Knowledge, attitude and practice towards blood donation and associated factors among adults in Debre Markos town, Northwest Ethiopia
ConclusionThe prevalence of knowledge and practice of blood donation is found to be higher compared to similar study conducted in Mekelle, whereas the level of attitude is found to be lower. The finding of this study also justified any possible interventions on the independent predictors. There should be a regularly scheduled awareness creation and voluntary blood donation campaigns organized at the community level to utilize potential blood donors. (Source: BMC Hematology)
Source: BMC Hematology - September 5, 2016 Category: Hematology Source Type: research

Anticoagulated patient ’s perception of their illness, their beliefs about the anticoagulant therapy prescribed and the relationship with adherence: impact of novel oral anticoagulant therapy – study protocol for The Switching Study: a prospective cohort study
AbstractBackgroundAnticoagulant therapy is prescribed for millions of patients worldwide for the prevention and treatment of both arterial and venous thrombosis. Historically, only vitamin K antagonists have been available for clinicians to prescribe. The anticoagulation landscape is changing. The recent availability of the novel oral anticoagulants overcome many of the disadvantages associated with vitamin K antagonists. However the lack of formal monitoring and clinic follow-up is a concern for clinicians, as medication adherence is being assumed, which is known to decline in patients prescribed medications for chronic c...
Source: BMC Hematology - August 23, 2016 Category: Hematology Source Type: research

A randomized controlled trial studying the effectiveness of group medical appointments on self-efficacy and adherence in sickle cell disease (TEAM study): study protocol
DiscussionThis is the first RCT to investigate the effectiveness of GMA ’s on self-efficacy and adherence in pediatric and adult patients with SCD, including a cost-effectiveness analysis.Trial registrationNTR4750 (NL42182.000.12). Registered 13 August 2014. (Source: BMC Hematology)
Source: BMC Hematology - August 4, 2016 Category: Hematology Source Type: research

Ferumoxytol versus iron sucrose treatment: a post-hoc analysis of randomized controlled trials in patients with varying renal function and iron deficiency anemia
Conclusions The efficacy and safety of ferumoxytol is at least comparable to iron sucrose in patients with varying degrees of renal function. Trial registration ( CKD-201 ; ClinicalTrials.gov identifier: NCT01052779 ; registered 15 January, 2010), ( IDA-302 ; ClinicalTrials.gov identifier: NCT01114204 ; registered 29 April, 2010). (Source: BMC Hematology)
Source: BMC Hematology - July 26, 2016 Category: Hematology Source Type: research

Chronic Epstein Barr virus infection leading to classical Hodgkin lymphoma
Conclusion EBV-related lymphomagenesis is complex and through the utilization of its nuclear antigens and latent membrane proteins the virus is able to shape the microenvironment to promote the various pathologies seen. Moreover, the diagnosis of EBV-associated lymphoproliferative disorders might be challenging when they present in immunocompetent individuals. Our case also represents an emphatic reminder for clinicians that spontaneous regression of lymphadenopathy is not exclusive of low-grade lymphoid malignancies. (Source: BMC Hematology)
Source: BMC Hematology - July 19, 2016 Category: Hematology Source Type: research

Diagnostic predictive value of platelet indices for discriminating hypo productive versus immune thrombocytopenia purpura in patients attending a tertiary care teaching hospital in Addis Ababa, Ethiopia
This study assessed the diagnostic value of Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Platelet Large Cell-Ratio (P-LCR) in discriminating causes of thrombocytopenia as hypoproductive or hyperdestructive (Immune thrombocytopenia purpura). Method A prospective cross-sectional study was conducted on 83 thrombocytopenic patients (Plt 
Source: BMC Hematology - July 1, 2016 Category: Hematology Source Type: research

A systematic review of using and reporting survival analyses in acute lymphoblastic leukemia literature
Conclusions The use and reporting of survival analysis in adult ALL patients undergoing allo-SCT have significant limitations. Notably, the finding of crossing survival curves was common and none of the studies assessed for the proportional hazards assumption. We encourage authors, reviewers and editors to improve the quality of the use and reporting of survival analysis in the hematology literature. (Source: BMC Hematology)
Source: BMC Hematology - June 8, 2016 Category: Hematology Source Type: research

Challenges in achieving a target international normalized ratio for deep vein thrombosis among HIV-infected patients with tuberculosis: a case series
Conclusion We recommend more frequent monitoring and timely dose adjustment of the INR, as well as studies on alternative strategies for the treatment of DVT in TB-HIV co-infected patients. (Source: BMC Hematology)
Source: BMC Hematology - June 4, 2016 Category: Hematology Source Type: research

Prevalence of neutropenia in children by nationality
This study aims to ascertain the prevalence of neutropenia (NP) in a large cohort of children from North African, Middle Eastern, and Asian countries residing in the United Arab Emirates. Methods Neutrophil counts of 26,542 children (one day to six years of age) from 86 countries were analyzed. The subjects were enrolled in the Well-Child-Care program of Ambulatory Health Services of Emirate of Abu Dhabi, United Arab Emirates. NP was defined as a neutrophil count
Source: BMC Hematology - May 21, 2016 Category: Hematology Source Type: research

The MUK five protocol: a phase II randomised, controlled, parallel group, multi-centre trial of carfilzomib, cyclophosphamide and dexamethasone (CCD) vs. cyclophosphamide, bortezomib (Velcade) and dexamethasone (CVD) for first relapse and primary refractory multiple myeloma
Discussion The development of carfilzomib offers the opportunity to further explore the anti-tumour efficacy of proteasome inhibition and, based on the available evidence, it is important and timely to obtain data on the activity, toxicity and tolerability of this drug. In contrast to ongoing phase III trials, this phase II trial has a unique subset of participants diagnosed with multiple myeloma at first relapse or refractory to no more than 1 line of treatment and will also evaluate the utility of maintenance with carfilzomib for up to 18 months and investigate minimal residual disease status to provide i...
Source: BMC Hematology - May 17, 2016 Category: Hematology Source Type: research

Generic and disease-specific quality of life among youth and young men with Hemophilia in Canada
Conclusion Despite having hemophilia, the youth in this cohort have minimal joint disease and good HRQoL. The young adults demonstrated more joint disease and slightly worse HRQoL in the domains of physical functioning and pain. The data presented here provide new information to inform the selection of Health Related Quality of Life (HRQoL) instruments for use in future clinical trials involving persons with hemophilia. Trial registration ClinicalTrials.gov : NCT01034904. Study funded by CSL Behring Canada. (Source: BMC Hematology)
Source: BMC Hematology - May 5, 2016 Category: Hematology Source Type: research

Design and rationale of the QUAZAR Lower-Risk MDS (AZA-MDS-003) trial: a randomized phase 3 study of CC-486 (oral azacitidine) plus best supportive care vs placebo plus best supportive care in patients with IPSS lower-risk myelodysplastic syndromes and poor prognosis due to red blood cell transfusion–dependent anemia and thrombocytopenia
Conclusions This study will provide data on the efficacy and safety of CC-486 in the treatment of IPSS lower-risk MDS with poor prognosis due to the presence of both RBC transfusion–dependent anemia and thrombocytopenia. Positive results of the AZA-MDS-003 study may expand treatment options for patients with IPSS lower-risk MDS. Trial registration ClinicalTrials.gov NCT01566695, registered March 27, 2012. (Source: BMC Hematology)
Source: BMC Hematology - May 3, 2016 Category: Hematology Source Type: research

Kinetics of Langerhans cell chimerism in the skin of dogs following 2  Gy TBI allogeneic hematopoietic stem cell transplantation
Conclusion Our study indicates that LC donor chimerism correlates with chimerism development in the peripheral blood but occurs delayed following NM-HSCT. (Source: BMC Hematology)
Source: BMC Hematology - April 27, 2016 Category: Hematology Source Type: research

Kinetics of Langerhans cell chimerism in the skin of dogs following 2 Gy TBI allogeneic hematopoietic stem cell transplantation
Conclusion Our study indicates that LC donor chimerism correlates with chimerism development in the peripheral blood but occurs delayed following NM-HSCT. (Source: BMC Hematology)
Source: BMC Hematology - April 27, 2016 Category: Hematology Source Type: research

Characteristics of chronic lymphocytic leukemia in Senegal
Conclusion Africans may present with CLL at a younger age and our data suggest that CLL in Senegal may be more aggressive than in Western populations. (Source: BMC Hematology)
Source: BMC Hematology - April 23, 2016 Category: Hematology Source Type: research

Endothelial fibrinolytic response onto an evolving matrix of fibrin
Abstract Background Fibrin provides a temporary matrix at the site of vascular injury. The aims of the present work were (1) to follow fibrin formation and lysis onto the surface of human dermal microvascular endothelial cells (HMEC-1), and (2) to quantify the secretion of fibrinolytic components in the presence of fibrin. Methods Fibrin clots at different fibrinogen concentrations were formed on top of (model 1) or beneath (model 2) the endothelial cells. Fibrin formation or lysis onto the surface of HMEC-1 cells, was followed by turbidity. Clot ...
Source: BMC Hematology - April 14, 2016 Category: Hematology Source Type: research

A case of multiple myeloma presenting as a distal renal tubular acidosis with extensive bilateral nephrolithiasis
Conclusion Isolated distal renal tubular acidosis is a rare presentation of multiple myeloma. In the absence of hypercalciuria and demonstrable light chain excretion in urine, we assumed that the distal renal tubular acidosis could have been caused by monoclonal hypergammaglobulinaemic state of multiple myeloma. (Source: BMC Hematology)
Source: BMC Hematology - March 17, 2016 Category: Hematology Source Type: research

Randomized double-blind safety comparison of intravenous iron dextran versus iron sucrose in an adult non-hemodialysis outpatient population: A feasibility study
Conclusion In this limited feasibility study, no major differences in immediate reactions were seen, but a significantly higher number of delayed reactions were seen in the iron sucrose group. Further, under our assumptions and design a full RCT to evaluate the safety of different intravenous iron preparations is not feasible. Future studies should consider modifying the clinical outcomes, utilize multiple centers, and consider other emerging parenteral iron formulations. (ClinicalTrials.gov NCT005936197 January 3, 2008). (Source: BMC Hematology)
Source: BMC Hematology - March 11, 2016 Category: Hematology Source Type: research

Hospitalization for pulmonary embolism associated with antecedent testosterone or estrogen therapy in patients found to have familial and acquired thrombophilia
Conclusions Of 154 men hospitalized for PE, 8 (5 %) used TT, and of 193 women, 24 (12 %) used ET. Our data suggests that PE is an important complication of TT in men and ET in women, in part reflecting an interaction between familial and acquired thrombophilia and exogenous hormone use. (Source: BMC Hematology)
Source: BMC Hematology - March 8, 2016 Category: Hematology Source Type: research

BMC Hematology reviewer acknowledgement 2015
Contributing reviewers The editors of BMC Hematology would like to thank all our reviewers who have contributed to the journal in Volume 15 (2015). (Source: BMC Hematology)
Source: BMC Hematology - February 22, 2016 Category: Hematology Source Type: research

The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate
Conclusion These results indicate that primitive erythropoiesis occurs in adult mice to rescue critical anemia because primitive erythropoiesis does not require macrophages as stroma whereas macrophages play a pivotal role in definitive erythropoiesis even outside the medulla. The cells expressing embryonic hemoglobin in this study were similar to primitive erythrocytes, indicating the possibility that yolk sac-derived primitive erythroid cells may persist into adulthood in mice. (Source: BMC Hematology)
Source: BMC Hematology - February 11, 2016 Category: Hematology Source Type: research

Hypersplenism in liver disease and SLE revisited: current evidence supports an active rather than passive process
Discussion Cytopenias and splenomegaly in both liver disease and systemic lupus erythematosus (SLE) poorly correlate with portal hypertension, and likely reflect an active process allocating stem cell resources in response to injury. Organ injury is repaired partly by bone-marrow-derived stem cells. Signaling would thus be needed to allocate resources between repair and routine marrow activities, hematologic and bone production. Granulocyte-colony stimulating factor (G-CSF) may play a central role: mobilizing stem cells, increasing spleen size and downregulating bone production. Serum G-CSF rises with liver inju...
Source: BMC Hematology - February 9, 2016 Category: Hematology Source Type: research

Drug-related problems and potential contributing factors in the management of deep vein thrombosis
Conclusions The most prevalent anticoagulation drug-related problems were subtherapeutic doses, overtherapeutic doses and potential drug interactions. Institutional validated decision support tools for dosing decisions during maintenance anticoagulation therapy should be developed and used accordingly in order to prevent recurrent and hemorrhagic complications and to improve clinical outcomes. (Source: BMC Hematology)
Source: BMC Hematology - February 4, 2016 Category: Hematology Source Type: research

Effect of anti-tuberculosis drugs on hematological profiles of tuberculosis patients attending at University of Gondar Hospital, Northwest Ethiopia
Abstract Background Tuberculosis (TB) treatment may present significant hematological disorder and some anti-TB drugs also have serious side effects. Although many other diseases may be reflected by the blood and its constituents, the abnormalities of red cells, white cells, platelets, and clotting factors are considered to be primary hematologic disorder as a result of tuberculosis treatment. The aim of this study was to determine hematological profiles of TB patients before and after intensive phase treatment. Objective The aim of this study was...
Source: BMC Hematology - January 8, 2016 Category: Hematology Source Type: research

Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study
Conclusion These findings reveal a novel effect of GA, which may be used to foster fetal hemoglobin production. Trial registration ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015. (Source: BMC Hematology)
Source: BMC Hematology - December 29, 2015 Category: Hematology Source Type: research

Bleeding complications from the direct oral anticoagulants
Conclusions Management of DOAC bleeding is variable. Clinical trial data regarding DOAC reversal is needed to facilitate optimization and standardization of bleeding treatment algorithms. (Source: BMC Hematology)
Source: BMC Hematology - December 24, 2015 Category: Hematology Source Type: research

Decreased erythrocyte nucleoside transport and hENT1 transporter expression in glucose 6-phosphate dehydrogenase deficiency
This study investigated hENT1 expression and nucleoside transport in G6PD-deficient erythrocytes to determine if decreased hENT1 activity might be a contributory feature in the variable pathology of this enzymopathy. Methods Uptake of 3H-uridine was measured at room temperature using an inhibitor-oil stop protocol and 5-s incubations. Erythrocyte membranes were analyzed by SDS-PAGE and nucleoside (hENT1), glucose (GLUT-1), and anion exchange (Band 3) transporter polypeptides quantitated on immunoblots. Results In G6PD-deficient cells, u...
Source: BMC Hematology - December 19, 2015 Category: Hematology Source Type: research

Therapeutic dilemma in the management of a patient with the clinical picture of TTP and severe B 12 deficiency
Conclusions TTP is a rare condition with fatal consequences if left untreated. Guidelines recommend TPE even if there is uncertainty about the diagnosis of TTP. B12 deficiency is common, though not typically associated with severe hematologic abnormalities. We compare the presenting characteristics of all thirteen cases of pseudo-TTP reported in the literature with those from patients in case series of TTP to suggest a set of parameters that can help clinicians distinguish between pseudo-TTP and TTP and guide decision making regarding intervention. Evaluation of all TTP cases should include a B12, methylmalonic ...
Source: BMC Hematology - December 1, 2015 Category: Hematology Source Type: research

Anemia in prospective blood donors deferred by the copper sulphate technique of hemoglobin estimation
Conclusion The study showed that a significant number of the prospective blood donors deferred for having low hemoglobin by the copper sulphate method turned out to have anemia by the standard method of diagnosis. Prevalence of anemia among apparently healthy blood donors was therefore higher than expected. Measures must therefore be taken to address this in order not to lose potential blood donors due to a correctable and preventable cause such as anemia. (Source: BMC Hematology)
Source: BMC Hematology - October 22, 2015 Category: Hematology Source Type: research

Numerical analysis of in vivo platelet consumption data from ITP patients
Abstract Background Numerical methods have recently allowed quantitative interpretation of in vivo murine platelet consumption data in terms of values for the random destruction rate constant (RD), intrinsic lifespan (LS), and the standard deviation of ln LS (SD), as well as the platelet production rate (PR) and age distribution (AD). But application of these methods to data obtained in thrombocytopenic patients is problematic for two reasons. First, such data has in all cases been obtained with radiolabeled platelets, and uptake of the radio-isotope by long lived cells complicates the anal...
Source: BMC Hematology - October 19, 2015 Category: Hematology Source Type: research

Prevalence and factors associated with severe anaemia amongst under-five children hospitalized at Bugando Medical Centre, Mwanza, Tanzania
Conclusion The prevalence of anaemia among under-five children admitted at BMC was high. Iron deficiency anaemia was the most common type. Factors associated with severe anaemia were unemployment among caretakers, malaria parasitaemia and presence of sickle haemoglobin. (Source: BMC Hematology)
Source: BMC Hematology - October 12, 2015 Category: Hematology Source Type: research

Prevalence and associated risk factors of anemia among HIV infected children attending Gondar university hospital, Northwest Ethiopia: a cross sectional study
Conclusions The majority of HIV positive children in Northwest Ethiopia have a mild type of anemia and the increase in prevalence of anemia is due to being on cotrimoxazole and eating green leafy vegetables. Therefore, early diagnosis and treatment of anemia is essential in these patients. (Source: BMC Hematology)
Source: BMC Hematology - September 24, 2015 Category: Hematology Source Type: research

Detection of coagulopathy in paediatric heart surgery [DECISION study]: study protocol
Discussion The DECISION study will identify the most useful thromboeastometry tests of blood coagulation for the prediction of excessive bleeding in children after cardiac surgery and will inform the design of future randomised controlled trials. Trial registration The trail was registered as ISRCTN55439761 on 23rd April 2015. (Source: BMC Hematology)
Source: BMC Hematology - August 19, 2015 Category: Hematology Source Type: research

Case-report: EBV driven lymphoproliferative disorder associated with Ruxolitinib
Conclusions Our report further underlines that patients treated with Ruxolitinib should be monitored closely for reactivations of opportunistic pathogens and viral infections. (Source: BMC Hematology)
Source: BMC Hematology - July 11, 2015 Category: Hematology Source Type: research

A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal-bone marrow: a simple and rapid method for the isolation of mouse central bone marrow
Conclusions A simple, rapid and efficient method for the isolation of cBM from the femora and tibiae of mice is detailed. Harvest of tibial cBM yielded about half as many cells as from the femora, representing 6.4 % and 13 %, respectively, of the total cBM of a mouse based on our analysis and a review of the literature. HSC populations were enriched within the eBM and the yield of HSCs from the mouse and human long bones was increased notably by harvest of eBM. (Source: BMC Hematology)
Source: BMC Hematology - July 9, 2015 Category: Hematology Source Type: research

Use of Valacyclovir for the treatment of cytomegalovirus antigenemia after hematopoietic stem cell transplantation
Conclusion High dose Valacyclovir is a potential alternative to Valganciclovir and Foscarnet in the stable post-HSCT patient who has cytopenia and is not keen for inpatient treatment of CMV antigenemia. (Source: BMC Hematology)
Source: BMC Hematology - June 19, 2015 Category: Hematology Source Type: research

An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome
Conclusion To our knowledge, this is the first reported case of venous thromboembolism in pregnancy associated with heterotaxy syndrome. A discussion on pathophysiology of venous thromboembolism in pregnancy and heterotaxy syndrome has been undertaken along with treatment approach in such situations. (Source: BMC Hematology)
Source: BMC Hematology - May 12, 2015 Category: Hematology Source Type: research

Prevalence and correlates of anemia among HIV infected patients on highly active anti-retroviral therapy at Zewditu Memorial Hospital, Ethiopia
In this study, we investigated the magnitude and correlates of anemia among HIV infected patients receiving HAART at a referral hospital in Ethiopia. Methods A retrospective cohort study was conducted from November 2011 to February 2012 in Zewditu Memorial Hospital, Addis Ababa, Ethiopia. Records of 1061 patients on HAART were selected using simple random sampling technique. Socio-demographic and clinical characteristics of the study patients were collected using standardized data extraction instrument. Data were analyzed using STATA version 11.0. Odds ratios with 95% confidence ...
Source: BMC Hematology - April 30, 2015 Category: Hematology Source Type: research

BMC Hematology reviewer acknowledgement 2014
Contributing reviewers The editors of BMC Hematology would like to thank all our reviewers who have contributed to the journal in Volume 14 (2014). (Source: BMC Hematology)
Source: BMC Hematology - February 25, 2015 Category: Hematology Source Type: research

Prophylaxis in older Canadian adults with hemophilia A: lessons and more questions
Conclusion A significant number of older adults use secondary/tertiary continuous prophylaxis in Canada, accounting for a significant fraction of factor concentrate utilization. (Source: BMC Hematology)
Source: BMC Hematology - February 14, 2015 Category: Hematology Source Type: research

Case report: paroxysmal cold hemoglobinuria presenting during pregnancy
Conclusion This patient had a classic presentation of paroxysmal cold hemoglobinuria with rapid onset of hemolytic anemia that resolved spontaneously. To our knowledge, this is the first report of paroxysmal cold hemoglobinuria presenting during pregnancy. (Source: BMC Hematology)
Source: BMC Hematology - February 13, 2015 Category: Hematology Source Type: research

Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report
Conclusion The missed and delayed diagnosis may be attributable to insufficient awareness of this rare disease on the background of frequent infections even in the immunocompetent pediatric population in Vietnam. Our results indicate further evidence for the role of ELANE in SCN. (Source: BMC Hematology)
Source: BMC Hematology - January 24, 2015 Category: Hematology Source Type: research

The IL-10 polarized cytokine pattern in innate and adaptive immunity cells contribute to the development of FVIII inhibitors
Conclusions The global cytokine profiles of innate and adaptive immune cells showed an anti-inflammatory/regulatory pattern in HAα-FVIII(+) patients and a mixed pattern, with a bias toward inflammatory cytokine profile, in HAα-FVIII(−) patients. The occurrence of these profiles seems to be associated with presence FVIII inhibitors. (Source: BMC Hematology)
Source: BMC Hematology - January 16, 2015 Category: Hematology Source Type: research

Thrombosis as a complication of central venous access in pediatric patients with malignancies: a 5-year single-center experience
Conclusions We conclude that pediatric surgeons and oncologists should pay close attention to ensuring optimal and accurate CVC placement, as this appears the most effective tool to minimize CVC-associated complications. (Source: BMC Hematology)
Source: BMC Hematology - October 1, 2014 Category: Hematology Source Type: research

Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia
Conclusion Elevations in CRP and IL-6 levels occurring with increases in basophil counts to high levels revealed that febrile episodes with abdominal pain seen in our patient were induced by increase in IL-6 levels released from neoplastic basophils. Neoplastic basophils with diffuse and coarse basophilic granules possibly mimic neutrophils with toxic granules and cause wrong characterization of neoplastic basophils as neutrophils by the automated blood cell counters and misleaded physicians. (Source: BMC Hematology)
Source: BMC Hematology - September 13, 2014 Category: Hematology Source Type: research

A case of congenital TTP presenting with microganiopathy in adulthood
Conclusion Congenital TTP is a rare condition, and the above case is atypical as the patient did not present with clear evidence of microangiopathy until adulthood. Although this a rare condition it is important for physicians to be aware of as it, especially the possibility of atypical presentations, as the condition is potentially fatal and effective treatment exists. (Source: BMC Hematology)
Source: BMC Hematology - September 12, 2014 Category: Hematology Source Type: research

Profile of blood cell abnormalities among antiretroviral therapy naïve HIV patients attending the Yaounde University Teaching Hospital, Cameroon
Abstract Background Abnormal hemograms are common manifestations and important predictive tools for morbidity in the human immunodeficiency virus (HIV) infection. Few studies have been reported on the blood profile of HIV antiretroviral therapy (ART) naive subjects, therefore this study aimed to quantitatively and qualitatively describe the blood cell profile of HIV ART naive patients, and to describe the occurrence of the blood cytopenias by CD4 cell counts and WHO clinical stage. Methods This cross-sectional study of ART naive HIV patients was d...
Source: BMC Hematology - September 8, 2014 Category: Hematology Source Type: research

Impact of clinical factors and allograft leukocyte content on post-transplant lymphopenia, monocytopenia, and survival in patients undergoing allogeneic peripheral blood haematopoietic cell transplant
Abstract Background We have previously shown that lymphopenia and monocytopenia at 2–3 months post-allogeneic haematopoietic cell transplant (HCT) is associated with poor survival in recipients of both myeloablative and reduced intensity conditioning regimens. It is not known whether the graft leukocyte content has a role in early lymphocyte and monocyte recovery following allogeneic T-cell replete peripheral blood HCT. Methods Haematologic recovery data, including absolute lymphocyte and monocyte counts (ALC and AMC, respectively) at day +1...
Source: BMC Hematology - September 1, 2014 Category: Hematology Source Type: research

Anemia and associated factors among school-age children in Filtu Town, Somali region, Southeast Ethiopia
Conclusion Anemia is a moderate public health problem in school-age children for the study area. Interventions targeting nutritional deficiencies and parasitic infections are recommended. (Source: BMC Hematology)
Source: BMC Hematology - August 18, 2014 Category: Hematology Source Type: research

Vitamin D levels are low in adult patients with sickle cell disease in Jamaica and West Africa
Conclusions Low 25(OH)D levels in tropical Africa where the burden of sickle cell disease is highest, deserve further investigation, and a randomized trial is warranted to address efficacy of supplementation. (Source: BMC Hematology)
Source: BMC Hematology - August 16, 2014 Category: Hematology Source Type: research