Hematological profile of pregnant women at St. Paul ’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
This study aimed to assess hematological profiles of pregnant women at a tertiary care teaching hospital.MethodThis cross sectional study was conducted among 284 consecutive pregnant women at St. Paul ’s Hospital Millennium Medical College. Socio-demographic characteristics were collected using pre-tested structured questionnaire. About 4 ml of venous blood was collected from each participant for hematological parameters analysis using Cell-Dyn1800 (Abbott Laboratories Diagnostics Division, US A) and peripheral blood film review.ResultThere were differences in mean hematological parameters between trimesters: sp...
Source: BMC Hematology - July 9, 2018 Category: Hematology Source Type: research

Anemia and associated factors among children aged 6 –23 months in Damot Sore District, Wolaita Zone, South Ethiopia
ConclusionPrevalence of anemia among children (6 –23 months) was a severe public health problem in the study area. Most important predictors are suboptimal child feeding practices, household food insecurity, and poor diet. Multi-sectoral efforts are needed to improve health and interventions targeting nutrition security are recommended. (Source: BMC Hematology)
Source: BMC Hematology - July 3, 2018 Category: Hematology Source Type: research

Experimental folate deficiency in human subjects: what is the influence of vitamin C status on time taken to develop megaloblastic anaemia?
ConclusionBecause of the importance of folate in one-carbon metabolism, the potential influence of vitamin C intake on the time taken to deplete the liver folate store should be experimentally investigated. (Source: BMC Hematology)
Source: BMC Hematology - June 19, 2018 Category: Hematology Source Type: research

Adapting medical guidelines to be patient-centered using a patient-driven process for individuals with sickle cell disease and their caregivers
ConclusionsIndividuals with SCD and their caregivers want access to guidelines through multiple channels, including technology. Guidelines written for health care providers can be adapted to be patient-centered using Community-engaged research involving providers and patients. These patient-centered guidelines provide a framework for patients to discuss their medical care with their health care providers. (Source: BMC Hematology)
Source: BMC Hematology - June 8, 2018 Category: Hematology Source Type: research

Hemostatic state augmented with platelet indices among Sudanese diabetic septic foot
AbstractBackgroundDiabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot.MethodsA case-control study was conducted during the period from July to September 2017 at Dr. Awaad medical center, Red Sea State, Sudan. 57 diabetic patients with septic foot, ag...
Source: BMC Hematology - May 11, 2018 Category: Hematology Source Type: research

Blood factory: which stem cells?
AbstractBlood transfusions are often essential for treatment of severe anaemia and pregnancy complications. The unavailability of blood is a medical concern, especially in developing countries. New sources of red blood cells (RBC) are under investigation. Several studies have attempted to produce functional RBC from CD34+ haematopoietic stem cells (HSC) isolated from peripheral blood and umbilical cord blood, from embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). A recent article published in Nature Communications describes a novel model for generating RBC from a stable erythroid cell line obtained from...
Source: BMC Hematology - May 10, 2018 Category: Hematology Source Type: research

Prevalence of thrombocytopenia before and after initiation of HAART among HIV infected patients at black lion specialized hospital, Addis Ababa, Ethiopia: a cross sectional study
AbstractBackgroundHematological abnormalities are common in HIV positive patients. Of these, thrombocytopenia is a known complication which has been associated with a variety of bleeding disorders. However, its magnitude and related factors have not been well-characterized in the era of highly active antiretroviral therapy (HAART) in Ethiopia. Therefore, this study aimed to assess the prevalence of thrombocytopenia before and after initiation of HAART among HIV positive patients attending Black Lion Specialized Hospital, Addis Ababa, Ethiopia.MethodsA cross sectional study was conducted from February to April 2017 in Black...
Source: BMC Hematology - May 9, 2018 Category: Hematology Source Type: research

Prevalence of cytopenias in both HAART and HAART na ïve HIV infected adult patients in Ethiopia: a cross sectional study
AbstractBackgroundIn individuals infected with HIV, hematological abnormalities are common and are associated with increased risk of disease progression and death. However, the profile of hematological abnormalities in HIV infected adult patients is not known in Ethiopia. Thus, the aim of this study was to assess the hematological manifestations of HIV infection and to identify the factors associated with cytopenias in both HAART and HAART na ïve HIV infected adult patients in Ethiopia.MethodWe conducted a cross-sectional quantitative study of HIV-infected adult patients attending the ART follow-up clinic of Jimma Uni...
Source: BMC Hematology - April 5, 2018 Category: Hematology Source Type: research

Prevalence of anemia before and after initiation of antiretroviral therapy among HIV infected patients at Black Lion Specialized Hospital, Addis Ababa, Ethiopia: a cross sectional study
This study was aimed to assess the prevalence of anemia before and after initiation of antiretroviral therapy (ART) among HIV positive patients attending Black Lion Specialized Hospital, Addis Ababa, Ethiopia.MethodsA cross sectional study was conducted from January to April, 2017 in Black Lion Specialized Hospital, Addis Ababa, Ethiopia. A total of 255 patients on ART were selected using simple random sampling techniques. Socio-demographic and clinical characteristics of the study subjects were collected using structured questionnaire. Measurements of complete blood cell counts and CD4  + T cell counts were ...
Source: BMC Hematology - March 15, 2018 Category: Hematology Source Type: research

A pilot study on the usefulness of peripheral blood flow cytometry for the diagnosis of lower risk myelodysplastic syndromes: the “MDS thermometer”
ConclusionsPeripheral blood neutrophil and monocyte immunophenotyping provide useful information for the diagnosis of LR-MDS, as a complement to cytomorphology. If validated by subsequent studies in larger series of MDS patients and extended to non-MDS patients with cytopenias, our findings may improve the diagnostic assessment and avoid invasive procedures in selected groups of MDS patients. (Source: BMC Hematology)
Source: BMC Hematology - March 13, 2018 Category: Hematology Source Type: research

A rare case of avascular necrosis in sickle cell trait: a case report
ConclusionThere have only been scarce reports of avascular necrosis in patients with sickle cell trait. This manuscript presents such a case and includes the trials and tribulations associated with its management. (Source: BMC Hematology)
Source: BMC Hematology - February 22, 2018 Category: Hematology Source Type: research

More is less, less is more, or does it really matter? The curious case of impact of azacitidine administration schedules on outcomes in patients with myelodysplastic syndromes
AbstractMyelodysplastic syndromes (MDS) encompass a diverse group of hematologic disorders characterized by ineffective and malignant hematopoiesis, peripheral cytopenias and significantly increased risk of progression to acute myeloid leukemia (AML). The hypomethylating agents (HMA) azacitidine and decitabine induce meaningful clinical responses in a significant subset of patients with MDS. Though never compared directly with decitabine, only azacitidine has improved overall survival (OS) compared to conventional care in a randomized trial in patients with higher-risk MDS. The azacitidine regimen used in this pivotal tria...
Source: BMC Hematology - February 1, 2018 Category: Hematology Source Type: research

Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia
ConclusionsIndirect comparison of alternative azacitidine dosing regimens in MDS and AML shows a benefit for the 7-day regimen in attaining ORR. Additional RCTs are required to definitively address this comparison. (Source: BMC Hematology)
Source: BMC Hematology - January 31, 2018 Category: Hematology Source Type: research

Factor V Leiden G1691A and prothrombin G20210A mutations among Palestinian patients with sickle cell disease
ConclusionsFVL was more prevalent among SS patients compared to controls and it was associated with higher incidence of disease complications among SCD patients. (Source: BMC Hematology)
Source: BMC Hematology - January 16, 2018 Category: Hematology Source Type: research

Pregnant mothers are more anemic than lactating mothers, a comparative cross-sectional study, Bahir Dar, Ethiopia
ConclusionThe burden of anemia was higher in pregnant women than lactating women. (Source: BMC Hematology)
Source: BMC Hematology - January 16, 2018 Category: Hematology Source Type: research

A novel fibrinogen mutation: FGA g. 3057 C   & gt;  T (p. Arg104  & gt;  Cys) impairs fibrinogen secretion
ConclusionsThe low expression of the A α Arg104 >  Cys chain in circulation could account for the observed hypodysfibrinogenemia. (Source: BMC Hematology)
Source: BMC Hematology - December 22, 2017 Category: Hematology Source Type: research

A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia
ConclusionHypertension has impact on hematological parameters. In this study, the mean and median values of haematological parameters in hypertensive individuals were significantly different compared to apparently healthy normotensive individuals. Hence, hematological parameters can be used to monitor the prognosis of the disease and manage hypertensive related complications, and it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated hematological disorders. (Source: BMC Hematology)
Source: BMC Hematology - November 28, 2017 Category: Hematology Source Type: research

Knowledge, attitude and practice of students towards blood donation in Arsi university and Adama science and technology university: a comparative cross sectional study
AbstractBackgroundBlood can save millions of lives. Even though people do not donate blood regularly, there is a constant effort to balance the supply and demand of blood. The aim of this study was, therefore, to determine the knowledge, attitude and practice of blood donation between university students.MethodsThe comparative cross sectional study design was used in Adama Science and Technology University and Arsi University from April 11 –May 2, 2016.360 students were selected using stratified sampling. Frequencies and proportions were computed. Chi-Square and logistic regressions were carried out and associations ...
Source: BMC Hematology - November 21, 2017 Category: Hematology Source Type: research

Emergency blood transfusion practices among anaemic children presenting to an urban emergency department of a tertiary hospital in Tanzania
AbstractBackgroundSevere anaemia contributes significantly to mortality, especially in children under 5  years of age. Timely blood transfusion is known to improve outcomes. We investigated the magnitude of anaemia and emergency blood transfusion practices amongst children under 5 years presenting to the Emergency Department (ED) of Muhimbili National Hospital (MNH) in Tanzania.MethodsThis prospective observational study enrolled children under 5  years old with anaemia, over a 7-week period in August and September of 2015. Anaemia was defined as haemoglobin of
Source: BMC Hematology - November 10, 2017 Category: Hematology Source Type: research

Coagulation profile of Sudanese children with homozygous sickle cell disease and the effect of treatment with omega-3 fatty acid on the coagulation parameters
In this study, we investigated whether Sudanese sickle cell patients have an abnormal coagulation profile. In addition, the effect of treatment with either omega-3 fatty acids or hydroxyurea on coagulation profile was assessed.MethodsHomozygous SCD patients untreated (n = 52), omega-3 treated (n = 44), hydroxyurea (HU) treated (n = 8) and healthy (HbAA) controls (n = 52) matched for age (4–20 years), gender and socioeconomic status were enrolled. Patients on omega-3 fatty acids, according to age, received one to four capsules containing 277.8 mg DHA and 39.0 mg e...
Source: BMC Hematology - November 9, 2017 Category: Hematology Source Type: research

Prevalence and determinants of anemia among pregnant women in Ethiopia; a systematic review and meta-analysis
ConclusionsAlmost one-third of pregnant women in Ethiopia were anemic. Statistically significant association was observed between anemia during pregnancy and residence, gravidity, pregnancy interval, and malaria infection during pregnancy. Regions with higher anemia prevalence among pregnant women should be given due emphasis. The concerned body should intervene on the identified factors to reduce the high prevalence of anemia among pregnant women. (Source: BMC Hematology)
Source: BMC Hematology - October 17, 2017 Category: Hematology Source Type: research

Significantly elevated foetal haemoglobin levels in individuals with glucose 6-phosphate dehydrogenase disease and/or sickle cell trait: a cross-sectional study in Cape Coast, Ghana
This study sought to assess how inheritance of G6PD enzymopathy affects the level of Hb F and haemoglobin concentration in adults in steady state.MethodsThis cross-sectional study selected 100 out-patients (41 males and 59 females) visiting the University of Cape Coast hospital, between January, 2016 and May, 2016. Cellulose acetate electrophoresis (pH  8.2–8.6), methaemoglobin reductase test, modified Betke alkaline denaturation methods were used to investigate haemoglobin variants, qualitative G6PD status, and %Hb F levels in venous blood samples drawn from these participants. Data was analysed with GraphPad P...
Source: BMC Hematology - September 25, 2017 Category: Hematology Source Type: research

Comparative study of sickle cell anemia and hemoglobin SC disease: clinical characterization, laboratory biomarkers and genetic profiles
ConclusionsOur data emphasize the differences between SCA and HbSC patients based on laboratory parameters and the clinical and genetic profile of both genotypes. (Source: BMC Hematology)
Source: BMC Hematology - September 15, 2017 Category: Hematology Source Type: research

Alterations in hematologic indices during long-duration spaceflight
ConclusionsWhile susceptible to the possible influence of dehydration or plasma volume alterations, these results suggest astronauts do not develop persistent anemia during spaceflight. (Source: BMC Hematology)
Source: BMC Hematology - September 8, 2017 Category: Hematology Source Type: research

The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study
ConclusionsOur results suggest that in eastern Uganda, children with sickle cell anaemia experience epistaxis more frequently and with greater severity than children without sickle cell anaemia. Further studies are indicated to confirm this conclusion and investigate aetiology. (Source: BMC Hematology)
Source: BMC Hematology - September 7, 2017 Category: Hematology Source Type: research

An outline of anemia among adolescent girls in Bangladesh: findings from a cross-sectional study
AbstractBackgroundAnemia is a significant wide spread public health threat especially among the adolescent girls who are more vulnerable towards low level of hemoglobin particularly of low and middle income countries (LMICs). We investigated the prevalence of anemia among the adolescent girls (10 –19 years) in Bangladesh and its socio-demographics distribution.MethodsWe collected data digitally in ODK platform from a sub-sample of a nationwide cross-sectional survey of 1314 adolescent girls in 2015. Capillary blood hemoglobin level was estimated using HemoCue ®; anthropometric measurements through standardiz...
Source: BMC Hematology - August 22, 2017 Category: Hematology Source Type: research

Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan preschool children: a community-based survey
ConclusionsIn young children, whole blood ZPP and erythrocyte ZPP have added diagnostic value in detecting iron deficiency compared to haemoglobin concentration alone. A single diagnostic score based on haemoglobin concentration and whole blood ZPP can rule out iron deficiency in a substantial proportion of children screened.Trial registrationClinicalTrials.gov NCT02073149 (25 February 2014). (Source: BMC Hematology)
Source: BMC Hematology - July 27, 2017 Category: Hematology Source Type: research

Prevalence of Anaemia and Associated Risk Factors among Children in North-western Uganda: A Cross Sectional Study
This study investigated, for the first time, the prevalence of childhood anaemia and its risk factors in an urban setting in Uganda.MethodsA total of 342 children were enrolled. Venous blood samples were collected in EDTA tubes and analyzed using Symex 500i (Symex Corp. Japan). Stool and urine samples were analyzed according to established standard methods. Anthropometric indicators were calculated according to the CDC/WHO 1978 references. Ethical approval was granted.ResultsCategorically, the prevalence of anaemia was; 37.2, 33.3 and 11.8% among children aged 1 –5 years, 6–11 years and 12–14&nb...
Source: BMC Hematology - July 3, 2017 Category: Hematology Source Type: research

Portal hypertension as the initial manifestation of POEMS syndrome: a case report
ConclusionThis case highlights the manifestation of portal hypertension in POEMS syndrome. Lenalidomide with or without dexamethasone is effective for portal hypertension due to POEMS syndrome, though esophageal and gastric varices seems not reversible so easily. (Source: BMC Hematology)
Source: BMC Hematology - May 11, 2017 Category: Hematology Source Type: research

Circumcision in hemophilia using low quantity of factor concentrates: experience from Dakar, Senegal
ConclusionThe study shows treatment protocol using low quantity of factor concentrates is efficient in hemophilia patients who underwent circumcision. (Source: BMC Hematology)
Source: BMC Hematology - April 24, 2017 Category: Hematology Source Type: research

Prevention practices influencing frequency of occurrence of vaso-occlusive crisis among sickle cell patients in Abeokuta South Local Government Area of Ogun State, Nigeria
ConclusionThe study reveals that majority of the participants have high frequency of crisis in a month. Drug prophylaxis rather than lifestyle factors may be more important in the prevention of vaso-occlusive crisis among sickle cell patients. (Source: BMC Hematology)
Source: BMC Hematology - April 20, 2017 Category: Hematology Source Type: research

Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study
ConclusionsIn this population of patients living with SCD, chronic complications are frequent and their QOL is consequently poor. Our results highlight the need for national guidelines for SCD control, which should include new-born screening programs and strategies to prevent chronic complications. (Source: BMC Hematology)
Source: BMC Hematology - April 20, 2017 Category: Hematology Source Type: research

Case report: primary osteonecrosis associated with thrombophilia-hypofibrinolysis and worsened by testosterone therapy
ConclusionsIdiopathic ON, often caused by thrombophilia-hypofibrinolysis, is worsened by TT, and its progression may be slowed or stopped by discontinuation of TT and, thereafter, anticoagulation. Recognition of thrombophilia-hypofibrinolysis before joint collapse facilitates anticoagulation which may stop ON, preserving joints. (Source: BMC Hematology)
Source: BMC Hematology - March 27, 2017 Category: Hematology Source Type: research

Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial
AbstractBackgroundSickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protecting against experimental hepatic, renal and cardiac toxicities in rats. We hypothesized that regular intake of GA increases anti-o...
Source: BMC Hematology - March 16, 2017 Category: Hematology Source Type: research

Chronic lymphocytic leukemia with clinical debut as neurological involvement: a rare phenomenon and the need for better predictive markers
ConclusionsThese data suggest that the expression profile of CD49d and CD82 may represent potential biomarkers for patients with increased propensity of CNS involvement. Moreover, this study illustrates the critical need for a better mechanistic understanding of how specific adhesion proteins regulate the interactions between CLL cells and various tissue sites. (Source: BMC Hematology)
Source: BMC Hematology - February 2, 2017 Category: Hematology Source Type: research

Effect of malaria infection on hematological profiles of people living with human immunodeficiency virus in Gambella, southwest Ethiopia
AbstractBackgroundMalaria and human immunodeficiency virus are the two most devastating global health problems causing more than two million deaths each year. Hematological abnormalities such as anemia, thrombocytopenia and leucopenia are the common complications in malaria and HIV co-infected individuals. The aim of this study was to determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia.ObjectiveTo determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART...
Source: BMC Hematology - February 2, 2017 Category: Hematology Source Type: research

Prevalence of anemia in renal insufficiency among HIV infected patients initiating ART at a hospital in Northeast Ethiopia
In this study, we investigated the prevalence of anemia and its association with renal insufficiency among HIV infected patients initiating ART at a hospital in Northeast Ethiopia.MethodsIn this retrospective cohort study, records of 373 patients on ART were selected in Dessie Referral hospital, South Wollo, Northeast Ethiopia from September 2010 to August 2013. Socio-demographic and clinical characteristics of the study patients were collected using standardized data extraction instrument. The abbreviated 4-variable Modification of Diet in Renal Disease (MDRD) study equation was used to estimate renal function (GFR) from ...
Source: BMC Hematology - January 17, 2017 Category: Hematology Source Type: research

Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections
ConclusionThe prevalence of SCD among under-five children presenting with fever was high in the study population. No association was found between SCT and malaria but few viruses, especially parechovirus, seem to play an important role in the occurrence of pneumoniae among SCD patients. (Source: BMC Hematology)
Source: BMC Hematology - December 1, 2016 Category: Hematology Source Type: research

Anaemia and its association with month and blood phenotype in blood donors in Fako division, Cameroon
This study was undertaken to determine the prevalence of anaemia and its association with month and blood phenotype in blood donors in Fako division of Cameroon.MethodsBlood donors were recruited between the 1st of January and 31st of December 2014, and their haemoglobin concentration (Hb) was determined using a haemoglobinometer. Anaemia was considered as Hb  
Source: BMC Hematology - November 28, 2016 Category: Hematology Source Type: research

Hemophagocytic lymphohistiocytosis complicating a T-cell rich B-cell lymphoma
ConclusionPrompt etiologic diagnosis and treatment of hemophagocytic lymphohistiocytosis leads to satisfactory outcome. (Source: BMC Hematology)
Source: BMC Hematology - November 24, 2016 Category: Hematology Source Type: research

Prevalence of transfusion transmissible infections in blood donors of Pakistan
ConclusionA substantial percentage of the blood donor ’s harbored transfusion-transmitted infections. Prevention of TTIs should be the main goal right now. There is a need for stringent selection of blood donors with the emphasis on getting voluntary donations and comprehensive screening of donor’s blood for TTIs using standard methods to ensure th e safety of blood recipient. (Source: BMC Hematology)
Source: BMC Hematology - November 18, 2016 Category: Hematology Source Type: research

Adherence to treatment regimen and bleeding rates in a prospective cohort of youth and young adults on low-dose daily prophylaxis for severe hemophilia A
ConclusionsThis prospective longitudinal study in youth and young adults shows that LDDP may be associated with low ABRs, adequate adherence and HRQoL comparable to previously reported. (Source: BMC Hematology)
Source: BMC Hematology - November 8, 2016 Category: Hematology Source Type: research

KIR repertory in patients with hematopoietic diseases and healthy family members
AbstractBackgroundSince the discovery of specific histocompatibility, literature has associated genes involved in the immune response, like the Human Leucocyte Antigen (HLA), with a better prognosis in transplantation. However, other non-HLA genes may also influence the immune process, such as the genes encoding the immunoglobulin-like receptors of natural killer cells (KIRs). The discovery that NK cell KIR receptors interact with conservative epitopes (C1, C2, Bw4) presented in HLA class I molecules that are genetically polymorphic, also observed in KIR genes, led to the investigation of the relevance of the KIR system to...
Source: BMC Hematology - September 29, 2016 Category: Hematology Source Type: research

Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol
DiscussionThis research into the response to treatment of lower limb DVT and predictive factors for DVT resolution, recurrence and PTS could inform a more tailored approach to anticoagulation therapy for the future management of DVT.UKCRN ID: 16016. Registered on 20 January 2014. (Source: BMC Hematology)
Source: BMC Hematology - September 15, 2016 Category: Hematology Source Type: research