Comparative genomics and host range analysis of four Ralstonia pseudosolanacearum strains isolated from sunflower reveals genomic and phenotypic differences
Bacterial wilt caused by Ralstonia solanacearum species complex (RSSC) is one of the devastating diseases in crop production, seriously reducing the yield of crops. R. pseudosolanacearum, is known for its broad i... (Source: BMC Genomics)
Source: BMC Genomics - February 19, 2024 Category: Genetics & Stem Cells Authors: Shanwen Ding, Zijun Ma, Lin Yu, Guobing Lan, Yafei Tang, Zhenggang Li, Zifu He and Xiaoman She Tags: Research Source Type: research
Validated WGS and WES protocols proved saliva-derived gDNA as an equivalent to blood-derived gDNA for clinical and population genomic analyses
Whole exome sequencing (WES) and whole genome sequencing (WGS) have become standard methods in human clinical diagnostics as well as in population genomics (POPGEN). Blood-derived genomic DNA (gDNA) is routine... (Source: BMC Genomics)
Source: BMC Genomics - February 17, 2024 Category: Genetics & Stem Cells Authors: Katerina Kvapilova, Pavol Misenko, Jan Radvanszky, Ondrej Brzon, Jaroslav Budis, Juraj Gazdarica, Ondrej Pos, Marie Korabecna, Martin Kasny, Tomas Szemes, Petr Kvapil, Jan Paces and Zbynek Kozmik Tags: Research Source Type: research
Transcriptome reveals the roles and potential mechanisms of lncRNAs in the regulation of albendazole resistance in Haemonchus contortus
Haemonchus contortus (H. contortus) is the most common parasitic nematode in ruminants and is prevalent worldwide. H. contortus resistance to albendazole (ABZ) hinders the efficacy of anthelmintic drugs, but litt... (Source: BMC Genomics)
Source: BMC Genomics - February 17, 2024 Category: Genetics & Stem Cells Authors: Xindi Chen, Tengyu Wang, Wenrui Guo, Xu Yan, Huilin Kou, Yu Yu, Chunxia Liu, Wa Gao, Wenlong Wang and Rui Wang Tags: Research Source Type: research
Decoding the complexity of on-target integration: characterizing DNA insertions at the CRISPR-Cas9 targeted locus using nanopore sequencing
CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively cur... (Source: BMC Genomics)
Source: BMC Genomics - February 17, 2024 Category: Genetics & Stem Cells Authors: Juan-Juan Zhao, Xin-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin, Mei Zhao, Feng Zhang, Si-Ang Li, Zhi-Xue Yang, Wei Wen, Tao Cheng, An Gong, Jian-Ping Zhang and Xiao-Bing Zhang Tags: Research Source Type: research
Distinct regulatory networks control toxin gene expression in elapid and viperid snakes
Venom systems are ideal models to study genetic regulatory mechanisms that underpin evolutionary novelty. Snake venom glands are thought to share a common origin, but there are major distinctions between venom... (Source: BMC Genomics)
Source: BMC Genomics - February 16, 2024 Category: Genetics & Stem Cells Authors: Cassandra M. Modahl, Summer Xia Han, Jory van Thiel, Candida Vaz, Nathan L. Dunstan, Seth Frietze, Timothy N. W. Jackson, Stephen P. Mackessy and R. Manjunatha Kini Tags: Research Source Type: research
Upregulation of CALD1 predicted a poor prognosis for platinum-treated ovarian cancer and revealed it as a potential therapeutic resistance target
Ovarian cancer (OC) has the worst prognosis among gynecological malignancies, most of which are found to be in advanced stage. Cell reduction surgery based on platinum-based chemotherapy is the current standar... (Source: BMC Genomics)
Source: BMC Genomics - February 16, 2024 Category: Genetics & Stem Cells Authors: Wei Li, Limei Huang, Nana Qi, Qinle Zhang and Zailong Qin Tags: Research Source Type: research
In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code
Almost all extant organisms use the same, so-called canonical, genetic code with departures from it being very rare. Even more exceptional are the instances when a eukaryote with non-canonical code can be easi... (Source: BMC Genomics)
Source: BMC Genomics - February 16, 2024 Category: Genetics & Stem Cells Authors: Fred R. Opperdoes, Krist ína Záhonová, Ingrid Škodová-Sveráková, Barbora Bučková, Ľubomíra Chmelová, Julius Lukeš and Vyacheslav Yurchenko Tags: Research Source Type: research
Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype
Alpaca is a domestic South American camelid probably arising from the domestication of two wild camelids, the vicugna and the guanaco. Two phenotypes are described for alpaca, known as huacaya and suri. Huacay... (Source: BMC Genomics)
Source: BMC Genomics - February 16, 2024 Category: Genetics & Stem Cells Authors: Stefano Pallotti, Matteo Picciolini, Giovanni Deiana, Dario Pediconi, Marco Antonini, Valerio Napolioni and Carlo Renieri Tags: Research Source Type: research
Transcriptome profile of pecan scab resistant and susceptible trees from a pecan provenance collection
Pecan scab is a devastating disease that causes damage to pecan (Carya illinoinensis (Wangenh.) K. Koch) fruit and leaves. The disease is caused by the fungus Venturia effusa (G. Winter) and the main management p... (Source: BMC Genomics)
Source: BMC Genomics - February 15, 2024 Category: Genetics & Stem Cells Authors: Jordan Brungardt, Yanina Alarcon, Jason Shiller, Carolyn Young, Maria J. Monteros, Jennifer J. Randall and Clive H. Bock Tags: Research Source Type: research
Metatranscriptome analysis of symptomatic bitter apple plants revealed mixed viral infections with a putative novel polerovirus
In this study, leaf samples from bitte... (Source: BMC Genomics)
Source: BMC Genomics - February 15, 2024 Category: Genetics & Stem Cells Authors: Shahrbanou Ghorani, Hossein Massumi, Samin H. Farhangi, Mehdi Mansouri, Jahangir Heydarnejad and Akbar Hosseinipour Tags: Research Source Type: research
Comprehensive bioinformation analysis of homeodomain-leucine zipper gene family and expression pattern of HD-Zip I under abiotic stress in Salix suchowensis
Homeodomain-leucine zipper (HD-Zip) transcription factors are plant-specific and play important roles in plant defense against environmental stresses. Identification and functional studies have been carried ou... (Source: BMC Genomics)
Source: BMC Genomics - February 15, 2024 Category: Genetics & Stem Cells Authors: Yujiao Wang, Hongjuan Wang, Chun Yu, Xiaoming Yan, Jiasong Chu, Benli Jiang and Jiabao Zhu Tags: Research Source Type: research
Identification of gene biomarkers for brain diseases via multi-network topological semantics extraction and graph convolutional network
Brain diseases pose a significant threat to human health, and various network-based methods have been proposed for identifying gene biomarkers associated with these diseases. However, the brain is a complex sy... (Source: BMC Genomics)
Source: BMC Genomics - February 14, 2024 Category: Genetics & Stem Cells Authors: Ping Zhang, Weihan Zhang, Weicheng Sun, Jinsheng Xu, Hua Hu, Lei Wang and Leon Wong Tags: Research Source Type: research
Whole-genome resequencing provides insights into the diversity and adaptation to desert environment in Xinjiang Mongolian cattle
Xinjiang Mongolian cattle is an indigenous breed that inhabits the Taklimakan Desert and is characterized by its small body size. However, the genomic diversity, origin, and genetic basis underlying the adapta... (Source: BMC Genomics)
Source: BMC Genomics - February 14, 2024 Category: Genetics & Stem Cells Authors: Lei Xu, Kaiqing Zhou, Xixia Huang, Hong Chen, Hong Dong and Qiuming Chen Tags: Research Source Type: research
Single nucleotide polymorphisms (SNPs) in the open reading frame (ORF) of prion protein gene (PRNP) in Nigerian livestock species
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) remain one of the deleterious disorders, which have affected several animal species. Polymorphism of the prion protein (PRNP) gene ma... (Source: BMC Genomics)
Source: BMC Genomics - February 14, 2024 Category: Genetics & Stem Cells Authors: Adeniyi C. Adeola, Semiu F. Bello, Abdussamad M. Abdussamad, Rahamon A. M. Adedokun, Sunday C. Olaogun, Nasiru Abdullahi, Akanbi I. Mark, Anyebe B. Onoja, Oscar J. Sanke, Godwin F. Mangbon, Jebi Ibrahim, Philip M. Dawuda, Adebowale E. Salako, Samia Kdidi Tags: Research Source Type: research
Genomic mining of Vibrio parahaemolyticus highlights prevalence of antimicrobial resistance genes and new genetic markers associated with AHPND and tdh + /trh + genotypes
Acute Hepatopancreatic Necrosis Disease (AHPND) causes significant mortality in shrimp aquaculture. The infection is primarily instigated by Vibrio parahaemolyticus (Vp) strains carrying a plasmid encoding the bi... (Source: BMC Genomics)
Source: BMC Genomics - February 14, 2024 Category: Genetics & Stem Cells Authors: Marieke Vandeputte, Sieglinde Coppens, Peter Bossier, Nick Vereecke and Daisy Vanrompay Tags: Research Source Type: research
