TNF-{alpha}-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging
Aging and chronic inflammation are independent risk factors for the development of atherothrombosis and cardiovascular disease. We hypothesized that aging-associated inflammation promotes the development of platelet hyperreactivity and increases thrombotic risk during aging. Functional platelet studies in aged-frail adults and old mice demonstrated that their platelets are hyperreactive and form larger thrombi. We identified tumor necrosis factor α (TNF-α) as the key aging-associated proinflammatory cytokine responsible for platelet hyperreactivity. We further showed that platelet hyperreactivity is neutralized...
Source: Blood - August 28, 2019 Category: Hematology Authors: Davizon-Castillo, P., McMahon, B., Aguila, S., Bark, D., Ashworth, K., Allawzi, A., Campbell, R. A., Montenont, E., Nemkov, T., DAlessandro, A., Clendenen, N., Shih, L., Sanders, N. A., Higa, K., Cox, A., Padilla-Romo, Z., Hernandez, G., Wartchow, E., Tra Tags: Plenary Papers, Platelets and Thrombopoiesis Source Type: research
APC ameliorates pulmonary complications in cGVHD
(Source: Blood)
Source: Blood - August 28, 2019 Category: Hematology Authors: Afshar-Kharghan, V. Tags: Free Research Articles COMMENTS Source Type: research
Platelet hyperreactivity: a new twist in old mice
(Source: Blood)
Source: Blood - August 28, 2019 Category: Hematology Authors: Podrez, E. A. Tags: Free Research Articles COMMENTS Source Type: research
Steele AJ, Prentice AG, Hoffbrand AV, et al. 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood. 2009;114(6):1217-1225.
(Source: Blood)
Source: Blood - August 21, 2019 Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research
Abnormal mast cells in myeloid neoplasm with eosinophilia and PDGFRB rearrangement
(Source: Blood)
Source: Blood - August 21, 2019 Category: Hematology Authors: Bourrienne, M.-C., Debus, J. Tags: Free Research Articles, BloodWork, Myeloid Neoplasia BLOOD WORK Source Type: research
Cutaneous composite small lymphocytic lymphoma and primary cutaneous follicle center lymphoma
(Source: Blood)
Source: Blood - August 21, 2019 Category: Hematology Authors: Wang, H.-Y., Hinds, B. R. Tags: Free Research Articles, BloodWork, Lymphoid Neoplasia BLOOD WORK Source Type: research
Daratumumab eradicates minimal residual disease in a preclinical model of pediatric T-cell acute lymphoblastic leukemia
(Source: Blood)
Source: Blood - August 21, 2019 Category: Hematology Authors: Vogiatzi, F., Winterberg, D., Lenk, L., Buchmann, S., Cario, G., Schrappe, M., Peipp, M., Richter-Pechanska, P., Kulozik, A. E., Lentes, J., Bergmann, A. K., Valerius, T., Frielitz, F.-S., Kellner, C., Schewe, D. M. Tags: Pediatric Hematology, Lymphoid Neoplasia Letter to Blood Source Type: research
Single-cell MYD88 sequencing of isolated B cells from vitreous biopsies aids vitreoretinal lymphoma diagnosis
(Source: Blood)
Source: Blood - August 21, 2019 Category: Hematology Authors: Tan, W. J., Wang, M. M., Ricciardi-Castagnoli, P., Tang, T., Chee, S. P., Lim, T. S., Chan, A. S. Y. Tags: Lymphoid Neoplasia Letter to Blood Source Type: research
NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition
We present a high-resolution structure and dynamics of Ixolaris and describe the structural basis for recognition of FX. Ixolaris consists of 2 Kunitz domains (K1 and K2) in which K2 is strikingly dynamic and encompasses several residues involved in FX binding. This indicates that the backbone plasticity of K2 is critical for Ixolaris biological activity. Notably, a nuclear magnetic resonance–derived model reveals a mechanism for an electrostatically guided, high-affinity interaction between Ixolaris and FX heparin-binding (pro)exosite, resulting in an allosteric switch in the catalytic site. This is the first report...
Source: Blood - August 21, 2019 Category: Hematology Authors: De Paula, V. S., Sgourakis, N. G., Francischetti, I. M. B., Almeida, F. C. L., Monteiro, R. Q., Valente, A. P. Tags: Thrombosis and Hemostasis Source Type: research
Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia
We examined the impact of epitype in 1286 CLL patients from 4 independent cohorts representing a comprehensive view of CLL disease course and therapies. We found that epitype significantly predicted TTFT and OS among newly diagnosed CLL patients. Additionally, epitype predicted TTP and OS with 2 common CLL therapies: chemoimmunotherapy and ibrutinib. Epitype retained significance after stratifying by biologically related biomarkers, immunoglobulin heavy chain mutational status, and ZAP70 expression, as well as other common prognostic markers. Furthermore, among several biological traits enriched between epitypes, we found ...
Source: Blood - August 21, 2019 Category: Hematology Authors: Giacopelli, B., Zhao, Q., Ruppert, A. S., Agyeman, A., Weigel, C., Wu, Y.-Z., Gerber, M. M., Rabe, K. G., Larson, M. C., Lu, J., Blachly, J. S., Rogers, K. A., Wierda, W. G., Brown, J. R., Rai, K. R., Keating, M., Rassenti, L. Z., Kipps, T. J., Zenz, T., Tags: Lymphoid Neoplasia Source Type: research
Multicenter analysis of outcomes in blastic plasmacytoid dendritic cell neoplasm offers a pretargeted therapy benchmark
This study highlights poor outcomes for patients with BPDCN in the modern era and the need for new treatments. Outcomes from ongoing clinical trials for BPDCN can be evaluated relative to this contemporary cohort. (Source: Blood)
Source: Blood - August 21, 2019 Category: Hematology Authors: Taylor, J., Haddadin, M., Upadhyay, V. A., Grussie, E., Mehta-Shah, N., Brunner, A. M., Louissaint, A., Lovitch, S. B., Dogan, A., Fathi, A. T., Stone, R. M., Tallman, M. S., Rampal, R. K., Neuberg, D. S., Stevenson, K. E., Horwitz, S. M., Lane, A. A. Tags: Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
Subcutaneous delivery of daratumumab in relapsed or refractory multiple myeloma
This study was registered at www.clinicaltrials.gov as #NCT02519452. (Source: Blood)
Source: Blood - August 21, 2019 Category: Hematology Authors: Usmani, S. Z., Nahi, H., Mateos, M.-V., van de Donk, N. W. C. J., Chari, A., Kaufman, J. L., Moreau, P., Oriol, A., Plesner, T., Benboubker, L., Hellemans, P., Masterson, T., Clemens, P. L., Luo, M., Liu, K., San-Miguel, J. Tags: Multiple Myeloma, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
ETV6-related thrombocytopenia and leukemia predisposition
Germ line mutations in ETV6 are responsible for a familial thrombocytopenia and leukemia predisposition syndrome. Thrombocytopenia is almost completely penetrant and is usually mild. Leukemia is reported in ~30% of carriers and is most often B-cell acute lymphoblastic leukemia. The mechanisms by which ETV6 dysfunction promotes thrombocytopenia and leukemia remain unclear. Care for individuals with ETV6-related thrombocytopenia and leukemia predisposition includes genetic counseling, treatment or prevention of excessive bleeding and surveillance for the development of hematologic malignancy. (Source: Blood)
Source: Blood - August 21, 2019 Category: Hematology Authors: Di Paola, J., Porter, C. C. Tags: Thrombocytopenia, Myeloid Neoplasia, Platelets and Thrombopoiesis, Lymphoid Neoplasia, Blood Spotlight Source Type: research
Ticks provide insight into human coagulation
(Source: Blood)
Source: Blood - August 21, 2019 Category: Hematology Authors: Wood, J. P. Tags: Free Research Articles COMMENTS Source Type: research
Oral arsenic for acute promyelocytic leukemia
(Source: Blood)
Source: Blood - August 14, 2019 Category: Hematology Tags: Free Research Articles, CME article CONTINUING MEDICAL EDUCATION (CME) QUESTIONS Source Type: research
