Li-Fraumeni syndrome presenting as precursor B lymphoblastic leukemia mimicking intravascular large B-cell lymphoma
(Source: Blood)
Source: Blood - September 18, 2019 Category: Hematology Authors: Khatri, S. S., Kim, A. S. Tags: Free Research Articles, BloodWork, Lymphoid Neoplasia BLOOD WORK Source Type: research
Posttransplant lymphoproliferative disorder: EBV- plasma cell myeloma with large multinucleated plasma cells
(Source: Blood)
Source: Blood - September 18, 2019 Category: Hematology Authors: Annunziata, J. F., Bhagat, G. Tags: Hematopoiesis and Stem Cells, Transplantation, Free Research Articles, BloodWork BLOOD WORK Source Type: research
Recurrent somatic JAK3 mutations in NK-cell enteropathy
(Source: Blood)
Source: Blood - September 18, 2019 Category: Hematology Authors: Xiao, W., Gupta, G. K., Yao, J., Jang, Y. J., Xi, L., Baik, J., Sigler, A., Kumar, A., Moskowitz, A. J., Arcila, M. E., Raffeld, M., Pittaluga, S., Dogan, A., Jaffe, E. S. Tags: Lymphoid Neoplasia Letter to Blood Source Type: research
Hypertension is a modifiable risk factor for osteonecrosis in acute lymphoblastic leukemia
(Source: Blood)
Source: Blood - September 18, 2019 Category: Hematology Authors: Janke, L. J., Van Driest, S. L., Portera, M. V., Atreya, R. V., Denny, J. C., Pei, D., Cheng, C., Kaste, S. C., Inaba, H., Jeha, S., Pui, C.-H., Relling, M. V., Karol, S. E. Tags: Lymphoid Neoplasia, Clinical Trials and Observations Letter to Blood Source Type: research
Proximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of von Willebrand factor secretion
Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular hemostasis and local inflammation. Endothelial activation triggers rapid exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rolling (P-selectin) and platelet capture (von Willebrand factor [VWF]). Despite its role as an important secretory organelle, a comprehensive compilation of factors associated with WPB has not been carried out. We addressed this via a proximity proteomics approach employing the peroxidase APEX2 coupled with 2 known WPB-associated prote...
Source: Blood - September 18, 2019 Category: Hematology Authors: Holthenrich, A., Drexler, H. C. A., Chehab, T., Nass, J., Gerke, V. Tags: Thrombosis and Hemostasis, Vascular Biology, Brief Reports Source Type: research
Venous stasis-induced fibrinolysis prevents thrombosis in mice: role of {alpha}2-antiplasmin
We examined the relationship between stasis, fibrinolysis, and the development of experimental venous thrombosis. Effects of stasis-induced deep vein thrombosis and fibrinolysis on thrombosis were examined by inferior vena cava ligation in congenic mice with and without α2-antiplasmin (α2AP), the primary inhibitor of plasmin. Venous thrombus weights were measured and thrombus composition was determined by Martius scarlet blue and immunofluorescence staining. Venous thrombi from α2AP+/+ mice contained plasminogen activators, plasminogen activator inhibitor-1, plasminogen, and α2AP, which changed with...
Source: Blood - September 18, 2019 Category: Hematology Authors: Singh, S., Houng, A. K., Reed, G. L. Tags: Thrombosis and Hemostasis Source Type: research
Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk
Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematologica...
Source: Blood - September 18, 2019 Category: Hematology Authors: Sud, A., Chattopadhyay, S., Thomsen, H., Sundquist, K., Sundquist, J., Houlston, R. S., Hemminki, K. Tags: Pediatric Hematology, Free Research Articles, Myeloid Neoplasia, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia
By combining the analysis of mutations with aberrant expression of genes previously related to poorer prognosis in both acute promyelocytic leukemia (APL) and acute myeloid leukemia, we arrived at an integrative score in APL (ISAPL) and demonstrated its relationship with clinical outcomes of patients treated with all-trans retinoic acid (ATRA) in combination with anthracycline-based chemotherapy. Based on fms-like tyrosine kinase-3–internal tandem duplication mutational status; the Np73/TAp73 expression ratio; and ID1, BAALC, ERG, and KMT2E gene expression levels, we modeled ISAPL in 159 patients (median ISAPL score,...
Source: Blood - September 18, 2019 Category: Hematology Authors: Lucena-Araujo, A. R., Coelho-Silva, J. L., Pereira-Martins, D. A., Silveira, D. R., Koury, L. C., Melo, R. A. M., Bittencourt, R., Pagnano, K., Pasquini, R., Nunes, E. C., Fagundes, E. M., Gloria, A. B., Kerbauy, F., de Lourdes Chauffaille, M., Bendit, I. Tags: Myeloid Neoplasia Source Type: research
High frequency of inactivating tetraspanin CD37 mutations in diffuse large B-cell lymphoma at immune-privileged sites
This study provides novel insight into the molecular pathogenesis of IP-DLBCL and indicates that anti-CD37 therapies will be more beneficial for DLBCL patients without CD37 mutations. (Source: Blood)
Source: Blood - September 18, 2019 Category: Hematology Authors: Elfrink, S., de Winde, C. M., van den Brand, M., Berendsen, M., Roemer, M. G. M., Arnold, F., Janssen, L., van der Schaaf, A., Jansen, E., Groenen, P. J. T. A., Eijkelenboom, A., Stevens, W., Hess, C. J., van Krieken, J. H., Vermaat, J. S. P., Cleven, A. Tags: Lymphoid Neoplasia, Brief Reports Source Type: research
GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia
In conclusion, AuSCT may still have a role in FR and IR MRD-negative categories. In the IR MRD-positive category, AlloSCT prolongs OS and DFS to equal those of the FR category. Using all the available sources of stem cells, AlloSCT was delivered to 71% of the candidates.This trial was registered at www.clinicaltrials.gov as #NCT01452646 and EudraCT as #2010-023809-36. (Source: Blood)
Source: Blood - September 18, 2019 Category: Hematology Authors: Venditti, A., Piciocchi, A., Candoni, A., Melillo, L., Calafiore, V., Cairoli, R., de Fabritiis, P., Storti, G., Salutari, P., Lanza, F., Martinelli, G., Luppi, M., Mazza, P., Martelli, M. P., Cuneo, A., Albano, F., Fabbiano, F., Tafuri, A., Chierichini, Tags: Myeloid Neoplasia, Clinical Trials and Observations Source Type: research
Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR
Allogeneic hematopoietic cell transplantation involves consideration of both donor and recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution donor–recipient HLA match is of primary importance in transplantation with adult unrelated donors, using conventional graft-versus-host disease prophylaxis. In cord blood transplantation, optimal unit selection requires consideration of unit quality, cell dose and HLA-match. In this summary, the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow Transplant Research, jointly with the NMDP Histocompatib...
Source: Blood - September 18, 2019 Category: Hematology Authors: Dehn, J., Spellman, S., Hurley, C. K., Shaw, B. E., Barker, J. N., Burns, L. J., Confer, D. L., Eapen, M., Fernandez-Vina, M., Hartzman, R., Maiers, M., Marino, S. R., Mueller, C., Perales, M.-A., Rajalingam, R., Pidala, J. Tags: Special Reports, Transplantation, Free Research Articles, CME article Source Type: research
Sepsis alters the transcriptional and translational landscape of human and murine platelets
There is increasing recognition that platelets have a functional role in the pathophysiology of sepsis, though this role has not been precisely defined. Whether sepsis alters the human platelet transcriptome and translational landscape has never been established. We used parallel techniques of RNA sequencing and ribosome footprint profiling to interrogate the platelet transcriptome and translatome in septic patients and healthy donors. We identified 1806 significantly differentially expressed (false discovery rate <0.05) transcripts in platelets from septic patients. Platelet translational events during sepsis were also...
Source: Blood - September 18, 2019 Category: Hematology Authors: Middleton, E. A., Rowley, J. W., Campbell, R. A., Grissom, C. K., Brown, S. M., Beesley, S. J., Schwertz, H., Kosaka, Y., Manne, B. K., Krauel, K., Tolley, N. D., Eustes, A. S., Guo, L., Paine, R., Harris, E. S., Zimmerman, G. A., Weyrich, A. S., Rondina, Tags: Plenary Papers, Platelets and Thrombopoiesis Source Type: research
WPBs: making a mark and leaving a trail
(Source: Blood)
Source: Blood - September 18, 2019 Category: Hematology Authors: Carter, T., Bierings, R. Tags: Free Research Articles COMMENTS Source Type: research
Martin P, Bartlett NL, Blum KA, et al. A phase 1 trial of ibrutinib plus palbociclib in previously treated mantle cell lymphoma. Blood. 2019;133(11):1201-1204.
(Source: Blood)
Source: Blood - September 11, 2019 Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research
Pay attention to neutrophil inclusions in pediatric patients with thrombocytopenia
(Source: Blood)
Source: Blood - September 11, 2019 Category: Hematology Authors: Iqbal, N. T., Li, W. Tags: Free Research Articles, BloodWork, Platelets and Thrombopoiesis BLOOD WORK Source Type: research
