swiss adult population following the public policy changes that took place between 1993 and 2014, while considering individual characteristics and secular trends. Design Cross-sectional study. Setting Swiss general adult population. Participants Data from 18 963 participants were collected between 1993 and 2014 (aged 18–75 years). Outcome measures We used data from the ‘Bus Santé’ study, an ...
Source: BMJ Open - March 14, 2017 Category: Journals (General) Authors: Dumont, S., Marques-Vidal, P., Favrod-Coune, T., Theler, J.-M., Gaspoz, J.-M., Broers, B., Guessous, I. Tags: Open access, Addiction, Epidemiology, Public health Research Source Type: research

Trajectories of urinary incontinence in childhood and bladder and bowel symptoms in adolescence: prospective cohort study
Conclusions Trajectories of childhood urinary incontinence are differentially associated with adolescent bladder and bowel symptoms. Children exhibiting persistent bedwetting with daytime wetting had the poorest outcomes in adolescence. (Source: BMJ Open)
Source: BMJ Open - March 13, 2017 Category: Journals (General) Authors: Heron, J., Grzeda, M. T., von Gontard, A., Wright, A., Joinson, C. Tags: Open access, Epidemiology, Paediatrics Research Source Type: research

Examining sufficiency and equity in the geographic distribution of physicians in Japan: a longitudinal study
Conclusions Although the total number of physicians increased in Japan, demand-adjusted physician supply decreased in recent years in all areas except for urban areas with a lower initial physician supply. In addition, the equity of physician distribution had consistently deteriorated since 2000. The results indicate that failing to adjust healthcare demand will produce misleading results, and that there is a need for major reform of Japan's healthcare system to improve physician distribution. (Source: BMJ Open)
Source: BMJ Open - March 13, 2017 Category: Journals (General) Authors: Hara, K., Otsubo, T., Kunisawa, S., Imanaka, Y. Tags: Open access, Health policy, Public health Research Source Type: research

Soil transmitted helminthiasis in indigenous groups. A community cross sectional study in the Amazonian southern border region of Ecuador
Conclusions The prevalence of geohelminth infection was high. Our study suggests that it is necessary to conduct studies focusing on communities, and not simply on captive groups, such as schoolchildren, with the object of proposing more suitable and effective strategies to control this problem. (Source: BMJ Open)
Source: BMJ Open - March 13, 2017 Category: Journals (General) Authors: Romero-Sandoval, N., Ortiz-Rico, C., Sanchez-Perez, H. J., Valdivieso, D., Sandoval, C., Pastor, J., Martin, M. Tags: Open access, Epidemiology, General practice / Family practice, Infectious diseases, Public health Research Source Type: research

Adult and adolescent livestock productive asset transfer programmes to improve mental health, economic stability and family and community relationships in rural South Kivu Province, Democratic Republic of Congo: a protocol of a randomised controlled trial
Introduction People living in poverty have limited access to traditional financial institutions. Microfinance programmes are designed to meet this gap and show promise in improving income, economic productivity and health. Our Congolese–US community academic research partnership developed two livestock productive asset transfer programmes, Pigs for Peace (PFP) and Rabbits for Resilience (RFR), to address the interlinked health, social and economic well-being of individuals, their families and communities. The community-based randomised controlled trials examine the effectiveness of PFP and RFR to improve health, econ...
Source: BMJ Open - March 13, 2017 Category: Journals (General) Authors: Kohli, A., Perrin, N. A., Remy, M. M., Alfred, M. B., Arsene, K. B., Nadine, M. B., Heri, B. J., Clovis, M. M., Glass, N. Tags: Open access, Global health, Research methods Protocol Source Type: research

212: scientometrics study of published retractions in pubmed
Conclusion: Retractions publish in two types of self-reported by author or editors discernments. Also two main reasons for retraction are "misconducts" and "unintentional mistakes" of authors that the second reason has the largest numbers of retractions. Therefore, notifying of retracted articles and raising awareness of readers and authors are the best mechanisms for controlling of negative effects of retracted articles. However, publishing of retraction in journals reflects how much importance they are considering to the accuracy of published information. (Source: BMJ Open)
Source: BMJ Open - March 12, 2017 Category: Journals (General) Authors: Jalalzadeh, S., Abbasi, F., Pashazadeh, F. Tags: Open access Poster Source Type: research

Paediatric early warning systems for detecting and responding to clinical deterioration in children: a systematic review
Conclusions Despite many studies reporting on the complexity and multifaceted nature of PEWS, no evidence was sourced which examined PEWS as a complex healthcare intervention. Future research needs to investigate PEWS as a complex multifaceted sociotechnical system that is embedded in a wider safety culture influenced by many organisational and human factors. PEWS should be embraced as a part of a larger multifaceted safety framework that will develop and grow over time with strong governance and leadership, targeted training, ongoing support and continuous improvement. (Source: BMJ Open)
Source: BMJ Open - March 12, 2017 Category: Journals (General) Authors: Lambert, V., Matthews, A., MacDonell, R., Fitzsimons, J. Tags: Open access, Communication, Paediatrics Research Source Type: research

Knowledge and attitudes of UK university students in relation to ultraviolet radiation (UVR) exposure and their sun-related behaviours: a qualitative study
Conclusions Knowledge about the risk of skin cancer associated with UVR did not strongly influence sun-related behaviours, whereas body image appeared as a key motivator. Attitudes towards sun protection and tanning stemmed from the media, peers and family, and particularly from childhood habits. Public health strategies may benefit from appearance-related skin cancer prevention campaigns, encouraging safer parental sun-related habits and correcting sun-related misconceptions. (Source: BMJ Open)
Source: BMJ Open - March 12, 2017 Category: Journals (General) Authors: Kirk, L., Greenfield, S. Tags: Open access, Dermatology, Oncology, Public health, Qualitative research, Sociology Source Type: research

Kids in Communities Study (KiCS) study protocol: a cross-sectional mixed-methods approach to measuring community-level factors influencing early child development in Australia
Introduction Healthy childhood development in the early years is critical for later adult health and well-being. Early childhood development (ECD) research has focused primarily on individual, family and school factors, but largely ignored community factors. The Kids in Communities Study (KiCS) will test and investigate community-level influences on child development across Australia. Methods and analysis Cross-sectional mixed-methods study exploring community-level effects in 25 Australian local communities; selection based on community socioeconomic status (SES) and ECD using the Australian Early Development Census (AED...
Source: BMJ Open - March 12, 2017 Category: Journals (General) Authors: Goldfeld, S., Villanueva, K., Tanton, R., Katz, I., Brinkman, S., Woolcock, G., Giles-Corti, B. Tags: Open access, Paediatrics, Public health, Research methods Protocol Source Type: research

Health risk of inhalation exposure to sub-10 {micro}m particulate matter and gaseous pollutants in an urban-industrial area in South Africa: an ecological study
Conclusions Long-term chronic exposure to airborne PM10, NO2 and SO2 pollutants may result in health risks among the study population. (Source: BMJ Open)
Source: BMJ Open - March 12, 2017 Category: Journals (General) Authors: Morakinyo, O. M., Adebowale, A. S., Mokgobu, M. I., Mukhola, M. S. Tags: Open access, Occupational and environmental medicine, Public health Research Source Type: research

Are patients with cancer with sepsis and bacteraemia at a higher risk of mortality? A retrospective chart review of patients presenting to a tertiary care centre in Lebanon
Objective Most sepsis studies have looked at the general population. The aim of this study is to report on the characteristics, treatment and hospital mortality of patients with cancer diagnosed with sepsis or septic shock. Setting A single-centre retrospective study at a tertiary care centre looking at patients with cancer who presented to our tertiary hospital with sepsis, septic shock or bacteraemia between 2010 and 2015. Participants 176 patients with cancer were compared with 176 cancer-free controls. Primary and secondary outcomes The primary outcome of this study was the in hospital mortality in both cohorts. Sec...
Source: BMJ Open - March 12, 2017 Category: Journals (General) Authors: Abou Dagher, G., El Khuri, C., Chehadeh, A. A.-H., Chami, A., Bachir, R., Zebian, D., Bou Chebl, R. Tags: Open access, Emergency medicine, Infectious diseases, Oncology Research Source Type: research

Efficacy and safety of lapatinib and trastuzumab for HER2-positive breast cancer: a systematic review and meta-analysis of randomised controlled trials
Objectives The anti-HER2 monoclonal antibody trastuzumab and the tyrosine kinase inhibitor lapatinib have complementary mechanisms of action and synergistic antitumour actively in models of HER2-positive breast cancer. However, the efficacy of trastuzumab in combination with lapatinib remains controversial. Therefore, we conducted this meta-analysis to compare combination treatment with lapatinib and trastuzumab to trastuzumab or lapatinib alone in the treatment of HER2-positive breast cancer. Methods Randomised controlled trials (RCTs), published in PubMed, Embase and Web of Science, were systematically reviewed to asses...
Source: BMJ Open - March 12, 2017 Category: Journals (General) Authors: Xu, Z.-q., Zhang, Y., Li, N., Liu, P.-j., Gao, L., Gao, X., Tie, X.-j. Tags: Open access, Evidence based practice, Oncology Research Source Type: research

Exploiting social influence to magnify population-level behaviour change in maternal and child health: study protocol for a randomised controlled trial of network targeting algorithms in rural Honduras
Introduction Despite global progress on many measures of child health, rates of neonatal mortality remain high in the developing world. Evidence suggests that substantial improvements can be achieved with simple, low-cost interventions within family and community settings, particularly those designed to change knowledge and behaviour at the community level. Using social network analysis to identify structurally influential community members and then targeting them for intervention shows promise for the implementation of sustainable community-wide behaviour change. Methods and analysis We will use a detailed understanding ...
Source: BMJ Open - March 12, 2017 Category: Journals (General) Authors: Shakya, H. B., Stafford, D., Hughes, D. A., Keegan, T., Negron, R., Broome, J., McKnight, M., Nicoll, L., Nelson, J., Iriarte, E., Ordonez, M., Airoldi, E., Fowler, J. H., Christakis, N. A. Tags: Open access, Epidemiology, Global health, Research methods, Sociology Protocol Source Type: research

STEMS pilot trial: a pilot cluster randomised controlled trial to investigate the addition of patient direct access to physiotherapy to usual GP-led primary care for adults with musculoskeletal pain
Conclusions A full RCT is feasible and will provide trial evidence about the clinical and cost-effectiveness of patient direct access to physiotherapy. Trial registration number ISRCTN23378642. (Source: BMJ Open)
Source: BMJ Open - March 11, 2017 Category: Journals (General) Authors: Bishop, A., Ogollah, R. O., Jowett, S., Kigozi, J., Tooth, S., Protheroe, J., Hay, E. M., Salisbury, C., Foster, N. E., and the STEMS study team Tags: Open access, General practice / Family practice, Health services research Source Type: research